Literature summary for 6.1.1.20 extracted from

Yu, X.Y.; Finn, J.; Hill, J.M.; Wang, Z.G.; Keith, D.; Silverman, J.; Oliver, N.
A series of spirocyclic analogues as potent inhibitors of bacterial phenylalanyl-tRNA synthetase (2004), Bioorg. Med. Chem. Lett., 14, 1339-1342.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(3a'R,6a'S)-5'-(3,4-dichlorophenyl)-3'-phenyl-3a',6a'-dihydro-2'H-spiro[indene-2,1'-pyrrolo[3,4-c]pyrrole]-1,3,4',6'(3'H,5'H)-tetrone	IC50: 40 nM, high selectivity over the human enzyme	Enterococcus faecalis
(3a'R,6a'S)-5'-(3,4-dichlorophenyl)-3'-phenyl-3a',6a'-dihydro-2'H-spiro[indene-2,1'-pyrrolo[3,4-c]pyrrole]-1,3,4',6'(3'H,5'H)-tetrone	IC50: 40 nM, high selectivity over the human enzyme	Staphylococcus aureus
(3a'R,6a'S)-5'-(3-chloro-4-methylphenyl)-3'-phenyl-3a',6a'-dihydro-2'H-spiro[indene-2,1'-pyrrolo[3,4-c]pyrrole]-1,3,4',6'(3'H,5'H)-tetrone	IC50: 0.00099 mM, high selectivity over the human enzyme	Enterococcus faecalis
(3a'R,6a'S)-5'-(3-chloro-4-methylphenyl)-3'-phenyl-3a',6a'-dihydro-2'H-spiro[indene-2,1'-pyrrolo[3,4-c]pyrrole]-1,3,4',6'(3'H,5'H)-tetrone	IC50: 0.00073 mM, high selectivity over the human enzyme	Staphylococcus aureus
(3a'S,6a'R)-5'-(3,4-dichlorophenyl)-3'-phenyl-3a',6a'-dihydro-2'H-spiro[indene-2,1'-pyrrolo[3,4-c]pyrrole]-1,3,4',6'(3'H,5'H)-tetrone	IC50: 0.004 mM, high selectivity over the human enzyme	Enterococcus faecalis
(3a'S,6a'R)-5'-(3,4-dichlorophenyl)-3'-phenyl-3a',6a'-dihydro-2'H-spiro[indene-2,1'-pyrrolo[3,4-c]pyrrole]-1,3,4',6'(3'H,5'H)-tetrone	IC50: 0.003 mM, high selectivity over the human enzyme	Staphylococcus aureus
(3a'S,6a'R)-5'-(3-chloro-4-methylphenyl)-3'-phenyl-3a',6a'-dihydro-2'H-spiro[indene-2,1'-pyrrolo[3,4-c]pyrrole]-1,3,4',6'(3'H,5'H)-tetrone	IC50: 0.0087 mM, high selectivity over the human enzyme	Enterococcus faecalis
(3a'S,6a'R)-5'-(3-chloro-4-methylphenyl)-3'-phenyl-3a',6a'-dihydro-2'H-spiro[indene-2,1'-pyrrolo[3,4-c]pyrrole]-1,3,4',6'(3'H,5'H)-tetrone	IC50: 0.0061 mM, high selectivity over the human enzyme	Staphylococcus aureus
(3aR,6aS)-5-(3,4-dichlorophenyl)-3-phenyl-3a,6a-dihydrospiro[furo[3,4-c]pyrrole-1,2'-indene]-1',3',4,6(3H,5H)-tetrone	IC50: 0.00085 mM, high selectivity over the human enzyme	Enterococcus faecalis
(3aR,6aS)-5-(3,4-dichlorophenyl)-3-phenyl-3a,6a-dihydrospiro[furo[3,4-c]pyrrole-1,2'-indene]-1',3',4,6(3H,5H)-tetrone	IC50: 0.00056 mM, high selectivity over the human enzyme	Staphylococcus aureus
(3aR,6aS)-5-(3-chloro-4-methylphenyl)-3-phenyl-3a,6a-dihydrospiro[furo[3,4-c]pyrrole-1,2'-indene]-1',3',4,6(3H,5H)-tetrone	IC50: 0.00022 mM, high selectivity over the human enzyme	Enterococcus faecalis
