Information on EC 6.1.1.20 - Phenylalanine-tRNA ligase

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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea

EC NUMBER
COMMENTARY
6.1.1.20
-
RECOMMENDED NAME
GeneOntology No.
Phenylalanine-tRNA ligase
PATHWAY
KEGG Link
MetaCyc Link
Aminoacyl-tRNA biosynthesis
-
tRNA charging
-
SYSTEMATIC NAME
IUBMB Comments
L-Phenylalanine:tRNAPhe ligase (AMP-forming)
-
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
CML33
-
-
-
-
CML33
O95363
-
CML33
Q9Y285
-
CML33
Methanobacterium thermoautotrophicus
-
-
CML33
Q76KA8 and Q76KA8
-
CML33
Q5SGX2 and Q5SGX1
-
ctPheRS
-
cytoplasmic type
cytoplasmic phenylalanyl-tRNA synthetase
-
-
cytoplasmic phenylalanyl-tRNA synthetase
O95363
-
cytosolic phenylalanyl-tRNA synthetase
O95363
-
cytosolic phenylalanyl-tRNA synthetase
Q9NSD9, Q9Y285
-
cytosolic PheRS
Q9NSD9, Q9Y285
-
EcPheRS
-
-
FRS
-
-
-
-
FRS
O95363
-
FRS
Q9Y285
-
FRS
Methanobacterium thermoautotrophicus
-
-
FRS
Q76KA8 and Q76KA8
-
FRS
Q5SGX2 and Q5SGX1
-
hcPheRS
O95363
-
hcPheRS
Q9NSD9, Q9Y285
-
HSPC173
-
-
-
-
HSPC173
Q8RPZ8
-
HSPC173
O95363
-
HSPC173
Q9Y285
-
HSPC173
Methanobacterium thermoautotrophicus
-
-
HSPC173
Q76KA8 and Q76KA8
-
HSPC173
Q5SGX2 and Q5SGX1
-
L-Phenylalanyl-tRNA synthetase
-
-
-
-
L-Phenylalanyl-tRNA synthetase
Q8RPZ8
-
L-Phenylalanyl-tRNA synthetase
-
-
L-Phenylalanyl-tRNA synthetase
-
-
L-Phenylalanyl-tRNA synthetase
-
-
L-Phenylalanyl-tRNA synthetase
O95363
-
L-Phenylalanyl-tRNA synthetase
Q9Y285
-
L-Phenylalanyl-tRNA synthetase
Methanobacterium thermoautotrophicus
-
-
L-Phenylalanyl-tRNA synthetase
-
-
L-Phenylalanyl-tRNA synthetase
-
-
L-Phenylalanyl-tRNA synthetase
-
-
L-Phenylalanyl-tRNA synthetase
-
-
L-Phenylalanyl-tRNA synthetase
Q76KA8 and Q76KA8
-
L-Phenylalanyl-tRNA synthetase
-
-
L-Phenylalanyl-tRNA synthetase
Q5SGX2 and Q5SGX1
-
mitochondrial phenylalanyl-tRNA synthetase
-
-
mitochondrial PheRS
-
-
mtPheRS
-
mitochondrial type
mtPheRS
O95363
-
mtPheRS
-
mitochondrial type
Phenylalanine translase
-
-
-
-
Phenylalanine translase
Q8RPZ8
-
Phenylalanine translase
-
-
Phenylalanine translase
-
-
Phenylalanine translase
-
-
Phenylalanine translase
O95363
-
Phenylalanine translase
Q9Y285
-
Phenylalanine translase
Methanobacterium thermoautotrophicus
-
-
Phenylalanine translase
-
-
Phenylalanine translase
-
-
Phenylalanine translase
-
-
Phenylalanine translase
-
-
Phenylalanine translase
Q76KA8 and Q76KA8
-
Phenylalanine translase
Q5SGX2 and Q5SGX1
-
phenylalanine tRNA synthetase
-
-
Phenylalanine--tRNA ligase
-
-
-
-
Phenylalanine--tRNA ligase
Q8RPZ8
-
Phenylalanine--tRNA ligase
-
-
Phenylalanine--tRNA ligase
-
-
Phenylalanine--tRNA ligase
-
-
Phenylalanine--tRNA ligase
O95363
-
Phenylalanine--tRNA ligase
Q9Y285
-
Phenylalanine--tRNA ligase
Methanobacterium thermoautotrophicus
-
-
Phenylalanine--tRNA ligase
-
-
Phenylalanine--tRNA ligase
-
-
Phenylalanine--tRNA ligase
-
-
Phenylalanine--tRNA ligase
-
-
Phenylalanine--tRNA ligase
Q76KA8 and Q76KA8
-
Phenylalanine--tRNA ligase
Q5SGX2 and Q5SGX1
-
