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Literature summary for 1.8.3.5 extracted from
- Prenylcysteine lyase deficiency in mice results in the accumulation of farnesylcysteine and geranylgeranylcysteine in brain and liver (2002), J. Biol. Chem., 277, 38358-38363.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-prenyl-L-cysteine + O2 + H2O | Mus musculus | physiologic role in cleaving prenylcysteines in mammals, cleaves the thioether bond of prenylcysteines to yield free cysteine and the aldehyde of the isoprenoid lipid | prenal + L-cysteine + H2O2 | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | Q9CQF9 | mouse, wild type and knockout mutants | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Mus musculus | - |
| heart | - |
Mus musculus | - |
| kidney | - |
Mus musculus | - |
| liver | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| farnesyl-L-cysteine + O2 + H2O | - |
Mus musculus | farnesal + L-cysteine + H2O2 | - |
? | |
| geranylgeranyl-L-cysteine + O2 + H2O | - |
Mus musculus | geranylgeranal + L-cysteine + H2O2 | - |
? | |
| S-prenyl-L-cysteine + O2 + H2O | - |
Mus musculus | prenal + L-cysteine + H2O2 | - |
? | |
| S-prenyl-L-cysteine + O2 + H2O | physiologic role in cleaving prenylcysteines in mammals, cleaves the thioether bond of prenylcysteines to yield free cysteine and the aldehyde of the isoprenoid lipid | Mus musculus | prenal + L-cysteine + H2O2 | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.7 | - |
assay at | Mus musculus |
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Release 2023.1 (January 2023)
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