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Ligand pyruvic acid

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Basic Ligand Information

Molecular Structure
Picture of pyruvic acid (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
Molfile
C3H4O3
pyruvic acid
LCTONWCANYUPML-UHFFFAOYSA-N
 Download
Synonyms:
2-oxo-3-propanoate, 2-Oxo-propanoate analogues, 2-oxo-propanoic acid, 2-Oxopropanoate, 2-Oxopropanoic acid, 2-Oxopropionate, 2-Oxopropionic acid, alpha-Keto-propanoic acid, CH3C(O)CO2-, methylglyoxalate, pyruvate

Related pathways

Pathway Source
Pathways
BRENDA
3-phenylpropionate degradation, 4-hydroxyphenylacetate degradation, acetate fermentation, acetoin degradation, acetyl CoA biosynthesis more
KEGG
2-Oxocarboxylic acid metabolism, Alanine, aspartate and glutamate metabolism, AMPK signaling pathway, Arginine and proline metabolism, Ascorbate and aldarate metabolism more
MetaCyc
(R)-cysteate degradation, (S)-lactate fermentation to propanoate, acetate and hydrogen, (Z)-phenylmethanethial S-oxide biosynthesis, 1-butanol autotrophic biosynthesis (engineered), 2,3-dihydroxybenzoate biosynthesis more


Show all pahtways known for Show all BRENDA pathways known for pyruvic acid

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (246 results)

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EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
pyruvate + NAD+ = ?
show the reaction diagram
-
pyruvate + NADH + H+ = L-lactate + NAD+
show the reaction diagram
pyruvate + CO2 + NADH + H+ = (S)-malate + NAD+
show the reaction diagram
pyruvate + 2 NADH + 2 oxidized ferredoxin [iron-sulfur] cluster = lactate + 2 NAD+ + 2 reduced ferredoxin [iron-sulfur] cluster
show the reaction diagram
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pyruvate + NADPH + H+ = ?
show the reaction diagram
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pyruvate + CoA + NADP+ = acetyl-CoA + CO2 + NADPH
show the reaction diagram
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pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+
show the reaction diagram
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pyruvate + methylamine + NADPH = N-methyl-L-alanine + H2O + NADP+
show the reaction diagram
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L-arginine + pyruvate + NADH + H+ = N2-(D-1-carboxyethyl)-L-arginine + NAD+ + H2O
show the reaction diagram
glycine + pyruvate + NADH + H+ = N-(carboxymethyl)-D-alanine + NAD+ + H2O
show the reaction diagram
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taurine + NADH + H+ + pyruvate = tauropine + NAD+ + H2O
show the reaction diagram
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beta-alanine + pyruvate + NADH = beta-alanopine + NAD+ + H2O
show the reaction diagram
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amino acid + pyruvate + NADH + H+ = opine + NAD+ + H2O
show the reaction diagram
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(2S)-2-amino-4-[[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino]butanoate + pyruvate + NADPH + H+ = staphylopine + NADP+ + H2O
show the reaction diagram
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(2S)-2-amino-4-([(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino)butanoate + pyruvate + NADPH + H+ = yersinopine + NADP+ + H2O
show the reaction diagram
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(S)-methylmalonyl-CoA + pyruvate = propanoyl-CoA + oxaloacetate
show the reaction diagram
pyruvate + (E)-oct-2-enal = (S)-3-acetyloctanal + CO2
show the reaction diagram
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(3S)-3-aminobutanoyl-CoA + pyruvate = acetoacetyl-CoA + L-alanine
show the reaction diagram
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pyruvate + vanillylamine = L-alanine + vanillin
show the reaction diagram
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L-asparagine + pyruvate = 2-oxosuccinamate + L-alanine
show the reaction diagram
