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Aberrant Crypt Foci
Metformin suppresses azoxymethane-induced colorectal aberrant crypt foci by activating AMP-activated protein kinase.
Acidosis
Differential regulation of eEF2 and p70S6K by AMPKalpha2 in heart.
Acquired Immunodeficiency Syndrome
Trehalose limits opportunistic mycobacterial survival during HIV co-infection by reversing HIV-mediated autophagy block.
Acute Kidney Injury
AMP-activated protein kinase contributes to cisplatin-induced renal epithelial cell apoptosis and acute kidney injury.
Acute Kidney Injury
AMPK-mediated activation of Akt protects renal tubular cells from stress-induced apoptosis in vitro and ameliorates ischemic AKI in vivo.
Acute Kidney Injury
Rationale and Design of Assessing the Effectiveness of Short-Term Low-Dose Lithium Therapy in Averting Cardiac Surgery-Associated Acute Kidney Injury: A Randomized, Double Blinded, Placebo Controlled Pilot Trial.
Acute Kidney Injury
Redox-sensitive glycogen synthase kinase 3?-directed control of mitochondrial permeability transition: rheostatic regulation of acute kidney injury.
Acute Lung Injury
Activation of AMP-Activated Protein Kinase by A769662 Ameliorates Sepsis-Induced Acute Lung Injury in Adult Mice.
Acute Lung Injury
GSK-3Beta-Dependent Activation of GEF-H1/ROCK Signaling Promotes LPS-Induced Lung Vascular Endothelial Barrier Dysfunction and Acute Lung Injury.
Acute Lung Injury
Protective Effects of Licochalcone A Ameliorates Obesity and Non-Alcoholic Fatty Liver Disease Via Promotion of the Sirt-1/AMPK Pathway in Mice Fed a High-Fat Diet.
Acute Lung Injury
Stimulation of Brain AMP-Activated Protein Kinase Attenuates Inflammation and Acute Lung Injury in Sepsis.
Acute Lung Injury
Xanthohumol ameliorates lipopolysaccharide (LPS)-induced acute lung injury via induction of AMPK/GSK3?-Nrf2 signal axis.
Adenocarcinoma
A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers.
Adenocarcinoma
CAMKK2 Promotes Prostate Cancer Independently of AMPK via Increased Lipogenesis.
Adenocarcinoma
Desmoplasia suppression by metformin-mediated AMPK activation inhibits pancreatic cancer progression.
Adenocarcinoma
Different expression of GSK3? and pS9GSK3? depending on phenotype of cervical cancer: possible association of GSK3? with squamous cell carcinoma and pS9GSK3? with adenocarcinoma.
Adenocarcinoma
LncRNA LINK-A regulates ROCK1 expression in early-stage pancreatic adenocarcinoma.
Adenocarcinoma
MicroRNA-216b reduces growth, migration and invasion of pancreatic ductal adenocarcinoma cells by directly targeting ?-associated coiled-coil containing protein kinase 1.
Adenocarcinoma
Regulation and function of autophagy in pancreatic cancer.
Adenocarcinoma
Resveratrol inhibits oesophageal adenocarcinoma cell proliferation via AMP-activated protein kinase signaling.
Adenocarcinoma
Retracted: Resveratrol inhibits oesophageal adenocarcinoma cell proliferation via AMP-activated protein kinase signaling
Adenocarcinoma
Selective Requirement of PI3K/PDK1 Signaling for Kras Oncogene-Driven Pancreatic Cell Plasticity and Cancer.
Adenocarcinoma
Targeting autophagy in disease: established and new strategies.
Adenocarcinoma
Upregulation of glycogen synthase kinase 3? in human colorectal adenocarcinomas correlates with accumulation of CTNNB1.
Adenocarcinoma of Lung
Alternate paths from epidermal growth factor receptor to Akt in malignant versus nontransformed lung epithelial cells: ErbB3 versus Gab1.
Adenocarcinoma of Lung
Dasatinib promotes paclitaxel-induced necroptosis in lung adenocarcinoma with phosphorylated caspase-8 by c-Src.
Adenocarcinoma of Lung
SGK1 protein expression is a prognostic factor of lung adenocarcinoma that regulates cell proliferation and survival.
Adenoma
Loss of expression for the Wnt pathway components adenomatous polyposis coli and glycogen synthase kinase 3-beta in parathyroid carcinomas.
Adenoma
Non-invasive Potential Circulating mRNA Markers for Colorectal Adenoma Using Targeted Sequencing.
Adenoma, Liver Cell
Exercise Attenuates the Transition from Fatty Liver to Steatohepatitis and Reduces Tumor Formation in Mice.
Adenomatous Polyposis Coli
A miR-135b-TAZ positive feedback loop promotes epithelial-mesenchymal transition (EMT) and tumorigenesis in osteosarcoma.
Adenomatous Polyposis Coli
Alteration of the ?-catenin pathway in spiradenoma.
Adenomatous Polyposis Coli
APC and Smad7 link TGF? type I receptors to the microtubule system to promote cell migration.
Adenomatous Polyposis Coli
Association between polymorphisms in Wnt signaling pathway genes and bone mineral density in postmenopausal Korean women.
Adenomatous Polyposis Coli
Fas-associated factor 1 Antagonizes Wnt Signaling by Promoting {beta}-catenin Degradation.
Adenomatous Polyposis Coli
Killing me softly - suicidal erythrocyte death.
Adenomatous Polyposis Coli
Long non-coding RNA miR143HG predicts good prognosis and inhibits tumor multiplication and metastasis by suppressing mitogen-activated protein kinase and Wnt signaling pathways in hepatocellular carcinoma.
Adenomatous Polyposis Coli
Loss of expression for the Wnt pathway components adenomatous polyposis coli and glycogen synthase kinase 3-beta in parathyroid carcinomas.
Adenomatous Polyposis Coli
Lycopene induces apoptosis by inhibiting nuclear translocation of ?-catenin in gastric cancer cells.
Adenomatous Polyposis Coli
Manilkara zapota (L.) P. Royen leaf water extract triggered apoptosis and activated caspase-dependent pathway in HT-29 human colorectal cancer cell line.
Adenomatous Polyposis Coli
Mechanisms and Significance of Eryptosis, the Suicidal Death of Erythrocytes.
Adenomatous Polyposis Coli
Nuclear GSK-3? segregation in desmoid-type fibromatosis.
Adenomatous Polyposis Coli
Pathway pathology: histological differences between ErbB/Ras and Wnt pathway transgenic mammary tumors.
Adenomatous Polyposis Coli
Phase separation of Axin organizes the ?-catenin destruction complex.
Adenomatous Polyposis Coli
Physiology and pathophysiology of eryptosis.
Adenomatous Polyposis Coli
Protective effect of Matricaria chamomilla extract against 1,2-dimethylhydrazine-induced colorectal cancer in mice.
Adenomatous Polyposis Coli
Simvastatin attenuates axonal injury after experimental traumatic brain injury and promotes neurite outgrowth of primary cortical neurons.
Adenomatous Polyposis Coli
Suppression of ?-catenin Signaling Pathway in Human Prostate Cancer PC3 Cells by Delphinidin.
Adenomatous Polyposis Coli
Tanshinone IIA promotes cardiac differentiation and improves cell motility by modulating the Wnt/??catenin signaling pathway.
Adenomatous Polyposis Coli
The evolving roles of canonical WNT signaling in stem cells and tumorigenesis: implications in targeted cancer therapies.
Adenomatous Polyposis Coli
Wnt Pathway Gene Expression Is Associated With Arterial Stiffness.
Adenomyosis
Metformin inhibits growth of eutopic stromal cells from adenomyotic endometrium via AMPK activation and subsequent inhibition of AKT phosphorylation: a possible role in the treatment of adenomyosis.
Adrenocortical Carcinoma
Regulation of proteins in the cholesterol side-chain cleavage system in JEG-3 and Y-1 cells.
Adrenoleukodystrophy
Loss of AMP-activated protein kinase in X-linked adrenoleukodystrophy patient-derived fibroblasts and lymphocytes.
Albuminuria
Acute leptin exposure reduces megalin expression and upregulates TGF?1 in cultured renal proximal tubule cells.
Albuminuria
Maintenance of endothelial guanosine triphosphate cyclohydrolase I ameliorates diabetic nephropathy.
aldehyde dehydrogenase (nad+) deficiency
Retinaldehyde dehydrogenase 1 coordinates hepatic gluconeogenesis and lipid metabolism.
Alzheimer Disease
(Z)-2-(3-Chlorobenzylidene)-3,4-dihydro-N-(2-methoxyethyl)-3-oxo-2H-benzo[b][1,4]oxazine-6-carboxamide as GSK-3? inhibitor: Identification by virtual screening and its validation in enzyme- and cell-based assay.
Alzheimer Disease
(±)-BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3? Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease.
Alzheimer Disease
17beta-estradiol attenuates glycogen synthase kinase-3beta activation and tau hyperphosphorylation in Akt-independent manner.
Alzheimer Disease
A new protocol for predicting novel GSK-3? ATP competitive inhibitors.
Alzheimer Disease
A noncatalytic domain of glycogen synthase kinase-3 (GSK-3) is essential for activity.
Alzheimer Disease
A scintillation proximity assay for studying inhibitors of human tau protein kinase II/cdk5 using a 96-well format.
Alzheimer Disease
A systematic review on anti-Alzheimer's disease activity of prescription Kangen-karyu.
Alzheimer Disease
Adult onset pan-neuronal human tau tubulin kinase 1 expression causes severe cerebellar neurodegeneration in mice.
Alzheimer Disease
aFGF Promotes Neurite Growth by Regulating GSK3?-CRMP2 Signaling Pathway in Cortical Neurons Damaged by Amyloid-?.
Alzheimer Disease
Alteration of the Wnt/GSK3?/??catenin signalling pathway by rapamycin ameliorates pathology in an Alzheimer's disease model.
Alzheimer Disease
Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells.
Alzheimer Disease
AMP-activated protein kinase modulates tau phosphorylation and tau pathology in vivo.
Alzheimer Disease
AMP-activated protein kinase: a potential player in Alzheimer's disease.
Alzheimer Disease
Amyloid beta-induced glycogen synthase kinase 3? phosphorylated VDAC1 in Alzheimer's disease: Implications for synaptic dysfunction and neuronal damage.
Alzheimer Disease
Antisense oligonucleotide against GSK-3? in brain of SAMP8 mice improves learning and memory and decreases oxidative stress: Involvement of transcription factor Nrf2 and implications for Alzheimer disease.
Alzheimer Disease
Association analysis of GSK3B and MAPT polymorphisms with Alzheimer's disease in Han Chinese.
Alzheimer Disease
Association of GSK3B with Alzheimer disease and frontotemporal dementia.
Alzheimer Disease
Astroglial activation of extracellular-regulated kinase in early stages of Alzheimer disease.
Alzheimer Disease
Beta-secretase (BACE) and GSK-3 mRNA levels in Alzheimer's disease.
