EC Number   |
General Information |
Reference |
|---|
   2.7.11.12 | evolution |
cGMP-dependent protein kinases belong to the group of serine/threonine kinases. The complete amino acid sequence of SmcGK1 indicates a greater similarity to type II cGKsof other organisms, but the sequence of SmcGK1 lacks a myristoylation motive typically found in mammalian membrane-bound cGKII, the homology to mammalian cGKII is mainly due to a high similarity of the kinase domains. SmcGK1 seems to occupy an intermediate position with respect to cGK classifications |
721270 |
| 2.7.11.12 | evolution |
cyclic GMP-dependent protein kinases constitute a small family of enzymes that are encoded by two genes |
723796 |
| 2.7.11.12 | evolution |
PKG maintains both its regulatory and catalytic elements on the same polypeptide chain.in contrast to PKA, EC 2.7.11.11 |
723780 |
| 2.7.11.12 | malfunction |
accumulation of poly-ubiquitinated PKG-I induced by hypoxia is not affected by the endogenous activation of PKG-I by a cGMP analogue, or by the endogenous inhibition of PKG-I activity via a cell-permeable inhibitor |
721982 |
| 2.7.11.12 | malfunction |
acute inhibition of cGKI prevented stimulus-evoked enhancement of BKCa channel activity |
722222 |
| 2.7.11.12 | malfunction |
acute inhibition of cGKI prevents stimulus-evoked enhancement of BKCa channel activity |
722222 |
| 2.7.11.12 | malfunction |
blockade of isoform PKG-I strongly slows cardiogenesis |
762478 |
| 2.7.11.12 | malfunction |
blocking of the enzyme stops both replication and transmission of the Plasmodium falciparum |
739520 |
| 2.7.11.12 | malfunction |
Drosophila embryos display targeting defects during axon development in the absence of the enzyme gene |
761719 |
| 2.7.11.12 | malfunction |
enzyme inhibition decreases parasite egress from hepatocytes by inhibiting either the formation or release of merosomes |
739092 |
