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Literature summary for 2.3.1.199 extracted from
- Impaired epidermal permeability barrier in mice lacking elovl1, the gene responsible for very-long-chain fatty acid production (2013), Mol. Cell. Biol., 33, 2787-2796.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ELOVL1 | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | Elovl1 knockout mice die shortly after birth due to epidermal barrier defects. The lipid lamellae in the stratum corneum are largely diminished in these mice. In the epidermis of the Elovl1-null mice, the levels of Cers with more than C26 fatty acids are decreased, while those of Cers with less than C24 fatty acids are increased. The levels of C24 sphingomyelin are reduced, accompanied by an increase in C20 sphingomyelin levels. Ceramide synthases, CerS2 and CerS3, expressed in an epidermal layer-specific manner, regulate Elovl1 to produce acyl coenzyme As with different chain lengths | Mus musculus |
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Release 2023.1 (January 2023)
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