Information on EC - L-glutamate-5-semialdehyde N-acetyltransferase

for references in articles please use BRENDA:EC2.3.1.271
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IUBMB Comments
The enzyme, characterized from the yeast Saccharomyces cerevisiae Sigma1278b, N-acetylates L-glutamate-5-semialdehyde, an L-proline biosynthesis/utilization intermediate, into N-acetyl-L-glutamate 5-semialdehyde, an intermediate of L-arginine biosynthesis, under oxidative stress conditions. Its activity results in conversion of L-proline to L-arginine, and reduction in the concentration of L-glutamate 5-semialdehyde and its equilibrium partner, (S)-1-pyrroline-5-carboxylate, which has been linked to production of reactive oxygen species stress. The enzyme also acts on (S)-1-acetylazetidine-2-carboxylate, a toxic L-proline analog produced by some plants, resulting in its detoxification and conferring resistance on the yeast.
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Word Map
  • l-azetidine-2-carboxylic
  • l-proline
  • schizosaccharomyces
  • signalosome
  • sigma1278b
  • detoxifies
  • pombe
  • four-membered
  • binuclear
  • spacing
  • triplets
  • misfolded
  • photomorphogenesis
  • fission
  • znii2cys6
The enzyme appears in viruses and cellular organisms
AZC acetyltransferase, AZC-detoxifying enzyme, L-azetidine-2-carboxylate N-acetyltransferase, MPR1, Mpr1p, MPR2, ppr1(+), Ppr1p, more
acetyl-CoA + L-glutamate-5-semialdehyde = CoA + N-acetyl-L-glutamate 5-semialdehyde
show the reaction diagram
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