Cloned (Comment) | Organism |
---|---|
expressed in Saccharomyces cerevisiae | Arabidopsis thaliana |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
mefluidide | selective inhibitor of KCS1, CER6, and CER60 enzyme activities in vivo. FAE1 and KCS2 are inhibited by mefluidide only slightly. At 0.1 mM mefluidide, isozymes FAE1, KCS1, KCS2, KCS20, CER60, and CER6 are inhibited by 5.1%, 91%, 0.3%, 26.9%, 71.8%, 51.2% respectively | Arabidopsis thaliana | |
mefluidide | - |
Lemna aequinoctialis | |
metazachlor | selective inhibitor of KCS1, CER6, and CER60 enzyme activities in vivo. Strong micromolar inhibitor of FAE1 and KCS2. At 0.1 mM metazachlor, isozymes FAE1, KCS1, KCS2, KCS20, CER60, CER6, and KCS17 are inhibited by 95.7%, 93%, 82.4%, 97.5%, 100%, 100%, and 100%, respectively | Arabidopsis thaliana | |
metazachlor | - |
Lemna aequinoctialis | |
perfluidone | selective inhibitor of KCS1, CER6, and CER60 enzyme activities in vivo. Strong micromolar inhibitor of FAE1 and KCS2 | Arabidopsis thaliana | |
perfluidone | - |
Lemna aequinoctialis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Arabidopsis thaliana | - |
- |
- |
Lemna aequinoctialis | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidoyl-CoA + malonyl-CoA | - |
Arabidopsis thaliana | ? | - |
? | |
arachidoyl-CoA + malonyl-CoA | - |
Lemna aequinoctialis | ? | - |
? | |
behenoyl-CoA + malonyl-CoA | - |
Arabidopsis thaliana | ? | - |
? | |
behenoyl-CoA + malonyl-CoA | - |
Lemna aequinoctialis | ? | - |
? | |
cerotoyl-CoA + malonyl-CoA | - |
Arabidopsis thaliana | ? | - |
? | |
cerotoyl-CoA + malonyl-CoA | - |
Lemna aequinoctialis | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
3-ketoacyl-CoA synthase | - |
Arabidopsis thaliana |
3-ketoacyl-CoA synthase | - |
Lemna aequinoctialis |
CER6 | KCS6 | Arabidopsis thaliana |
CER60 | KCS5 | Arabidopsis thaliana |
FAE1 | KCS18 | Arabidopsis thaliana |
KCS | - |
Lemna aequinoctialis |
Kcs1 | - |
Arabidopsis thaliana |
KCS17 | - |
Arabidopsis thaliana |
KCS2 | - |
Arabidopsis thaliana |
KCS20 | - |
Arabidopsis thaliana |
VLCFA elongase | - |
Arabidopsis thaliana |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000032 | - |
isozyme CER6, pH and temperature not specified in the publication | Arabidopsis thaliana | mefluidide | |
0.00021 | - |
isozyme CER6, pH and temperature not specified in the publication | Arabidopsis thaliana | perfluidone | |
0.00199 | - |
isozyme FAE1, pH and temperature not specified in the publication | Arabidopsis thaliana | mefluidide | |
0.0076 | - |
isozyme FAE1, pH and temperature not specified in the publication | Arabidopsis thaliana | metazachlor | |
0.114 | - |
isozyme CER6, pH and temperature not specified in the publication | Arabidopsis thaliana | metazachlor | |
0.5 | - |
IC50 above 0.5 mM, isozyme FAE1, pH and temperature not specified in the publication | Arabidopsis thaliana | perfluidone |