Ligand malonate semialdehyde

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Basic Ligand Information

Molecular Structure
Picture of malonate semialdehyde (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C3H4O3
malonate semialdehyde
OAKURXIZZOAYBC-UHFFFAOYSA-N
Synonyms:
3-oxo-propionic acid, 3-oxopropanoate, 3-oxopropanoic acid, 3-oxopropionate, malonate-semialdehyde, malonic semialdehyde


Show all pahtways known for Show all BRENDA pathways known for malonate semialdehyde

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
3-oxopropanoate + NAD+ + H2O = malonate + NADH
show the reaction diagram
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3-oxopropanoate + CoA + NAD+ = acetyl-CoA + CO2 + NADH
show the reaction diagram
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malonate semialdehyde + CoA + NAD+ = acetyl-CoA + CO2 + NADH
show the reaction diagram
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L-alanine + 3-oxopropanoate = pyruvate + beta-alanine
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
3-hydroxypropanoate + NAD+ = 3-oxopropanoate + NADH + H+
show the reaction diagram
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3 propionate-3-nitronate + O2 = 3 malonic semialdehyde + nitrite + 2 nitrate + H2O2
show the reaction diagram
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malonyl-CoA + NADPH = malonate-semialdehyde + CoA + NADP+
show the reaction diagram
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beta-alanine + pyruvate = 3-oxopropionate + alanine
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (21 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
malonic semialdehyde + NADH = 3-hydroxypropanoate + NAD+
show the reaction diagram
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malonic semialdehyde + NADP+ + H2O = malonate + NADPH + H+
show the reaction diagram
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malonate semialdehyde + NAD+ + H2O = malonate + NADH + 2 H+
show the reaction diagram
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malonic semialdehyde + NAD+ = ?
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malonate semialdehyde + coenzyme A + NADP+ = malonyl-CoA + NADPH + H+
show the reaction diagram
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malonate semialdehyde + NADP+ + H2O = malonate + NADPH + 2 H+
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (48 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
3-hydroxypropanoate + NADP+ = 3-oxopropanoate + NADPH
show the reaction diagram
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3 propionate-3-nitronate + O2 = 3 malonic semialdehyde + nitrite + 2 nitrate + H2O2
show the reaction diagram
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malonyl-CoA + NADPH = malonate-semialdehyde + CoA + NADP+
show the reaction diagram
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malonate + NADH = malonic semialdehyde + NAD+ + H2O
show the reaction diagram
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3-aci-nitropropanoate + O2 = 3-oxopropanoate + nitrite + H2O2
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beta-alanine + pyruvate = 3-oxopropionate + alanine
show the reaction diagram
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beta-alanine + 2-oxoglutarate = malonic semialdehyde + L-glutamate
show the reaction diagram
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beta-alanine + 2-oxoglutarate = malonic semialdehyde + L-glutamate
show the reaction diagram
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beta-alanine + pyruvate = malonic semialdehyde + L-alanine
show the reaction diagram
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glycine + 2-oxoglutarate = 3-oxopropionate + L-glutamate
show the reaction diagram
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beta-alanine + 4,5-dioxopentanoate = 5-aminolevulinate + malonic semialdehyde
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beta-alanine + 2-oxoglutarate = 3-oxopropanoate + L-glutamate
show the reaction diagram
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beta-alanine + pyruvate = 3-oxopropanoate + L-alanine
show the reaction diagram
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4-(phenylthio)-N-(4-phenyl-2-oxobutyl)azetidin-2-one + H2O = thiophenol + 3-oxopropanoic acid + 1-amino-4-phenyl-2-butanone
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3-oxauracil + H2O = malonate semialdehyde + CO2 + NH3
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6-phospho-5-dehydro-2-deoxy-D-gluconate = glycerone phosphate + malonate semialdehyde
show the reaction diagram
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propynoate + H2O = 3-oxopropanoate
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive inhibitor
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3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (3 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
115
-
pH 7.4, 65°C

KM Value (6 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.07
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pH 7.4, 65°C
0.2
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0.043
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0.0045
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References & Links

Links to other databases for malonate semialdehyde

ChEBI
PubChem
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PubChem