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Literature summary for 2.7.11.12 extracted from

  • Li, Z.; Zhang, G.; Marjanovic, J.A.; Ruan, C.; Du, X.
    A platelet secretion pathway mediated by cGMP-dependent protein kinase (2004), J. Biol. Chem., 279, 42469-42475.
    View publication on PubMed
Search for more literature for 2.7.11.12

Activating Compound

Activating Compound Comment Organism Structure
cGMP
-
 Mus musculus
cGMP
-
 Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information construction of PKGI knockout mutant mice, phenotype analysis, platelet secretion, platelet aggregation, and Ca2+ mobilization are affected Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
KT5823
-
 Homo sapiens
KT5823
-
 Mus musculus
additional information inhibition of PKG affects platelet secretion, platelet aggregation, and Ca2+ mobilization Homo sapiens
Rp-8-Br-PET-cGMPS
-
 Homo sapiens
Rp-8-Br-PET-cGMPS
-
 Mus musculus
Rp-8-pCPT-cGMP Rp-i.e. 8-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphate Homo sapiens
Rp-pCPT-cGMPS
-
 Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Mus musculus
Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus the enzyme mediates an exocytosis pathway via glycoprotein Ib-IX, and an aggregation-dependent platelet secretion pathway important for amplifying platelet activation, in stabilizing thrombi, and in arteriosclerosis and vascular remodeling, signaling mechanism activating the enzyme, overview ?
-
 ?
additional information Homo sapiens the enzyme mediates an exocytosis pathway via glycoprotein Ib-IX, and an aggregation-dependent platelet secretion pathway important for amplifying platelet activation, in stabilizing thrombi, and in arteriosclerosis and vascular remodeling, signaling mechanism activating the enzyme, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood platelet
-
 Mus musculus
-
blood platelet
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme mediates an exocytosis pathway via glycoprotein Ib-IX, and an aggregation-dependent platelet secretion pathway important for amplifying platelet activation, in stabilizing thrombi, and in arteriosclerosis and vascular remodeling, signaling mechanism activating the enzyme, overview Mus musculus ?
-
 ?
additional information the enzyme mediates an exocytosis pathway via glycoprotein Ib-IX, and an aggregation-dependent platelet secretion pathway important for amplifying platelet activation, in stabilizing thrombi, and in arteriosclerosis and vascular remodeling, signaling mechanism activating the enzyme, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
PKG
-
 Homo sapiens
PKGI
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus
ATP
-
 Homo sapiens