Alzheimer Disease
CDK5 activator protein p25 preferentially binds and activates GSK3?.
Alzheimer Disease
Characterization of the in vitro phosphorylation of human tau by tau protein kinase II (cdk5/p20) using mass spectrometry.
Alzheimer Disease
Computational study of the inhibitory mechanism of the kinase CDK5 hyperactivity by peptide p5 and derivation of a pharmacophore.
Alzheimer Disease
Copper(II) complexes of hybrid hydroxyquinoline-thiosemicarbazone ligands: GSK3? inhibition due to intracellular delivery of copper.
Alzheimer Disease
Deep Learning and Random Forest Approach for Finding the Optimal Traditional Chinese Medicine Formula for Treatment of Alzheimer's Disease.
Alzheimer Disease
Delta-secretase (AEP) mediates tau-splicing imbalance and accelerates cognitive decline in tauopathies.
Alzheimer Disease
Delta-Secretase Phosphorylation by SRPK2 Enhances Its Enzymatic Activity, Provoking Pathogenesis in Alzheimer's Disease.
Alzheimer Disease
Detection of elevated antibodies against SR protein kinase 1 in the serum of Alzheimer's disease patients.
Alzheimer Disease
Development of a Cellular Tau Enzyme-Linked Immunosorbent Assay Method for Screening GSK-3? Inhibitors.
Alzheimer Disease
Discovery of potent glycogen synthase kinase 3/cholinesterase inhibitors with neuroprotection as potential therapeutic agent for Alzheimer's disease.
Alzheimer Disease
Disturbed cross talk between insulin-like growth factor I and AMP-activated protein kinase as a possible cause of vascular dysfunction in the amyloid precursor protein/presenilin 2 mouse model of Alzheimer's disease.
Alzheimer Disease
Down-Regulation of Amyloid-? Through AMPK Activation by Inhibitors of GSK-3? in SH-SY5Y and SH-SY5Y-A?PP695 Cells.
Alzheimer Disease
Endogenous beta-amyloid peptide synthesis modulates cAMP response element-regulated gene expression in PC12 cells.
Alzheimer Disease
Evidence for a new binding mode to GSK-3: Allosteric regulation by the marine compound palinurin.
Alzheimer Disease
Genetic Variants of GSK3B are Associated with Biomarkers for Alzheimer's Disease and Cognitive Function.
Alzheimer Disease
Glycogen synthase kinase 3 alpha and 3 beta do not colocalize with neurofibrillary tangles.
Alzheimer Disease
Glycogen synthase kinase-3 in insulin and Wnt signalling: a double-edged sword?
Alzheimer Disease
Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: generation of paired helical filament epitopes and neuronal localisation of the kinase.
Alzheimer Disease
GSK-3 inhibitors for Alzheimer's disease.
Alzheimer Disease
GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides.
Alzheimer Disease
GSK3alpha exhibits beta-catenin and tau directed kinase activities that are modulated by Wnt.
Alzheimer Disease
GSK3b, a centre-staged kinase in neuropsychiatric disorders, modulates long term memory by inhibitory phosphorylation at Ser-9.
Alzheimer Disease
Hyperphosphorylated Tau in an ?-synuclein-overexpressing transgenic model of Parkinson's disease.
Alzheimer Disease
Icaritin and icariin reduce p-Tau levels in a cell model of Alzheimer's disease by downregulating glycogen synthase kinase 3?.
Alzheimer Disease
Identifying GSK-3? kinase inhibitors of Alzheimer's disease: Virtual screening, enzyme, and cell assays.
Alzheimer Disease
Identifying natural compounds as multi-target directed ligands against Alzheimer's disease: an in silico approach.
Alzheimer Disease
Immunocytochemistry of tau phosphoserine 413 and tau protein kinase I in Alzheimer pathology.
Alzheimer Disease
Increased iPLA2 activity and levels of phosphorylated GSK3B in platelets are associated with donepezil treatment in Alzheimer's disease patients.
Alzheimer Disease
Increased platelet GSK3B activity in patients with mild cognitive impairment and Alzheimer's disease.
Alzheimer Disease
Increased prefrontal cortex interleukin-2 protein levels and shift in the peripheral T cell population in progressive supranuclear palsy patients.
Alzheimer Disease
Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?
Alzheimer Disease
Inhibition of Wnt and PI3K signaling modulates GSK-3beta activity and induces morphological changes in cortical neurons: role of tau phosphorylation.
Alzheimer Disease
Interactions of isoorientin and its Semi-synthetic analogs with human serum albumin.
Alzheimer Disease
Is there a role of the cyclin-dependent kinase 5 activator p25 in Alzheimer's disease?
Alzheimer Disease
Isoform-specific dysregulation of AMP-activated protein kinase signaling in a non-human primate model of Alzheimer's disease.
Alzheimer Disease
Lithium Inhibits GSK3? and Augments GluN2A Receptor Expression in the Prefrontal Cortex.
Alzheimer Disease
Lithium reduces Gsk3b mRNA levels: implications for Alzheimer Disease.
Alzheimer Disease
Lithium Use During Pregnancy in a Patient With Bipolar Disorder and Multiple Sclerosis.
Alzheimer Disease
Lithium, a potential protective drug in Alzheimer's disease.
Alzheimer Disease
Loss of miR-369 Promotes Tau Phosphorylation by Targeting the Fyn and Serine/Threonine-Protein Kinase 2 Signaling Pathways in Alzheimer's Disease Mice.
Alzheimer Disease
MAPT/Tau accumulation represses autophagy flux by disrupting IST1-regulated ESCRT-III complex formation: a vicious cycle in Alzheimer neurodegeneration.
Alzheimer Disease
Mechanism of zinc-induced phosphorylation of p70 S6 kinase and glycogen synthase kinase 3beta in SH-SY5Y neuroblastoma cells.
Alzheimer Disease
Microsecond molecular dynamics simulations and dynamic network analysis provide understanding of the allosteric inactivation of GSK3? induced by the L343R mutation.
Alzheimer Disease
miR-219-5p inhibits tau phosphorylation by targeting TTBK1 and GSK-3? in Alzheimer's disease.
Alzheimer Disease
Mitogen- and stress-activated protein kinase 1: convergence of the ERK and p38 pathways in Alzheimer's disease.
Alzheimer Disease
Molecular docking based screening analysis of GSK3B.
Alzheimer Disease
Monosodium glutamate neurotoxicity increases beta amyloid in the rat hippocampus: a potential role for cyclic AMP protein kinase.
Alzheimer Disease
Necrosome-positive granulovacuolar degeneration is associated with TDP-43 pathological lesions in the hippocampus of ALS/FTLD cases.
Alzheimer Disease
Neurons derived from sporadic Alzheimer's disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation.
Alzheimer Disease
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Alzheimer Disease
Overexpression of GSK-3? in Adult Tet-OFF GSK-3? Transgenic Mice, and Not During Embryonic or Postnatal Development, Induces Tau Phosphorylation, Neurodegeneration and Learning Deficits.
Alzheimer Disease
Overview of cannabidiol (CBD) and its analogues: Structures, biological activities, and neuroprotective mechanisms in epilepsy and Alzheimer's disease.
Alzheimer Disease
p73 haploinsufficiency causes tau hyperphosphorylation and tau kinase dysregulation in mouse models of aging and Alzheimer's disease.
Alzheimer Disease
Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration.
Alzheimer Disease
Peripheral Administration of GSK-3? Antisense Oligonucleotide Improves Learning and Memory in SAMP8 and Tg2576 Mouse Models of Alzheimer's Disease.
Alzheimer Disease
Phosphorylation and Inactivation of Glycogen Synthase Kinase 3? (GSK3?) by Dual-specificity Tyrosine Phosphorylation-regulated Kinase 1A (Dyrk1A).
Alzheimer Disease
Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. Implications for neurofibrillary degeneration in Alzheimer's disease.
Alzheimer Disease
Protein kinase FA/glycogen synthase kinase-3 alpha after heparin potentiation phosphorylates tau on sites abnormally phosphorylated in Alzheimer's disease brain.
Alzheimer Disease
Protein kinase FA/GSK-3 phosphorylates tau on Ser235-Pro and Ser404-Pro that are abnormally phosphorylated in Alzheimer's disease brain.
Alzheimer Disease
PSEN2 (presenilin 2) mutants linked to familial Alzheimer disease impair autophagy by altering Ca2+ homeostasis.
Alzheimer Disease
PTML Modeling for Alzheimer's Disease: Design and Prediction of Virtual Multi-Target Inhibitors of GSK3B, HDAC1, and HDAC6.
Alzheimer Disease
Radiosynthesis and preliminary PET evaluation of glycogen synthase kinase 3? (GSK-3?) inhibitors containing [(11)C]methylsulfanyl, [(11)C]methylsulfinyl or [(11)C]methylsulfonyl groups.
Alzheimer Disease
Receptor-Interacting Protein Kinase 1 (RIPK1) as a Potential Therapeutic Target: An Overview of Its Possible Role in the Pathogenesis of Alzheimer's Disease.
Alzheimer Disease
Regulation of mitochondrial pyruvate dehydrogenase activity by tau protein kinase I/glycogen synthase kinase 3beta in brain.
Alzheimer Disease
Rho-associated protein kinase 1 (ROCK1) is increased in Alzheimer's disease and ROCK1 depletion reduces amyloid-? levels in brain.
Alzheimer Disease
RNA Interference Silencing of Glycogen Synthase Kinase 3? Inhibites Tau Phosphorylation in Mice with Alzheimer Disease.
Alzheimer Disease
Role of glycogen synthase kinase-3 in Alzheimer's disease pathogenesis and glycogen synthase kinase-3 inhibitors.
Alzheimer Disease
Roles of AMP-activated Protein Kinase in Alzheimer's Disease.
Alzheimer Disease
Rosmarinic Acid Derivatives' Inhibition of Glycogen Synthase Kinase-3? Is the Pharmacological Basis of Kangen-Karyu in Alzheimer's Disease.
Alzheimer Disease
S6 kinase phosphorylated at T229 is involved in tau and actin pathologies in Alzheimer's disease.
Alzheimer Disease
Serine-arginine protein kinases: new players in neurodegenerative diseases?
Alzheimer Disease
Single-nucleotide polymorphisms of GSK3B, GAB2 and SORL1 in late-onset Alzheimer's disease: interactions with the APOE genotype.
Alzheimer Disease
Soluble 3',6-substituted indirubins with enhanced selectivity toward glycogen synthase kinase -3 alter circadian period.
Alzheimer Disease
SRPK2 phosphorylates tau and mediates the cognitive defects in Alzheimer's disease.
Alzheimer Disease
Structural Basis for MARK1 Kinase Autoinhibition by Its KA1 Domain.
Alzheimer Disease
Structural Plasticity of Dendritic Spines Requires GSK3? and GSK3?.
Alzheimer Disease
Structure-based design of benzo[e]isoindole-1,3-dione derivatives as selective GSK-3? inhibitors to activate Wnt/?-catenin pathway.
