Any feedback?
Information on EC 2.7.1.49 - hydroxymethylpyrimidine kinase
for references in articles please use BRENDA:EC2.7.1.49Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
2.7.1.49 hydroxymethylpyrimidine kinaseIUBMB Comments
CTP, UTP and GTP can act as donors.
Specify your search results
Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
hmp kinase, hmppk, hmp-p kinase, sthmppk, tthmppk, hydroxymethylpyrimidine kinase, 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate kinase, 4-amino-5-hydroxymethyl-2-methylpyrimidine kinase, 
more
topPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
4-amino-5-hydroxymethyl-2-methylpyrimidine kinase
HMP kinase
HMP-P kinase
HMP/HMP phosphate kinase
HMPK
HMPPK
HVO_2666
hydroxymethylpyrimidine kinase (phosphorylating)
-
-
-
-
hydroxymethylpyrimidine phosphate kinase
SAV0580
THI3
-
the enzyme shows two essentially different enzymatic activities of 4-amino-5-hydroxymethyl-2-methylpyrimidne (phosphate) kinase and thiamine monophosphate synthase
ThiD
additional information
hydroxymethylpyrimidine phosphate kinase
-
hydroxymethylpyrimidine phosphate kinase
-
-
hydroxymethylpyrimidine phosphate kinase
-
-
additional information
-
the enzyme is probably identical with EC 2.7.4.7, 4-amino-5-hydroxymethyl-2-methylpyrimidine monophosphate kinase, or HMP-P kinase
additional information
-
the enzyme is probably identical with EC 2.7.4.7, 4-amino-5-hydroxymethyl-2-methylpyrimidine monophosphate kinase, or HMP-P kinase
-
additional information
see also EC 2.7.4.7
additional information
see also EC 2.7.4.7
-
additional information
see also EC 2.7.4.7
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
-
-
-
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
ordered sequential mechanism
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
ordered sequential mechanism
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
CTP, UTP and GTP can act as donors
-
-
-
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
ordered sequential mechanism
-
-
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
ordered sequential mechanism
-
-
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
ordered sequential mechanism
-
-
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
ordered sequential mechanism
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
PATHWAY SOURCE
PATHWAYS
BRENDA
KEGG
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYSTEMATIC NAME
IUBMB Comments
ATP:4-amino-5-hydroxymethyl-2-methylpyrimidine 5-phosphotransferase
CTP, UTP and GTP can act as donors.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CAS REGISTRY NUMBER
COMMENTARY
9026-55-5
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + 2-methyl-4-amino-5-hydroxymethylpyrimidine
ADP + 2-methyl-4-amino-5-phosphomethylpyrimidine
ATP + 2-methyl-4-amino-5-phosphomethylpyrimidine
ADP + 2-methyl-4-amino-5-diphosphomethylpyrimidine
-
the enzyme shows lower affinity to 2-methyl-4-amino-5-hydroxymethylpyrimidine monophosphate than to 2-methyl-4-amino-5-hydroxymethylpyrimidine
-
-
ir
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
ATP + 4-amino-5-hydroxy-2-methylpyrimidine
ADP + 4-amino-2-methyl-5-phosphopyrimidine
-
-
-
?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine
ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine
ADP + 4-amino-5-phosphomethyl-2-methylpyrimidine
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine
ADP + 4-amino-5-phosphonooxymethyl-2-methylpyrimidine
-
-
-
?
ATP + 4-amino-5-phosphomethyl-2-methylpyrimidine
ADP + 4-amino-5-diphosphomethyl-2-methylpyrimidine
CTP + 5-hydroxy-2-methylpyrimidine
CDP + 2-methyl-5-phosphopyrimidine
-
-
-
?
GTP + 5-hydroxy-2-methylpyrimidine
GDP + 2-methyl-5-phosphopyrimidine
-
-
-
?
UTP + 5-hydroxy-2-methylpyrimidine
UDP + 5-hydroxy-2-methylpyrimidine monophosphate
-
-
-
?
ATP + 2-methyl-4-amino-5-hydroxymethylpyrimidine
ADP + 2-methyl-4-amino-5-phosphomethylpyrimidine
-
-
-
?