Phenylalanine-tRNA synthetase
-
-
-
-
Phenylalanine-tRNA synthetase
Q8RPZ8
-
Phenylalanine-tRNA synthetase
-
-
Phenylalanine-tRNA synthetase
-
-
Phenylalanine-tRNA synthetase
Haemophilus influenzae Spain
-
-
-
Phenylalanine-tRNA synthetase
-
-
Phenylalanine-tRNA synthetase
O95363
-
Phenylalanine-tRNA synthetase
Q9Y285
-
Phenylalanine-tRNA synthetase
Methanobacterium thermoautotrophicus
-
-
Phenylalanine-tRNA synthetase
-
-
Phenylalanine-tRNA synthetase
Moraxella catarrhalis 489
-
-
-
Phenylalanine-tRNA synthetase
-
-
Phenylalanine-tRNA synthetase
Staphylococcus aureus 133
-
-
-
Phenylalanine-tRNA synthetase
-
-
Phenylalanine-tRNA synthetase
Streptococcus pneumoniae G9A
-
-
-
Phenylalanine-tRNA synthetase
-
-
Phenylalanine-tRNA synthetase
-
-
-
Phenylalanine-tRNA synthetase
-
-
Phenylalanine-tRNA synthetase
Q76KA8 and Q76KA8
-
Phenylalanine-tRNA synthetase
-
-
Phenylalanine-tRNA synthetase
Q5SGX2 and Q5SGX1
-
Phenylalanyl transfer ribonucleic acid synthetase
-
-
-
-
Phenylalanyl transfer ribonucleic acid synthetase
Q8RPZ8
-
Phenylalanyl transfer ribonucleic acid synthetase
-
-
Phenylalanyl transfer ribonucleic acid synthetase
-
-
Phenylalanyl transfer ribonucleic acid synthetase
-
-
Phenylalanyl transfer ribonucleic acid synthetase
O95363
-
Phenylalanyl transfer ribonucleic acid synthetase
Q9Y285
-
Phenylalanyl transfer ribonucleic acid synthetase
Methanobacterium thermoautotrophicus
-
-
Phenylalanyl transfer ribonucleic acid synthetase
-
-
Phenylalanyl transfer ribonucleic acid synthetase
-
-
Phenylalanyl transfer ribonucleic acid synthetase
-
-
Phenylalanyl transfer ribonucleic acid synthetase
-
-
Phenylalanyl transfer ribonucleic acid synthetase
Q76KA8 and Q76KA8
-
Phenylalanyl transfer ribonucleic acid synthetase
-
-
Phenylalanyl transfer ribonucleic acid synthetase
Q5SGX2 and Q5SGX1
-
Phenylalanyl-transfer ribonucleate synthetase
-
-
-
-
Phenylalanyl-transfer ribonucleate synthetase
Q8RPZ8
-
Phenylalanyl-transfer ribonucleate synthetase
-
-
Phenylalanyl-transfer ribonucleate synthetase
-
-
Phenylalanyl-transfer ribonucleate synthetase
Haemophilus influenzae Spain
-
-
-
Phenylalanyl-transfer ribonucleate synthetase
-
-
Phenylalanyl-transfer ribonucleate synthetase
O95363
-
Phenylalanyl-transfer ribonucleate synthetase
Q9Y285
-
Phenylalanyl-transfer ribonucleate synthetase
Methanobacterium thermoautotrophicus
-
-
Phenylalanyl-transfer ribonucleate synthetase
-
-
Phenylalanyl-transfer ribonucleate synthetase
Moraxella catarrhalis 489
-
-
-
Phenylalanyl-transfer ribonucleate synthetase
-
-
Phenylalanyl-transfer ribonucleate synthetase
Staphylococcus aureus 133
-
-
-
Phenylalanyl-transfer ribonucleate synthetase
-
-
Phenylalanyl-transfer ribonucleate synthetase
Streptococcus pneumoniae G9A
-
-
-
Phenylalanyl-transfer ribonucleate synthetase
-
-
Phenylalanyl-transfer ribonucleate synthetase
Q76KA8 and Q76KA8
-
Phenylalanyl-transfer ribonucleate synthetase
-
-
Phenylalanyl-transfer ribonucleate synthetase
Q5SGX2 and Q5SGX1
-
Phenylalanyl-transfer RNA ligase
-
-
-
-
Phenylalanyl-transfer RNA ligase