Alzheimer Disease
Sulfhydration of AKT triggers Tau-phosphorylation by activating glycogen synthase kinase 3? in Alzheimer's disease.
Alzheimer Disease
Synthesis and biological evaluation of 3-substituted 2-oxindole derivatives as new glycogen synthase kinase 3? inhibitors.
Alzheimer Disease
Tau neurofibrillary pathology and microtubule stability.
Alzheimer Disease
Tau phosphorylation at serine 396 and serine 404 by human recombinant tau protein kinase II inhibits tau's ability to promote microtubule assembly.
Alzheimer Disease
Tau phosphorylation in the mouse brain during aversive conditioning.
Alzheimer Disease
Tau protein kinase I/GSK-3 beta/kinase FA in heparin phosphorylates tau on Ser199, Thr231, Ser235, Ser262, Ser369, and Ser400 sites phosphorylated in Alzheimer disease brain.
Alzheimer Disease
Tau protein kinase II is involved in the regulation of the normal phosphorylation state of tau protein.
Alzheimer Disease
Tau-based therapeutics for Alzheimer's disease: active and passive immunotherapy.
Alzheimer Disease
Tau-Centric Multitarget Approach for Alzheimer's Disease: Development of First-in-Class Dual Glycogen Synthase Kinase 3? and Tau-Aggregation Inhibitors.
Alzheimer Disease
Tau-tubulin kinase-1 gene variants are associated with Alzheimer's disease in Han Chinese.
Alzheimer Disease
Tau-tubulin kinase.
Alzheimer Disease
Testosterone prevents the heat shock-induced overactivation of glycogen synthase kinase-3 beta but not of cyclin-dependent kinase 5 and c-Jun NH2-terminal kinase and concomitantly abolishes hyperphosphorylation of tau: implications for Alzheimer's disease.
Alzheimer Disease
The crystal structure of the catalytic domain of tau tubulin kinase 2 in complex with a small-molecule inhibitor.
Alzheimer Disease
The neuron-specific isoform of glycogen synthase kinase-3beta is required for axon growth.
Alzheimer Disease
The role of CDK5 and GSK3B kinases in hyperphosphorylation of microtubule associated protein tau (MAPT) in Alzheimer's disease.
Alzheimer Disease
The small-molecule activators of AMPK, RSVA314 and RSVA405, inhibit adipogenesis.
Alzheimer Disease
Therapeutic Potential of AMP-Activated Protein Kinase in Alzheimer's Disease.
Alzheimer Disease
Thienyl and phenyl alpha-halomethyl ketones: new inhibitors of glycogen synthase kinase (GSK-3beta) from a library of compound searching.
Alzheimer Disease
Transcriptomic Analysis of Porcine Granulosa Cells Overexpressing Retinol Binding Protein 4.
Alzheimer Disease
X-ray Structural Analysis of Tau-Tubulin Kinase?1 and Its Interactions with Small Molecular Inhibitors.
Alzheimer Disease
[GSK-3beta: a central kinase for neurodegenerative diseases?]
Ameloblastoma
Activation of Wnt signalling reduces the population of cancer stem cells in ameloblastoma.
Amyloidosis
Abeta amyloidosis induces the initial stage of tau accumulation in APP(Sw) mice.
Amyotrophic Lateral Sclerosis
Aberrant activation of AMP-activated protein kinase contributes to the abnormal distribution of HuR in amyotrophic lateral sclerosis.
Amyotrophic Lateral Sclerosis
Activation of AMP-activated protein kinase ?1 mediates mislocalization of TDP-43 in amyotrophic lateral sclerosis.
Amyotrophic Lateral Sclerosis
Adult onset pan-neuronal human tau tubulin kinase 1 expression causes severe cerebellar neurodegeneration in mice.
Amyotrophic Lateral Sclerosis
C9orf72 ALS-FTD: recent evidence for dysregulation of the autophagy-lysosome pathway at multiple levels.
Amyotrophic Lateral Sclerosis
Immunohistochemical study on the distribution of glycogen synthase kinase 3alpha in the central nervous system of SOD1(G93A) transgenic mice.
Amyotrophic Lateral Sclerosis
Metabolic Aspects of Adenosine Functions in the Brain.
Amyotrophic Lateral Sclerosis
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Amyotrophic Lateral Sclerosis
Targeting autophagy in disease: established and new strategies.
Anaphylaxis
AMP-activated protein kinase negatively regulates Fc?RI-mediated mast cell signaling and anaphylaxis in mice.
Anaphylaxis
ERK1/2 antagonize AMPK-dependent regulation of Fc?RI-mediated mast cell activation and anaphylaxis.
Anaphylaxis
Sirt1 negatively regulates Fc?RI-mediated mast cell activation through AMPK- and PTP1B-dependent processes.
Anemia
Killing me softly - suicidal erythrocyte death.
Anemia
Mechanisms and Significance of Eryptosis, the Suicidal Death of Erythrocytes.
Anemia
Physiology and pathophysiology of eryptosis.
Anemia
PRKAA1/AMPK?1 is required for autophagy-dependent mitochondrial clearance during erythrocyte maturation.
Anemia, Diamond-Blackfan
A de novo 1.6Mb microdeletion at 19q13.2 in a boy with Diamond-Blackfan anemia, global developmental delay and multiple congenital anomalies.
Anemia, Sickle Cell
Killing me softly - suicidal erythrocyte death.
Anemia, Sickle Cell
Mechanisms and Significance of Eryptosis, the Suicidal Death of Erythrocytes.
Anemia, Sickle Cell
Physiology and pathophysiology of eryptosis.
Aortic Aneurysm, Abdominal
Activation of AMP-activated protein kinase ?2 by nicotine instigates formation of abdominal aortic aneurysms in mice in vivo.
Aortic Aneurysm, Abdominal
Inhibition of Receptor-Interacting Protein Kinase 1 with Necrostatin-1s ameliorates disease progression in elastase-induced mouse abdominal aortic aneurysm model.
Arrhythmias, Cardiac
A novel domain in AMP-activated protein kinase causes glycogen storage bodies similar to those seen in hereditary cardiac arrhythmias.
Arrhythmias, Cardiac
Metformin prevents ischaemic ventricular fibrillation in metabolically normal pigs.
Arrhythmias, Cardiac
TGFB-INHB/activin signaling regulates age-dependent autophagy and cardiac health through inhibition of MTORC2.
Arthritis
Suppression of experimental arthritis through AMP-activated protein kinase activation and autophagy modulation.
Arthritis, Gouty
[Effect of Electroacupuncture on Synovial M 1/M 2 Macrophage Polarization in Rats with Acute Gouty Arthritis].
Arthritis, Rheumatoid
Glycogen Metabolism and Rheumatoid Arthritis: The Role of Glycogen Synthase 1 in Regulation of Synovial Inflammation via Blocking AMP-Activated Protein Kinase Activation.
Arthritis, Rheumatoid
Hypermetabolic macrophages in rheumatoid arthritis and coronary artery disease due to glycogen synthase kinase 3b inactivation.
Arthritis, Rheumatoid
Immunometabolic Pathways and Its Therapeutic Implication in Autoimmune Diseases.
Arthritis, Rheumatoid
Mining susceptibility gene modules and disease risk genes from SNP data by combining network topological properties with support vector regression.
Asthma
Adiponectin alleviates exacerbation of airway inflammation and oxidative stress in obesity-related asthma mice partly through AMPK signaling pathway.
Asthma
Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets.
Asthma
Formation of Fructose-Mediated Advanced Glycation End Products and Their Roles in Metabolic and Inflammatory Diseases.
Asthma
The role of vitamin D in asthma.
Astrocytoma
Valproic acid enhances protein L-isoaspartyl methyltransferase expression by stimulating extracellular signal-regulated kinase signaling pathway.
Ataxia
Missense exchanges in the TTBK2 gene mutated in SCA11.
Ataxia
Next generation sequencing for molecular diagnosis of neurological disorders using ataxias as a model.
Ataxia
Spinocerebellar ataxia type 11 in the Chinese Han population.
Ataxia
TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development.
Ataxia Telangiectasia
A role for AMPK in increased insulin action after serum starvation.
Ataxia Telangiectasia
A role for ataxia telangiectasia mutated in insulin-independent stimulation of glucose transport.
Ataxia Telangiectasia
Chloroquine increases phosphorylation of AMPK and Akt in myotubes.
Ataxia Telangiectasia
DNA-dependent protein kinase regulates lysosomal AMP-dependent protein kinase activation and autophagy.
Ataxia Telangiectasia
The regulation of p53 by phosphorylation: a model for how distinct signals integrate into the p53 pathway.
Atherosclerosis
A potential strategy for treating atherosclerosis: improving endothelial function via AMP-activated protein kinase.
Atherosclerosis
Activation of AMP-activated protein kinase is required for berberine-induced reduction of atherosclerosis in mice: the role of uncoupling protein 2.
Atherosclerosis
Activation of sterol regulatory element binding protein and NLRP3 inflammasome in atherosclerotic lesion development in diabetic pigs.
Atherosclerosis
AMP-activated protein kinase ?1 promotes atherogenesis by increasing monocyte-to-macrophage differentiation.
Atherosclerosis
AMP-Activated Protein Kinase Alpha 2 Deletion Induces VSMC Phenotypic Switching and Reduces Features of Atherosclerotic Plaque Stability.
Atherosclerosis
AMP-activated protein kinase mediates the effects of lipoprotein-associated phospholipase A2 on endothelial dysfunction in atherosclerosis.
Atherosclerosis
An Integrated Pharmacokinetic Study of an Acanthopanax senticosus Extract Preparation by Combination of Virtual Screening, Systems Pharmacology, and Multi-Component Pharmacokinetics in Rats.
Atherosclerosis
Association of AMPK Pathway-Related Gene Polymorphisms with Symptomatic Intracranial Atherosclerotic Stenosis in a Chinese Han Population.
Atherosclerosis
Augmented AMPK activity inhibits cell migration by phosphorylating the novel substrate Pdlim5.
Atherosclerosis
Comparative transcriptomic analysis of mice liver treated with different AMPK activators in a mice model of atherosclerosis.
Atherosclerosis
Deletion of Myeloid GSK3? Attenuates Atherosclerosis and Promotes an M2 Macrophage Phenotype.
Atherosclerosis
Endoplasmic reticulum stress and glycogen synthase kinase-3? activation in apolipoprotein E-deficient mouse models of accelerated atherosclerosis.
Atherosclerosis
Functional interplay between liver X receptor and AMP-activated protein kinase ? inhibits atherosclerosis in apolipoprotein E-deficient mice - a new anti-atherogenic strategy.
Atherosclerosis
Glucose and palmitate uncouple AMPK from autophagy in human aortic endothelial cells.
Atherosclerosis
Glycogen synthase kinase 3? deficiency attenuates atherosclerosis and hepatic steatosis in high fat diet-fed low density lipoprotein receptor-deficient mice.
