Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + glycogen synthase kinase-3beta
ADP + phosphorylated glycogen synthase kinase-3beta
-
-
-
?
ATP + a protein
ADP + a phosphoprotein
-
-
-
-
?
ATP + BAD protein
ADP + BAD phosphoprotein
-
phosphorylation on Ser155 by PKG I
-
-
?
ATP + big potassium channel BKCa
ADP + phosphorylated big potassium channel BKCa
ATP + cysteine-riche protein 2
ADP + phosphorylated vasodilator-stimulated phosphoprotein
-
i.e. CRP2, phosphorylation by cGKI and cGKII
-
-
?
ATP + EKRKRTYETF
ADP + phosphorylated EKRKRTYETF
-
p65-derived synthetic peptide substrate
-
-
?
ATP + FoxO1a
ADP + phosphorylated FoxO1a
ATP + Glasstide
ADP + phosphorylated Glasstide
-
-
-
-
?
ATP + GSK-3beta protein
ADP + GSK-3beta phosphoprotein
-
the enzyme phosphorylates GSK-3beta at serine-9 and inactivates it leading to the accumulation of beta-catenin and promoting the process of decidualization
-
-
?
ATP + histone H1
ADP + phosphorylated histone H1
-
-
-
-
?
ATP + IRAG
ADP + phosphorylated IRAG
ATP + Kemptide
ADP + phosphorylated Kemptide
-
i.e. LRRASLG
i.e. LRRA-phosphoserine-LG
-
?
ATP + MQLRRPSDRE
ADP + phosphorylated MQLRRPSDRE
-
p65-derived synthetic peptide substrate
-
-
?
ATP + NF-kappaB
ADP + phosphorylated NF-kappaB
-
recombinant human NF-kappaB p49 and p50 expressed in 293T cells
-
-
?
ATP + p65
ADP + phosphorylated p65
-
activity with recombinant wild-type p65 and mutants T305A and S276A
-
-
?
ATP + phospholamban
ADP + phosphorylated phospholamban
ATP + protein
ADP + phosphoprotein
autophosphorylation
-
-
?
ATP + Rho
ADP + phosphorylated rho
ATP + serine/threonine protein
ADP + serine/threonine phosphorylated protein
-
-
-
-
?
ATP + vasodilator-stimulated phosphoprotein
ADP + phosphorylated vasodilator-stimulated phosphoprotein
ATP + VASP protein
ADP + phosphorylated VASP protein
-
-
-
-
?
additional information
?
-
ATP + big potassium channel BKCa
ADP + phosphorylated big potassium channel BKCa
-
phosphorylation by cGKI leads to activation of the channel, a mechanism leading to Ca2+-dependent smooth muscle relaxation
-
-
?
ATP + big potassium channel BKCa
ADP + phosphorylated big potassium channel BKCa
-
phosphorylation by cGKI
-
-
?
ATP + FoxO1a
ADP + phosphorylated FoxO1a
-
interaction of enzyme with FocO1a is involved in regulation of myoblast cell fusion during myogenesis
-
-
?
ATP + FoxO1a
ADP + phosphorylated FoxO1a
-
enzyme expression is activated by FoxO1a which is then phosphorylated by cGKI for feedback inhibition of FoxO1a DNA binding, phosphorylation of Ser152-155 and Ser184, and weakly of Ser266 and Ser268
-
-
?
ATP + IRAG
ADP + phosphorylated IRAG
-
phosphorylation by cGKIbeta mediates the inhibition of inositol-1,4,5-trisphosphate-dependent Ca2+-release, one mechanism leading to smooth muscle relaxation, involved in platelet aggregation
-
-
?
ATP + IRAG
ADP + phosphorylated IRAG
-
i.e. inositol-1,4,5-trisphosphate-receptor-associated cGMP kinase substrate, phosphorylation by cGKIbeta
-
-
?
ATP + phospholamban
ADP + phosphorylated phospholamban
-
-
-
-
?
ATP + phospholamban
ADP + phosphorylated phospholamban
-
phosphorylation leads to stimulation of the sarcoendoplasmic reticulum pump Ca2+-ATPase, i.e. SERCA
-
-
?
ATP + Rho
ADP + phosphorylated rho
-
phosphorylation leads to inhibition of Rho
-
-
?
ATP + Rho
ADP + phosphorylated rho
-
a small GTP-binding protein, cGKI
-
-
?