(3aR,6aS)-5-(3-chloro-4-methylphenyl)-3-phenyl-3a,6a-dihydrospiro[furo[3,4-c]pyrrole-1,2'-indene]-1',3',4,6(3H,5H)-tetrone	IC50: 0.00007 mM, high selectivity over the human enzyme	Staphylococcus aureus
(3aS,6aR)-5-(3,4-dichlorophenyl)-3-phenyl-3a,6a-dihydrospiro[furo[3,4-c]pyrrole-1,2'-indene]-1',3',4,6(3H,5H)-tetrone	IC50: 5 nM, high selectivity over the human enzyme	Enterococcus faecalis
(3aS,6aR)-5-(3,4-dichlorophenyl)-3-phenyl-3a,6a-dihydrospiro[furo[3,4-c]pyrrole-1,2'-indene]-1',3',4,6(3H,5H)-tetrone	IC50: 2 nM, high selectivity over the human enzyme	Staphylococcus aureus
(3aS,6aR)-5-(3-chloro-4-methylphenyl)-3-phenyl-3a,6a-dihydrospiro[furo[3,4-c]pyrrole-1,2'-indene]-1',3',4,6(3H,5H)-tetrone	IC50: 0.0083 mM, high selectivity over the human enzyme	Enterococcus faecalis
(3aS,6aR)-5-(3-chloro-4-methylphenyl)-3-phenyl-3a,6a-dihydrospiro[furo[3,4-c]pyrrole-1,2'-indene]-1',3',4,6(3H,5H)-tetrone	IC50: 0.0137 mM, high selectivity over the human enzyme	Staphylococcus aureus
(3aS,6aR)-5-[4-chloro-3-(trifluoromethyl)phenyl]-3-phenyl-3a,6a-dihydrospiro[furo[3,4-c]pyrrole-1,2'-indene]-1',3',4,6(3H,5H)-tetrone	IC50: 0.032 mM, high selectivity over the human enzyme	Enterococcus faecalis
(3aS,6aR)-5-[4-chloro-3-(trifluoromethyl)phenyl]-3-phenyl-3a,6a-dihydrospiro[furo[3,4-c]pyrrole-1,2'-indene]-1',3',4,6(3H,5H)-tetrone	IC50: 0.045 mM, high selectivity over the human enzyme	Staphylococcus aureus

Organism

Organism	UniProt	Comment	Textmining
Enterococcus faecalis	-	-	-
Staphylococcus aureus	-	-	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.000002	-	IC50: 2 nM, high selectivity over the human enzyme	Staphylococcus aureus	(3aS,6aR)-5-(3,4-dichlorophenyl)-3-phenyl-3a,6a-dihydrospiro[furo[3,4-c]pyrrole-1,2'-indene]-1',3',4,6(3H,5H)-tetrone
0.000005	-	IC50: 5 nM, high selectivity over the human enzyme	Enterococcus faecalis	(3aS,6aR)-5-(3,4-dichlorophenyl)-3-phenyl-3a,6a-dihydrospiro[furo[3,4-c]pyrrole-1,2'-indene]-1',3',4,6(3H,5H)-tetrone
0.00004	-	IC50: 40 nM, high selectivity over the human enzyme	Staphylococcus aureus	(3a'R,6a'S)-5'-(3,4-dichlorophenyl)-3'-phenyl-3a',6a'-dihydro-2'H-spiro[indene-2,1'-pyrrolo[3,4-c]pyrrole]-1,3,4',6'(3'H,5'H)-tetrone
0.00004	-	IC50: 40 nM, high selectivity over the human enzyme	Enterococcus faecalis	(3a'R,6a'S)-5'-(3,4-dichlorophenyl)-3'-phenyl-3a',6a'-dihydro-2'H-spiro[indene-2,1'-pyrrolo[3,4-c]pyrrole]-1,3,4',6'(3'H,5'H)-tetrone
0.00007	-	IC50: 0.00007 mM, high selectivity over the human enzyme	Staphylococcus aureus	(3aR,6aS)-5-(3-chloro-4-methylphenyl)-3-phenyl-3a,6a-dihydrospiro[furo[3,4-c]pyrrole-1,2'-indene]-1',3',4,6(3H,5H)-tetrone
0.00022	-	IC50: 0.00022 mM, high selectivity over the human enzyme	Enterococcus faecalis	(3aR,6aS)-5-(3-chloro-4-methylphenyl)-3-phenyl-3a,6a-dihydrospiro[furo[3,4-c]pyrrole-1,2'-indene]-1',3',4,6(3H,5H)-tetrone