Atherosclerosis
Inhibitory effects of resveratrol on foam cell formation are mediated through monocyte chemotactic protein-1 and lipid metabolism-related proteins.
Atherosclerosis
Liraglutide, a GLP-1 receptor agonist, inhibits vascular smooth muscle cell proliferation by enhancing AMP-activated protein kinase and cell cycle regulation, and delays atherosclerosis in ApoE deficient mice.
Atherosclerosis
Loss of CLOCK under high glucose upregulates ROCK1-mediated endothelial to mesenchymal transition and aggravates plaque vulnerability.
Atherosclerosis
Mechanisms linking diabetes mellitus to the development of atherosclerosis: a role for endoplasmic reticulum stress and glycogen synthase kinase-3.
Atherosclerosis
Myeloid deletion and therapeutic activation of AMPK do not alter atherosclerosis in male or female mice.
Atherosclerosis
Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient mice.
Atherosclerosis
Pre-germinated brown rice extract ameliorates high-fat diet-induced metabolic syndrome.
Atherosclerosis
Promising Anti-atherosclerotic Effect of Berberine: Evidence from In Vitro, In Vivo, and Clinical Studies.
Atherosclerosis
Reduction of AMP-activated protein kinase alpha2 increases endoplasmic reticulum stress and atherosclerosis in vivo.
Atherosclerosis
Targeting AMPK signalling pathway with natural medicines for atherosclerosis therapy: an integration of in silico screening and in vitro assay.
Atherosclerosis
[Investigating the role of ceramide metabolism-associated CERS5 (LASS5) gene in atherosclerosis pathogenesis in endothelial cells].
Atrial Fibrillation
Energy metabolic alterations in the progression of atrial fibrillation: Potential role of AMP-activated protein kinase as a critical regulator.
Atrial Fibrillation
Novel PRKAG2 mutation responsible for the genetic syndrome of ventricular preexcitation and conduction system disease with childhood onset and absence of cardiac hypertrophy.
Atrial Fibrillation
Phosphorylated AMP-activated protein kinase slows down the atrial fibrillation progression by activating Connexin43.
Atrioventricular Block
Constitutively active AMP kinase mutations cause glycogen storage disease mimicking hypertrophic cardiomyopathy.
Atrioventricular Block
[Same genotype and different phenotypes in a family with PRKAG2 gene mutation]
Atypical Squamous Cells of the Cervix
MoSnt2-dependent deacetylation of histone H3 mediates MoTor-dependent autophagy and plant infection by the rice blast fungus Magnaporthe oryzae.
Bile Duct Neoplasms
Metformin Induces Apoptosis and Inhibits Proliferation through the AMP-Activated Protein Kinase and Insulin-like Growth Factor 1 Receptor Pathways in the Bile Duct Cancer Cells.
Bone Neoplasms
Blocking mammalian target of rapamycin alleviates bone cancer pain and morphine tolerance via µ-opioid receptor.
Bone Resorption
Runx2 Controls Bone Resorption through the Down-Regulation of the Wnt Pathway in Osteoblasts.
Brain Diseases
Delayed treatment of 6-Bromoindirubin-3'-oxime stimulates neurogenesis and functional recovery after focal ischemic stroke in mice.
Brain Infarction
The protective mechanism underlying total flavones of Dracocephalum (TFD) effects on rat cerebral ischemia reperfusion injury.
Brain Injuries
A dual role for AMP-activated protein kinase (AMPK) during neonatal hypoxic-ischaemic brain injury in mice.
Brain Injuries
GSK-3? inhibitor TDZD-8 reduces neonatal hypoxic-ischemic brain injury in mice.
Brain Injuries
Identifying New AMP-Activated Protein Kinase Inhibitors That Protect against Ischemic Brain Injury.
Brain Injuries
Neuroprotection against permanent focal cerebral ischemia by ginkgolides A and B is associated with obstruction of the mitochondrial apoptotic pathway via inhibition of c-Jun N-terminal kinase in rats.
Brain Injuries
Recombinant Adiponectin Peptide Ameliorates Brain Injury Following Intracerebral Hemorrhage by Suppressing Astrocyte-Derived Inflammation via the Inhibition of Drp1-Mediated Mitochondrial Fission.
Brain Injuries
SIRT1/PGC-1? Signaling Promotes Mitochondrial Functional Recovery and Reduces Apoptosis after Intracerebral Hemorrhage in Rats.
Brain Injuries, Traumatic
Neuroprotective effects of metformin on traumatic brain injury in rats is associated with the AMP-activated protein kinase signaling pathway.
Brain Injuries, Traumatic
Regulation of PRKN-independent mitophagy.
Brain Injuries, Traumatic
Traumatic brain injury decreases AMP-activated protein kinase activity and pharmacological enhancement of its activity improves cognitive outcome.
Brain Ischemia
Activation of AMP-activated protein kinase by metformin protects against global cerebral ischemia in male rats: interference of AMPK/PGC-1? pathway.
Brain Ischemia
Anisomycin prevents OGD-induced necroptosis by regulating the E3 ligase CHIP.
Brain Ischemia
Commentary: Death Associated Protein Kinase 1: A Perp in Cerebral Ischemia.
Brain Ischemia
Effects of AMP-activated protein kinase in cerebral ischemia.
Brain Ischemia
Hypothermia Blocks Nuclear ?-catenin Translocation Downstream of glycogen synthase kinase 3-? in Focal Cerebral Ischemia in Rats: Paper 12.
Brain Ischemia
Inhibition of AMP-activated Protein Kinase Alleviates Focal Cerebral Ischemia Injury in Mice: Interference with mTOR and Autophagy.
Brain Ischemia
Inhibition of GSK-3? alleviates cerebral ischemia/reperfusion injury in rats by suppressing NLRP3 inflammasome activation through autophagy.
Brain Ischemia
Ischemic Preconditioning Provides Neuroprotection by Induction of AMP-Activated Protein Kinase-Dependent Autophagy in a Rat Model of Ischemic Stroke.
Brain Ischemia
Neuroprotection against permanent focal cerebral ischemia by ginkgolides A and B is associated with obstruction of the mitochondrial apoptotic pathway via inhibition of c-Jun N-terminal kinase in rats.
Brain Ischemia
Possible Involvement of PI3-K/Akt-Dependent GSK-3? Signaling in Proliferation of Neural Progenitor Cells After Hypoxic Exposure.
Brain Ischemia
Pre-treatment with metformin activates Nrf2 antioxidant pathways and inhibits inflammatory responses through induction of AMPK after transient global cerebral ischemia.
Brain Neoplasms
Expression of PDK-1 and DMBT1 in the thyroid carcinoma and its clinicopathological significance.
Breast Neoplasms
?-hydroxyundec-9-enoic acid induction of breast cancer cells apoptosis through generation of mitochondrial ROS and phosphorylation of AMPK.
Breast Neoplasms
A novel function of HER2/Neu in the activation of G2/M checkpoint in response to ?-irradiation.
Breast Neoplasms
AMP-Activated Protein Kinase ? 2 Isoform Suppression in Primary Breast Cancer Alters AMPK Growth Control and Apoptotic Signaling.
Breast Neoplasms
AMP-activated protein kinase and energy balance in breast cancer.
Breast Neoplasms
AMP-activated protein kinase protects against anti-epidermal growth factor receptor-Pseudomonas exotoxin A immunotoxin-induced MA11 breast cancer cell death.
Breast Neoplasms
AMPK lifts the PRC2-implemented gene repression.
Breast Neoplasms
An immunohistochemical evaluation of the proteins Wnt1 and glycogen synthase kinase (GSK)-3? in invasive breast carcinomas.
Breast Neoplasms
Anticancer properties of pomolic acid-induced AMP-activated protein kinase activation in MCF7 human breast cancer cells.
Breast Neoplasms
Antiproliferative and pro-apoptotic effects of three fungal exocellular ?-glucans in MCF-7 breast cancer cells is mediated by oxidative stress, AMP-activated protein kinase (AMPK) and the Forkhead transcription factor, FOXO3a.
Breast Neoplasms
Bradykinin stimulates cell proliferation through an extracellular-regulated kinase 1 and 2-dependent mechanism in breast cancer cells in primary culture.
Breast Neoplasms
BRCA1-mediated G2/M cell cycle arrest requires ERK1/2 kinase activation.
Breast Neoplasms
Capsaicin causes cell-cycle arrest and apoptosis in ER-positive and -negative breast cancer cells by modulating the EGFR/HER-2 pathway.
Breast Neoplasms
Celastrol suppresses breast cancer MCF-7 cell viability via the AMP-activated protein kinase (AMPK)-induced p53-polo like kinase 2 (PLK-2) pathway.
Breast Neoplasms
Circadian gating of epithelial-to-mesenchymal transition in breast cancer cells via melatonin-regulation of GSK3?.
Breast Neoplasms
Clinical significance of pAkt and pErk1/2 expression in early-stage breast cancer patients treated with anthracycline-based adjuvant chemotherapy.
Breast Neoplasms
Compound C enhances the anticancer effect of aspirin in HER-2-positive breast cancer by regulating lipid metabolism in an AMPK-independent pathway.
Breast Neoplasms
Discovery of a Small-Molecule Bromodomain-Containing Protein 4 (BRD4) Inhibitor That Induces AMP-Activated Protein Kinase-Modulated Autophagy-Associated Cell Death in Breast Cancer.
Breast Neoplasms
Down-regulation of RIP1 by 2-deoxy-D-glucose sensitizes breast cancer cells to TRAIL-induced apoptosis.
Breast Neoplasms
Downregulation of GSK3B by miR-132-3p Enhances Etoposide-Induced Breast Cancer Cell Apoptosis.
Breast Neoplasms
Epithelial mesenchymal transition and resistance in endocrine-related cancers.
Breast Neoplasms
Epithelial morphological reversion drives Profilin-1-induced elevation of p27(kip1) in mesenchymal triple-negative human breast cancer cells through AMP-activated protein kinase activation.
Breast Neoplasms
Erratum to: Honokiol activates AMP-activated protein kinase in breast cancer cells via LKB1-dependent pathway and inhibits breast carcinogenesis.
Breast Neoplasms
Ethoxysanguinarine, a Novel Direct Activator of AMP-Activated Protein Kinase, Induces Autophagy and Exhibits Therapeutic Potential in Breast Cancer Cells.
Breast Neoplasms
Evaluation of the prognostic and physiological functions of death associated protein kinase 1 in breast cancer.
Breast Neoplasms
FBXO22 Possesses Both Protumorigenic and Antimetastatic Roles in Breast Cancer Progression.
Breast Neoplasms
Furanodiene alters mitochondrial function in doxorubicin-resistant MCF-7 human breast cancer cells in an AMPK-dependent manner.
Breast Neoplasms
GABA(A) Receptor Pi (GABRP) Stimulates Basal-like Breast Cancer Cell Migration through Activation of Extracellular-regulated Kinase 1/2 (ERK1/2).