ATP + vasodilator-stimulated phosphoprotein
ADP + phosphorylated vasodilator-stimulated phosphoprotein
-
-
-
-
?
ATP + vasodilator-stimulated phosphoprotein
ADP + phosphorylated vasodilator-stimulated phosphoprotein
-
i.e. VASP, phosphorylation at Ser239 by cGKI
-
-
?
additional information
?
-
-
cGK is a key enzyme in the nitric oxide-cGMP and natriuretic signalling cascades, it modulates smooth muscle relaxation, platelet aggregation, renin release, intestinal secretion, learning amd memory, cGKII is involved in androsterone homeostasis, pleiotropic effets of the enzyme on diverse tissues, overview
-
-
?
additional information
?
-
-
cGKI mediates NO signaling and plays a proatherogenic role in vascular smooth muscle cells, enzyme activation in primary smoothe muscle cells results in increased levels of proliferation and vascular cell adhesion molecule-1, peroxisome proliferato-activated receptor gamma, and phosphatidylinositol 3-kinase/Akt signaling, and in decreased plasminogen activator inhibitor 1 mRNA, overview
-
-
?
additional information
?
-
-
PKGII modulates mPer1 and mPer2 gene induction, not by phosphorylation of CREB at Ser133, and influences phase shifts of the circadian clock, regulation model, overview
-
-
?
additional information
?
-
-
sequential activation of p38 and ERK pathways by the enzyme leading to activation of the platelet integrin alphaIIb beta3
-
-
?
additional information
?
-
-
the enzyme mediates an exocytosis pathway via glycoprotein Ib-IX, and an aggregation-dependent platelet secretion pathway important for amplifying platelet activation, in stabilizing thrombi, and in arteriosclerosis and vascular remodeling, signaling mechanism activating the enzyme, overview
-
-
?
additional information
?
-
-
the enzyme mediates NO- but not acetylcholine-induced dilations in resistance vessels in vivo
-
-
?
additional information
?
-
-
the enzyme performs autophosphorylation at serines 110, 114, 117, 126, and 445 and at Thr109 in vitro and in vivo
-
-
?
additional information
?
-
-
no activity with the cAMP-responsive element binding protein, i.e. CREB
-
-
?
additional information
?
-
-
cGMP-activated PKGI inhibits TAB1-p38 mitogen-activated protein kinase apoptosis signaling in cardiac myocytes and protects them from ischemia and reperfusion injury, cGMP-activated PKG I does not inhibit MKK3- and MKK6-p38 MAPK signaling, overview
-
-
?
additional information
?
-
the cGMP/cGMP-dependent protein kinase I signaling pathway plays an important role in spinal nociceptive processing and interacts with cysteine-rich protein 2
-
-
?
additional information
?
-
-
PKG phosphorylates several substrates and interacts, by engaging its N-terminal, with numerous proteins
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + a protein
ADP + a phosphoprotein
-
-
-
-
?
ATP + BAD protein
ADP + BAD phosphoprotein
-
phosphorylation on Ser155 by PKG I
-
-
?
ATP + big potassium channel BKCa
ADP + phosphorylated big potassium channel BKCa
-
phosphorylation by cGKI leads to activation of the channel, a mechanism leading to Ca2+-dependent smooth muscle relaxation
-
-
?
ATP + cysteine-riche protein 2
ADP + phosphorylated vasodilator-stimulated phosphoprotein
-
i.e. CRP2, phosphorylation by cGKI and cGKII
-
-
?
ATP + FoxO1a
ADP + phosphorylated FoxO1a
-
interaction of enzyme with FocO1a is involved in regulation of myoblast cell fusion during myogenesis
-
-
?
ATP + GSK-3beta protein
ADP + GSK-3beta phosphoprotein
-
the enzyme phosphorylates GSK-3beta at serine-9 and inactivates it leading to the accumulation of beta-catenin and promoting the process of decidualization
-
-
?
ATP + IRAG
ADP + phosphorylated IRAG
-
phosphorylation by cGKIbeta mediates the inhibition of inositol-1,4,5-trisphosphate-dependent Ca2+-release, one mechanism leading to smooth muscle relaxation, involved in platelet aggregation
-
-
?
ATP + phospholamban
ADP + phosphorylated phospholamban
-
phosphorylation leads to stimulation of the sarcoendoplasmic reticulum pump Ca2+-ATPase, i.e. SERCA
-
-
?