0.00056	-	IC50: 0.00056 mM, high selectivity over the human enzyme	Staphylococcus aureus	(3aR,6aS)-5-(3,4-dichlorophenyl)-3-phenyl-3a,6a-dihydrospiro[furo[3,4-c]pyrrole-1,2'-indene]-1',3',4,6(3H,5H)-tetrone
0.00073	-	IC50: 0.00073 mM, high selectivity over the human enzyme	Staphylococcus aureus	(3a'R,6a'S)-5'-(3-chloro-4-methylphenyl)-3'-phenyl-3a',6a'-dihydro-2'H-spiro[indene-2,1'-pyrrolo[3,4-c]pyrrole]-1,3,4',6'(3'H,5'H)-tetrone
0.00085	-	IC50: 0.00085 mM, high selectivity over the human enzyme	Enterococcus faecalis	(3aR,6aS)-5-(3,4-dichlorophenyl)-3-phenyl-3a,6a-dihydrospiro[furo[3,4-c]pyrrole-1,2'-indene]-1',3',4,6(3H,5H)-tetrone
0.00099	-	IC50: 0.00099 mM, high selectivity over the human enzyme	Enterococcus faecalis	(3a'R,6a'S)-5'-(3-chloro-4-methylphenyl)-3'-phenyl-3a',6a'-dihydro-2'H-spiro[indene-2,1'-pyrrolo[3,4-c]pyrrole]-1,3,4',6'(3'H,5'H)-tetrone
0.003	-	IC50: 0.003 mM, high selectivity over the human enzyme	Staphylococcus aureus	(3a'S,6a'R)-5'-(3,4-dichlorophenyl)-3'-phenyl-3a',6a'-dihydro-2'H-spiro[indene-2,1'-pyrrolo[3,4-c]pyrrole]-1,3,4',6'(3'H,5'H)-tetrone
0.004	-	IC50: 0.004 mM, high selectivity over the human enzyme	Enterococcus faecalis	(3a'S,6a'R)-5'-(3,4-dichlorophenyl)-3'-phenyl-3a',6a'-dihydro-2'H-spiro[indene-2,1'-pyrrolo[3,4-c]pyrrole]-1,3,4',6'(3'H,5'H)-tetrone
0.0061	-	IC50: 0.0061 mM, high selectivity over the human enzyme	Staphylococcus aureus	(3a'S,6a'R)-5'-(3-chloro-4-methylphenyl)-3'-phenyl-3a',6a'-dihydro-2'H-spiro[indene-2,1'-pyrrolo[3,4-c]pyrrole]-1,3,4',6'(3'H,5'H)-tetrone
0.0083	-	IC50: 0.0083 mM, high selectivity over the human enzyme	Enterococcus faecalis	(3aS,6aR)-5-(3-chloro-4-methylphenyl)-3-phenyl-3a,6a-dihydrospiro[furo[3,4-c]pyrrole-1,2'-indene]-1',3',4,6(3H,5H)-tetrone
0.0087	-	IC50: 0.0087 mM, high selectivity over the human enzyme	Enterococcus faecalis	(3a'S,6a'R)-5'-(3-chloro-4-methylphenyl)-3'-phenyl-3a',6a'-dihydro-2'H-spiro[indene-2,1'-pyrrolo[3,4-c]pyrrole]-1,3,4',6'(3'H,5'H)-tetrone
0.0137	-	IC50: 0.0137 mM, high selectivity over the human enzyme	Staphylococcus aureus	(3aS,6aR)-5-(3-chloro-4-methylphenyl)-3-phenyl-3a,6a-dihydrospiro[furo[3,4-c]pyrrole-1,2'-indene]-1',3',4,6(3H,5H)-tetrone
0.032	-	IC50: 0.032 mM, high selectivity over the human enzyme	Enterococcus faecalis	(3aS,6aR)-5-[4-chloro-3-(trifluoromethyl)phenyl]-3-phenyl-3a,6a-dihydrospiro[furo[3,4-c]pyrrole-1,2'-indene]-1',3',4,6(3H,5H)-tetrone
0.045	-	IC50: 0.045 mM, high selectivity over the human enzyme	Staphylococcus aureus	(3aS,6aR)-5-[4-chloro-3-(trifluoromethyl)phenyl]-3-phenyl-3a,6a-dihydrospiro[furo[3,4-c]pyrrole-1,2'-indene]-1',3',4,6(3H,5H)-tetrone

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Release 2023.1 (January 2023)