Reference on EC 2.3.1.97 - glycylpeptide N-tetradecanoyltransferase and Organism(s) Homo sapiens and UniProt Accession O60551
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Duronio, R.J.; Read, S.I.; Gordon, J.I.
Mutations of human myristoyl-CoA:protein N-myristoyltransferase cause temperature-sensitive myristic acid auxotrophy in Saccharomyces cerevisiae
Proc. Natl. Acad. Sci. USA
89
4129-4133
1992
Homo sapiens
Raju, R.V.S.; Datla, R.S.S.; Sharma, R.K.
Expression of human N-myristoyltransferase in Escherichia coli. Comparison with N-myristoyltransferases expressed in different tissues
Mol. Cell. Biochem.
155
69-76
1996
Homo sapiens
McIlhinney, R.A.J.; McGlone, K.
Immunocytochemical characterization and subcellular localization of human myristoyl-CoA: protein N-myristoyltransferase in HeLa cells
Exp. Cell Res.
223
348-356
1996
Homo sapiens
Young, K.; Egerton, M.; Camble, R.; White, A.; McIlhinney, R.A.J.
Immunochemical characterization of human N-myristoyltransferase: evidence for more than one form of the enzyme
Biochem. Soc. Trans.
25
S631
1997
Homo sapiens
Giang, D.K.; Cravatt, B.F.
A second mammalian N-myristoyltransferase
J. Biol. Chem.
273
6595-6598
1998
Homo sapiens (O60551), Homo sapiens (P30419), Homo sapiens, Mus musculus (O70310), Mus musculus (O70311), Mus musculus
Raju, R.V.S.; Datla, R.S.S.; Warrington, R.C.; Sharma, R.K.
Effects of L-histidine and its structural analogs on human N-myristoyltransferase activity and importance of EEVEH amino acid sequence for enzyme activity
Biochemistry
37
14928-14936
1998
Homo sapiens, Rattus norvegicus
McIlhinney, R.A.; Young, K.; Egerton, M.; Camble, R.; White, A.; Soloviev, M.
Characterization of human and rat brain myristoyl-CoA:protein N-myristoyltransferase: evidence for an alternative splice variant of the enzyme
Biochem. J.
333
491-495
1998
Homo sapiens, Rattus norvegicus
-
Pasha, M.K.; Dimmock, J.R.; Hollenberg, M.D.; Sharma, R.K.
Enhanced activity of human N-myristoyltransferase by dimethyl sulfoxide and related solvents in the presence of serine/threonine-containing peptide substrates
Biochem. Pharmacol.
64
1461-1467
2002
Homo sapiens
Selvakumar, P.; Lakshmikuttyamma, A.; Lawman, Z.; Bonham, K.; Dimmock, J.R.; Sharma, R.K.
Expression of methionine aminopeptidase 2,N-myristoyltransferase, and N-myristoyltransferase inhibitor protein 71 in HT29
Biochem. Biophys. Res. Commun.
322
1012-1017
2004
Homo sapiens
Hill, B.T.; Skowronski, J.
Human N-myristoyltransferases form stable complexes with lentiviral nef and other viral and cellular substrate proteins
J. Virol.
79
1133-1141
2005
Homo sapiens
Ma, H.H.; Yang, L.; Yang, X.Y.; Xu, Z.P.; Li, B.L.
Bacterial expression, purification, and in vitro N-myristoylation of fusion hepatitis B virus preS1 with the native-type N-terminus
Protein Expr. Purif.
27
49-54
2003
Homo sapiens
Selvakumar, P.; Lakshmikuttyamma, A.; Charavaryamath, C.; Singh, B.; Tuchek, J.; Sharma, R.K.
Expression of myristoyltransferase and its interacting proteins in epilepsy
Biochem. Biophys. Res. Commun.
335
1132-1139
2005
Bos taurus, Saccharomyces cerevisiae, Candida sp. (in: Saccharomycetales), Oryctolagus cuniculus, Dictyostelium sp., Homo sapiens, Mus musculus, Rattus norvegicus
Breuer, S.; Gerlach, H.; Kolaric, B.; Urbanke, C.; Opitz, N.; Geyer, M.
Biochemical indication for myristoylation-dependent conformational changes in HIV-1 Nef
Biochemistry
45
2339-2349
2006
Homo sapiens
Yamazaki, K.; Kaneko, Y.; Suwa, K.; Ebara, S.; Nakazawa, K.; Yasuno, K.
Synthesis of potent and selective inhibitors of Candida albicans N-myristoyltransferase based on the benzothiazole structure
Bioorg. Med. Chem.
13
2509-2522
2005
Candida albicans (P30418), Candida albicans, Homo sapiens (P30419)
Selvakumar, P.; Sharma, R.K.
