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Literature summary for 1.3.1.1 extracted from

  • Serve, K.M.; Darnell, J.L.; Takemoto, J.K.; Davies, N.M.; Black, M.E.
    Validation of an isocratic HPLC method to detect 2-fluoro-beta-alanine for the analysis of dihydropyrimidine dehydrogenase activity (2010), J. Chromatogr. B, 878, 1889-1892.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5-fluorouracil + NADH + H+ Homo sapiens
-
 5-fluoro-5,6-dihydrouracil + NAD+ dihydrofluorouracil is further metabolized to 2'-fluoro-beta-alanine ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HCT-116 cell colorectal cancer cells Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-fluorouracil + NADH + H+
-
 Homo sapiens 5-fluoro-5,6-dihydrouracil + NAD+ dihydrofluorouracil is further metabolized to 2'-fluoro-beta-alanine ?
5-fluorouracil + NADH + H+ development of a detection method using 2'-fluoro-beta-alanine derivatization with o-phthalaldehyde at room temperature and mass spectrometric analysis by the liquid chromatography-mass spectrometry-electrospray ionization system, method evaluation and optimization, overview Homo sapiens 5-fluoro-5,6-dihydrouracil + NAD+ dihydrofluorouracil is further metabolized to 2'-fluoro-beta-alanine ?

Synonyms

Synonyms Comment Organism
dihydropyrimidine dehydrogenase
-
 Homo sapiens
DPD
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism efficacy of the chemotherapeutic drug 5'-fluorouracil is reduced by catabolism to 2'-fluoro-beta-alanine, a three-step reaction in which dihydropyrimidine dehydrogenase catalyzes the rate limiting step Homo sapiens