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L-glutamine + pyruvate = 2-oxoglutaramate + L-alanine
show the reaction diagram
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4-aminobutanoate + pyruvate = succinate semialdehyde + L-alanine
show the reaction diagram
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pyridoxamine + pyruvate = pyridoxal + L-alanine
show the reaction diagram
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(2-aminoethyl)phosphonate + pyruvate = 2-phosphonoacetaldehyde + L-alanine
show the reaction diagram
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(R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine
show the reaction diagram
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D-methionine + pyruvate = 4-methylthio-2-oxobutanoate + L-alanine
show the reaction diagram
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L-alanine + pyruvate = pyruvate + L-alanine
show the reaction diagram
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L-serine + pyruvate = 3-hydroxypyruvate + L-alanine
show the reaction diagram
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L-2,4-diaminobutanoate + pyruvate = L-2-amino-4-oxobutanoate + L-alanine
show the reaction diagram
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L-serine + pyruvate = 3-hydroxypyruvate + L-alanine
show the reaction diagram
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L-phenylalanine + pyruvate = phenylpyruvate + L-alanine
show the reaction diagram
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L-lysine + pyruvate = 2-aminoadipate 6-semialdehyde + L-alanine
show the reaction diagram
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L-arginine + pyruvate = 5-guanidino-2-oxopentanoate + L-alanine
show the reaction diagram
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4-aminobutanoate + pyruvate = succinate semialdehyde + L-alanine
show the reaction diagram
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L-tryptophan + pyruvate = indole-3-pyruvate + L-alanine
show the reaction diagram
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(2S,3S,5R,10S,12R,14R,15S,16S)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + pyruvate = (3S,5R,10S,12R,14R,15S,16S)-3,5,10,14,15-pentahydroxy-12,16-dimethylicosan-2-one + L-alanine
show the reaction diagram
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D-glucose oxime + pyruvate = pyruvic oxime + D-glucose
show the reaction diagram
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ATP + pyruvate + phosphate = AMP + phosphoenolpyruvate + diphosphate
show the reaction diagram
ATP + pyruvate + H2O = AMP + phosphoenolpyruvate + phosphate
show the reaction diagram
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pyruvate + H2O = ?
show the reaction diagram
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2,2-dialkylglycine + pyruvate = dialkyl ketone + CO2 + L-alanine
show the reaction diagram
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2 pyruvate = (S)-acetolactate + CO2
show the reaction diagram
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pyruvate + D-glyceraldehyde 3-phosphate = 2-dehydro-3-deoxy-6-phospho-D-galactonate
show the reaction diagram
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pyruvate + succinic semialdehyde = 4-hydroxy-2-oxo-1,7-heptanedioate
show the reaction diagram
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pyruvate + (S)-lactaldehyde = 2-dehydro-3-deoxy-L-rhamnonate
show the reaction diagram
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N1-methylguanine37 in tRNAPhe + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine37 in tRNAPhe + L-methionine + 5'-deoxyadenosine + CO2 + H2O
show the reaction diagram
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3-hydroxybenzoate + pyruvate + H2O = chorismate
show the reaction diagram
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phenol + pyruvate + NH3 = L-tyrosine + H2O
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (396 results)

