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Information on EC 1.2.7.12 - formylmethanofuran dehydrogenase

for references in articles please use BRENDA:EC1.2.7.12

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IUBMB Comments

Contains a molybdopterin cofactor and numerous [4Fe-4S] clusters. In some organisms an additional subunit enables the incorporation of tungsten when molybdenum availability is low. The enzyme catalyses a reversible reaction in methanogenic archaea, and is involved in methanogenesis from CO2 as well as the oxidation of coenzyme M to CO2. The reaction is endergonic, and is driven by coupling with the soluble CoB-CoM heterodisulfide reductase via electron bifurcation.

The expected taxonomic range for this enzyme is: Bacteria, Archaea
Reaction Schemes
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a formylmethanofuran
+
H2O
+
2
oxidized ferredoxin [iron-sulfur] cluster
=
CO2
+
a methanofuran
+
2
reduced ferredoxin [iron-sulfur] cluster
+
2
H+
+
+
2
oxidized ferredoxin [iron-sulfur] cluster
=
+
+
2
reduced ferredoxin [iron-sulfur] cluster
+
2

Synonyms
formylmethanofuran dehydrogenase, formyl-methanofuran dehydrogenase, pf02663, formyl-mfr dehydrogenase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a formylmethanofuran + H2O + 2 oxidized ferredoxin [iron-sulfur] cluster = CO2 + a methanofuran + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
methanogenesis from H2 and CO2, methoxylated aromatic compound degradation II, methyl-coenzyme M oxidation to CO2, reductive acetyl coenzyme A pathway II (autotrophic methanogens)