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Literature summary for 2.7.11.12 extracted from

  • Spinelli, V.; Vona, A.; Corti, F.; Diolaiuti, L.; Zanardelli, M.; Sartiani, L.; Failli, P.
    Role of nitric oxide, nitric oxide synthase, soluble guanylyl cyclase, and cGMP-dependent protein kinase I in mouse stem cell cardiac development (2016), Stem Cells Int., 2016, 2868323 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.12

Activating Compound

Activating Compound Comment Organism Structure
1,4:3,6-dianhydro-D-glucitol 5-nitrate isosorbide mononitrate Mus musculus
cGMP
-
 Mus musculus
S-nitroso-N-acetyl-DL-penicillamine
-
 Mus musculus
Sp-8-pCPT-PET-cGMPS the compound significantly increases protein phosphorylation by 250% Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
KT5823 selective inhibitor of isoform PKG-I Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
CGR-8 cell
-
 Mus musculus
-
embryonic stem cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + serine/threonine protein
-
 Mus musculus ADP + serine/threonine phosphorylated protein
-
 ?

Synonyms

Synonyms Comment Organism
cGMP activated protein kinase I
-
 Mus musculus
cGMP-dependent protein kinase I
-
 Mus musculus
PKG-I
-
 Mus musculus
PRKG1
-
 Mus musculus
protein kinase G type I
-
 Mus musculus

General Information

General Information Comment Organism
malfunction blockade of isoform PKG-I strongly slows cardiogenesis Mus musculus