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EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-malate + NAD+ = pyruvate + CO2 + NADH
show the reaction diagram
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D-lactate + ferricytochrome c-553 = pyruvate + ferrocytochrome c-553
show the reaction diagram
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(S)-lactate + O2 = pyruvate + H2O2
show the reaction diagram
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L-lactate + oxidized 2,6-dichlorophenolindophenol = pyruvate + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
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(R)-lactate + acceptor = pyruvate + reduced acceptor
show the reaction diagram
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(S)-lactate + oxaloacetate = malate + pyruvate
show the reaction diagram
287845, -
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methylglyoxal + NAD+ + H2O = pyruvate + NADH + H+
show the reaction diagram
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2-oxopropanal + H2O + O2 = pyruvate + H2O2
show the reaction diagram
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D-alanine + H2O + O2 = pyruvate + NH3 + H2O2
show the reaction diagram
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D-alanine + H2O + FAD = pyruvate + NH3 + FADH2
show the reaction diagram
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N2-(D-1-carboxyethyl)-L-arginine + NAD+ + H2O = L-arginine + pyruvate + NADH + H+
show the reaction diagram
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2,2'-iminodipropanoate + NAD+ + H2O = L-alanine + pyruvate + NADH + H+
show the reaction diagram
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beta-alanopine + NAD+ + H2O = beta-alanine + pyruvate + NADH + H+
show the reaction diagram
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N2-(D-1-carboxyethyl)-L-arginine + FAD + H2O = L-arginine + pyruvate + FADH2
show the reaction diagram
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propionyl-CoA + oxaloacetate = (S)-methylmalonyl-CoA + pyruvate
show the reaction diagram
(2S)-2-hydroxy-2-methylbutanedioate = acetate + pyruvate
show the reaction diagram
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L-alanine + 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate = pyruvate + 5-(aminomethyl)-3-furanmethanol phosphate
show the reaction diagram
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L-alanine + vanillin = pyruvate + vanillylamine
show the reaction diagram
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L-alanine + 3-oxopropanoate = pyruvate + beta-alanine
show the reaction diagram
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L-alanine + 2-oxoglutarate = pyruvate + L-glutamate
show the reaction diagram
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D-alanine + 2-oxoglutarate = pyruvate + D-glutamate
show the reaction diagram
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L-alanine + 4,5-dioxopentanoate = 5-aminolevulinate + pyruvate
show the reaction diagram
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L-alanine + glyoxylate = pyruvate + glycine
show the reaction diagram
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DL-alanine + oxomalonate = pyruvate + aminomalonic acid
show the reaction diagram
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L-alanine + 3-hydroxypyruvate = pyruvate + L-serine
show the reaction diagram
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L-alanine + 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol = pyruvate + 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol
show the reaction diagram
640163, -
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L-alanine + 3-methyl-2-oxobutanoate = L-valine + pyruvate
show the reaction diagram
640187, -
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phosphoenolpyruvate + glycerone = pyruvate + glycerone phosphate
show the reaction diagram
640691, -
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phosphoenolpyruvate + glycerone = pyruvate + glycerone phosphate
show the reaction diagram
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AMP + phosphoenolpyruvate + diphosphate = ATP + pyruvate + phosphate
show the reaction diagram
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AMP + phosphoenolpyruvate + phosphate = ATP + pyruvate + H2O
show the reaction diagram
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phosphoenolpyruvate + H2O = pyruvate + phosphate
show the reaction diagram
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3-phosphonopyruvate + H2O = pyruvate + phosphate
show the reaction diagram
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(5S,6S)-6-amino-5-[(1-carboxyethenyl)oxy]cyclohexa-1,3-diene-1-carboxylate + H2O = (5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxylic acid + pyruvate
show the reaction diagram
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D-cysteine + H2O = sulfide + NH3 + pyruvate
show the reaction diagram
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(2R,3S)-2,3-dimethylmalate = pyruvate + propionic acid
show the reaction diagram
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3-maleylpyruvate + H2O = maleate + pyruvate
show the reaction diagram
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2,4-didehydro-3-deoxy-L-rhamnonate + H2O = pyruvate + (S)-lactate
show the reaction diagram
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L-alanine + pyridoxal 5'-phosphate = pyruvate + pyridoxamine 5'-phosphate
show the reaction diagram
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acetylpyruvate + H2O = acetate + pyruvate
show the reaction diagram
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2-chloroacrylate + H2O = pyruvate + HCl
show the reaction diagram
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acetylene dicarboxylate = pyruvate + CO2
show the reaction diagram
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3-deoxy-D-manno-octulosonate = pyruvate + D-arabinose
show the reaction diagram
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2-dehydro-3-deoxy-D-gluconate = pyruvate + D-glyceraldehyde
show the reaction diagram
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2-dehydro-3-deoxy-L-galactonate = pyruvate + L-glyceraldehyde
show the reaction diagram
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2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate = (2S)-3-sulfolactaldehyde + pyruvate
show the reaction diagram
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D-xylulose 5-phosphate = pyruvate + acetyl phosphate
show the reaction diagram
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4-Hydroxy-2-oxoglutarate = Pyruvate + glyoxylate
show the reaction diagram
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(2R,3S)-2,3-dimethylmalate = propanoate + pyruvate
show the reaction diagram
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chorismate = 4-hydroxybenzoate + pyruvate
show the reaction diagram
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(S)-4-hydroxy-2-oxohexanoate = propanal + pyruvate
show the reaction diagram
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4-carboxy-4-hydroxy-2-oxoadipate = oxaloacetate + pyruvate
show the reaction diagram
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5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate = (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate + pyruvate
show the reaction diagram
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isochorismate = salicylate + pyruvate
show the reaction diagram
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2,3-diaminopropanoate + H2O = pyruvate + 2 NH3
show the reaction diagram
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L-serine = pyruvate + NH3
show the reaction diagram
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L-serine = pyruvate + NH3
show the reaction diagram
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L-alanine + pyridoxal 5'-phosphate = pyruvate + pyridoxamine 5'-phosphate
show the reaction diagram
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L-cysteine + H2O = sulfide + NH3 + pyruvate
show the reaction diagram
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beta-chloro-D-alanine + H2O = pyruvate + chloride + NH3
show the reaction diagram
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-

