Ligand taurine

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Basic Ligand Information

Molecular Structure
Picture of taurine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C2H7NO3S
taurine
XOAAWQZATWQOTB-UHFFFAOYSA-N
Synonyms:
2-Aminoethane sulfonate, 2-aminoethanesulfonic acid, ethylamine-2-sulfonic acid, taurin, taurine[side 2]


Show all pahtways known for Show all BRENDA pathways known for taurine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (17 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
PROVEN IN VIVO REACTION
ENZYME 3D STRUCTURE
show the reaction diagram
Cl- + H2O2 + H+ + taurine + H+ = taurine monochloroamine + 2 H2O
-
show the reaction diagram
taurine + NADH + H+ + pyruvate = tauropine + NAD+ + H2O
-
show the reaction diagram
choloyl-CoA + taurine = CoA + taurocholate
-
show the reaction diagram
taurine + 2-oxoglutarate = 2-sulfoacetaldehyde + L-glutamate
-
show the reaction diagram
ATP + H2O + taurine/out = ADP + phosphate + taurine/in
-

In Vivo Product in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
PROVEN IN VIVO REACTION
ENZYME 3D STRUCTURE
-
show the reaction diagram
tauropine + NAD+ + H2O = taurine + pyruvate + NADH
-
show the reaction diagram
hypotaurine + H2O + NAD+ = taurine + NADH
-
-
show the reaction diagram
ATP + H2O + taurine/out = ADP + phosphate + taurine/in
-

Substrate in Enzyme-catalyzed Reactions (72 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
REACTION
ENZYME 3D STRUCTURE
show the reaction diagram
taurine + Br- + peracetic acid = bromotaurine + ?
-
show the reaction diagram
taurine + Cl- + H2O2 = taurine chloramine + HOCl + H2O
-
show the reaction diagram
arginine + taurine = 2-guanidinoethanesulfonic acid + ornithine
-
show the reaction diagram
acetyl-CoA + 2-aminoethanesulfonic acid = CoA + ?
-
show the reaction diagram
pyruvate + taurine = L-alanine + 2-oxoethanesulfonic acid
-
show the reaction diagram
ATP + H2O + taurine/out = ADP + phosphate + taurine/in
-

Product in Enzyme-catalyzed Reactions (48 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
REACTION
ENZYME 3D STRUCTURE
-
show the reaction diagram
tauropine + NAD+ + H2O = taurine + pyruvate + NADH
-
show the reaction diagram
hypotaurine + H2O + NAD+ = taurine + NADH
-
-
show the reaction diagram
N-acetyl-taurine + H2O = taurine + acetate
-
-
show the reaction diagram
N-oleoyl taurine + H2O = oleic acid + taurine
-
-
show the reaction diagram
N-oleoyltaurine + H2O = taurine + oleic acid
-
show the reaction diagram
taurocyamine + H2O = taurine + urea
-
-
show the reaction diagram
Cysteic acid = 2-Aminoethane sulfonate + CO2
-
-
show the reaction diagram
ATP + H2O + taurine-[sulfonate-binding protein][side 1] = ADP + phosphate + taurine[side 2] + [sulfonate-binding protein][side 1]
-
-
show the reaction diagram
ATP + H2O + taurine/out = ADP + phosphate + taurine/in
-

Activator in Enzyme-catalyzed Reactions (4 results)

COMMENTARY
EC NUMBER
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (9 results)

COMMENTARY
EC NUMBER
LITERATURE
ENZYME 3D STRUCTURE
about 19% inhibition at 0.1 mM
-
i.e. taurine, competitive
-
slight inhibition
-
uncompetitive inhibition of glycocholic acid hydrolysis
52% inhibition at 1 mM
-

3D Structure of Enzyme-Ligand-Complex (PDB) (42 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (7 results)

COMMENTARY
EC NUMBER
LITERATURE
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
mutant D101E, 30°C
0.74
-
mutant H255E, 30°C
1.1
-
mutant H255Q, 30°C
2.7
-
wild type enzyme
3
-
wild-type, 30°C
3.3
-
pH 7.5, 25°C
14.8
-
pH 7.2, 37°C, recombinant enzyme
3.7
-

KM Value (32 results)

COMMENTARY
EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
LITERATURE
mutant D101E, 30°C
0.061
-
wild-type, 30°C
0.019
-
wild type enzyme
0.052
-
mutant H255Q, 30°C
0.021
-
mutant H255E, 30°C
0.019
-
alpha-transamidinase
392
-
pH 7.5, 25°C
18.9
-
-
6.7
-
+ 0.05 mM deoxycholoyl-CoA
0.8
-
wild type enzyme, at pH 8.4 and 37°C
1.86
-
-
0.6
-
recombinant enzyme, expressed in Escherichia coli
1.9
-
rats fed with pectin
1.02
-
rats fed with cellulose
0.83
-
mutant enzyme BAAT-SKL, at pH 8.4 and 37°C
1.01
-
mutant enzyme BAAT-S, at pH 8.4 and 37°C
1.77
-
37°C, pH 8.4
1
-
-
12
-
pH 8.0, 37°C
12
-
pH 7.2, 37°C, recombinant enzyme
1.1
-
pH 9.0, 35°C
7.1
-
pH 9.0, 37°C
5.3
-

Ki Value (2 results)

COMMENTARY
EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
LITERATURE
pH 8.6, 25°C
68
-
pH 8.0, 50°C
2.5
-

References & Links

Links to other databases for taurine

ChEBI
PubChem
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PubChem