Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.1.97 extracted from

  • Olaleye, T.O.; Brannigan, J.A.; Roberts, S.M.; Leatherbarrow, R.J.; Wilkinson, A.J.; Tate, E.W.
    Peptidomimetic inhibitors of N-myristoyltransferase from human malaria and leishmaniasis parasites (2014), Org. Biomol. Chem., 12, 8132-8137.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.97

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with both myristoyl-CoA and inhibitor N-(10-aminodecanoyl)-L-seryl-N-(2-cyclohexylethyl)-L-lysinamide. The inhibitor sits in the peptide-binding pocket, and mimics the key recognition elements involved in binding the parent peptide Plasmodium vivax

Inhibitors

Inhibitors Comment Organism Structure
N-(10-aminodecanoyl)-L-seryl-N-(2-cyclohexylethyl)-L-lysinamide peptidomimetic inhibitor Homo sapiens
N-(10-aminodecanoyl)-L-seryl-N-(2-cyclohexylethyl)-L-lysinamide peptidomimetic inhibitor Leishmania donovani
N-(10-aminodecanoyl)-L-seryl-N-(2-cyclohexylethyl)-L-lysinamide peptidomimetic inhibitor Plasmodium falciparum
N-(10-aminodecanoyl)-L-seryl-N-(2-cyclohexylethyl)-L-lysinamide peptidomimetic inhibitor Plasmodium vivax

Organism

Organism UniProt Comment Textmining
Homo sapiens P30419
-
-
Leishmania donovani D0AB09
-
-
Plasmodium falciparum
-
-
-
Plasmodium vivax A5K1A2
-
-
Plasmodium vivax Salvador I A5K1A2
-
-

Synonyms

Synonyms Comment Organism
PVX_085815
-
 Plasmodium vivax

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000024
-
 pH not specified in the publication, temperature not specified in the publication Leishmania donovani N-(10-aminodecanoyl)-L-seryl-N-(2-cyclohexylethyl)-L-lysinamide
0.00006
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens N-(10-aminodecanoyl)-L-seryl-N-(2-cyclohexylethyl)-L-lysinamide
0.00068
-
 pH not specified in the publication, temperature not specified in the publication Plasmodium vivax N-(10-aminodecanoyl)-L-seryl-N-(2-cyclohexylethyl)-L-lysinamide
0.0243
-
 pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum N-(10-aminodecanoyl)-L-seryl-N-(2-cyclohexylethyl)-L-lysinamide