Substrate in Enzyme-catalyzed Reactions (1529 results)

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EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
pyruvate + NAD(P)H + H+ = lactate + NAD(P)+
show the reaction diagram
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pyruvate + NAD+ = ? + NADH
show the reaction diagram
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pyruvate + NADPH = 2-hydroxypropanoic acid + NADP+
show the reaction diagram
-
pyruvate + NADPH + H+ = lactate + NADP+
show the reaction diagram
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pyruvate + NADPH + H+ = D-lactate + NADP+
show the reaction diagram
-
pyruvate + NAD+ = ?
show the reaction diagram
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pyruvate + NADH + H+ = ?
show the reaction diagram
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pyruvate + NADH + H+ = D-lactate + NADH
show the reaction diagram
-
pyruvate + NADPH + H+ = ?
show the reaction diagram
-
pyruvate + NADPH + H+ = lactate + NADP+
show the reaction diagram
-
D-2-hydroxyglutarate + pyruvate = 2-oxoglutarate + D-lactate
show the reaction diagram
-
pyruvate + L-malate = (S)-lactate + oxaloacetate
show the reaction diagram
-
pyruvate + ferrocytochrome c3 = lactate + ferricytochrome c3
show the reaction diagram
-
pyruvate + CoA + O2 = acetyl-CoA + CO2 + H2O2
show the reaction diagram
-
pyruvate + NAD+ + CoA = acetyl-CoA + CO2 + NADH
show the reaction diagram
-
pyruvate + methyl viologen = ?
show the reaction diagram
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pyruvate + CoA + oxidized ferredoxin = acetyl-CoA + CO2 + reduced ferredoxin
show the reaction diagram
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pyruvate + methylamine + NADPH = N-methyl-L-alanine + H2O + NADP+
show the reaction diagram
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pyruvate + NADPH + NH3 = L-alanine + NADP+ + H2O
show the reaction diagram
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pyruvate + NH3 + NAD(P)H + H+ = L-alanine + H2O + NAD(P)+
show the reaction diagram
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2-oxopropanoate + NH3 + NADH + H+ = D,L-alanine + H2O + NAD+
show the reaction diagram
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pyruvate + methylamine = N-methylalanine
show the reaction diagram
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(2S)-2-amino-4-[[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino]butanoate + pyruvate + NADPH + H+ = staphylopine + NADP+ + H2O
show the reaction diagram
-
L-lysine + pyruvate + NADH = ?
show the reaction diagram
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pyruvate + NADH = ?
show the reaction diagram
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selenate + pyruvate = ?
show the reaction diagram
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S-adenosyl-L-methionine + pyruvate = S-adenosyl-L-homocysteine + 2-oxobutyrate
show the reaction diagram
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5,10-methylenetetrahydrofolate + pyruvate = tetrahydrofolate + ?
show the reaction diagram
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(S)-methylmalonyl-CoA + pyruvate = propanoyl-CoA + oxaloacetate
show the reaction diagram
pyruvate + D-erythrose 4-phosphate = ?
show the reaction diagram
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pyruvate + acetyl-CoA = citramalate + CoA
show the reaction diagram
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lauroyl-CoA + H2O + pyruvate = ?
show the reaction diagram
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acetyl-CoA + H2O + pyruvate = ?
show the reaction diagram
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(3S)-3-aminobutanoyl-CoA + pyruvate = acetoacetyl-CoA + L-alanine
show the reaction diagram
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beta-alanine + pyruvate = 3-oxopropanoate + L-alanine
show the reaction diagram
-
L-arginine + pyruvate = ?
show the reaction diagram
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L-ornithine + pyruvate = DELTA1-pyrroline-5-carboxylate + L-alanine
show the reaction diagram
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(S)-3-amino-2-methylpropanoate + pyruvate = D-methylmalonate semialdehyde + L-alanine
show the reaction diagram
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L-3,5,3'-triiodothyronine + pyruvate = 3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-2-oxopropanoate + L-alanine
show the reaction diagram
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D-tryptophan + pyruvate = 3-indole-2-oxopropanoate + L-alanine
show the reaction diagram