ATP + Rho
ADP + phosphorylated rho
-
phosphorylation leads to inhibition of Rho
-
-
?
ATP + vasodilator-stimulated phosphoprotein
ADP + phosphorylated vasodilator-stimulated phosphoprotein
-
-
-
-
?
ATP + VASP protein
ADP + phosphorylated VASP protein
-
-
-
-
?
additional information
?
-
additional information
?
-
-
cGK is a key enzyme in the nitric oxide-cGMP and natriuretic signalling cascades, it modulates smooth muscle relaxation, platelet aggregation, renin release, intestinal secretion, learning amd memory, cGKII is involved in androsterone homeostasis, pleiotropic effets of the enzyme on diverse tissues, overview
-
-
?
additional information
?
-
-
cGKI mediates NO signaling and plays a proatherogenic role in vascular smooth muscle cells, enzyme activation in primary smoothe muscle cells results in increased levels of proliferation and vascular cell adhesion molecule-1, peroxisome proliferato-activated receptor gamma, and phosphatidylinositol 3-kinase/Akt signaling, and in decreased plasminogen activator inhibitor 1 mRNA, overview
-
-
?
additional information
?
-
-
PKGII modulates mPer1 and mPer2 gene induction, not by phosphorylation of CREB at Ser133, and influences phase shifts of the circadian clock, regulation model, overview
-
-
?
additional information
?
-
-
sequential activation of p38 and ERK pathways by the enzyme leading to activation of the platelet integrin alphaIIb beta3
-
-
?
additional information
?
-
-
the enzyme mediates an exocytosis pathway via glycoprotein Ib-IX, and an aggregation-dependent platelet secretion pathway important for amplifying platelet activation, in stabilizing thrombi, and in arteriosclerosis and vascular remodeling, signaling mechanism activating the enzyme, overview
-
-
?
additional information
?
-
-
the enzyme mediates NO- but not acetylcholine-induced dilations in resistance vessels in vivo
-
-
?
additional information
?
-
-
the enzyme performs autophosphorylation at serines 110, 114, 117, 126, and 445 and at Thr109 in vitro and in vivo
-
-
?
additional information
?
-
-
cGMP-activated PKGI inhibits TAB1-p38 mitogen-activated protein kinase apoptosis signaling in cardiac myocytes and protects them from ischemia and reperfusion injury, cGMP-activated PKG I does not inhibit MKK3- and MKK6-p38 MAPK signaling, overview
-
-
?
additional information
?
-
the cGMP/cGMP-dependent protein kinase I signaling pathway plays an important role in spinal nociceptive processing and interacts with cysteine-rich protein 2
-
-
?
additional information
?
-
-
PKG phosphorylates several substrates and interacts, by engaging its N-terminal, with numerous proteins
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Uhler, M.D.
Cloning and expression of a novel cyclic GMP-dependent protein kinase from mouse brain
J. Biol. Chem.
268
13586-13591
1993
Mus musculus (Q61410), Mus musculus
brenda
Collins, S.P.; Uhler, M.D.
Cyclic AMP- and cyclic GMP-dependent protein kinases differ in their regulation of cyclic AMP response element-dependent gene transcription
J. Biol. Chem.
274
8391-8404
1999
Mus musculus (P0C605)
brenda
Li, Z.; Zhang, G.; Feil, R.; Han, J.; Du, X.
Sequential activation of p38 and ERK pathways by cGMP-dependent protein kinase leading to activation of the platelet integrin alphaIIb beta3
Blood
107
965-972
2006
Homo sapiens, Mus musculus
brenda
Oster, H.; Werner, C.; Magnone, M.C.; Mayser, H.; Feil, R.; Seeliger, M.W.; Hofmann, F.; Albrecht, U.
cGMP-dependent protein kinase II modulates mPer1 and mPer2 gene induction and influences phase shifts of the circadian clock
Curr. Biol.
13
725-733
2003
Mus musculus
brenda
Schlossmann, J.; Hofmann, F.
cGMP-dependent protein kinases in drug discovery
Drug Discov. Today
10
627-634
2005
Homo sapiens, Mus musculus, Rattus norvegicus
brenda
He, B.; Weber, G.F.