Breast Neoplasms
Gene expression profile of rat left ventricles reveals persisting changes following chronic mild exercise protocol: implications for cardioprotection.
Breast Neoplasms
Ginseng saponin metabolite induces apoptosis in MCF-7 breast cancer cells through the modulation of AMP-activated protein kinase.
Breast Neoplasms
Glycogen synthase kinase-3 protects estrogen receptor alpha from proteasomal degradation and is required for full transcriptional activity of the receptor.
Breast Neoplasms
H-prune-nm23-H1 protein complex and correlation to pathways in cancer metastasis.
Breast Neoplasms
HIF-1? stimulates aromatase expression driven by prostaglandin E2 in breast adipose stroma.
Breast Neoplasms
High expressions of LDHA and AMPK as prognostic biomarkers for breast cancer.
Breast Neoplasms
High metastaticgastric and breast cancer cells consume oleic acid in an AMPK dependent manner.
Breast Neoplasms
Homeodomain-interacting protein kinase 1 (HIPK1) expression in breast cancer tissues.
Breast Neoplasms
Honokiol activates AMP-activated protein kinase in breast cancer cells via LKB1-dependent pathway and inhibits breast carcinogenesis.
Breast Neoplasms
Hypoxia stimulates 18F-fluorodeoxyglucose uptake in breast cancer cells via hypoxia inducible factor-1 and AMP-activated protein kinase.
Breast Neoplasms
Identification of key pathways and genes in response to trastuzumab treatment in breast cancer using bioinformatics analysis.
Breast Neoplasms
Intracellularly transported adenosine induces MCF-7 human breast cancer cells by accumulating AMID in the nucleus.
Breast Neoplasms
KDM5B promotes breast cancer cell proliferation and migration via AMPK-mediated lipid metabolism reprogramming.
Breast Neoplasms
Mechanotransduction of mitochondrial AMPK and its distinct role in flow-induced breast cancer cell migration.
Breast Neoplasms
Metformin Inhibits Advanced Glycation End Products (AGEs)-induced Growth and VEGF Expression in MCF-7 Breast Cancer Cells by Suppressing AGEs Receptor Expression via AMP-activated Protein Kinase.
Breast Neoplasms
Metformin reverses multidrug resistance and epithelial-mesenchymal transition (EMT) via activating AMP-activated protein kinase (AMPK) in human breast cancer cells.
Breast Neoplasms
Metformin, insulin, breast cancer and more...
Breast Neoplasms
MiR-27a Facilitates Breast Cancer Progression via GSK-3?.
Breast Neoplasms
Mitogen-activated protein/extracellular signal-regulated kinase kinase (MEK) inhibitors restore anoikis sensitivity in human breast cancer cell lines with a constitutively activated extracellular-regulated kinase (ERK) pathway.
Breast Neoplasms
Molecular docking based screening analysis of GSK3B.
Breast Neoplasms
Molecular mechanism of suppression of MDR1 by puerarin from Pueraria lobata via NF-kappaB pathway and cAMP-responsive element transcriptional activity-dependent up-regulation of AMP-activated protein kinase in breast cancer MCF-7/adr cells.
Breast Neoplasms
Novel post-transcriptional and post-translational regulation of pro-apoptotic protein BOK and anti-apoptotic protein Mcl-1 determine the fate of breast cancer cells to survive or die.
Breast Neoplasms
NRF1 motif sequence-enriched genes involved in ER/PR -ve HER2 +ve breast cancer signaling pathways.
Breast Neoplasms
Obesity, hyperinsulinemia and breast cancer: novel targets and a novel role for metformin.
Breast Neoplasms
Oleanolic acid induces metabolic adaptation in cancer cells by activating the AMP-activated protein kinase pathway.
Breast Neoplasms
Overexpression of novel lncRNA NLIPMT inhibits metastasis by reducing phosphorylated glycogen synthase kinase 3? in breast cancer.
Breast Neoplasms
p53 modulates the AMPK inhibitor compound C induced apoptosis in human skin cancer cells.
Breast Neoplasms
Phosphorylation of androgen receptors at serine 515 is a potential prognostic marker for triple negative breast cancer.
Breast Neoplasms
Placental growth factor (PlGF) enhances breast cancer cell motility by mobilising ERK1/2 phosphorylation and cytoskeletal rearrangement.
Breast Neoplasms
POU4F1 confers trastuzumab resistance in HER2-positive breast cancer through regulating ERK1/2 signaling pathway.
Breast Neoplasms
RAC1 GTPase plays an important role in ?-irradiation induced G2/M checkpoint activation.
Breast Neoplasms
Raloxifene Induces Autophagy-Dependent Cell Death in Breast Cancer Cells via the Activation of AMP-Activated Protein Kinase.
Breast Neoplasms
Regulation of heregulin beta1-induced differentiation in a human breast carcinoma cell line by the extracellular-regulated kinase (ERK) pathway.
Breast Neoplasms
Regulation of mutual inhibitory activities between AMPK and Akt with quercetin in MCF-7 breast cancer cells.
Breast Neoplasms
Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase.
Breast Neoplasms
Serine-arginine protein kinase 1 is associated with breast cancer progression and poor patient survival.
Breast Neoplasms
Sodium-glucose co-transporter-2 (SGLT-2) inhibition reduces glucose uptake to induce breast cancer cell growth arrest through AMPK/mTOR pathway.
Breast Neoplasms
TAK1 is required for TGF-beta 1-mediated regulation of matrix metalloproteinase-9 and metastasis.
Breast Neoplasms
TAK1-TAB2 Signaling Contributes to Bone Destruction by Breast Carcinoma Cells.
Breast Neoplasms
Targeting AMP-activated protein kinase in adipocytes to modulate obesity-related adipokine production associated with insulin resistance and breast cancer cell proliferation.
Breast Neoplasms
Targeting AMPK: a new therapeutic opportunity in breast cancer.
Breast Neoplasms
Targeting of TGF-?-activated protein kinase 1 inhibits chemokine (C-C motif) receptor 7 expression, tumor growth and metastasis in breast cancer.
Breast Neoplasms
The anti-proliferative effect of metformin in triple-negative MDA-MB-231 breast cancer cells is highly dependent on glucose concentration: Implications for cancer therapy and prevention.
Breast Neoplasms
Treating breast cancer through novel inhibitors of the phosphatidylinositol 3'-kinase pathway.
Breast Neoplasms
Tumor cell migration screen identifies SRPK1 as breast cancer metastasis determinant.
Breast Neoplasms
Tumor necrosis factor-alpha induces interleukin-6 production via extracellular-regulated kinase 1 activation in breast cancer cells.
Breast Neoplasms
Type 2 diabetes and obesity metabolic interactions: common factors for breast cancer risk and novel approaches to prevention and therapy.
Breast Neoplasms
Validation of a Phosphoprotein Array Assay for Characterization of Human Tyrosine Kinase Receptor Downstream Signaling in Breast Cancer.
Breast Neoplasms
Variation in genes coding for AMP-activated protein kinase (AMPK) and breast cancer risk in the European Prospective Investigation on Cancer (EPIC).
Bronchitis, Chronic
Formation of Fructose-Mediated Advanced Glycation End Products and Their Roles in Metabolic and Inflammatory Diseases.
Caliciviridae Infections
Glycolysis Is an Intrinsic Factor for Optimal Replication of a Norovirus.
carboxylesterase deficiency
Ces1d deficiency protects against high-sucrose diet-induced hepatic triacylglycerol accumulation.
Carcinogenesis
AMP-activated protein kinase ?1 serves a carcinogenic role via regulation of vascular endothelial growth factor expression in patients with non-small cell lung cancer.
Carcinogenesis
AMP-activated protein kinase mediates the antioxidant effects of resveratrol through regulation of the transcription factor FoxO1.
Carcinogenesis
AMPK Inhibition Suppresses the Malignant Phenotype of Pancreatic Cancer Cells in Part by Attenuating Aerobic Glycolysis.
Carcinogenesis
AMPK Inhibits the Stimulatory Effects of TGF-? on Smad2/3 Activity, Cell Migration, and Epithelial-to-Mesenchymal Transition.
Carcinogenesis
Association of AMP-activated Protein Kinase with Risk and Progression of Non-Hodgkin Lymphoma.
Carcinogenesis
Berberine and cinnamaldehyde together prevent lung carcinogenesis.
Carcinogenesis
Berberine regulates AMP-activated protein kinase signaling pathways and inhibits colon tumorigenesis in mice.
Carcinogenesis
Copper Promotes Tumorigenesis by Activating the PDK1-AKT Oncogenic Pathway in a Copper Transporter 1 Dependent Manner.
Carcinogenesis
Diabetes and cancer: the mechanistic implications of epidemiological analyses from the Hong Kong Diabetes Registry.
Carcinogenesis
ERK5?regulated RERG expression promotes cancer progression in prostatic carcinoma.
Carcinogenesis
Erratum to: Honokiol activates AMP-activated protein kinase in breast cancer cells via LKB1-dependent pathway and inhibits breast carcinogenesis.
Carcinogenesis
Functional characterization of AMP-activated protein kinase signaling in tumorigenesis.
Carcinogenesis
Genetic deletion of glycogen synthase kinase-3beta abrogates activation of IkappaBalpha kinase, JNK, Akt, and p44/p42 MAPK but potentiates apoptosis induced by tumor necrosis factor.
Carcinogenesis
Glycogen synthase kinase 3? and cyclin D1 expression in cervical carcinogenesis.
Carcinogenesis
Glycogen synthase kinase 3? in tumorigenesis and oncotherapy (Review).
Carcinogenesis
Glycogen synthase kinase 3? inhibition as a therapeutic approach in the treatment of endometrial cancer.
Carcinogenesis
Glycogen synthase kinase3 beta phosphorylates serine 33 of p53 and activates p53's transcriptional activity.
Carcinogenesis
GSK-3? suppresses the proliferation of rat hepatic oval cells through modulating Wnt/?-catenin signaling pathway.
Carcinogenesis
GSK3{beta} inactivation induces apoptosis of leukemia cells by repressing the function of c-Myb.
Carcinogenesis
Honokiol activates AMP-activated protein kinase in breast cancer cells via LKB1-dependent pathway and inhibits breast carcinogenesis.
Carcinogenesis
Identification and characterization of primary cilia-positive salivary gland tumours exhibiting basaloid/myoepithelial differentiation.
Carcinogenesis
Loss of TAB3 expression by shRNA exhibits suppressive bioactivity and increased chemical sensitivity of ovarian cancer cell lines via the NF-?B pathway.
Carcinogenesis
Luteolin inhibits cell proliferation during Azoxymethane-induced experimental colon carcinogenesis via Wnt/ beta-catenin pathway.
Carcinogenesis
Metformin and Ara-a Effectively Suppress Brain Cancer by Targeting Cancer Stem/Progenitor Cells.
Carcinogenesis
MiR-181c-5p Mitigates Tumorigenesis in Cervical Squamous Cell Carcinoma via Targeting Glycogen Synthase Kinase 3? Interaction Protein (GSKIP).
