Ligand 5,6-dihydrouracil

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Basic Ligand Information

Molecular Structure
Picture of 5,6-dihydrouracil (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C4H6N2O2
5,6-dihydrouracil
SYQNUQSGEWNWKV-XUIVZRPNSA-N
Synonyms:
2,4-dioxotetrahydropyrimidine, dihydropyrimidine-2,4(1H,3H)-dione, dihydrouracil, hydrouracil


Show all pahtways known for Show all BRENDA pathways known for 5,6-dihydrouracil

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5,6-dihydrouracil + NAD+ = uracil + NADH
show the reaction diagram
-
dihydrouracil + H2O = N-carbamoyl-beta-alanine
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5,6-dihydrouracil-DNA + H2O = 5,6-dihydrouracil + DNA
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (27 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5,6-dihydrouracil + O2 = uracil + H2O2
show the reaction diagram
-
dihydrouracil + H2O = N-carbamoyl-beta-alanine
show the reaction diagram
-
dihydrouracil + H2O = ?
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
N-carbamoyl beta-alanine + H2O = 5,6-dihydrouracil
show the reaction diagram
-

Inhibitor in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

3D Structure of Enzyme-Ligand-Complex (PDB) (2 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (6 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.65
-
pH 11.0, 30°C
0.4
-
-
9.14
-
-

KM Value (20 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.16
-
pH 11.0, 30°C
0.05
-
-
0.083
-
-

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.15
-
-

References & Links

Links to other databases for 5,6-dihydrouracil

ChEBI
PubChem
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PubChem