Ligand taurine

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Basic Ligand Information

Molecular Structure
Picture of taurine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C2H7NO3S
taurine
XOAAWQZATWQOTB-UHFFFAOYSA-N
Synonyms:
2-Aminoethane sulfonate, 2-aminoethanesulfonic acid, ethylamine-2-sulfonic acid, taurine[side 2]


Show all pahtways known for Show all BRENDA pathways known for taurine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (17 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
Cl- + H2O2 + H+ + taurine + H+ = taurine monochloroamine + 2 H2O
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taurine + NADH + H+ + pyruvate = tauropine + NAD+ + H2O
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choloyl-CoA + taurine = CoA + taurocholate
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taurine + 2-oxoglutarate = 2-sulfoacetaldehyde + L-glutamate
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ATP + H2O + taurine/out = ADP + phosphate + taurine/in
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
tauropine + NAD+ + H2O = taurine + pyruvate + NADH
show the reaction diagram
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hypotaurine + H2O + NAD+ = taurine + NADH
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ATP + H2O + taurine/out = ADP + phosphate + taurine/in
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (72 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
taurine + Br- + peracetic acid = bromotaurine + ?
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taurine + Cl- + H2O2 = taurine chloramine + HOCl + H2O
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arginine + taurine = 2-guanidinoethanesulfonic acid + ornithine
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acetyl-CoA + 2-aminoethanesulfonic acid = CoA + ?
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pyruvate + taurine = L-alanine + 2-oxoethanesulfonic acid
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ATP + H2O + taurine/out = ADP + phosphate + taurine/in
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Product in Enzyme-catalyzed Reactions (47 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
tauropine + NAD+ + H2O = taurine + pyruvate + NADH
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hypotaurine + H2O + NAD+ = taurine + NADH
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N-acetyl-taurine + H2O = taurine + acetate
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N-oleoyl taurine + H2O = oleic acid + taurine
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N-oleoyltaurine + H2O = taurine + oleic acid
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taurocyamine + H2O = taurine + urea
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Cysteic acid = 2-Aminoethane sulfonate + CO2
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ATP + H2O + taurine-[sulfonate-binding protein][side 1] = ADP + phosphate + taurine[side 2] + [sulfonate-binding protein][side 1]
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ATP + H2O + taurine/out = ADP + phosphate + taurine/in
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activates the enzyme, and acts as antagonist and reduces the hypochlorous acid toxicity
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0.5 M taurine activates the enzyme 3fold in the absence of monovalent cations
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Inhibitor in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
about 19% inhibition at 0.1 mM
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i.e. taurine, competitive
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slight inhibition
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uncompetitive inhibition of glycocholic acid hydrolysis

3D Structure of Enzyme-Ligand-Complex (PDB) (41 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (7 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
14.8
-
pH 7.5, 25°C
3.7
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pH 7.2, 37°C, recombinant enzyme

KM Value (32 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
392
-
alpha-transamidinase
18.9
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pH 7.5, 25°C

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
68
-
pH 8.6, 25°C
2.5
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pH 8.0, 50°C

References & Links

Links to other databases for taurine

ChEBI
PubChem
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PubChem