Q8RPZ8
-
Phenylalanyl-transfer RNA ligase
-
-
Phenylalanyl-transfer RNA ligase
-
-
Phenylalanyl-transfer RNA ligase
-
-
Phenylalanyl-transfer RNA ligase
O95363
-
Phenylalanyl-transfer RNA ligase
Q9Y285
-
Phenylalanyl-transfer RNA ligase
Methanobacterium thermoautotrophicus
-
-
Phenylalanyl-transfer RNA ligase
-
-
Phenylalanyl-transfer RNA ligase
-
-
Phenylalanyl-transfer RNA ligase
-
-
Phenylalanyl-transfer RNA ligase
-
-
Phenylalanyl-transfer RNA ligase
Q76KA8 and Q76KA8
-
Phenylalanyl-transfer RNA ligase
-
-
Phenylalanyl-transfer RNA ligase
Q5SGX2 and Q5SGX1
-
Phenylalanyl-transfer RNA synthetase
-
-
-
-
Phenylalanyl-transfer RNA synthetase
Q8RPZ8
-
Phenylalanyl-transfer RNA synthetase
-
-
Phenylalanyl-transfer RNA synthetase
-
-
Phenylalanyl-transfer RNA synthetase
Haemophilus influenzae Spain
-
-
-
Phenylalanyl-transfer RNA synthetase
-
-
Phenylalanyl-transfer RNA synthetase
O95363
-
Phenylalanyl-transfer RNA synthetase
Q9Y285
-
Phenylalanyl-transfer RNA synthetase
-
-
Phenylalanyl-transfer RNA synthetase
Methanobacterium thermoautotrophicus
-
-
Phenylalanyl-transfer RNA synthetase
-
-
Phenylalanyl-transfer RNA synthetase
Moraxella catarrhalis 489
-
-
-
Phenylalanyl-transfer RNA synthetase
-
-
Phenylalanyl-transfer RNA synthetase
Staphylococcus aureus 133
-
-
-
Phenylalanyl-transfer RNA synthetase
-
-
Phenylalanyl-transfer RNA synthetase
Streptococcus pneumoniae G9A
-
-
-
Phenylalanyl-transfer RNA synthetase
-
-
Phenylalanyl-transfer RNA synthetase
Q76KA8 and Q76KA8
-
Phenylalanyl-transfer RNA synthetase
-
-
Phenylalanyl-transfer RNA synthetase
Q5SGX2 and Q5SGX1
-
Phenylalanyl-tRNA ligase
-
-
-
-
Phenylalanyl-tRNA ligase
Q8RPZ8
-
Phenylalanyl-tRNA ligase
-
-
Phenylalanyl-tRNA ligase
-
-
Phenylalanyl-tRNA ligase
-
-
Phenylalanyl-tRNA ligase
O95363
-
Phenylalanyl-tRNA ligase
Q9Y285
-
Phenylalanyl-tRNA ligase
Methanobacterium thermoautotrophicus
-
-
Phenylalanyl-tRNA ligase
-
-
Phenylalanyl-tRNA ligase
-
-
Phenylalanyl-tRNA ligase
-
-
Phenylalanyl-tRNA ligase
-
-
Phenylalanyl-tRNA ligase
Q76KA8 and Q76KA8
-
Phenylalanyl-tRNA ligase
Q5SGX2 and Q5SGX1
-
Phenylalanyl-tRNA synthetase
-
-
-
-
Phenylalanyl-tRNA synthetase
Q8RPZ8
-
Phenylalanyl-tRNA synthetase
-
-
Phenylalanyl-tRNA synthetase
-
-
Phenylalanyl-tRNA synthetase
C9QTZ3
-
Phenylalanyl-tRNA synthetase
Escherichia coli NP37
-
;
-
Phenylalanyl-tRNA synthetase
-
-
Phenylalanyl-tRNA synthetase
Haemophilus influenzae Spain
-
-
-
Phenylalanyl-tRNA synthetase
-
-
Phenylalanyl-tRNA synthetase
O95363
-
Phenylalanyl-tRNA synthetase
Q9Y285
-
Phenylalanyl-tRNA synthetase
-
-
Phenylalanyl-tRNA synthetase
Methanobacterium thermoautotrophicus
-
-
Phenylalanyl-tRNA synthetase
-
-
Phenylalanyl-tRNA synthetase
Moraxella catarrhalis 489
-
-
-
Phenylalanyl-tRNA synthetase
-
-
Phenylalanyl-tRNA synthetase
-
-
Phenylalanyl-tRNA synthetase
-
-
Phenylalanyl-tRNA synthetase
Staphylococcus aureus 133
-
-
-
Phenylalanyl-tRNA synthetase
-
-
Phenylalanyl-tRNA synthetase
Streptococcus pneumoniae G9A
-
-
-
Phenylalanyl-tRNA synthetase