Phosphorylation and dephosphorylation of human myristoyltransferase type 1
Can. J. Physiol. Pharmacol.
84
707-712
2006
Homo sapiens (P30419), Homo sapiens
Selvakumar, P.; Smith-Winsor, E.; Bonham, K.; Sharma, R.K.
N-Myristoyltransferase 2 expression in human colon cancer: Cross-talk between the calpain and caspase system
FEBS Lett.
580
2021-2026
2006
Homo sapiens
Selvakumar, P.; Sharma, R.K.
Role of calpain and caspase system in the regulation of N-myristoyltransferase in human colon cancer (Review)
Int. J. Mol. Med.
19
823-827
2007
Homo sapiens (O60551), Homo sapiens
Ducker, C.E.; Upson, J.J.; French, K.J.; Smith, C.D.
Two N-myristoyltransferase isozymes play unique roles in protein myristoylation, proliferation, and apoptosis
Mol. Cancer Res.
3
463-476
2005
Homo sapiens (O60551), Homo sapiens (P30419), Homo sapiens
Lu, Y.; Selvakumar, P.; Ali, K.; Shrivastav, A.; Bajaj, G.; Resch, L.; Griebel, R.; Fourney, D.; Meguro, K.; Sharma, R.K.
Expression of N-myristoyltransferase in human brain tumors
Neurochem. Res.
30
9-13
2005
Homo sapiens (O60551), Homo sapiens (P30419), Homo sapiens
Selvakumar, P.; Lakshmikuttyamma, A.; Shrivastav, A.; Das, S.B.; Dimmock, J.R.; Sharma, R.K.
Potential role of N-myristoyltransferase in cancer
Prog. Lipid Res.
46
1-36
2007
Oryctolagus cuniculus, Homo sapiens (O60551), Homo sapiens (P30419), Homo sapiens, Saccharomyces cerevisiae (P14743), Bos taurus (P31717), Bos taurus (Q9N181), Rattus norvegicus (Q8K1Q0)
Seaton, K.; Smith, C.
N-Myristoyltransferase isozymes exhibit differential specificity for human immunodeficiency virus type 1 Gag and Nef
J. Gen. Virol.
89
288-296
2008
Homo sapiens (O60551), Homo sapiens (P30419), Homo sapiens
Shrivastav, A.; Varma, S.; Lawman, Z.; Yang, S.H.; Ritchie, S.A.; Bonham, K.; Singh, S.M.; Saxena, A.; Sharma, R.K.
Requirement of N-myristoyltransferase 1 in the development of monocytic lineage
J. Immunol.
180
1019-1028
2008
Homo sapiens, Mus musculus (O70310), Mus musculus (O70311), Mus musculus
Lakshmikuttyamma, A.; Selvakumar, P.; Tuchek, J.; Sharma, R.
Myristoyltransferase and calcineurin: novel molecular therapeutic target for epilepsy
Prog. Neurobiol.
84
77-84
2008
Homo sapiens
Goncalves, V.; Brannigan, J.A.; Thinon, E.; Olaleye, T.O.; Serwa, R.; Lanzarone, S.; Wilkinson, A.J.; Tate, E.W.; Leatherbarrow, R.J.
A fluorescence-based assay for N-myristoyltransferase activity
Anal. Biochem.
421
342-344
2012
Homo sapiens
Morgan, C.R.; Miglionico, B.V.; Engen, J.R.
Effects of HIV-1 Nef on human N-myristoyltransferase 1
Biochemistry
50
3394-3403
2011
Homo sapiens
Kumar, S.; Singh, B.; Dimmock, J.R.; Sharma, R.K.
N-myristoyltransferase in the leukocytic development processes
Cell Tissue Res.
345
203-211
2011
Homo sapiens, Mus musculus, Rattus norvegicus
Brand, S.; Cleghorn, L.A.; McElroy, S.P.; Robinson, D.A.; Smith, V.C.; Hallyburton, I.; Harrison, J.R.; Norcross, N.R.; Spinks, D.; Bayliss, T.; Norval, S.; Stojanovski, L.; Torrie, L.S.; Frearson, J.A.; Brenk, R.; Fairlamb, A.H.; Ferguson, M.A.; Read, K.D.; Wyatt, P.G.; Gilbert, I.H.
Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors
J. Med. Chem.
55
140-152
2012
Homo sapiens, Trypanosoma brucei
Bell, A.S.; Mills, J.E.; Williams, G.P.; Brannigan, J.A.; Wilkinson, A.J.; Parkinson, T.; Leatherbarrow, R.J.; Tate, E.W.; Holder, A.A.; Smith, D.F.
Selective inhibitors of protozoan protein N-myristoyltransferases as starting points for tropical disease medicinal chemistry programs
PLoS Negl. Trop. Dis.