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putrescine + pyruvate = 4-aminobutanal + L-alanine
show the reaction diagram
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L-lysine + pyruvate = 2-aminoadipate 6-semialdehyde + L-alanine
show the reaction diagram
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L-histidine + pyruvate = imidazol-5-yl-pyruvate + L-alanine
show the reaction diagram
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L-glutamate + pyruvate = 2-oxoglutarate + L-alanine
show the reaction diagram
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L-phenylalanine + pyruvate = phenylpyruvate + L-alanine
show the reaction diagram
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L-kynurenine + pyruvate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-alanine
show the reaction diagram
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6-acetamido-3-aminohexanoate + pyruvate = 6-acetamido-3-oxohexanoate + L-alanine
show the reaction diagram
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L-methionine + pyruvate = 4-methylsulfanyl-2-oxobutanoate + L-alanine
show the reaction diagram
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L-ornithine + pyruvic acid = ?
show the reaction diagram
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pyruvate + L-aspartate = L-alanine + oxaloacetate
show the reaction diagram
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pyruvate + L-glutamate = L-alanine + 2-oxoglutarate
show the reaction diagram
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pyruvate + putrescine = L-alanine + 4-aminobutanal
show the reaction diagram
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L-histidinol phosphate + pyruvate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-Ala
show the reaction diagram
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4-aminobutanoate + pyruvate = succinate semialdehyde + L-alanine
show the reaction diagram
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L-tryptophan + pyruvate = indole-3-pyruvate + L-alanine
show the reaction diagram
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(2S,3S,5R,10S,12R,14R,15S,16S)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + pyruvate = (3S,5R,10S,12R,14R,15S,16S)-3,5,10,14,15-pentahydroxy-12,16-dimethylicosan-2-one + L-alanine
show the reaction diagram
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D-glucose oxime + pyruvate = pyruvic oxime + D-glucose
show the reaction diagram
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pyruvate + phosphorylated histidine-containing protein = phosphoenolpyruvate + histidine-containing protein
show the reaction diagram
ATP + pyruvate + H2O = AMP + phosphoenolpyruvate + phosphate
show the reaction diagram
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dopamine + pyruvate = (R)-salsolinol-1-carboxylate + H2O
show the reaction diagram
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pyruvate + H2O = ?
show the reaction diagram
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Pyruvate + CO2 = Oxaloacetate
show the reaction diagram
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pyruvate + 3-(2-furyl)acrolein = (3E,5E)-6-(furan-2-yl)-2-hydroxyhexa-3,5-dienoic acid
show the reaction diagram
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pyruvic acid = ?
show the reaction diagram
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pyruvate = acetaldehyde + CO2
show the reaction diagram
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pyruvate = acetaldehyde + CO2
show the reaction diagram
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acetyl-CoA + pyruvate = (3S)-citramalyl-CoA
show the reaction diagram
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N1-methylguanine37 in tRNAPhe + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine37 in tRNAPhe + L-methionine + 5'-deoxyadenosine + CO2 + H2O
show the reaction diagram
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3-hydroxybenzoate + pyruvate + H2O = chorismate
show the reaction diagram
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indole + pyruvate + NH4+ = L-Trp + H2O
show the reaction diagram
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pyruvate = lactate
show the reaction diagram
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ATP + pyruvate + diphosphate = ?
show the reaction diagram
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malate + pyruvate + O2 = ?
show the reaction diagram
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Pyruvate + CO2 = Oxaloacetate
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (1466 results)