Carcinogenesis
Mps1 is associated with the BRAFV600E mutation and predicts poor outcome in patients with colorectal cancer.
Carcinogenesis
NPM-ALK signals through glycogen synthase kinase 3? to promote oncogenesis.
Carcinogenesis
p-HPEA-EDA, a phenolic compound of virgin olive oil, activates AMP-activated protein kinase to inhibit carcinogenesis.
Carcinogenesis
PDK1 regulates vascular remodeling and promotes epithelial-mesenchymal transition in cardiac development.
Carcinogenesis
Screening methods for AMP-activated protein kinase modulators: a patent review.
Carcinogenesis
STAT3 activates MSK1-mediated histone H3 phosphorylation to promote NFAT signaling in gastric carcinogenesis.
Carcinogenesis
The crucial role of SRPK1 in TGF-?-induced proliferation and apoptosis in the esophageal squamous cell carcinomas.
Carcinogenesis
The dietary phytochemical 3,3'-diindolylmethane induces G2/M arrest and apoptosis in oral squamous cell carcinoma by modulating Akt-NF-?B, MAPK, and p53 signaling.
Carcinogenesis
Tight regulation between cell survival and programmed cell death in GBM stem-like cells by EGFR/GSK3b/PP2A signaling.
Carcinogenesis
Transcription Factor Sp1 Promotes the Expression of Porcine ROCK1 Gene.
Carcinogenesis
Upregulation of glycogen synthase kinase 3? in human colorectal adenocarcinomas correlates with accumulation of CTNNB1.
Carcinoma
? adrenergic receptor modulated signaling in glioma models: promoting ? adrenergic receptor-? arrestin scaffold-mediated activation of extracellular-regulated kinase 1/2 may prove to be a panacea in the treatment of intracranial and spinal malignancy and extra-neuraxial carcinoma.
Carcinoma
A 5' AMP-Activated Protein Kinase Enzyme Activator, Compound 59, Induces Autophagy and Apoptosis in Human Oral Squamous Cell Carcinoma.
Carcinoma
Abnormal expression of the pre-mRNA splicing regulators SRSF1, SRSF2, SRPK1 and SRPK2 in non small cell lung carcinoma.
Carcinoma
AMP-activated Protein Kinase (AMPK) Control of mTORC1 Is p53- and TSC2-independent in Pemetrexed-treated Carcinoma Cells.
Carcinoma
AMP-activated protein kinase antagonizes pro-apoptotic extracellular signal-regulated kinase activation by inducing dual-specificity protein phosphatases in response to glucose deprivation in HCT116 carcinoma.
Carcinoma
An agonist to the A3 adenosine receptor inhibits colon carcinoma growth in mice via modulation of GSK-3 beta and NF-kappa B.
Carcinoma
Analysis of the effect of rutin on GSK-3? and TNF-? expression in lung cancer.
Carcinoma
Association between phosphorylated AMP-activated protein kinase and acetyl-CoA carboxylase expression and outcome in patients with squamous cell carcinoma of the head and neck.
Carcinoma
Bitter melon juice activates cellular energy sensor AMP-activated protein kinase causing apoptotic death of human pancreatic carcinoma cells.
Carcinoma
CD44(high) /ALDH1(high) head and neck squamous cell carcinoma cells exhibit mesenchymal characteristics and GSK3?-dependent cancer stem cell properties.
Carcinoma
Correction: AMP-activated protein kinase antagonizes pro-apoptotic extracellular signal-regulated kinase activation by inducing dual-specificity protein phosphatases in response to glucose deprivation in HCT116 carcinoma.
Carcinoma
Critical roles of AMP-activated protein kinase in the carcinogenic metal-induced expression of VEGF and HIF-1 proteins in DU145 prostate carcinoma.
Carcinoma
Diallyl trisulfide induces apoptosis and mitotic arrest in AGS human gastric carcinoma cells through reactive oxygen species-mediated activation of AMP-activated protein kinase.
Carcinoma
Dietary energy restriction modulates the activity of AMP-activated protein kinase, Akt, and mammalian target of rapamycin in mammary carcinomas, mammary gland, and liver.
Carcinoma
Different expression of GSK3? and pS9GSK3? depending on phenotype of cervical cancer: possible association of GSK3? with squamous cell carcinoma and pS9GSK3? with adenocarcinoma.
Carcinoma
Down-regulation of AMP-activated protein kinase sensitizes DU145 carcinoma to Fas-induced apoptosis via c-FLIP degradation.
Carcinoma
Fibronectin increases matrix metalloproteinase 9 expression through activation of c-Fos via extracellular-regulated kinase and phosphatidylinositol 3-kinase pathways in human lung carcinoma cells.
Carcinoma
Gene expression analysis identifies two groups of ovarian high-grade serous carcinomas with different prognosis.
Carcinoma
Glucose deprivation increases mRNA stability of vascular endothelial growth factor through activation of AMP-activated protein kinase in DU145 prostate carcinoma.
Carcinoma
GSK-3 phosphorylates delta-catenin and negatively regulates its stability via ubiquitination/proteosome-mediated proteolysis.
Carcinoma
GSK3A is redundant with GSK3B in modulating drug resistance and chemotherapy-induced necroptosis.
Carcinoma
High metastaticgastric and breast cancer cells consume oleic acid in an AMPK dependent manner.
Carcinoma
Identification of genes specifically methylated in Epstein-Barr virus-associated gastric carcinomas.
Carcinoma
Inactivation of the AMPK-GATA3-ECHS1 Pathway Induces Fatty Acid Synthesis That Promotes Clear Cell Renal Cell Carcinoma Growth.
Carcinoma
Inhibition of GSK3B bypass drug resistance of p53-null colon carcinomas by enabling necroptosis in response to chemotherapy.
Carcinoma
Isoflurane activates AMP-activated protein kinase to inhibit proliferation, and promote apoptosis and autophagy in cervical carcinoma both in vitro and in vivo.
Carcinoma
Knockdown of MAGEA6 Activates AMP-Activated Protein Kinase (AMPK) Signaling to Inhibit Human Renal Cell Carcinoma Cells.
Carcinoma
Knockdown of Serine-Arginine Protein Kinase 1 Inhibits the Growth and Migration in Renal Cell Carcinoma Cells.
Carcinoma
Long noncoding RNA POU3F3 promotes cancer cell proliferation in prostate carcinoma by upregulating rho-associated protein kinase 1.
Carcinoma
Loss of expression for the Wnt pathway components adenomatous polyposis coli and glycogen synthase kinase 3-beta in parathyroid carcinomas.
Carcinoma
Matrix metalloproteinases (MMP), EMMPRIN (extracellular matrix metalloproteinase inducer) and mitogen-activated protein kinases (MAPK): co-expression in metastatic serous ovarian carcinoma.
Carcinoma
MiR-181c-5p Mitigates Tumorigenesis in Cervical Squamous Cell Carcinoma via Targeting Glycogen Synthase Kinase 3? Interaction Protein (GSKIP).
Carcinoma
MiR-98 inhibits cell proliferation and invasion of non-small cell carcinoma lung cancer by targeting PAK1.
Carcinoma
Mitogen-activated protein kinases (MAPK) as predictors of clinical outcome in serous ovarian carcinoma in effusions.
Carcinoma
Morphine Stimulates Migration and Growth and Alleviates the Effects of Chemo Drugs via AMPK-Dependent Induction of Epithelial-Mesenchymal Transition in Esophageal Carcinoma Cells.
Carcinoma
Phosphatidylinositol 3'-kinase, mTOR, and Glycogen synthase kinase-3 beta mediated regulation of p21 in human urothelial carcinoma cells.
Carcinoma
Phosphorylated AMP-activated protein kinase expression is significantly associated with poor clinical outcomes in bladder carcinoma patients.
Carcinoma
Potential therapeutic effect of targeting glycogen synthase kinase 3? in esophageal squamous cell carcinoma.
Carcinoma
Prognostic impact of AMP-activated protein kinase expression in ovarian carcinoma: correlation of protein expression and GC/TOF-MS-based metabolomics.
Carcinoma
Prognostic Implication of pAMPK Immunohistochemical Staining by Subcellular Location and Its Association with SMAD Protein Expression in Clear Cell Renal Cell Carcinoma.
Carcinoma
Rebamipide induces the gastric mucosal protective factor, cyclooxygenase-2, via activation of 5'-AMP-activated protein kinase.
Carcinoma
Retraction. Fibronectin increases matrix metalloproteinase 9 expression through activation of c-Fos via extracellular-regulated kinase and phosphatidylinositol 3-kinase pathways in human lung carcinoma cells.
Carcinoma
Reversine induces autophagic cell death through the AMP-activated protein kinase pathway in urothelial carcinoma cells.
Carcinoma
Role of the AMPK/ACC Signaling Pathway in TRPP2-Mediated Head and Neck Cancer Cell Proliferation.
Carcinoma
Role of Wnt/?-catenin, Wnt/c-Jun N-terminal kinase and Wnt/Ca(2+) pathways in cisplatin-induced chemoresistance in ovarian cancer.
Carcinoma
Serine-arginine protein kinase 1 overexpression is associated with tumorigenic imbalance in mitogen-activated protein kinase pathways in breast, colonic, and pancreatic carcinomas.
Carcinoma
Sipi soup inhibits cancer?associated fibroblast activation and the inflammatory process by downregulating long non?coding RNA HIPK1?AS.
Carcinoma
Targeting 3-phosphoinositide-dependent protein kinase 1 associated with drug-resistant renal cell carcinoma using new oridonin analogs.
Carcinoma
The activated nerve growth factor receptor p-TrkA is selectively expressed in advanced-stage ovarian carcinoma.
Carcinoma
Underactivation of the adiponectin-adiponectin receptor 1 axis in clear cell renal cell carcinoma: implications for progression.
Carcinoma
Withdrawal: Glucose deprivation increases mRNA stability of vascular endothelial growth factor through activation of AMP-activated protein kinase in DU145 prostate carcinoma.
Carcinoma
[Expression and clinical significance of nuclear factor ?B/B cell lymphoma-2 signal pathway and glycogen synthase kinase 3? in oral squamous cell carcinoma].
Carcinoma
[Expression and its clinical significance of AMP-activated protein kinase in esophageal squamous cell carcinoma].
Carcinoma
[Inhibition of PDK1 gene expression in esophageal cancer EC9706 cells by RNA interference and its effect on their malignant biological behavior].
Carcinoma, Ductal
Molecular docking based screening analysis of GSK3B.
Carcinoma, Hepatocellular
5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase.
Carcinoma, Hepatocellular
9-O-benzoyl-substituted berberine exerts a triglyceride-lowering effect through AMPK signaling pathway in human hepatoma HepG2 cells.
Carcinoma, Hepatocellular
?-hydroxybutyrate protects hepatocytes against endoplasmic reticulum stress in a sirtuin 1-independent manner.
