Application | Comment | Organism |
---|---|---|
diagnostics | the Mycobacterium tuberculosis-specific lipid 1-tuberculosinyladenosine is a target for diagnosing tuberculosis disease | Mycobacterium tuberculosis |
Crystallization (Comment) | Organism |
---|---|
vapor diffusion, and 2.2 A resolution, crystal structure reveals a cis-prenyl transferase fold with hydrophobic residues for isoprenoid binding and a second binding pocket suitable for the nucleoside substrate | Mycobacterium tuberculosis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
tuberculosinyl diphosphate + adenosine | Mycobacterium tuberculosis | the enzyme produces 1-tuberculosinyladenosine, an abundant amphiphile that is exported outside Mycobacterium tuberculosis | 1-tuberculosinyladenosine + diphosphate | - |
? | |
tuberculosinyl diphosphate + adenosine | Mycobacterium tuberculosis ATCC 25618 | the enzyme produces 1-tuberculosinyladenosine, an abundant amphiphile that is exported outside Mycobacterium tuberculosis | 1-tuberculosinyladenosine + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | P9WJ61 | - |
- |
Mycobacterium tuberculosis ATCC 25618 | P9WJ61 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Mycobacterium tuberculosis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
tuberculosinyl diphosphate + adenosine | - |
Mycobacterium tuberculosis | 1-tuberculosinyladenosine + diphosphate | - |
? | |
tuberculosinyl diphosphate + adenosine | the enzyme produces 1-tuberculosinyladenosine, an abundant amphiphile that is exported outside Mycobacterium tuberculosis | Mycobacterium tuberculosis | 1-tuberculosinyladenosine + diphosphate | - |
? | |
tuberculosinyl diphosphate + adenosine | - |
Mycobacterium tuberculosis ATCC 25618 | 1-tuberculosinyladenosine + diphosphate | - |
? | |
tuberculosinyl diphosphate + adenosine | the enzyme produces 1-tuberculosinyladenosine, an abundant amphiphile that is exported outside Mycobacterium tuberculosis | Mycobacterium tuberculosis ATCC 25618 | 1-tuberculosinyladenosine + diphosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
homodimer | - |
Mycobacterium tuberculosis |
Synonyms | Comment | Organism |
---|---|---|
Rv3378c | - |
Mycobacterium tuberculosis |
General Information | Comment | Organism |
---|---|---|
evolution | adenosine tuberculosinyltransferase is known only in Mycobacterium tuberculosis. This intersection of nucleoside andterpene pathways likely arose late in the evolution of the Mycobacterium tuberculosis complex | Mycobacterium tuberculosis |
physiological function | the extracellular export of the amphipathic molecule 1-tuberculosinyladenosine likely accounts for the known virulence-promoting effects of the Rv3378c enzyme | Mycobacterium tuberculosis |