Reference on EC 1.14.99.63 - beta-carotene 4-ketolase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kim, J.; Cheng, K.; Craft, N.; Hamberger, B.; Douglas, C.
Over-expression of Arabidopsis thaliana carotenoid hydroxylases individually and in combination with a beta-carotene ketolase provides insight into in vivo functions
Phytochemistry
71
168-178
2010
Haematococcus lacustris
Huang, J.C.; Wang, Y.; Sandmann, G.; Chen, F.
Isolation and characterization of a carotenoid oxygenase gene from Chlorella zofingiensis (Chlorophyta)
Appl. Environ. Microbiol.
71
473-479
2006
Chromochloris zofingiensis (Q5U931), Chromochloris zofingiensis ATCC 30412 (Q5U931)
Choi, S.K.; Harada, H.; Matsuda, S.; Misawa, N.
Characterization of two beta-carotene ketolases, CrtO and CrtW, by complementation analysis in Escherichia coli
Appl. Environ. Microbiol.
75
1335-1341
2007
Synechocystis sp. (Q55808)
Zhu, C.; Naqvi, S.; Capell, T.; Christou, P.
Metabolic engineering of ketocarotenoid biosynthesis in higher plants
Arch. Biochem. Biophys.
483
182-190
2009
Synechocystis sp. (Q55808), Rhodococcus erythropolis (Q5IKE4), Gloeobacter violaceus (Q7NNL7), Anabaena sp. (Q8YQS5), Anabaena sp. PCC 7120 (Q8YQS5)
Mochimaru, M.; Masukawa, H.; Takaichi, S.
The cyanobacterium Anabaena sp. PCC 7120 has two distinct beta-carotene ketolases: CrtO for echinenone and CrtW for ketomyxol synthesis
FEBS Lett.
579
6111-6114
2005
Anabaena sp. (Q8YQS5), Anabaena sp. PCC 7120 (Q8YQS5)
Fernandez-Gonzales, B; Sandmann, G.; Vioques, A.
A new type of asymmetrically acting beta-carotene ketolase is required for the synthesis of echinenone in the cyanobacterium Synechocystis sp. PCC 6803
J. Biol. Chem.
272
9728-9733
1997
Synechocystis sp.
Schpf, L.; Mautz, J.; Sandmann, G.
Multiple ketolases involved in light regulation of canthaxanthin biosynthesis in Nostoc punctiforme PCC 73102
Planta
237
1279-1285
2013
Nostoc punctiforme
Zhou, P.; Xie, W.; Li, A.; Wang, F.; Yao, Z.; Bian, Q.; Zhu, Y.; Yu, H.; Ye, L.
Alleviation of metabolic bottleneck by combinatorial engineering enhanced astaxanthin synthesis in Saccharomyces cerevisiae
Enzyme Microb. Technol.
100
28-36
2017
Haematococcus lacustris (E2DRF9)
Wang, R.; Gu, X.; Yao, M.; Pan, C.; Liu, H.; Xiao, W.; Wang, Y.; Yuan, Y.
Engineering of beta-carotene hydroxylase and ketolase for astaxanthin overproduction in Saccharomyces cerevisiae
Front. Chem. Sci. Engin.
11
89-99
2017
Brevundimonas vesicularis (Q0H2C9), Brevundimonas vesicularis DC263 (Q0H2C9)
-
Kathiresan, S.; Chandrashekar, A.; Ravishankar, G.A.; Sarada, R.
Regulation of astaxanthin and its intermediates through cloning and genetic transformation of beta-carotene ketolase in Haematococcus pluvialis
J. Biotechnol.
196-197
33-41
2015
Haematococcus lacustris (C7DT95), Haematococcus lacustris SAG 34-1a (C7DT95)
Lu, Q.; Bu, Y.F.; Liu, J.Z.
Metabolic engineering of Escherichia coli for producing astaxanthin as the predominant carotenoid
Mar. Drugs
15
E296
2017
Sphingomonas sp. DC18 (A3QQZ2), Paracoccus sp. N81106 (P54972), Paracoccus sp. PC1 (Q44261), Brevundimonas sp. NBRC 101024 (Q4W8B8)
Bai, C.; Berman, J.; Farre, G.; Capell, T.; Sandmann, G.; Christou, P.; Zhu, C.
Reconstruction of the astaxanthin biosynthesis pathway in rice endosperm reveals a metabolic bottleneck at the level of endogenous beta-carotene hydroxylase activity
Transgenic Res.
26
13-23
2017
Chlamydomonas reinhardtii (Q4VKB4)
Sandmann, G.; Mautz, J.; Breitenbach, J.
Control of light-dependent keto carotenoid biosynthesis in Nostoc 7120 by the transcription factor NtcA
Z. Naturforsch. C
71
303-311
2016
Nostoc sp. PCC 7120 = FACHB-418 (Q8YSA0)
Ye, R.W.; Stead, K.J.; Yao, H.; He, H.
Mutational and functional analysis of the beta-carotene ketolase involved in the production of canthaxanthin and astaxanthin
Appl. Environ. Microbiol.
72
5829-5837
2006
Paracoccus sp. N81106 (P54972)
Ukibe, K.; Hashida, K.; Yoshida, N.; Takagi, H.
Metabolic engineering of Saccharomyces cerevisiae for astaxanthin production and oxidative stress tolerance
Appl. Environ. Microbiol.
75
7205-7211
2009
Phaffia rhodozyma, Phaffia rhodozyma ATCC 24202
Choi, S.K.; Harada, H.; Matsuda, S.; Misawa, N.
Characterization of two beta-carotene ketolases, CrtO and CrtW, by complementation analysis in Escherichia coli
Appl. Microbiol. Biotechnol.
