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Literature summary for 1.3.1.1 extracted from
- Regulation of human dihydropyrimidine dehydrogenase: implications in the pharmacogenetics of 5-FU-based chemotherapy (2007), Pharmacogenomics, 8, 257-265.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| phorbol-12-myristate | activates gene expression | Homo sapiens |  |
| specificity protein 1 | transcription activator | Homo sapiens |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 110000 | - |
2 * 110000, SDS-PAGE | Homo sapiens |
| 220000 | - |
SDS-PAGE | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| breast cancer cell | - |
Homo sapiens | - |
| colorectal cancer cell | - |
Homo sapiens | - |
| gastric cancer cell | - |
Homo sapiens | - |
| lung cancer cell | - |
Homo sapiens | - |
| ovary cancer cell | - |
Homo sapiens | - |
| pancreatic cancer cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5-fluorouracil + NADH + H+ | - |
Homo sapiens | 5-fluoro-5,6-dihydrouracil + NAD+ | - |
? | |
| uracil + NADH + H+ | - |
Homo sapiens | 5,6-dihydrouracil + NAD+ | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homodimer | 2 * 110000, SDS-PAGE | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| dihydropyrimidine dehydrogenase | - |
Homo sapiens |
| DPD | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Homo sapiens | |
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