Phosphorylation of NF-kappaB proteins by cyclic GMP-dependent kinase. A noncanonical pathway to NF-kappaB activation
Eur. J. Biochem.
270
2174-2185
2003
Bos taurus, Mus musculus
brenda
Koeppen, M.; Feil, R.; Siegl, D.; Feil, S.; Hofmann, F.; Pohl, U.; de Wit, C.
cGMP-dependent protein kinase mediates NO- but not acetylcholine-induced dilations in resistance vessels in vivo
Hypertension
44
952-955
2004
Mus musculus
brenda
Vaandrager, A.B.; Hogema, B.M.; Edixhoven, M.; van den Burg, C.M.; Bot, A.G.; Klatt, P.; Ruth, P.; Hofmann, F.; Van Damme, J.; Vandekerckhove, J.; de Jonge, H.R.
Autophosphorylation of cGMP-dependent protein kinase type II
J. Biol. Chem.
278
28651-28658
2003
Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Li, Z.; Zhang, G.; Marjanovic, J.A.; Ruan, C.; Du, X.
A platelet secretion pathway mediated by cGMP-dependent protein kinase
J. Biol. Chem.
279
42469-42475
2004
Homo sapiens, Mus musculus
brenda
Bois, P.R.; Brochard, V.F.; Salin-Cantegrel, A.V.; Cleveland, J.L.; Grosveld, G.C.
FoxO1a-cyclic GMP-dependent kinase I interactions orchestrate myoblast fusion
Mol. Cell. Biol.
25
7645-7656
2005
Mus musculus
brenda
Feil, S.; Zimmermann, P.; Knorn, A.; Brummer, S.; Schlossmann, J.; Hofmann, F.; Feil, R.
Distribution of cGMP-dependent protein kinase type I and its isoforms in the mouse brain and retina
Neuroscience
135
863-868
2005
Mus musculus
brenda
Wolfsgruber, W.; Feil, S.; Brummer, S.; Kuppinger, O.; Hofmann, F.; Feil, R.
A proatherogenic role for cGMP-dependent protein kinase in vascular smooth muscle cells
Proc. Natl. Acad. Sci. USA
100
13519-13524
2003
Mus musculus
brenda
Fiedler, B.; Feil, R.; Hofmann, F.; Willenbockel, C.; Drexler, H.; Smolenski, A.; Lohmann, S.M.; Wollert, K.C.
cGMP-dependent protein kinase type I inhibits TAB1-p38 mitogen-activated protein kinase apoptosis signaling in cardiac myocytes
J. Biol. Chem.
281
32831-32840
2006
Mus musculus, Mus musculus C57BL/6, Rattus norvegicus
brenda
Yuasa, K.; Yamagami, S.; Nagahama, M.; Tsuji, A.
Trafficking of cGMP-dependent protein kinase II via interaction with Rab11
Biochem. Biophys. Res. Commun.
374
522-526
2008
Mus musculus
brenda
Kawasaki, Y.; Kugimiya, F.; Chikuda, H.; Kamekura, S.; Ikeda, T.; Kawamura, N.; Saito, T.; Shinoda, Y.; Higashikawa, A.; Yano, F.; Ogasawara, T.; Ogata, N.; Hoshi, K.; Hofmann, F.; Woodgett, J.R.; Nakamura, K.; Chung, U.I.; Kawaguchi, H.
Phosphorylation of GSK-3beta by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes
J. Clin. Invest.
118
2506-2515
2008
Mus musculus (Q61410), Mus musculus
brenda
Schmidtko, A.; Gao, W.; Sausbier, M.; Rauhmeier, I.; Sausbier, U.; Niederberger, E.; Scholich, K.; Huber, A.; Neuhuber, W.; Allescher, H.D.; Hofmann, F.; Tegeder, I.; Ruth, P.; Geisslinger, G.
Cysteine-rich protein 2, a novel downstream effector of cGMP/cGMP-dependent protein kinase I-mediated persistent inflammatory pain
J. Neurosci.
28
1320-1330
2008
Mus musculus (P0C605)
brenda
Schmidtko, A.; Gao, W.; Koenig, P.; Heine, S.; Motterlini, R.; Ruth, P.; Schlossmann, J.; Koesling, D.; Niederberger, E.; Tegeder, I.; Friebe, A.; Geisslinger, G.
cGMP produced by NO-sensitive guanylyl cyclase essentially contributes to inflammatory and neuropathic pain by using targets different from cGMP-dependent protein kinase I
J. Neurosci.
28
8568-8576
2008
Mus musculus (P0C605), Mus musculus
brenda
Wang, S.; Li, Y.
