1.2.7.12: formylmethanofuran dehydrogenase
This is an abbreviated version!
For detailed information about formylmethanofuran dehydrogenase, go to the full flat file.
Word Map on EC 1.2.7.12
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1.2.7.12
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methanogen
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methanogenesis
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methanobacterium
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thermoautotrophicum
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methanosarcina
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molybdopterin
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barkeri
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heterodisulfide
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formyltransferase
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methanothermobacter
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tungsten-containing
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wolfei
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molybdenum-containing
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formylmethanofuran:tetrahydromethanopterin
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molybdoenzyme
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hydrogenotrophic
- 1.2.7.12
-
methanogen
-
methanogenesis
-
methanobacterium
- thermoautotrophicum
- methanosarcina
- molybdopterin
- barkeri
-
heterodisulfide
-
formyltransferase
- methanothermobacter
-
tungsten-containing
- wolfei
-
molybdenum-containing
-
formylmethanofuran:tetrahydromethanopterin
-
molybdoenzyme
-
hydrogenotrophic
Reaction
+ + 2 oxidized ferredoxin [iron-sulfur] cluster = + + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+
Synonyms
CHO-methanofuran dehydrogenase, CHO-MFR dehydrogenase, Dehydrogenase, formylmethanofuran, EC 1.2.99.5, Fmd, FmdE, formyl-methanofuran dehydrogenase, formyl-MFR dehydrogenase, Fwd, FWD1, FWD2, FwdA-DFGH/FwdAFmdBCE, molybdenum-type formylmethanofuran dehydrogenase, PF02663, tungsten-dependent formylmethanofuran dehydrogenase, tungsten-type formylmethanofuran dehydrogenase
ECTree
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Systematic Name
Systematic Name on EC 1.2.7.12 - formylmethanofuran dehydrogenase
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formylmethanofuran:ferredoxin oxidoreductase
Contains a molybdopterin cofactor and numerous [4Fe-4S] clusters. In some organisms an additional subunit enables the incorporation of tungsten when molybdenum availability is low. The enzyme catalyses a reversible reaction in methanogenic archaea, and is involved in methanogenesis from CO2 as well as the oxidation of coenzyme M to CO2. The reaction is endergonic, and is driven by coupling with the soluble CoB-CoM heterodisulfide reductase via electron bifurcation.