EC Number   |
Protein Variants |
Reference |
|---|
   2.7.11.12 | C42L |
the mutant shows similar temperature factors, which are consistently lower than those of wild type dimers |
737711 |
| 2.7.11.12 | C43S |
the mutant enzyme is less responsive to cGMP-induced activation with about 5fold reduced affinity for cGMP compared to the wild type enzyme |
761478 |
| 2.7.11.12 | D412A/R415A |
the mutant shows reduced activity compared to the wild type enzyme |
738700 |
| 2.7.11.12 | D533A |
the mutant shows strongly reduced activity compared to the wild type enzyme |
739520 |
| 2.7.11.12 | E589A |
inactive |
-, 762280 |
| 2.7.11.12 | I24A |
site-directed mutagenesis, unaltered dimerization and molecular weight compared to the wild-type enzyme |
662170 |
| 2.7.11.12 | K482A |
site-directed mutagenesis, transfection of the catalytically inactive PKGII mutant inhibits aldosterone production in zona glomerulosa cells |
662148 |
| 2.7.11.12 | L17A |
site-directed mutagenesis, unaltered dimerization and molecular weight compared to the wild-type enzyme |
662170 |
| 2.7.11.12 | L17A/I24A |
site-directed mutagenesis, altered dimerization and molecular weight compared to the wild-type enzyme |
662170 |
| 2.7.11.12 | L17A/I24A/L31A/I38A/L45A/I52A |
site-directed mutagenesis, altered dimerization and molecular weight compared to the wild-type enzyme |
662170 |
