Reference on EC 2.6.1.42 - branched-chain-amino-acid transaminase and Organism(s) Homo sapiens and UniProt Accession O15382
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kido, R.
Pancreatic branched-chain-amino-acid aminotransferase
Methods Enzymol.
166
275-281
1988
Canis lupus familiaris, Homo sapiens, Rattus norvegicus
Schadewaldt, P.; Wendel, U.; Hammen, H.W.
Human branched-chain L-amino acid aminotransferase: activity and subcellular localization in cultured skin fibroblasts
Amino Acids
9
147-160
1995
Homo sapiens
Hutson, S.M.; Berkich, D.; Drown, P.; Xu, B.; Aschner, M.; LaNoue, K.F.
Role of branched-chain aminotransferase isoenzymes and gabapentin in neurotransmitter metabolism
J. Neurochem.
71
863-874
1998
Homo sapiens, Rattus norvegicus
Conway, M.E.; Hutson, S.M.
Mammalian branched-chain aminotransferases
Methods Enzymol.
324
355-365
2000
Homo sapiens, Rattus norvegicus
Schadewaldt, P.
Determination of branched-chain L-amino-acid aminotransferase activity
Methods Enzymol.
324
23-32
2000
Homo sapiens, Rattus norvegicus
Lin, H.M.; Kaneshige, M.; Zhao, L.; Zhang, X.; Hanover, J.A.; Cheng, S.Y.
An isoform of branched-chain aminotransferase is a novel co-repressor for thyroid hormone nuclear receptors
J. Biol. Chem.
276
48196-48205
2001
Homo sapiens, Homo sapiens (O15382), Saccharomyces cerevisiae (P47176), Saccharomyces cerevisiae
Yennawar, N.; Dunbar, J.; Conway, M.; Hutson, S.; Farber, G.
The structure of human mitochondrial branched-chain aminotransferase
Acta Crystallogr. Sect. D
57
506-515
2001
Homo sapiens
Cooper, A.J.; Conway, M.; Hutson, S.M.
A continuous 96-well plate spectrophotometric assay for branched-chain amino acid aminotransferases
Anal. Biochem.
308
100-105
2002
Homo sapiens, Rattus norvegicus
Conway, M.E.; Yennawar, N.; Wallin, R.; Poole, L.B.; Hutson, S.M.
Human mitochondrial branched chain aminotransferase: structural basis for substrate specificity and role of redox active cysteines
Biochim. Biophys. Acta
1647
61-65
2003
Homo sapiens
Cooper, A.J.; Bruschi, S.A.; Conway, M.; Hutson, S.M.
Human mitochondrial and cytosolic branched-chain aminotransferases are cysteine S-conjugate beta-lyases, but turnover leads to inactivation
Biochem. Pharmacol.
65
181-192
2003
Homo sapiens
Goto, M.; Miyahara, I.; Hirotsu, K.; Conway, M.; Yennawar, N.; Islam, M.M.; Hutson, S.M.
Structural determinants for branched-chain aminotransferase isozyme-specific inhibition by the anticonvulsant drug gabapentin
J. Biol. Chem.
280
37246-37256
2005
Homo sapiens (O15382), Homo sapiens
Hu, L.Y.; Boxer, P.A.; Kesten, S.R.; Lei, H.J.; Wustrow, D.J.; Moreland, D.W.; Zhang, L.; Ahn, K.; Ryder, T.R.; Liu, X.; Rubin, J.R.; Fahnoe, K.; Carroll, R.T.; Dutta, S.; Fahnoe, D.C.; Probert, A.W.; Roof, R.L.; Rafferty, M.F.; Kostlan, C.R.; Scholten, J.D.; Hood, M.; Ren, X.D.; Schielke, G.P.; Su, T.Z.; Taylor, C.P.; Mi, M.i.s.
The design and synthesis of human branched-chain amino acid aminotransferase inhibitors for treatment of neurodegenerative diseases
Bioorg. Med. Chem. Lett.
16
2337-2340
2006
Homo sapiens (P54687), Homo sapiens
Yennawar, N.H.; Islam, M.M.; Conway, M.; Wallin, R.; Hutson, S.M.
Human mitochondrial branched chain aminotransferase isozyme: structural role of the CXXC center in catalysis
J. Biol. Chem.
281
39660-39671
2006
Homo sapiens (O15382), Homo sapiens
Brosnan, J.T.; Brosnan, M.E.
