Information on EC - very-long-chain 3-oxoacyl-CoA synthase

for references in articles please use BRENDA:EC2.3.1.199
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IUBMB Comments
This is the first component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA (and modified forms thereof) to very-long-chain acyl CoAs. Multiple forms exist with differing preferences for the substrate, and thus the specific form expressed determines the local composition of very-long-chain fatty acids [6,7]. For example, the FAE1 form from the plant Arabidopsis thaliana accepts only 16 and 18 carbon substrates, with oleoyl-CoA (18:1) being the preferred substrate , while CER6 from the same plant prefers substrates with chain length of C22 to C32 [4,8]. cf. EC, very-long-chain 3-oxoacyl-CoA reductase, EC, very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase, and EC, very-long-chain enoyl-CoA reductase
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
3-ketoacyl CoA synthase, 3-ketoacyl-CoA synthase, acyl-CoA elongase, At1g01120, At2g26640, beta-ketoacyl CoA synthase, beta-ketoacyl-CoA synthase, Cer-zh, CER2-LIKE1, CER2-LIKE2, more
a very-long-chain acyl-CoA + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA
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