-
-
Phenylalanyl-tRNA synthetase
Q76KA8 and Q76KA8
-
Phenylalanyl-tRNA synthetase
Q5SGX2 and Q5SGX1
-
PheRS
-
-
-
-
PheRS
-
-
PheRS
C9QTZ3
-
PheRS
Escherichia coli NP37
-
;
-
PheRS
O95363
-
PheRS
Q9Y285
-
PheRS
Methanobacterium thermoautotrophicus
-
-
PheRS
Q76KA8 and Q76KA8
-
PheRS
Q5SGX2 and Q5SGX1
-
Synthetase, phenylalanyl-transfer ribonucleate
-
-
-
-
Synthetase, phenylalanyl-transfer ribonucleate
Q8RPZ8
-
Synthetase, phenylalanyl-transfer ribonucleate
-
-
Synthetase, phenylalanyl-transfer ribonucleate
-
-
Synthetase, phenylalanyl-transfer ribonucleate
Haemophilus influenzae Spain
-
-
-
Synthetase, phenylalanyl-transfer ribonucleate
-
-
Synthetase, phenylalanyl-transfer ribonucleate
O95363
-
Synthetase, phenylalanyl-transfer ribonucleate
Q9Y285
-
Synthetase, phenylalanyl-transfer ribonucleate
Methanobacterium thermoautotrophicus
-
-
Synthetase, phenylalanyl-transfer ribonucleate
-
-
Synthetase, phenylalanyl-transfer ribonucleate
Moraxella catarrhalis 489
-
-
-
Synthetase, phenylalanyl-transfer ribonucleate
-
-
Synthetase, phenylalanyl-transfer ribonucleate
Staphylococcus aureus 133
-
-
-
Synthetase, phenylalanyl-transfer ribonucleate
-
-
Synthetase, phenylalanyl-transfer ribonucleate
Streptococcus pneumoniae G9A
-
-
-
Synthetase, phenylalanyl-transfer ribonucleate
-
-
Synthetase, phenylalanyl-transfer ribonucleate
Q76KA8 and Q76KA8
-
Synthetase, phenylalanyl-transfer ribonucleate
-
-
Synthetase, phenylalanyl-transfer ribonucleate
Q5SGX2 and Q5SGX1
-
mitPheRS
-
-
additional information
C9QTZ3
the enzyme belongs to class II aminoacyl-tRNA synthetases
CAS REGISTRY NUMBER
COMMENTARY
9055-66-7
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
mutant strain UA22 carrying both wild-type and mutant alleles of gene pheS due to polyploidy
UniProt
Manually annotated by BRENDA team
wild-type strain 168, overproduced in Escherichia coli JM109
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
2 activities
-
-
Manually annotated by BRENDA team
overproducing strain carrying a hybrid pBR322 plasmid containing the pheS-pheT locus
-
-
Manually annotated by BRENDA team
p-fluorophenylalanine-resistant strain with Ala294Ser mutation
-
-
Manually annotated by BRENDA team
purified enzyme, strain CP78 and mutant relA- strain CP79
-
-
Manually annotated by BRENDA team
strain K
-
-
Manually annotated by BRENDA team
strain K-10
-
-
Manually annotated by BRENDA team
strain MRE-600
-
-
Manually annotated by BRENDA team
strain NP37 carrying the thermosensitive point mutation A294G in the active site
-
-
Manually annotated by BRENDA team
Escherichia coli K
strain K
-
-
Manually annotated by BRENDA team
Escherichia coli K-10
strain K-10
-
-
Manually annotated by BRENDA team
Escherichia coli MRE-600
strain MRE-600
-
-
Manually annotated by BRENDA team
Escherichia coli NP37
strain NP37 carrying the thermosensitive point mutation A294G in the active site
-
-
Manually annotated by BRENDA team
strain Spain 7
-
-
Manually annotated by BRENDA team
Haemophilus influenzae Spain
strain Spain 7
-
-
