Literature summary for 1.2.1.75 extracted from

Cheng, Z.; Jiang, J.; Wu, H.; Li, Z.; Ye, Q.
Enhanced production of 3-hydroxypropionic acid from glucose via malonyl-CoA pathway by engineered Escherichia coli (2016), Biores. Technol., 200, 897-904.

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Application

Application	Comment	Organism
synthesis	the combination of Escherichia coli BL21(DE3) and pET28a carrying heterogeneous acetyl-CoA carboxylase (Acc) from Corynebacterium glutamicum and codon-optimized malonyl-CoA reductase (MCR) from Chloroflexus aurantiacus is the most efficient host-vector system for 3-hydroxypropionic acid production, and the highest concentration of 3-hydroxypropionic attained in shake flask cultivation reaches 1.80 g/l with induction at 0.25 mM IPTG and 25°C, and supplementation of NaHCO3 and biotin	Chloroflexus aurantiacus

Organism

Organism	UniProt	Comment	Textmining
Chloroflexus aurantiacus	Q6QQP7	-	-

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Release 2023.1 (January 2023)