ATP + 2-methyl-4-amino-5-hydroxymethylpyrimidine
ADP + 2-methyl-4-amino-5-phosphomethylpyrimidine
-
involved in thiamine biosynthetic pathway, first steps
-
?
ATP + 2-methyl-4-amino-5-hydroxymethylpyrimidine
ADP + 2-methyl-4-amino-5-phosphomethylpyrimidine
-
-
?
ATP + 2-methyl-4-amino-5-hydroxymethylpyrimidine
ADP + 2-methyl-4-amino-5-phosphomethylpyrimidine
involved in thiamine biosynthetic pathway, first steps
-
?
ATP + 2-methyl-4-amino-5-hydroxymethylpyrimidine
ADP + 2-methyl-4-amino-5-phosphomethylpyrimidine
-
-
-
?
ATP + 2-methyl-4-amino-5-hydroxymethylpyrimidine
ADP + 2-methyl-4-amino-5-phosphomethylpyrimidine
-
-
-
?
ATP + 2-methyl-4-amino-5-hydroxymethylpyrimidine
ADP + 2-methyl-4-amino-5-phosphomethylpyrimidine
-
-
?
ATP + 2-methyl-4-amino-5-hydroxymethylpyrimidine
ADP + 2-methyl-4-amino-5-phosphomethylpyrimidine
-
involved in thiamine biosynthetic pathway, first steps
-
?
ATP + 2-methyl-4-amino-5-hydroxymethylpyrimidine
ADP + 2-methyl-4-amino-5-phosphomethylpyrimidine
-
involved in thiamine biosynthetic pathway, first steps
-
?
ATP + 2-methyl-4-amino-5-hydroxymethylpyrimidine
ADP + 2-methyl-4-amino-5-phosphomethylpyrimidine
involved in thiamine biosynthetic pathway, first steps
-
?
ATP + 2-methyl-4-amino-5-hydroxymethylpyrimidine
ADP + 2-methyl-4-amino-5-phosphomethylpyrimidine
-
-
-
?
ATP + 2-methyl-4-amino-5-hydroxymethylpyrimidine
ADP + 2-methyl-4-amino-5-phosphomethylpyrimidine
-
involved in thiamine biosynthetic pathway, first steps
-
?
ATP + 2-methyl-4-amino-5-hydroxymethylpyrimidine
ADP + 2-methyl-4-amino-5-phosphomethylpyrimidine
-
-
-
-
ir
ATP + 2-methyl-4-amino-5-hydroxymethylpyrimidine
ADP + 2-methyl-4-amino-5-phosphomethylpyrimidine
-
-
-
-
?
ATP + 2-methyl-4-amino-5-hydroxymethylpyrimidine
ADP + 2-methyl-4-amino-5-phosphomethylpyrimidine
-
-
-
?
ATP + 2-methyl-4-amino-5-hydroxymethylpyrimidine
ADP + 2-methyl-4-amino-5-phosphomethylpyrimidine
-
involved in thiamine biosynthetic pathway, first steps
-
?
ATP + 2-methyl-4-amino-5-hydroxymethylpyrimidine
ADP + 2-methyl-4-amino-5-phosphomethylpyrimidine
-
-
-
-
?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
-
-
-
?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
reaction of EC 2.7.4.7
-
-
?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
-
-
-
?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
reaction of EC 2.7.4.7
-
-
?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
-
-
-
?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
reaction of EC 2.7.4.7
-
-
?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
-
-
-
?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
reaction of EC 2.7.4.7
-
-
?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
-
-
-
?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
reaction of EC 2.7.4.7
-
-
?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
-
-
-
?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
reaction of EC 2.7.4.7
-
-
?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
-
-
-
?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
reaction of EC 2.7.4.7
-
-
?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
-
-
-
?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
reaction of EC 2.7.4.7
-
-
?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
-
-
-
?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
reaction of EC 2.7.4.7
-
-
?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
-
-
-
?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
reaction of EC 2.7.4.7
-
-
?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
-
-
-
?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
reaction of EC 2.7.4.7
-
-
?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
-
-
-
?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
reaction of EC 2.7.4.7
-
-
?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
-
-
-
?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
reaction of EC 2.7.4.7
-
-
?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
-
-
-
?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
reaction of EC 2.7.4.7
-
-
?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
-
-
-
?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
reaction of EC 2.7.4.7
-
-
?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
-
-
-
?
