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Information on EC 1.3.1.1 - dihydropyrimidine dehydrogenase (NAD+)

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IUBMB Comments
An iron-sulfur flavoenzyme. The enzyme was originally discovered in the uracil-fermenting bacterium, Clostridium uracilicum, which utilizes uracil and thymine as nitrogen and carbon sources for growth . Since then the enzyme was found in additional organisms including Alcaligenes eutrophus , Pseudomonas strains [3,4] and Escherichia coli [5,6].
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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
dihydrothymine dehydrogenase, pyrimidine reductase, uracil reductase, pyrimidine deaminase/reductase, more
REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
5,6-dihydrothymine + NAD+ = thymine + NADH + H+
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5,6-dihydrouracil + NAD+ = uracil + NADH + H+
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