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Literature summary for 2.7.11.12 extracted from
- The activity of cGMP-dependent protein kinase Ialpha is not directly regulated by oxidation-induced disulfide formation at cysteine 43 (2017), J. Biol. Chem., 292, 8262-8268 .
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| cGMP | - |
Mus musculus |  |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in HEK-293T cells | Mus musculus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| C43S | the mutant enzyme is less responsive to cGMP-induced activation with about 5fold reduced affinity for cGMP compared to the wild type enzyme | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + Glasstide | - |
Mus musculus | ADP + phosphorylated Glasstide | - |
? | |
| ATP + histone H1 | - |
Mus musculus | ADP + phosphorylated histone H1 | - |
? | |
| ATP + VASP protein | - |
Mus musculus | ADP + phosphorylated VASP protein | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 70000, SDS-PAGE | Mus musculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| cGMP-dependent protein kinase Ialpha | - |
Mus musculus |
| PKGIalpha | - |
Mus musculus |
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