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
reaction of EC 2.7.4.7
-
-
?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine
ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
-
-
?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine
ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
-
-
?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine
ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
-
-
?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine
ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
the enzyme is involved in biosynthesis of thiamine
-
-
?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine
ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
-
-
?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine
ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
the enzyme is involved in biosynthesis of thiamine
-
-
?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine
ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
-
-
?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine
ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
the enzyme is involved in biosynthesis of thiamine
-
-
?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine
ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
-
-
?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine
ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
the enzyme is involved in biosynthesis of thiamine
-
-
?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine
ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
-
-
?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine
ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
the enzyme is involved in biosynthesis of thiamine
-
-
?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine
ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
-
-
?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine
ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
the enzyme is involved in biosynthesis of thiamine
-
-
?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine
ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
-
-
?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine
ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
the enzyme is involved in biosynthesis of thiamine
-
-
?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine
ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
-
-
?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine
ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
the enzyme is involved in biosynthesis of thiamine
-
-
?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine
ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
-
-
?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine
ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
the enzyme catalyzes an essential step for the biosynthesis of thiamin pyrophosphate
-
-
?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine
ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
-
-
?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine
ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
the enzyme catalyzes an essential step for the biosynthesis of thiamin pyrophosphate
-
-
?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine
ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
-
-
?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine
ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
the enzyme catalyzes an essential step for the biosynthesis of thiamin pyrophosphate
-
-
?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine
ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
-
-
?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine
ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
the enzyme catalyzes an essential step for the biosynthesis of thiamin pyrophosphate
-
-
?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine
ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
-
-
?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine
ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
the enzyme catalyzes an essential step for the biosynthesis of thiamin pyrophosphate
-
-
?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine
ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
-
-
-
?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine
ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
the enzyme catalyzes an essential step for the biosynthesis of thiamin pyrophosphate
-
-
?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine
ADP + 4-amino-5-phosphomethyl-2-methylpyrimidine
-
-
-
-
?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine
ADP + 4-amino-5-phosphomethyl-2-methylpyrimidine
-
-
-
-
?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine
ADP + 4-amino-5-phosphomethyl-2-methylpyrimidine
-
-
-
-
?
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine
ADP + 4-amino-5-phosphomethyl-2-methylpyrimidine
-
-
-
?
ATP + 4-amino-5-phosphomethyl-2-methylpyrimidine
ADP + 4-amino-5-diphosphomethyl-2-methylpyrimidine
-
enzyme also performs the reaction of EC 2.7.4.7, phosphomethylpyrimidine kinase
-
-
?
ATP + 4-amino-5-phosphomethyl-2-methylpyrimidine
ADP + 4-amino-5-diphosphomethyl-2-methylpyrimidine
-
enzyme also performs the reaction of EC 2.7.4.7, phosphomethylpyrimidine kinase
-
-
?
ATP + 4-amino-5-phosphomethyl-2-methylpyrimidine
ADP + 4-amino-5-diphosphomethyl-2-methylpyrimidine
-
enzyme also performs the reaction of EC 2.7.4.7, phosphomethylpyrimidine kinase
-
-
?
ATP + pyridoxal
ADP + pyridoxal 5'-phosphate
reaction of EC 2.7.1.35
-
-
?
ATP + pyridoxal
ADP + pyridoxal 5'-phosphate
reaction of EC 2.7.1.35
-
-
?
ATP + pyridoxine
ADP + pyridoxine 5'-phosphate
reaction of EC 2.7.1.35
-
-
?
additional information
?
-
-
the enzyme has both a biosynthetic and a salvage pathway function
-
-
?
additional information
?
-
-
no activity with pyridoxal, pyridoxine, or pyridoxamine
-
-
?
additional information
?
-
bifunctional hydroxypyrimidine kinase/thiamin-phosphate pyrophosphorylase
-
-
?
additional information
?
-
-
bifunctional hydroxypyrimidine kinase/thiamin-phosphate pyrophosphorylase
-
-
?
additional information
?
-
-
bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase
-
-
?
additional information
?
-
bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase
-
-
?
additional information
?
-
-
enzyme is probably different from previously isolated HMP kinase, because the subunit molecular masses are significantly different
-
-
?
additional information
?
