Information on EC 2.5.1.153 - adenosine tuberculosinyltransferase

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IUBMB Comments
The enzyme, characterized from the bacterial pathogen Mycobacterium tuberculosis, produces 1-tuberculosinyladenosine, an unusual terpene nucleoside that acts as a phagolysosome disruptor by neutralizing the pH, resulting in swelling of the lysosome and obliteration of its multilamellar structure.
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Word Map
The expected taxonomic range for this enzyme is: Mycobacterium tuberculosis
Synonyms
Rv3378c, Rv3378c protein, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
tuberculosinyl diphosphate + adenosine = 1-tuberculosinyladenosine + diphosphate
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tuberculosinyl diphosphate + H2O = (13S)-isotuberculosinol + diphosphate
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PATHWAY SOURCE
PATHWAYS
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