6
e1625
2012
Trypanosoma brucei (D0A003), Trypanosoma brucei, Leishmania donovani (D0AB09), Leishmania donovani, Homo sapiens (O60551), Homo sapiens (P30419), Homo sapiens, Plasmodium falciparum (Q8ILW6), Plasmodium falciparum
Ohta, H.; Takamune, N.; Kishimoto, N.; Shoji, S.; Misumi, S.
N-Myristoyltransferase 1 enhances human immunodeficiency virus replication through regulation of viral RNA expression level
Biochem. Biophys. Res. Commun.
463
988-993
2015
Homo sapiens
Flamm, A.G.; Le Roux, A.L.; Mateos, B.; Diaz-Lobo, M.; Storch, B.; Breuker, K.; Konrat, R.; Pons, M.; Coudevylle, N.
N-Lauroylation during the expression of recombinant N-myristoylated proteins: implications and solutions
ChemBioChem
17
82-89
2016
Homo sapiens
Perinpanayagam, M.; Beauchamp, E.; Martin, D.; Sim, J.; Yap, M.; Berthiaume, L.
Regulation of co-and post-translational myristoylation of proteins during apoptosis: Interplay of N-myristoyltransferases and caspases
FASEB J.
27
811-821
2013
Homo sapiens
Olaleye, T.O.; Brannigan, J.A.; Roberts, S.M.; Leatherbarrow, R.J.; Wilkinson, A.J.; Tate, E.W.
Peptidomimetic inhibitors of N-myristoyltransferase from human malaria and leishmaniasis parasites
Org. Biomol. Chem.
12
8132-8137
2014
Plasmodium falciparum, Plasmodium vivax (A5K1A2), Leishmania donovani (D0AB09), Homo sapiens (P30419), Homo sapiens, Plasmodium vivax Salvador I (A5K1A2)
Kumar, S.; Sharma, R.
N-terminal region of the catalytic domain of human N-myristoyltransferase 1 acts as an inhibitory module
PLoS ONE
10
e0127661
2015
Homo sapiens (P30419), Homo sapiens
Garcia, M.; de Oliveira, A.; Bueno, R.; Nogueira, V.; de Souza, G.; Guido, R.
QSAR studies on benzothiophene derivatives as Plasmodium falciparum N-myristoyltransferase inhibitors Molecular insights into affinity and selectivity
Drug Dev. Res.
2020
1-21
2020
Homo sapiens, Plasmodium falciparum
Soupene, E.; Kao, J.; Cheng, D.; Wang, D.; Greninger, A.; Knudsen, G.; DeRisi, J.; Kuypers, F.
Association of NMT2 with the acyl-CoA carrier ACBD6 protects the N-myristoyltransferase reaction from palmitoyl-CoA
J. Lipid Res.
57
288-298
2016
Homo sapiens (O60551), Homo sapiens
Goncalves, V.; Brannigan, J.; Laporte, A.; Bell, A.; Roberts, S.; Wilkinson, A.; Leatherbarrow, R.; Tate, E.
Structure-guided optimization of quinoline inhibitors of Plasmodium N-myristoyltransferase
MedChemComm
8
191-197
2017
Plasmodium falciparum, Plasmodium vivax (A5K1A2), Plasmodium vivax, Homo sapiens (O60551), Homo sapiens (P30419), Plasmodium vivax Salvador I (A5K1A2)
Mousnier, A.; Bell, A.S.; Swieboda, D.P.; Morales-Sanfrutos, J.; Perez-Dorado, I.; Brannigan, J.A.; Newman, J.; Ritzefeld, M.; Hutton, J.A.; Guedan, A.; Asfor, A.S.; Robinson, S.W.; Hopkins-Navratilova, I.; Wilkinson, A.J.; Johnston, S.L.; Leatherbarrow, R.J.; Tuthill, T.J.; Solari, R.; Tate, E.W.
Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus
Nat. Chem.
10
599-606
2018
Homo sapiens (O60551), Homo sapiens (P30419), Homo sapiens
Dian, C.; Perez-Dorado, I.; Riviere, F.; Asensio, T.; Legrand, P.; Ritzefeld, M.; Shen, M.; Cota, E.; Meinnel, T.; Tate, E.; Giglione, C.
High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation
Nat. Commun.
11
1132
2020
Homo sapiens (P30419), Homo sapiens
Corbic Ramljak, I.; Stanger, J.; Real-Hohn, A.; Dreier, D.; Wimmer, L.; Redlberger-Fritz, M.; Fischl, W.; Klingel, K.; Mihovilovic, M.D.; Blaas, D.; Kowalski, H.
Cellular N-myristoyltransferases play a crucial picornavirus genus-specific role in viral assembly, virion maturation, and infectivity
PLoS Pathog.
14
e1007203
2018
Homo sapiens (P30419), Homo sapiens