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EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-lactate + NAD+ = pyruvate + NADH + H+
show the reaction diagram
-
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D-malate + NAD+ = pyruvate + CO2 + NADH
show the reaction diagram
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2-oxoglutarate + D-lactate = D-2-hydroxyglutarate + pyruvate
show the reaction diagram
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(S)-lactate + oxaloacetate = malate + pyruvate
show the reaction diagram
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lactate + ferrocytochrome c3 = pyruvate + ferricytochrome c3
show the reaction diagram
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L-alanine + O2 = 2-oxo-propanoic acid + NH3
show the reaction diagram
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alanine + propylamine + phenazine methosulfate = pyruvate + NH3 + reduced phenazine methosulfate
show the reaction diagram
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methylglyoxal + NAD+ + H2O = pyruvate + NADH
show the reaction diagram
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methylglyoxal + NAD+ + H2O = pyruvate + NADH + H+
show the reaction diagram
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pyruvaldehyde + NAD+ + H2O = pyruvate + NADH
show the reaction diagram
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methylglyoxal + NAD+ + H2O = pyruvate + NADH + H+
show the reaction diagram
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2-oxopropanal + H2O + O2 = pyruvate + H2O2
show the reaction diagram
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methylglyoxal + ferricyanide = 2-oxopropanoic acid + ferrocyanide + H+
show the reaction diagram
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hydroxypyruvate + NAD+ = pyruvate + NADH
show the reaction diagram
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L-alanine + H2O + NAD(P)+ = pyruvate + NH3 + NAD(P)H + H+
show the reaction diagram
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alanine + H2O + NAD(P)+ = pyruvate + NH3 + NAD(P)H
show the reaction diagram
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L-alanine + H2O + NAD+ = pyruvate + NH3 + NADH
show the reaction diagram
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L-Ala + H2O + NAD+ = 2-oxopropanoate + NH3 + NADH
show the reaction diagram
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D-alanine + H2O + 2 ferricytochrome = pyruvate + NH3 + 2 ferrocytochrome + 2 H+
show the reaction diagram
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N2-(D-1-carboxyethyl)-L-arginine + NAD+ + H2O = L-arginine + pyruvate + NADH + H+
show the reaction diagram
-
2,2'-iminodipropanoate + NAD+ + H2O = L-alanine + pyruvate + NADH + H+
show the reaction diagram
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beta-alanopine + NAD+ + H2O = beta-alanine + pyruvate + NADH + H+
show the reaction diagram
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N-methylalanine + H2O + O2 = methylamine + 2-oxo-propanoic acid + H2O2
show the reaction diagram
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D-alanine + oxidized 2,6-dichloroindophenol + H2O = pyruvate + NH3 + reduced 2,6-dichloroindophenol
show the reaction diagram
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N2-(D-1-carboxyethyl)-L-arginine + FAD + H2O = L-arginine + pyruvate + FADH2
show the reaction diagram
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3-nitropropanoic acid + H2O + O2 = 2-oxopropanoic acid + nitrite + H2O2
show the reaction diagram
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(2S)-2-hydroxy-2-methylbutanedioate = acetate + pyruvate
show the reaction diagram
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O-acetyl-L-serine + H2O = pyruvate + acetate + NH3
show the reaction diagram
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phosphoenolpyruvate + DL-glyceraldehyde 3-phosphate = pyruvate + phosphate
show the reaction diagram
637421, -
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L-alanine + 2-oxoglutarate = pyruvate + L-glutamate
show the reaction diagram
639873, -
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octanal + L-alanine = octyl-1-amine + pyruvate
show the reaction diagram
