Information on EC 1.3.1.1 - dihydropyrimidine dehydrogenase (NAD+)

for references in articles please use BRENDA:EC1.3.1.1

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EC Tree 1 Oxidoreductases 1.3 Acting on the CH-CH group of donors 1.3.1 With NAD⁺ or NADP⁺ as acceptor 1.3.1.1 dihydropyrimidine dehydrogenase (NAD+)

IUBMB Comments

An iron-sulfur flavoenzyme. The enzyme was originally discovered in the uracil-fermenting bacterium, Clostridium uracilicum, which utilizes uracil and thymine as nitrogen and carbon sources for growth . Since then the enzyme was found in additional organisms including Alcaligenes eutrophus , Pseudomonas strains [3,4] and Escherichia coli [5,6].

The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea