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Information on EC 1.8.3.5 - prenylcysteine oxidase

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EC Tree
     1 Oxidoreductases
         1.8 Acting on a sulfur group of donors
             1.8.3 With oxygen as acceptor
                1.8.3.5 prenylcysteine oxidase
IUBMB Comments
A flavoprotein (FAD). Cleaves the thioether bond of S-prenyl-L-cysteines, such as S-farnesylcysteine and S-geranylgeranylcysteine. N-Acetyl-prenylcysteine and prenylcysteinyl peptides are not substrates. May represent the final step in the degradation of prenylated proteins in mammalian tissues. Originally thought to be a simple lyase so it had been classified as EC 4.4.1.18.
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Word Map
  • 1.8.3.5
  • polycaprolactone
  • ligament
  • posterior
  • cruciate
  • knee
  • bone
  • fabric
  • biodegradable
  • graft
  • electrospun
  • biocompatibility
  • tibial
  • electrospinning
  • blend
  • copolymer
  • nanofibers
  • porous
  • flexion
  • film
  • femoral
  • polyepsilon-caprolactone
  • tensile
  • nanofibrous
  • modulus
  • biomaterials
  • arthroscopic
  • tendon
  • tear
  • porosity
  • biomechanical
  • laxity
  • arthroplasty
  • polyester
  • posterolateral
  • hamstring
  • screw
  • autograft
  • anterolateral
  • posteromedial
  • kinematics
  • avulsion
  • meniscal
  • osteoconductive
  • condyle
  • wettability
  • patellar
  • wettabl
  • bioresorbable
  • varus
  • cytocompatibility
The enzyme appears in viruses and cellular organisms
Synonyms
EC 4.4.1.18, farnesylcysteine lyase, FC lyase, FCLY, flavin adenine dinucleotide (FAD)-dependent thioether oxidase, PCL, PCL1, PCLY, PCYOX, PCYOX1, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
an S-prenyl-L-cysteine + O2 + H2O = a prenal + L-cysteine + H2O2
show the reaction diagram
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