75
1335-1341
2007
Rhodococcus erythropolis (C1A0Z0), Brevundimonas sp. NBRC 101024 (Q4W8B8), Synechocystis sp. PCC 6803 (Q55808), Rhodococcus erythropolis PR4 (C1A0Z0)
Scaife, M.A.; Burja, A.M.; Wright, P.C.
Characterization of cyanobacterial beta-carotene ketolase and hydroxylase genes in Escherichia coli, and their application for astaxanthin biosynthesis
Biotechnol. Bioeng.
103
944-955
2009
Nostoc punctiforme, Synechocystis sp. PCC 6803 (Q55808)
Steiger, S.; Sandmann, G.
Cloning of two carotenoid ketolase genes from Nostoc punctiforme for the heterologous production of canthaxanthin and astaxanthin
Biotechnol. Lett.
26
813-817
2004
Nostoc punctiforme
Lotan, T.; Hirschberg, J.
Cloning and expression in Escherichia coli of the gene encoding beta-C-4-oxygenase, that converts beta-carotene to the ketocarotenoid canthaxanthin in Haematococcus pluvialis
FEBS Lett.
364
125-128
1995
Haematococcus lacustris (Q39982), Haematococcus lacustris
Breitenbach, J.; Misawa, N.; Kajiwara, S.; Sandmann, G.
Expression in Escherichia coli and properties of the carotene ketolase from Haematococcus pluvialis
FEMS Microbiol. Lett.
140
241-246
1996
Haematococcus lacustris (Q39982)
Tao, L.; Rouviere, P.E.; Cheng, Q.
A carotenoid synthesis gene cluster from a non-marine Brevundimonas that synthesizes hydroxylated astaxanthin
Gene
379
101-108
2006
Brevundimonas vesicularis (Q0H2C9), Brevundimonas vesicularis DC2630 (Q0H2C9)
Fernandez-Gonzalez, B.; Sandmann, G.; Vioque, A.
A new type of asymmetrically acting beta-carotene ketolase is required for the synthesis of echinenone in the cyanobacterium Synechocystis sp. PCC 6803
J. Biol. Chem.
272
9728-9733
1997
Synechocystis sp. PCC 6803 (Q55808)
Zhong, Y.; Huang, J.; Liu, J.; Li, Y.; Jiang, Y.; Xu, Z.; Sandmann, G.; Chen, F.
Functional characterization of various algal carotenoid ketolases reveals that ketolating zeaxanthin efficiently is essential for high production of astaxanthin in transgenic Arabidopsis
J. Exp. Bot.
62
3659-3669
2011
Haematococcus lacustris (E2DRF9), Haematococcus lacustris
Choi, S.; Nishida, Y.; Matsuda, S.; Adachi, K.; Kasai, H.; Peng, X.; Komemushi, S.; Miki, W.; Misawa, N.
Characterization of beta-carotene ketolases, CrtW, from marine bacteria by complementation analysis in Escherichia coli
Mar. Biotechnol.
7
515-522
2005
Paracoccus sp. N81106 (P54972), Paracoccus sp. PC1 (Q44261), Brevundimonas sp. NBRC 101024 (Q4W8B8)
-
Tao, L.; Wilczek, J.; Odom, J.M.; Cheng, Q.
Engineering a beta-carotene ketolase for astaxanthin production
Metab. Eng.
8
523-531
2006
Sphingomonas sp. DC18 (A3QQZ2)
Martin, J.F.; Gudina, E.; Barredo, J.L.
Conversion of beta-carotene into astaxanthin Two separate enzymes or a bifunctional hydroxylase-ketolase protein?
Microb. Cell Fact.
7
3
2008
Phaffia rhodozyma, Phaffia rhodozyma ATCC 96815
Tao, L.; Cheng, Q.
Novel beta-carotene ketolases from non-photosynthetic bacteria for canthaxanthin synthesis
Mol. Genet. Genomics
272
530-537
2004
Rhodococcus erythropolis (Q5IKE4), Deinococcus radiodurans (Q9RY57), Rhodococcus erythropolis AN12 (Q5IKE4), Deinococcus radiodurans R1 (Q9RY57)
Ojima, K.; Breitenbach, J.; Visser, H.; Setoguchi, Y.; Tabata, K.; Hoshino, T.; van den Berg, J.; Sandmann, G.
Cloning of the astaxanthin synthase gene from Xanthophyllomyces dendrorhous (Phaffia rhodozyma) and its assignment as a beta-carotene 3-hydroxylase/4-ketolase
Mol. Genet. Genomics
275
148-158
2006
Phaffia rhodozyma, Phaffia rhodozyma ATCC 96594
Kildegaard, K.R.; Adiego-Perez, B.; Domenech Belda, D.; Khangura, J.K.; Holkenbrink, C.; Borodina, I.
Engineering of Yarrowia lipolytica for production of astaxanthin
Synth. Syst. Biotechnol.
2
287-294
2017
Paracoccus sp. N81106 (P54972)
Shindo, K.; Hasunuma, T.; Asagi, E.; Sano, A.; Hotta, E.; Minemura, N.; Miyake, C.; Maoka, T.; Misawa, N.
4-Ketoantheraxanthin, a novel carotenoid produced by the combination of the bacterial enzyme beta-carotene ketolase CrtW and endogenous carotenoid biosynthetic enzymes in higher plants
Tetrahedron Lett.
49
3294-3296
2008
Brevundimonas sp. NBRC 101024 (Q4W8B8)
-
Zhou, Y.; Huang, H.; Li, J.; Wang, R.; Luo, S.; Wu, T.; Zhong, Y.
Transient expression of beta-carotene ketolase of Chlamydomonas reinhardtii in pumpkin fruit
Acta Hortic. Sin.
44
2126-2134
2017
Chlamydomonas reinhardtii
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