Ligand 2-methyl-4-amino-5-hydroxymethylpyrimidine phosphate

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Basic Ligand Information

Molecular Structure
Picture of 2-methyl-4-amino-5-hydroxymethylpyrimidine phosphate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H10N3O4P
2-methyl-4-amino-5-hydroxymethylpyrimidine phosphate
PKYFHKIYHBRTPI-UHFFFAOYSA-N
Synonyms:
(4-amino-2-methylpyrimidin-5-yl)methyl phosphate, 2-methyl-4-amino-5-phosphomethylpyrimidine, 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine, 4-amino-2-methyl-5-phosphomethylpyrimidine, 4-amino-2-methyl-5- phosphomethylpyrimidine, 4-amino-2-methyl-phosphomethylpyrimidine, 4-amino-5-phosphomethyl-2-methylpyrimidine, 4-amino-5-phosphonooxymethyl-2-methylpyrimidine


Show all pahtways known for Show all BRENDA pathways known for 2-methyl-4-amino-5-hydroxymethylpyrimidine phosphate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + 4-amino-5-phosphomethyl-2-methylpyrimidine = ADP + 4-amino-5-diphosphomethyl-2-methylpyrimidine
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + 2-methyl-4-amino-5-hydroxymethylpyrimidine = ADP + 2-methyl-4-amino-5-phosphomethylpyrimidine
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Product in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-5-phosphomethyl-2-methylpyrimidine
show the reaction diagram
-
-
ATP + 2-methyl-4-amino-5-hydroxymethylpyrimidine = ADP + 2-methyl-4-amino-5-phosphomethylpyrimidine
show the reaction diagram
-

Inhibitor in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
0.1 mM, 18.2% inhibition
-

3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.07
-
pH 8.0, 25°C, recombinant ThiD

KM Value (1 result)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.023
-
pH 8.0, 25°C, recombinant ThiD

References & Links

Links to other databases for 2-methyl-4-amino-5-hydroxymethylpyrimidine phosphate

ChEBI
PubChem
ChEBI
PubChem