Any feedback?
Information on EC 1.5.1.23 - Tauropine dehydrogenase
for references in articles please use BRENDA:EC1.5.1.23Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
1.5.1.23 Tauropine dehydrogenaseIUBMB Comments
In the reverse reaction, alanine can act instead of taurine, but more slowly, and 2-oxobutanoate and 2-oxopentanoate can act instead of pyruvate.
Specify your search results
Word Map
- 1.5.1.23
-
haliotis
- abalone
-
polychaete
-
intrachain
-
triosephosphate
-
halichondria
-
heterosis
- adductor
- diversicolor
The expected taxonomic range for this enzyme is: Eukaryota, Archaea, Bacteria
Synonyms
tauropine dehydrogenase, tadh, 
more
topPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
NAD: tauropine oxidoreductase
-
-
-
-
TaDH
tauropine dehydrogenase
belongs to the family of opine dehydrogenases, phylogenetic analyses indicate that TaDH is only distantly related to the opine dehydrogenases from marine invertebrates, high sequence similarity to bacterial ornithine cyclodeaminases
tauropine [(carboxyethyl)-taurine/derived from sulfhydryl-amino acids] dehydrogenase
-
tauropine [(carboxyethyl)-taurine/derived from sulfhydrylamino acids] dehydrogenase
-
Tauropine: NAD oxidoreductase
-
-
-
-
TDH
TaDH
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
tauropine + NAD+ + H2O = taurine + pyruvate + NADH + H+
-
-
-
-
tauropine + NAD+ + H2O = taurine + pyruvate + NADH + H+
Cys146 might be essential for the catalytic reaction
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
-
-
-
-
reduction
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
PATHWAY SOURCE
PATHWAYS
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYSTEMATIC NAME
IUBMB Comments
N2-(D-1-carboxyethyl)taurine:NAD+ oxidoreductase (taurine-forming)
In the reverse reaction, alanine can act instead of taurine, but more slowly, and 2-oxobutanoate and 2-oxopentanoate can act instead of pyruvate.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CAS REGISTRY NUMBER
COMMENTARY
104645-74-1
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
Aminomethane sulfonic acid + pyruvate + NADH
N2-(1-Carboxyethyl)aminomethanesulfonic acid + NAD+ + H2O
Taurine + 2-oxohexanoate + NADH
?
-
at 4.8% of the activity with pyruvate
-
-
?
taurine + NADH + H+ + pyruvate
tauropine + NAD+ + H2O
taurine is involved in osmoregulation in marine animals
-
-
?
Ala + pyruvate + NADH
?
-
at 6% of the activity with taurine
-
-
?
Aminomethane sulfonic acid + pyruvate + NADH
N2-(1-Carboxyethyl)aminomethanesulfonic acid + NAD+ + H2O
-
at 1.8% of the activity with taurine
-
-
?
Aminomethane sulfonic acid + pyruvate + NADH
N2-(1-Carboxyethyl)aminomethanesulfonic acid + NAD+ + H2O
-
at 10.9% of the activity with taurine
-
-
?
Homotaurine + pyruvate + NADH
?
-
at 2.4% of the activity with taurine
-
-
?
Homotaurine + pyruvate + NADH
?
-
at 8.1% of the activity with taurine
-
-
?
Homotaurine + pyruvate + NADH
?
-
at 32.1% of the activity with taurine
-
-
?
Homotaurine + pyruvate + NADH
?
Rhodoglossum japonicum
-
at 12% of the activity with taurine
-
-
?
Hypotaurine + pyruvate + NADH
N2-(1-Carboxyethyl)aminoethanesulfinic acid + NAD+ + H2O
-
at 40% of the activity with taurine
-
-
?
Hypotaurine + pyruvate + NADH
N2-(1-Carboxyethyl)aminoethanesulfinic acid + NAD+ + H2O
-
at 35.2% of the activity with taurine
-
-
?
Hypotaurine + pyruvate + NADH
N2-(1-Carboxyethyl)aminoethanesulfinic acid + NAD+ + H2O
-
at 21.2% of the activity with taurine
-
-
?
Taurine + 2-oxobutanoate + NADH
?
-
,at 7.9% of the activity with pyruvate
-
-
?
Taurine + 2-oxobutanoate + NADH
?
-
at 4.4% of the activity with pyruvate
-
-
?
Taurine + 2-oxopentanoate + NADH
?
-
at 7.8% of the activity with pyruvate
-
-
?
