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Information on EC - glycine reductase

for references in articles please use BRENDA:EC1.21.4.2
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EC Tree
     1 Oxidoreductases
         1.21 Catalysing the reaction X-H + Y-H = X-Y
             1.21.4 With a disulfide as acceptor
       glycine reductase
IUBMB Comments
The reaction is observed only in the direction of glycine reduction. The enzyme from Eubacterium acidaminophilum consists of subunits A, B and C. Subunit B contains selenocysteine and a pyruvoyl group, and is responsible for glycine binding and ammonia release. Subunit A, which also contains selenocysteine, is reduced by thioredoxin, and is needed to convert the carboxymethyl group into a ketene equivalent, in turn used by subunit C to produce acetyl phosphate. Only subunit B distinguishes this enzyme from EC (sarcosine reductase) and EC (betaine reductase).
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Word Map
The enzyme appears in viruses and cellular organisms
glycine reductase, more
acetyl phosphate + NH3 + thioredoxin disulfide + H2O = glycine + phosphate + thioredoxin
show the reaction diagram