EC Number |
Reaction |
Reference |
---|
6.1.1.20 | ATP + L-phenylalanine + tRNAPhe = AMP + diphosphate + L-phenylalanyl-tRNAPhe |
- |
- |
6.1.1.20 | ATP + L-phenylalanine + tRNAPhe = AMP + diphosphate + L-phenylalanyl-tRNAPhe |
mechanism, the reaction intermediate is bound to the active site cleft in the catalytic alpha-subunit |
652792 |
6.1.1.20 | ATP + L-phenylalanine + tRNAPhe = AMP + diphosphate + L-phenylalanyl-tRNAPhe |
Phe391 in motif 2 and Arg472 in motif 3 bind to the adenosine moiety of tRNAPhe, Arg379 in motif 2 and Arg463 in motif 3 restrain the conformation with the triphosphate that interacts with the ribosyl hydroxyl and gamma-phosphate, Asp395 in motif 2 is unique and binds to phenylalanine to assure proper positioning of the substrate |
651809 |
6.1.1.20 | ATP + L-phenylalanine + tRNAPhe = AMP + diphosphate + L-phenylalanyl-tRNAPhe |
reaction mechanism |
649147 |
6.1.1.20 | ATP + L-phenylalanine + tRNAPhe = AMP + diphosphate + L-phenylalanyl-tRNAPhe |
reaction mechanism in which ATP and phenylalanine enter the reaction in an obligatory ordered fashion. A random mechanism is not completely eliminated |
332 |
6.1.1.20 | ATP + L-phenylalanine + tRNAPhe = AMP + diphosphate + L-phenylalanyl-tRNAPhe |
residue N217 is essential for catalysis |
676814 |
6.1.1.20 | ATP + L-phenylalanine + tRNAPhe = AMP + diphosphate + L-phenylalanyl-tRNAPhe |
substrate binding mechanism, residues S180, Q218, E220, W149, H178, R204, and Q218 are involved in binding of phenylalanine via hydrogen bonds |
653011 |
6.1.1.20 | ATP + L-phenylalanine + tRNAPhe = AMP + diphosphate + L-phenylalanyl-tRNAPhe |
tRNA channeling mechanism |
650377 |
6.1.1.20 | ATP + L-phenylalanine + tRNAPhe = AMP + diphosphate + L-phenylalanyl-tRNAPhe |
tRNA recognition and binding mode |
649540 |
6.1.1.20 | ATP + L-phenylalanine + tRNAPhe = AMP + diphosphate + L-phenylalanyl-tRNAPhe |
tRNAPhe substrate binding mechanism, base-specific interactions between the 3'-end of the tRNA and the enzymes alpha- and beta-subunit |
650182 |