Carcinoma, Hepatocellular
A Novel Partial Agonist of Peroxisome Proliferator-Activated Receptor ? with Excellent Effect on Insulin Resistance and Type 2 Diabetes.
Carcinoma, Hepatocellular
Activation of AMP-activated Protein Kinase and Phosphorylation of Glycogen Synthase Kinase3 ? Mediate Ursolic Acid Induced Apoptosis in HepG2 Liver Cancer Cells.
Carcinoma, Hepatocellular
Activation of AMP-activated protein kinase attenuates hepatocellular carcinoma cell adhesion stimulated by adipokine resistin.
Carcinoma, Hepatocellular
Activation of AMP-activated protein kinase by retinoic acid sensitizes hepatocellular carcinoma cells to apoptosis induced by sorafenib.
Carcinoma, Hepatocellular
Aldehyde dehydrogenase-2 (ALDH2) opposes hepatocellular carcinoma progression by regulating AMP-activated protein kinase signaling in mice.
Carcinoma, Hepatocellular
AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line.
Carcinoma, Hepatocellular
AMP-activated protein kinase suppresses LXR-dependent sterol regulatory element-binding protein-1c transcription in rat hepatoma McA-RH7777 cells.
Carcinoma, Hepatocellular
AMP-Activated Protein Kinase Suppresses the In Vitro and In Vivo Proliferation of Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
An ent-kaurane diterpenoid from Croton tonkinensis induces apoptosis by regulating AMP-activated protein kinase in SK-HEP1 human hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
Anti-proliferative Effect of 15,16-Dihydrotanshinone I Through Cell Cycle Arrest and the Regulation of AMP-activated Protein Kinase/Akt/mTOR and Mitogen-activated Protein Kinase Signaling Pathway in Human Hepatocellular Carcinoma Cells.
Carcinoma, Hepatocellular
ARK5 promotes doxorubicin resistance in hepatocellular carcinoma via epithelial-mesenchymal transition.
Carcinoma, Hepatocellular
Aspartate ?-hydroxylase modulates cellular senescence through glycogen synthase kinase 3? in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Aspirin regulates hepatocellular lipid metabolism by activating AMPK signaling pathway.
Carcinoma, Hepatocellular
Autophagy and glycolysis independently attenuate silibinin-induced apoptosis in human hepatocarcinoma HepG2 and Hep3B cells.
Carcinoma, Hepatocellular
Berberine-induced apoptotic and autophagic death of HepG2 cells requires AMPK activation.
Carcinoma, Hepatocellular
Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes.
Carcinoma, Hepatocellular
Cryptotanshinone induces G1 cell cycle arrest and autophagic cell death by activating the AMP-activated protein kinase signal pathway in HepG2 hepatoma.
Carcinoma, Hepatocellular
Effects of fucoidan on proliferation, AMP-activated protein kinase, and downstream metabolism- and cell cycle-associated molecules in poorly differentiated human hepatoma HLF cells.
Carcinoma, Hepatocellular
Effects of imidazoline-like drugs on liver and adipose tissues, and their role in preventing obesity and associated cardio-metabolic disorders.
Carcinoma, Hepatocellular
Expression of Phosphorylated AMP-Activated Protein Kinase Predicts Response to Transarterial Chemoembolization in Postoperative Cases of Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Fenofibrate and PBA prevent fatty acid-induced loss of adiponectin receptor and pAMPK in human hepatoma cells and in hepatitis C virus-induced steatosis.
Carcinoma, Hepatocellular
FK866-induced NAMPT inhibition activates AMPK and downregulates mTOR signaling in hepatocarcinoma cells.
Carcinoma, Hepatocellular
Ginsenoside Rg2 induces orphan nuclear receptor SHP gene expression and inactivates GSK3? via AMP-activated protein kinase to inhibit hepatic glucose production in HepG2 cells.
Carcinoma, Hepatocellular
HCAR1/MCT1 Regulates Tumor Ferroptosis through the Lactate-Mediated AMPK-SCD1 Activity and Its Therapeutic Implications.
Carcinoma, Hepatocellular
High dose of extracellular ATP switched autophagy to apoptosis in anchorage-dependent and anchorage-independent hepatoma cells.
Carcinoma, Hepatocellular
Histone acetyltransferase PCAF accelerates apoptosis by repressing a GLI1/BCL2/BAX axis in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Identification of PFTAIRE protein kinase 1, a novel cell division cycle-2 related gene, in the motile phenotype of hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
Inhibition of lipid synthesis through activation of AMP kinase: an additional mechanism for the hypolipidemic effects of berberine.
Carcinoma, Hepatocellular
Jujube leaf green tea extracts inhibits hepatocellular carcinoma cells by activating AMPK.
Carcinoma, Hepatocellular
LETM1 Knockdown Promotes Autophagy and Apoptosis Through AMP-Activated Protein Kinase Phosphorylation-Mediated Beclin-1/Bcl-2 Complex Dissociation in Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Lithium chloride inhibits the expression and secretion of insulin-like growth factor-binding protein-1.
Carcinoma, Hepatocellular
Matrine-induced autophagy regulated by p53 through AMP-activated protein kinase in human hepatoma cells.
Carcinoma, Hepatocellular
Metformin suppresses glucose-6-phosphatase expression by a complex I inhibition and AMPK activation-independent mechanism.
Carcinoma, Hepatocellular
MicroRNA-148b targets Rho-associated protein kinase 1 to inhibit cell proliferation, migration and invasion in hepatocellular carcinoma.
Carcinoma, Hepatocellular
MiR-506 suppresses cell proliferation and tumor growth by targeting Rho-associated protein kinase 1 in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Mitochondrial DNA Maintenance Is Regulated in Human Hepatoma Cells by Glycogen Synthase Kinase 3? and p53 in Response to Tumor Necrosis Factor ?.
Carcinoma, Hepatocellular
Negative regulation of Sirtuin 1 by AMP-activated protein kinase promotes metformin-induced senescence in hepatocellular carcinoma xenografts.
Carcinoma, Hepatocellular
Notch3 inhibition enhances sorafenib cytotoxic efficacy by promoting GSK3b phosphorylation and p21 down-regulation in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Phosphorylation of hepatic AMP-activated protein kinase and liver kinase B1 is increased after a single oral dose of green tea extract to mice.
Carcinoma, Hepatocellular
Prognostic and Clinical Implications of WNK Lysine Deficient Protein Kinase 1 Expression in Patients With Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Proliferating effect of orotic acid through mTORC1 activation mediated by negative regulation of AMPK in SK-Hep1 hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
Pu-erh tea attenuates hyperlipogenesis and induces hepatoma cells growth arrest through activating AMP-activated protein kinase (AMPK) in human HepG2 cells.
Carcinoma, Hepatocellular
RBMY, a novel inhibitor of glycogen synthase kinase 3?, increases tumor stemness and predicts poor prognosis of hepatocellular carcinoma.
Carcinoma, Hepatocellular
RIP1 upregulation promoted tumor progression by activating AKT/Bcl-2/BAX signaling and predicted poor postsurgical prognosis in HCC.
Carcinoma, Hepatocellular
Serine-arginine protein kinase 1 is associated with hepatocellular carcinoma progression and poor patient survival.
Carcinoma, Hepatocellular
Serine/arginine protein-specific kinase 2 promotes the development and progression of pancreatic cancer by downregulating Numb and p53.
Carcinoma, Hepatocellular
SRPK1 contributes to malignancy of hepatocellular carcinoma through a possible mechanism involving PI3K/Akt.
Carcinoma, Hepatocellular
Stimulation of IGF-binding protein-1 secretion by AMP-activated protein kinase.
Carcinoma, Hepatocellular
The Role of AMP-Activated Protein Kinase as a Potential Target of Treatment of Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Trypsin-Treated ?-Lactoglobulin Improves Glucose Tolerance in C57BL/6 Mice by Enhancing AMPK Activation and Glucose Uptake in Hepatocytes.
Carcinoma, Hepatocellular
Wnt signaling in hepatocellular carcinoma: analysis of mutation and expression of beta-catenin, T-cell factor-4 and glycogen synthase kinase 3-beta genes.
Carcinoma, Hepatocellular
[Establishment of a mice model with liver-specific AMP-activated protein kinase gene knockout].
Carcinoma, Non-Small-Cell Lung
Abnormal expression of the pre-mRNA splicing regulators SRSF1, SRSF2, SRPK1 and SRPK2 in non small cell lung carcinoma.
Carcinoma, Non-Small-Cell Lung
AMP-activated protein kinase ?1 serves a carcinogenic role via regulation of vascular endothelial growth factor expression in patients with non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Circular RNA circHIPK3 modulates autophagy via MIR124-3p-STAT3-PRKAA/AMPK? signaling in STK11 mutant lung cancer.
Carcinoma, Non-Small-Cell Lung
Downregulation of SRPK2 promotes cell cycle arrest though E2F1 in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Induction of cytoprotective autophagy by morusin via AMP-activated protein kinase activation in human non-small cell lung cancer cells.
Carcinoma, Non-Small-Cell Lung
LKB1 promotes metabolic flexibility in response to energy stress.
Carcinoma, Non-Small-Cell Lung
miR-135a inhibits malignant proliferation and diffusion of non-small cell lung cancer cells by down-regulating ROCK1 protein.
Carcinoma, Non-Small-Cell Lung
The influence of circular RNAs on autophagy and disease progression.
Carcinoma, Non-Small-Cell Lung
Up-regulation of SRPK1 in non-small cell lung cancer promotes the growth and migration of cancer cells.
Carcinoma, Non-Small-Cell Lung
[Effect of DAPK1 gene transfection on high-metastasis non-small lung cancer cell PGCl3]
Carcinoma, Ovarian Epithelial
MicroRNA?320 targets mitogen?activated protein kinase 1 to inhibit cell proliferation and invasion in epithelial ovarian cancer.
Carcinoma, Ovarian Epithelial
Misregulation of polo-like protein kinase 1, P53 and P21WAF1 in epithelial ovarian cancer suggests poor prognosis.
Carcinoma, Renal Cell
Inactivation of the AMPK-GATA3-ECHS1 Pathway Induces Fatty Acid Synthesis That Promotes Clear Cell Renal Cell Carcinoma Growth.
Carcinoma, Renal Cell
Knockdown of MAGEA6 Activates AMP-Activated Protein Kinase (AMPK) Signaling to Inhibit Human Renal Cell Carcinoma Cells.
Carcinoma, Renal Cell
Knockdown of Serine-Arginine Protein Kinase 1 Inhibits the Growth and Migration in Renal Cell Carcinoma Cells.
Carcinoma, Renal Cell
Prognostic Implication of pAMPK Immunohistochemical Staining by Subcellular Location and Its Association with SMAD Protein Expression in Clear Cell Renal Cell Carcinoma.
Carcinoma, Renal Cell
Regulation of angiogenic factors by HDM2 in renal cell carcinoma.
Carcinoma, Renal Cell
Targeting 3-phosphoinositide-dependent protein kinase 1 associated with drug-resistant renal cell carcinoma using new oridonin analogs.