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6-oxohexanoate + L-alanine = 6-aminohexanoate + pyruvate
show the reaction diagram
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L-alanine + vanillin = pyruvate + vanillylamine
show the reaction diagram
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2-oxosuccinamic acid + L-alanine = L-asparagine + pyruvate
show the reaction diagram
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dTDP-4-dehydro-6-deoxy-D-glucose + L-alanine = dTDP-4-amino-4,6-dideoxy-D-galactose + pyruvate
show the reaction diagram
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L-alanine + 2-oxoglutarate = pyruvate + L-glutamate
show the reaction diagram
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DL-alanine + oxomalonate = pyruvate + aminomalonic acid
show the reaction diagram
636686, -
-
L-alanine + 3-phosphonooxypyruvate = O-phospho-L-serine + pyruvate
show the reaction diagram
-
-
L-alanine + 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol = pyruvate + 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol
show the reaction diagram
640163, -
-
L-alanine + alpha-ketomethiobutyrate = pyruvate + L-methionine
show the reaction diagram
-
phenylpyruvate + L-alanine = L-phenylalanine + pyruvate
show the reaction diagram
-
-
L-alanine + 3-methyl-2-oxobutanoate = L-valine + pyruvate
show the reaction diagram
640187, -
-
L-alanine + 2-oxobutanoate = pyruvate + 2-aminobutanoate
show the reaction diagram
-
-
L-alanine + 2-oxoglutarate = pyruvate + L-glutamate
show the reaction diagram
-
-
phosphoenolpyruvate + N-acetyl-alpha-D-galactosamine = pyruvate + N-acetyl-alpha-D-galactosamine 1-phosphate
show the reaction diagram
-
-
AMP + phosphoenolpyruvate + phosphate = ATP + pyruvate + H2O
show the reaction diagram
-
-
L-cystine + Slr0077 = pyruvate + Slr0077-SSH
show the reaction diagram
-
-
acetyl-CoA + lactate = pyruvate + acetate + CoA
show the reaction diagram
-
phosphoenolpyruvate + H2O = pyruvate + phosphate
show the reaction diagram
-
-
phosphoenolpyruvate + H2O = pyruvate + phosphate
show the reaction diagram
-
phosphoenolpyruvate + H2O = pyruvate + phosphate
show the reaction diagram
-
-
phosphoenolpyruvate + H2O = pyruvate + phosphate
show the reaction diagram
-
-
phosphoenolpyruvate + H2O = pyruvate + phosphate
show the reaction diagram
-
phosphoenolpyruvate + H2O = pyruvate + phosphate
show the reaction diagram
-
-
phosphoenolpyruvate + H2O = pyruvate + phosphate
show the reaction diagram
-
phosphoenolpyruvate + H2O = pyruvate + phosphate
show the reaction diagram
-
glucose + phosphoenolpyruvate = glucose 6-phosphate + pyruvate
show the reaction diagram
-
-
D-cysteine + H2O = sulfide + NH3 + pyruvate
show the reaction diagram
-
-
phosphoenolpyruvate + H2O = pyruvate + phosphate
show the reaction diagram
-
-
phosphoenolpyruvate + H2O = pyruvate + phosphate
show the reaction diagram
-
-
(2R,3S)-2,3-dimethylmalate = pyruvate + propionic acid
show the reaction diagram
-
-
acetylpyruvate + H2O = acetate + pyruvate
show the reaction diagram
-
2-chloroacrylate + H2O = pyruvate + HCl
show the reaction diagram
-
-
beta-chloro-L-Ala + H2O = pyruvate + Cl- + NH4+
show the reaction diagram
-
oxaloacetate + ? = pyruvate + CO2
show the reaction diagram
phosphoenolpyruvate + phosphate = pyruvate + diphosphate
show the reaction diagram
-
benzylidenepyruvate = benzaldehyde + pyruvate
show the reaction diagram
-
-
D-malate + NAD+ = pyruvate + CO2 + NADH
show the reaction diagram
-
acetylene dicarboxylate = pyruvate + CO2
show the reaction diagram
-
-
2-dehydro-3-deoxy-D-pentonate = pyruvate + glycolaldehyde
show the reaction diagram
-
2-dehydro-3-deoxy-L-galactonate = pyruvate + L-glyceraldehyde
show the reaction diagram
-
-
2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate = (2S)-3-sulfolactaldehyde + pyruvate
show the reaction diagram
-
-
2-dehydro-3-deoxy-L-fuconate = pyruvate + (S)-lactaldehyde
show the reaction diagram
-
-
D-xylulose 5-phosphate = pyruvate + acetyl phosphate
show the reaction diagram
-
-
citramalate = acetate + pyruvate
show the reaction diagram
-
D-glycerate = pyruvate + H2O
show the reaction diagram
-
-
isochorismate = salicylate + pyruvate
show the reaction diagram
-
-
L-cysteine + H2O = 2-oxopropanoate + NH3 + ?
show the reaction diagram
-
-

