Any feedback?
Please rate this page

BRENDA support

Information on EC - 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase

for references in articles please use BRENDA:EC2.1.1.201

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
IUBMB Comments

This enzyme is involved in ubiquinone biosynthesis. Ubiquinones from different organisms have a different number of prenyl units (for example, ubiquinone-6 in Saccharomyces, ubiquinone-9 in rat and ubiquinone-10 in human), and thus the natural substrate for the enzymes from different organisms has a different number of prenyl units. However, the enzyme usually shows a low degree of specificity regarding the number of prenyl units. For example, when the COQ5 gene from Saccharomyces cerevisiae is introduced into Escherichia coli, it complements the respiratory deficiency of an ubiE mutant . The bifunctional enzyme from Escherichia coli also catalyses the methylation of demethylmenaquinol-8 (this activity is classified as EC .

The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea

bocoq5-2, bocoq5-2 methyltransferase, coq5 methyltransferase, 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, more

S-adenosyl-L-methionine + 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol = S-adenosyl-L-homocysteine + 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol
show the reaction diagram
Highest Expressing Human Cell Lines
Cell Line Links Gene Links