Manually annotated by BRENDA team
alpha chain
SwissProt
Manually annotated by BRENDA team
beta chain
SwissProt
Manually annotated by BRENDA team
class II enzyme
SwissProt
Manually annotated by BRENDA team
mitochondrial isozyme, class II enzyme
UniProt
Manually annotated by BRENDA team
i.e. Lactobacillus amylovorus, several strains, e.g. strains 16698T and AD5, from Finnish porcine isolates, housekeeping gene pheS encoding the alpha-subunit
-
-
Manually annotated by BRENDA team
Methanobacterium thermoautotrophicus
-
-
-
Manually annotated by BRENDA team
strain 489
-
-
Manually annotated by BRENDA team
Moraxella catarrhalis 489
strain 489
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain 133
-
-
Manually annotated by BRENDA team
strain WCUH29 and Oxford strain, genes pheS and pheT
-
-
Manually annotated by BRENDA team
Staphylococcus aureus 133
strain 133
-
-
Manually annotated by BRENDA team
Streptococcus pneumoniae G9A
strain G9A
-
-
Manually annotated by BRENDA team
KOD1, class II enzyme
Q76KA8 and Q76KA8
UniProt
Manually annotated by BRENDA team
-
Q5SGX2 and Q5SGX1
UniProt
Manually annotated by BRENDA team
class II enzyme
-
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
evolution
C9QTZ3
architecture of four helix-bundle interface, characteristic of class IIc heterotetrameric aaRSs, is changed, each of the two long helices belonging to CLM transformed into the coil-short helix structural fragments. The N-terminal domain of the alpha-subunit in EcPheRS forms compact triple helix domain
pH RANGE
pH RANGE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
6
8.5
-
no activity below pH 6.0 and above 8.5, higher activity range is pH 6.5-8.0
PDB
SCOP
CATH
ORGANISM
Bacteroides fragilis (strain ATCC 25285 / NCTC 9343)
Escherichia coli (strain ATCC 33849 / DSM 4235 / NCIB 12045 / K12 / DH1)
Porphyromonas gingivalis (strain ATCC BAA-308 / W83)
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Staphylococcus haemolyticus (strain JCSC1435)
Staphylococcus haemolyticus (strain JCSC1435)
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
GENERAL STABILITY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
2-mercaptoethanol stabilizes
-
APPLICATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
biotechnology
-
design of an enzyme variant which incorporates aryl ketones into proteins
biotechnology
-
misacylation of suppressor tRNAPhe CUA by the PheRS mutant A294G with 4-iodo-L-phenylalanine might be useful in application in protein engineering since an aryl iodide tag on proteins can be used for site-specific functionalization of proteins, used for cell-free protein synthesis as a stoichiometric reagent, overview
biotechnology
Escherichia coli NP37
-
misacylation of suppressor tRNAPhe CUA by the PheRS mutant A294G with 4-iodo-L-phenylalanine might be useful in application in protein engineering since an aryl iodide tag on proteins can be used for site-specific functionalization of proteins, used for cell-free protein synthesis as a stoichiometric reagent, overview
-