Activator in Enzyme-catalyzed Reactions (312 results)

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EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
1 mM, catecholase activity: 215%
-
crude extract
-
minor stimulatory effect
-
covalently bound
-
50% activation at 50 mM
-
crude enzyme fractions: pyruvate, ferredoxin, CoA and phosphate or arsenate required for maximal activity
-
pyruvate or oxamate are required for optimal activation
-
stimulation
-
5 mM, 1.15fold activation
-
2 mM stimulates
stimulates
-
0.5fold stimulation only for phlorizin activity
-
113% activity at 0.25 mM
-
activates
-
activates
-
increases the enzyme activity for fumarate
-
activation
-
required
-
0.030 mM
-

Inhibitor in Enzyme-catalyzed Reactions (380 results)

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EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
9% inhibition of the reductive reaction at 0.03 mM; slight
-
inactivation of isozyme CHCR2, not of isozymes CHCR1 and 3
-
weak
-
10 mM, 17.4% inhibition
-
with oxaloacetate, concomitantly added, less effective than glyoxylate + oxaloacetate
-
slight inhibition at 5 mM
-
5 mM, 33% inhibition
-
competitive inhibitor to acceptor
-
16% inhibition at 5 mM
-
50% inhibition above 10 mM, competitive
-
mixed type inhibitor
-
2-oxoglutarate dehydrogenase complex
-
slight inhibition
-
at 10 mM slight inhibitory
-
70% inhibition at 10 mM and 20% inhibition at 3 mM
-
slight, D-alanine oxidation
-
inhibited by an excess of substrate pyruvate; substrate inhibition, in excess, pyruvate enters in competition with the other substrate (glycine and/or NADH) preventing the site of reaction to take all the substrates to proceed with the enzymatic reaction. Its optimal concentration is determined to be round 2.0-2.3 mM
-
20% inhibition at 3.5 mM
-
5 mM, 38% inhibition
-
substrate inhibition
-
0.1 mM, 37% inhibition
-
inhibitory at 0.5 mM
-
20 mM, 85% inactivation after 1 h in the presence of cyanoborhydride, no inactivation in the absence of cyanoborhydride, preincubation with 5-enolpyruvylshikimate or a combination of shikimate 3-phosphate and glyphosate prevents from inactivation
-
alpha-keto acid acceptor, inhibitor at high concentrations
-
mixed type inhibition with L-alanine, competitive with glyoxylate; mixed type inhibitor with L-alanine as varied substrate and glyoxylate as fixed substrate. Competitive inhibitor with glyoxylate as varied substrate and L-alanine as fixed substrate
-
competitive vs. glyoxylate
-
3.5 mM, 10% inhibition
-
physiological concentrations of pyruvate and Mg2+ decrease the amount of dimeric, active dephospho-enzyme I
strongly inhibitory for the tartaric acid-stimulated phlorizin hydrolase
-
competitive inhibition
-
competitive inhibition, 2-10 mM
-
weak inhibition
added during growth of cells
-
weak substrate inhibition
-
competitive inhibition of glyoxylate binding
-
competitive inhibition
-
about 70% residual activity at 5 mM
-
12.5 mM, 25% inhibition
-
downstream thiosulfinate products petivericin (100 microM) and pyruvate (8.4 mM) inhibit alliinase activity by 60% and 29%, respectively, after 1 h, and a mixture of the two inhibits alliinase activity by 65%
-
-
-
less than 80% residual activity at 2 mM
-
20 mM, 12-15% inhibition
-
product inhibition competitive for oxaloacetate, Ki: 1.3 mM, noncompetitive inhibition for Na+, Ki: 2 mM
-

3D Structure of Enzyme-Ligand-Complex (PDB) (1931 results)

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EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (683 results)

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EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
1.3
-
in 50 mM Tris-HCl (pH 8.0) with 50 mM NaCl, 1 mM dithiothreitol, at 22°C
8
-
at pH 6.0 and 70°C
4.9
-
pH 9.5, 30°C
170
-
pH and temperature not specified in the publication
167
-
pH and temperature not specified in the publication
114
-
pH 9.5, 21°C
114
-
-
0.26
-
pH 8.0, 22°C
0.3
-
recombinant enzyme, with NADPH and L-histidine nicotianamine, pH 8.0, 22°C
0.17
-
at pH 8.0 and 32°C
0.4
-
pH 8.1, 28°C
1.25
-
cosubstrate beta-alanine, pH 8, temperature not specified in the publication
1.39
-
pH 7.5, 25°C, recombinant enzyme
15
-
pH 8.0, 25°C
38.6
-
calculated, pH 9.0, 37°C, coupled reaction with NAD+ and L-alanine dehydrogenase
22.3
-
pH 6.5, 25°C
0.12
-
pH 7.8, mutant enzyme Q52A
219.5
-
steady-state kinetic parameter, with acetaldehyde as aldehyde donor, pH 8.0 and 25°C