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Information on EC 1.2.1.75 - malonyl-CoA reductase (malonate semialdehyde-forming)

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IUBMB Comments
Requires Mg2+. Catalyses the reduction of malonyl-CoA to malonate semialdehyde, a key step in the 3-hydroxypropanoate and the 3-hydroxypropanoate/4-hydroxybutanoate cycles, autotrophic CO2 fixation pathways found in some green non-sulfur phototrophic bacteria and some thermoacidophilic archaea, respectively [1,2]. The enzyme from Sulfolobus tokodaii has been purified, and found to contain one RNA molecule per two subunits . The enzyme from Chloroflexus aurantiacus is bifunctional, and also catalyses the next reaction in the pathway, EC 1.1.1.298 [3-hydroxypropionate dehydrogenase (NADP+)] .
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The expected taxonomic range for this enzyme is: Bacteria, Archaea
Synonyms
malonate-semialdehyde dehydrogenase, malonyl CoA reductase (malonate semialdehyde-forming), malonyl-CoA reductase, MCR, more
REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
malonate semialdehyde + CoA + NADP+ = malonyl-CoA + NADPH + H+
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