Branched-chain amino acids: enzyme and substrate regulation
J. Nutr.
136
207S-211S
2006
Homo sapiens
Conway, M.E.; Coles, S.J.; Islam, M.M.; Hutson, S.M.
Regulatory control of human cytosolic branched-chain aminotransferase by oxidation and S-glutathionylation and its interactions with redox sensitive neuronal proteins
Biochemistry
47
5465-5479
2008
Homo sapiens
Hutson, S.M.; Poole, L.B.; Coles, S.; Conway, M.E.
Redox regulation and trapping sulfenic acid in the peroxide-sensitive human mitochondrial branched chain aminotransferase
Methods Mol. Biol.
476
135-148
2009
Homo sapiens
Caballero, J.; Vergara-Jaque, A.; Fernandez, M.; Coll, D.
Docking and quantitative structure-activity relationship studies for sulfonyl hydrazides as inhibitors of cytosolic human branched-chain amino acid aminotransferase
Mol. Divers.
13
493-500
2009
Homo sapiens (P54687), Homo sapiens
Coles, S.J.; Hancock, J.T.; Conway, M.E.
Differential redox potential between the human cytosolic and mitochondrial branched-chain aminotransferase
Acta Biochim. Biophys. Sin. (Shanghai)
44
172-176
2012
Homo sapiens
Hull, J.; Hindy, M.E.; Kehoe, P.G.; Chalmers, K.; Love, S.; Conway, M.E.
Distribution of the branched chain aminotransferase proteins in the human brain and their role in glutamate regulation
J. Neurochem.
123
997-1009
2012
Homo sapiens (O15382), Homo sapiens (P54687), Homo sapiens
Pereboom, T.; Bondt, A.; Pallaki, P.; Klasson, T.; Goos, Y.; Essers, P.; Groot Koerkamp, M.; Gazda, H.; Holstege, F.; Costa, L.; MacInnes, A.
Translation of branched-chain aminotransferase-1 transcripts is impaired in cells haploinsufficient for ribosomal protein genes
Exp. Hematol.
42
394-403
2014
Homo sapiens
Roncador, A.; Oppici, E.; Montioli, R.; Maset, F.; Cellini, B.
TAT-Mediated delivery of human alanine:glyoxylate aminotransferase in a cellular model of primary hyperoxaluria type I
Int. J. Pept. Res. Ther.
19
175-184
2013
Homo sapiens
-
Wang, X.L.; Li, C.J.; Xing, Y.; Yang, Y.H.; Jia, J.P.
Hypervalinemia and hyperleucine-isoleucinemia caused by mutations in the branched-chain-amino-acid aminotransferase gene
J. Inherit. Metab. Dis.
38
855-861
2015
Homo sapiens
Herbert, D.; Gibbs, S.; Riddick, A.; Conway, M.; Dong, M.
Crystal structure of an oxidized mutant of human mitochondrial branched-chain aminotransferase
Acta Crystallogr. Sect. F
76
14-19
2020
Homo sapiens (O15382), Homo sapiens
Conway, M.E.
Emerging moonlighting functions of the branched-chain aminotransferase proteins
Antioxid. Redox Signal.
34
1048-1067
2020
Homo sapiens (O15382), Homo sapiens (P54687)
Zhang, L.; Han, J.
Branched-chain amino acid transaminase 1 (BCAT1) promotes the growth of breast cancer cells through improving mTOR-mediated mitochondrial biogenesis and function
Biochem. Biophys. Res. Commun.
486
224-231
2017
Homo sapiens (P54687), Homo sapiens
Anderson, L.C.; Hakansson, M.; Walse, B.; Nilsson, C.L.
Intact protein analysis at 21 tesla and X-ray crystallography define structural differences in single amino acid variants of human mitochondrial branched-chain amino acid aminotransferase 2 (BCAT2)
J. Am. Soc. Mass Spectrom.
28
1796-1804
2017
Homo sapiens (O15382), Homo sapiens
Borthwick, J.A.; Ancellin, N.; Bertrand, S.M.; Bingham, R.P.; Carter, P.S.; Chung, C.W.; Churcher, I.; Dodic, N.; Fournier, C.; Francis, P.L.; Hobbs, A.; Jamieson, C.; Pickett, S.D.; Smith, S.E.; Somers, D.O.; Spitzfaden, C.; Suckling, C.J.; Young, R.J.
Structurally diverse mitochondrial branched chain aminotransferase (BCATm) leads with varying binding modes identified by fragment screening
J. Med. Chem.
59
2452-2467
2016
Homo sapiens (O15382)