Expression of constitutively active cGMP-dependent protein kinase inhibits glucose-induced vascular smooth muscle cell proliferation
Am. J. Physiol. Heart Circ. Physiol.
297
H2075-H2083
2009
Bos taurus, Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Nickl, C.K.; Raidas, S.K.; Zhao, H.; Sausbier, M.; Ruth, P.; Tegge, W.; Brayden, J.E.; Dostmann, W.R.
(D)-Amino acid analogues of DT-2 as highly selective and superior inhibitors of cGMP-dependent protein kinase Ialpha
Biochim. Biophys. Acta
1804
524-532
2010
Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Valtcheva, N.; Nestorov, P.; Beck, A.; Russwurm, M.; Hillenbrand, M.; Weinmeister, P.; Feil, R.
The commonly used cGMP-dependent protein kinase type I (cGKI) inhibitor Rp-8-Br-PET-cGMPS can activate cGKI in vitro and in intact cells
J. Biol. Chem.
284
556-562
2009
Bos taurus, Mus musculus
brenda
Sellak, H.; Choi, C.S.; Dey, N.B.; Lincoln, T.M.
Transcriptional and post-transcriptional regulation of cGMP-dependent protein kinase (PKG-I): pathophysiological significance
Cardiovasc. Res.
97
200-207
2013
Bos taurus, Oryctolagus cuniculus, Ovis aries, Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
brenda
Lee, J.H.; Li, S.; Liu, T.; Hsu, S.; Kim, C.; Woods, V.L.; Casteel, D.E.
The amino terminus of cGMP-dependent protein kinase Ibeta increases the dynamics of the proteins cGMP-binding pockets
Int. J. Mass Spectrom.
302
44-52
2011
Mus musculus
brenda
Leiss, V.; Illison, J.; Domes, K.; Hofmann, F.; Lukowski, R.
Expression of cGMP-dependent protein kinase type I in mature white adipocytes
Biochem. Biophys. Res. Commun.
452
151-156
2014
Mus musculus
brenda
Wang, R.; Kwon, I.K.; Singh, N.; Islam, B.; Liu, K.; Sridhar, S.; Hofmann, F.; Browning, D.D.
Type 2 cGMP-dependent protein kinase regulates homeostasis by blocking c-Jun N-terminal kinase in the colon epithelium
Cell Death Differ.
21
427-437
2014
Mus musculus
brenda
Vallur, R.; Kalbacher, H.; Feil, R.
Catalytic activity of cGMP-dependent protein kinase type I in intact cells is independent of N-terminal autophosphorylation
PLoS ONE
9
e98946
2014
Mus musculus
brenda
Patrucco, E.; Domes, K.; Sbroggio, M.; Blaich, A.; Schlossmann, J.; Desch, M.; Rybalkin, S.D.; Beavo, J.A.; Lukowski, R.; Hofmann, F.
Roles of cGMP-dependent protein kinase I (cGKI) and PDE5 in the regulation of Ang II-induced cardiac hypertrophy and fibrosis
Proc. Natl. Acad. Sci. USA
111
12925-12929
2014
Mus musculus (Q8I719), Mus musculus
brenda
Zhang, Y.; Yan, L.; Liu, J.; Cui, S.; Qiu, J.
cGMP-dependent protein kinase II determines beta-catenin accumulation that is essential for uterine decidualization in mice
Am. J. Physiol. Cell Physiol.
317
C1115-C1127
2019
Mus musculus
brenda
Kalyanaraman, H.; Zhuang, S.; Pilz, R.B.; Casteel, D.E.
The activity of cGMP-dependent protein kinase Ialpha is not directly regulated by oxidation-induced disulfide formation at cysteine 43
J. Biol. Chem.
292
8262-8268
2017
Mus musculus
brenda
Spinelli, V.; Vona, A.; Corti, F.; Diolaiuti, L.; Zanardelli, M.; Sartiani, L.; Failli, P.
Role of nitric oxide, nitric oxide synthase, soluble guanylyl cyclase, and cGMP-dependent protein kinase I in mouse stem cell cardiac development
Stem Cells Int.
2016
2868323
2016
Mus musculus
brenda