-
the enzyme performs double phosphorylation on 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP)
-
-
-
additional information
?
-
-
bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase
-
-
?
additional information
?
-
the enzyme performs double phosphorylation on 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP)
-
-
-
additional information
?
-
-
pyridoxine, pyridoxal, and pyridoxamine are no substrates
-
-
?
additional information
?
-
-
the isozymes Thi20p and Thi21p are bifunctional and show both phosphomethylpyrimidine kinase, EC 2.7.4.7, and hydroxymethylpyrimidine kinase, EC 2.7.1.49, activity, Thi20p exhibits higher activity than Thi21p
-
-
?
additional information
?
-
Thi20p is involved in thiamine synthesis from pyrithiamin and oxythiamin
-
-
?
additional information
?
-
-
the isozymes Thi20p and Thi21p are bifunctional and show both phosphomethylpyrimidine kinase, EC 2.7.4.7, and hydroxymethylpyrimidine kinase, EC 2.7.1.49, activity, Thi20p exhibits higher activity than Thi21p
-
-
?
additional information
?
-
the enzyme performs double phosphorylation on 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP), it is specific for HMP and does not use pyridoxal-like molecules (pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM)) as substrates
-
-
-
additional information
?
-
-
the enzyme performs double phosphorylation on 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP), it is specific for HMP and does not use pyridoxal-like molecules (pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM)) as substrates
-
-
-
additional information
?
-
the enzyme performs double phosphorylation on 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP), it is specific for HMP and does not use pyridoxal-like molecules (pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM)) as substrates
-
-
-
additional information
?
-
the enzyme performs double phosphorylation on 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP), it is specific for HMP and does not use pyridoxal-like molecules (pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM)) as substrates
-
-
-
additional information
?
-
the enzyme performs double phosphorylation on 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP), it is specific for HMP and does not use pyridoxal-like molecules (pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM)) as substrates
-
-
-
additional information
?
-
-
the enzyme performs double phosphorylation on 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP), it is specific for HMP and does not use pyridoxal-like molecules (pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM)) as substrates
-
-
-
additional information
?
-
the enzyme performs double phosphorylation on 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP), it is specific for HMP and does not use pyridoxal-like molecules (pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM)) as substrates
-
-
-
additional information
?
-
the enzyme performs double phosphorylation on 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP), it is specific for HMP and does not use pyridoxal-like molecules (pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM)) as substrates
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + 2-methyl-4-amino-5-hydroxymethylpyrimidine
ADP + 2-methyl-4-amino-5-phosphomethylpyrimidine
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine
ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine
ADP + 4-amino-5-phosphomethyl-2-methylpyrimidine
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine
ADP + 4-amino-5-phosphonooxymethyl-2-methylpyrimidine
-
-
-
?
ATP + 4-amino-5-phosphomethyl-2-methylpyrimidine
ADP + 4-amino-5-diphosphomethyl-2-methylpyrimidine
additional information
?
-
-
the enzyme has both a biosynthetic and a salvage pathway function
-
-
?
ATP + 2-methyl-4-amino-5-hydroxymethylpyrimidine
ADP + 2-methyl-4-amino-5-phosphomethylpyrimidine
-
involved in thiamine biosynthetic pathway, first steps
-
?
ATP + 2-methyl-4-amino-5-hydroxymethylpyrimidine
ADP + 2-methyl-4-amino-5-phosphomethylpyrimidine
involved in thiamine biosynthetic pathway, first steps
-
?
ATP + 2-methyl-4-amino-5-hydroxymethylpyrimidine
ADP + 2-methyl-4-amino-5-phosphomethylpyrimidine
-
involved in thiamine biosynthetic pathway, first steps
-
?
ATP + 2-methyl-4-amino-5-hydroxymethylpyrimidine
ADP + 2-methyl-4-amino-5-phosphomethylpyrimidine
-
involved in thiamine biosynthetic pathway, first steps
-
?
ATP + 2-methyl-4-amino-5-hydroxymethylpyrimidine
ADP + 2-methyl-4-amino-5-phosphomethylpyrimidine
involved in thiamine biosynthetic pathway, first steps
-
?
ATP + 2-methyl-4-amino-5-hydroxymethylpyrimidine