Literature summary for 2.1.1.201 extracted from

Yen, H.C.; Liu, Y.C.; Kan, C.C.; Wei, H.J.; Lee, S.H.; Wei, Y.H.; Feng, Y.H.; Chen, C.W.; Huang, C.C.
Disruption of the human COQ5-containing protein complex is associated with diminished coenzyme Q10 levels under two different conditions of mitochondrial energy deficiency (2016), Biochim. Biophys. Acta, 1860, 1864-1876 .

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Homo sapiens	5739	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q5HYK3	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
143B cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
COQ5	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	chemical uncoupler carbonyl cyanide-p-trifluoromethoxyphenylhydrazone suppresses the COQ5 in mitochondrion and in cybrids with MERRF mutation, associated with decreased mitochondrial membrane potential and mitochondrial ATP production. Total CoQ10 levels are decreased under both conditions, but the ubiquinol-10:ubiquinone-10 ratio is increased in mutant cybrids. The expression of COQ5 is increased but COQ5 protein maturation is suppressed in the mutant cybrids	Homo sapiens

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Release 2023.1 (January 2023)