Taurine + 2-oxopentanoate + NADH
?
-
at 4.8% of the activity with pyruvate
-
-
?
Taurine + 3-hydroxypyruvate + NADH
?
-
at 21.2% of the activity with pyruvate
-
-
?
Taurine + 3-hydroxypyruvate + NADH
?
-
at 4.1% of the activity with pyruvate
-
-
?
Taurine + glyoxylate + NADH
?
-
at 10.9% of the activity with pyruvate
-
-
?
Taurine + glyoxylate + NADH
?
-
at 12.8% of the activity with pyruvate
-
-
?
Taurine + glyoxylate + NADH
?
-
at 6.8% of the activity with pyruvate
-
-
?
taurine + oxaloacetate + NADH
?
-
at 85.8% of the activity with pyruvate
-
-
?
taurine + oxaloacetate + NADH
?
-
at 78.1% of the activity with pyruvate
-
-
?
Taurine + pyruvate + NADH
Tauropine + NAD+ + H2O
-
-
-
?
Taurine + pyruvate + NADH
Tauropine + NAD+ + H2O
-
no activity with NADPH
-
?
additional information
?
-
-
the enzyme is a dominant pyruvate reductase in this organism
-
-
?
additional information
?
-
-
the enzyme plays an important physiological role in energy production during shell fixation activity in the columnella muscle
-
-
?
additional information
?
-
involvement of the sponge TaDH in the final step of the glycolytic pathway in the regeneration of NAD+ under anaerobic conditions
-
-
?
additional information
?
-
opine production, opines are condensation products of an amino acid and a ketonic acid or a sugar
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
taurine + NADH + H+ + pyruvate
tauropine + NAD+ + H2O
taurine is involved in osmoregulation in marine animals
-
-
?
additional information
?
-
-
the enzyme is a dominant pyruvate reductase in this organism
-
-
?
additional information
?
-
-
the enzyme plays an important physiological role in energy production during shell fixation activity in the columnella muscle
-
-
?
additional information
?
-
involvement of the sponge TaDH in the final step of the glycolytic pathway in the regeneration of NAD+ under anaerobic conditions
-
-
?
additional information
?
-
opine production, opines are condensation products of an amino acid and a ketonic acid or a sugar
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
NAD(P)+
TaDH displays the GxGxxG/A motif known to be conserved among NAD(P)-dependent dehydrogenases
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
succinate
-
noncompetitive with respect to taurine and pyruvate
tauropine
-
mixed type inhibition with respect to pyruvate and taurine
additional information
-
the enzyme activity in adductor muscle decreases following the marine-brackish gradient
-
additional information
level of expression of TaDH is controlled by oxygen: TaDH is expressed when the oxygen level is low, during anaerobic glycolysis
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
additional information
-
effect of cosubstrate concentration on the Km-value of tauropine and pyruvate
-
additional information
additional information
-
effect of cosubstrate concentration on the Km-value of tauropine and pyruvate
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
-
enzyme activities (U*mg P-1) of tauropine dehydrogenase (TDH) in the foot and adductor muscles (combined) of hybrids, Haliotis rubra compared to Haliotis laevigata acclimated to 16°C and 100% air saturation (O2sat), or 16°C and 70% O2sat, or 23°C and 100% O2sat, or 23°C and 70% O2sat, overview
additional information
-
enzyme activities (U*mg P-1) of tauropine dehydrogenase (TDH) in the foot and adductor muscles (combined) of hybrids, Haliotis rubra compared to Haliotis laevigata acclimated to 16°C and 100% air saturation (O2sat), or 16°C and 70% O2sat, or 23°C and 100% O2sat, or 23°C and 70% O2sat, overview
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
7.2
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
5.1 - 7.2
-
50% of maximal activity at pH 5.1 and at pH 7.2, tauropine formation
5.5 - 7.4
-
50% of maximal activity at pH 5.5 and at pH 7.4, tauropine formation
5.5 - 7.9
-
50% of maximal activity at pH 5.5 and at pH 7.9, tauropine formation, enzyme form TaDH-1
6.8 - 8.5
-
50% of maximal activity at pH 6.8, optimum at pH 8.5, tauropine oxidation, enzyme form TaDH-1
8 - 9
-
pH 8.0: 50% of maximal activity, pH 9.0: optimum, tauropine oxidation
8.7 - 9.2
-
50% of maximal activity at pH 8.7 and at pH 9.2, tauropine oxidation
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
30