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Literature summary for 2.3.1.199 extracted from

  • Tresch, S.; Heilmann, M.; Christiansen, N.; Looser, R.; Grossmann, K.
    Inhibition of saturated very-long-chain fatty acid biosynthesis by mefluidide and perfluidone, selective inhibitors of 3-ketoacyl-CoA synthases (2012), Phytochemistry, 76, 162-171.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Saccharomyces cerevisiae Arabidopsis thaliana

Inhibitors

Inhibitors Comment Organism Structure
mefluidide selective inhibitor of KCS1, CER6, and CER60 enzyme activities in vivo. FAE1 and KCS2 are inhibited by mefluidide only slightly. At 0.1 mM mefluidide, isozymes FAE1, KCS1, KCS2, KCS20, CER60, and CER6 are inhibited by 5.1%, 91%, 0.3%, 26.9%, 71.8%, 51.2% respectively Arabidopsis thaliana
mefluidide
-
Lemna aequinoctialis
metazachlor selective inhibitor of KCS1, CER6, and CER60 enzyme activities in vivo. Strong micromolar inhibitor of FAE1 and KCS2. At 0.1 mM metazachlor, isozymes FAE1, KCS1, KCS2, KCS20, CER60, CER6, and KCS17 are inhibited by 95.7%, 93%, 82.4%, 97.5%, 100%, 100%, and 100%, respectively Arabidopsis thaliana
metazachlor
-
Lemna aequinoctialis
perfluidone selective inhibitor of KCS1, CER6, and CER60 enzyme activities in vivo. Strong micromolar inhibitor of FAE1 and KCS2 Arabidopsis thaliana
perfluidone
-
Lemna aequinoctialis

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
-
Lemna aequinoctialis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
arachidoyl-CoA + malonyl-CoA
-
Arabidopsis thaliana ?
-
?
arachidoyl-CoA + malonyl-CoA
-
Lemna aequinoctialis ?
-
?
behenoyl-CoA + malonyl-CoA
-
Arabidopsis thaliana ?
-
?
behenoyl-CoA + malonyl-CoA
-
Lemna aequinoctialis ?
-
?
cerotoyl-CoA + malonyl-CoA
-
Arabidopsis thaliana ?
-
?
cerotoyl-CoA + malonyl-CoA
-
Lemna aequinoctialis ?
-
?

Synonyms

Synonyms Comment Organism
3-ketoacyl-CoA synthase
-
Arabidopsis thaliana
3-ketoacyl-CoA synthase
-
Lemna aequinoctialis
CER6 KCS6 Arabidopsis thaliana
CER60 KCS5 Arabidopsis thaliana
FAE1 KCS18 Arabidopsis thaliana
KCS
-
Lemna aequinoctialis
Kcs1
-
Arabidopsis thaliana
KCS17
-
Arabidopsis thaliana
KCS2
-
Arabidopsis thaliana
KCS20
-
Arabidopsis thaliana
VLCFA elongase
-
Arabidopsis thaliana

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000032
-
isozyme CER6, pH and temperature not specified in the publication Arabidopsis thaliana mefluidide
0.00021
-
isozyme CER6, pH and temperature not specified in the publication Arabidopsis thaliana perfluidone
0.00199
-
isozyme FAE1, pH and temperature not specified in the publication Arabidopsis thaliana mefluidide
0.0076
-
isozyme FAE1, pH and temperature not specified in the publication Arabidopsis thaliana metazachlor
0.114
-
isozyme CER6, pH and temperature not specified in the publication Arabidopsis thaliana metazachlor
0.5
-
IC50 above 0.5 mM, isozyme FAE1, pH and temperature not specified in the publication Arabidopsis thaliana perfluidone