Carcinoma, Renal Cell
Underactivation of the adiponectin-adiponectin receptor 1 axis in clear cell renal cell carcinoma: implications for progression.
Carcinoma, Squamous Cell
Association between phosphorylated AMP-activated protein kinase and acetyl-CoA carboxylase expression and outcome in patients with squamous cell carcinoma of the head and neck.
Carcinoma, Squamous Cell
CD44(high) /ALDH1(high) head and neck squamous cell carcinoma cells exhibit mesenchymal characteristics and GSK3?-dependent cancer stem cell properties.
Carcinoma, Squamous Cell
Different expression of GSK3? and pS9GSK3? depending on phenotype of cervical cancer: possible association of GSK3? with squamous cell carcinoma and pS9GSK3? with adenocarcinoma.
Carcinoma, Squamous Cell
MiR-181c-5p Mitigates Tumorigenesis in Cervical Squamous Cell Carcinoma via Targeting Glycogen Synthase Kinase 3? Interaction Protein (GSKIP).
Carcinoma, Squamous Cell
Sipi soup inhibits cancer?associated fibroblast activation and the inflammatory process by downregulating long non?coding RNA HIPK1?AS.
Carcinoma, Squamous Cell
[Small interfering RNA-mediated RIP1 knockdown enhances L-OHP sensitivity of human oral squamous carcinoma cells].
Cardiomegaly
?-Catenin Regulates Cardiac Energy Metabolism in Sedentary and Trained Mice.
Cardiomegaly
A distinct AMP-activated protein kinase phosphorylation site characterizes cardiac hypertrophy induced by L-thyroxine and angiotensin II.
Cardiomegaly
A Modified Formulation of Sutaehwan Ameliorates Menopausal Anxiety, Depression and Heart Hypertrophy in the VCD-Induced Menopausal Mouse Model.
Cardiomegaly
A new mutation in PRKAG2 gene causing hypertrophic cardiomyopathy with conduction system disease and muscular glycogenosis.
Cardiomegaly
A novel, de novo mutation in the PRKAG2 gene: infantile-onset phenotype and the signaling pathway involved.
Cardiomegaly
Activation of AMP-activated protein kinase (AMPK) inhibits protein synthesis: a potential strategy to prevent the development of cardiac hypertrophy.
Cardiomegaly
Adiponectin-mediated modulation of hypertrophic signals in the heart.
Cardiomegaly
AMP-Activated Protein Kinase Signalling in Cancer and Cardiac Hypertrophy.
Cardiomegaly
AMPK activation counteracts cardiac hypertrophy by reducing O-GlcNAcylation.
Cardiomegaly
AMPK blunts chronic heart failure by inhibiting autophagy.
Cardiomegaly
AMPK deficiency in cardiac muscle results in dilated cardiomyopathy in the absence of changes in energy metabolism.
Cardiomegaly
AMPK signaling pathway is rapidly activated by T3 and regulates the cardiomyocyte growth.
Cardiomegaly
Characterization of the role of gamma2 R531G mutation in AMP-activated protein kinase in cardiac hypertrophy and Wolff-Parkinson-White syndrome.
Cardiomegaly
Constitutively active AMP kinase mutations cause glycogen storage disease mimicking hypertrophic cardiomyopathy.
Cardiomegaly
Critical role of X-box binding protein 1 in NADPH oxidase 4-triggered cardiac hypertrophy is mediated by receptor interacting protein kinase 1.
Cardiomegaly
Deficiency in AMP-activated protein kinase exaggerates high fat diet-induced cardiac hypertrophy and contractile dysfunction.
Cardiomegaly
Distinct roles of GSK-3alpha and GSK-3beta phosphorylation in the heart under pressure overload.
Cardiomegaly
DOCA-induced phosphorylation of glycogen synthase kinase 3beta.
Cardiomegaly
Downregulation of Ca2+ signalling proteins in cardiac hypertrophy.
Cardiomegaly
Dynamic regulation of MEK/Erks and Akt/GSK-3beta in human end-stage heart failure after left ventricular mechanical support: myocardial mechanotransduction-sensitivity as a possible molecular mechanism.
Cardiomegaly
Evidence that AMP-activated protein kinase can negatively modulate Ornithine decarboxylase activity in cardiac myoblasts.
Cardiomegaly
Functional analysis of mutations in the gamma 2 subunit of AMP-activated protein kinase associated with cardiac hypertrophy and Wolff-Parkinson-White syndrome.
Cardiomegaly
Gene expression profiling of exercise-induced cardiac hypertrophy in rats.
Cardiomegaly
Geniposide Protects against Obesity-Related Cardiac Injury through AMPK?- and Sirt1-Dependent Mechanisms.
Cardiomegaly
Globular adiponectin inhibits angiotensin II-induced nuclear factor kappaB activation through AMP-activated protein kinase in cardiac hypertrophy.
Cardiomegaly
Glucose metabolism and cardiac hypertrophy.
Cardiomegaly
Glycogen synthase kinase-3alpha reduces cardiac growth and pressure overload-induced cardiac hypertrophy by inhibition of extracellular signal-regulated kinases.
Cardiomegaly
Increased alpha2 subunit-associated AMPK activity and PRKAG2 cardiomyopathy.
Cardiomegaly
Inhibition of glycogen synthase kinase 3beta during heart failure is protective.
Cardiomegaly
Intermedin1-53 protects against cardiac hypertrophy by inhibiting endoplasmic reticulum stress via activating AMP-activated protein kinase.
Cardiomegaly
miR-199a impairs autophagy and induces cardiac hypertrophy through mTOR activation.
Cardiomegaly
Mutation in the ?2-Subunit of AMP-Activated Protein Kinase Stimulates Cardiomyocyte Proliferation and Hypertrophy Independent of Glycogen Storage.
Cardiomegaly
Phosphoinositide dependent protein kinase 1 is required for exercise-induced cardiac hypertrophy but not the associated mitochondrial adaptations.
Cardiomegaly
Pioglitazone attenuates cardiac hypertrophy in rats with salt-sensitive hypertension: role of activation of AMP-activated protein kinase and inhibition of Akt.
Cardiomegaly
Piperine Attenuates Pathological Cardiac Fibrosis Via PPAR-?/AKT Pathways.
Cardiomegaly
Resveratrol inhibits cardiac hypertrophy via AMP-activated protein kinase and Akt.
Cardiomegaly
RIP2 deficiency attenuates cardiac hypertrophy, inflammation and fibrosis in pressure overload induced mice.
Cardiomegaly
Soluble 3',6-substituted indirubins with enhanced selectivity toward glycogen synthase kinase -3 alter circadian period.
Cardiomegaly
Studying the Role of AMPK in Cardiac Hypertrophy and Protein Synthesis.
Cardiomegaly
The AMPK gamma1 R70Q mutant regulates multiple metabolic and growth pathways in neonatal cardiac myocytes.
Cardiomegaly
Ventricular pre-excitation and cardiac hypertrophy mimicking hypertrophic cardiomyopathy in a Turkish family with a novel PRKAG2 mutation.
Cardiomyopathies
A PRKAG2 mutation causes biphasic changes in myocardial AMPK activity and does not protect against ischemia.
Cardiomyopathies
Antigen-Based Nano-Immunotherapy Controls Parasite Persistence, Inflammatory and Oxidative Stress, and Cardiac Fibrosis, the Hallmarks of Chronic Chagas Cardiomyopathy, in A Mouse Model of Trypanosoma cruzi Infection.
Cardiomyopathies
Dissociation of Bcl-2-Beclin1 Complex by Activated AMPK Enhances Cardiac Autophagy and Protects Against Cardiomyocyte Apoptosis in Diabetes.
Cardiomyopathies
Familial hypertrophic cardiomyopathy: clinical features, molecular genetics and molecular genetic testing.
Cardiomyopathies
FGF21 ameliorates diabetic cardiomyopathy by activating the AMPK-paraoxonase 1 signaling axis in mice.
Cardiomyopathies
Increased alpha2 subunit-associated AMPK activity and PRKAG2 cardiomyopathy.
Cardiomyopathies
Mechanism of fibrotic cardiomyopathy in mice expressing truncated Rho-associated coiled-coil protein kinase 1.
Cardiomyopathies
Mutation analysis of AMP-activated protein kinase subunits in inherited cardiomyopathies: implications for kinase function and disease pathogenesis.
Cardiomyopathies
Mutation in the ?2-Subunit of AMP-Activated Protein Kinase Stimulates Cardiomyocyte Proliferation and Hypertrophy Independent of Glycogen Storage.
Cardiomyopathies
N488I mutation of the gamma2-subunit results in bidirectional changes in AMP-activated protein kinase activity.
Cardiomyopathies
SGLT1, a novel cardiac glucose transporter, mediates increased glucose uptake in PRKAG2 cardiomyopathy.
Cardiomyopathies
Sodium current abnormalities and deregulation of Wnt/?-catenin signaling in iPSC-derived cardiomyocytes generated from patient with arrhythmogenic cardiomyopathy harboring compound genetic variants in plakophilin 2 gene.
Cardiomyopathies
The effects of UCP2 on autophagy through the AMPK signaling pathway in septic cardiomyopathy and the underlying mechanism.
Cardiomyopathies
Transgenic mice overexpressing mutant PRKAG2 define the cause of Wolff-Parkinson-White syndrome in glycogen storage cardiomyopathy.
Cardiomyopathy, Dilated
Genomic analysis of an infant with intractable diarrhea and dilated cardiomyopathy.
Cardiomyopathy, Dilated
Regional evidence of modulation of cardiac adiponectin level in dilated cardiomyopathy: pilot study in a porcine animal model.
Cardiomyopathy, Hypertrophic
Fatal infantile cardiac glycogenosis with phosphorylase kinase deficiency and a mutation in the gamma2-subunit of AMP-activated protein kinase.
Cardiomyopathy, Hypertrophic
Glycogen storage diseases presenting as hypertrophic cardiomyopathy.
Cardiomyopathy, Hypertrophic
Modifier genes for hypertrophic cardiomyopathy.
Cardiomyopathy, Hypertrophic
Molecular genetic analysis of PRKAG2 in sporadic Wolff-Parkinson-White syndrome.
Cardiomyopathy, Hypertrophic
[Same genotype and different phenotypes in a family with PRKAG2 gene mutation]
Cardiomyopathy, Hypertrophic, Familial
Mutations in the gamma(2) subunit of AMP-activated protein kinase cause familial hypertrophic cardiomyopathy: evidence for the central role of energy compromise in disease pathogenesis.
Cardiotoxicity
High-mobility group box 1 protein-mediated necroptosis contributes to dasatinib-induced cardiotoxicity.
Cardiotoxicity
Inhibition of AMPK signalling by doxorubicin: at the crossroads of the cardiac responses to energetic, oxidative, and genotoxic stress.
Cardiotoxicity
Prior starvation mitigates acute doxorubicin cardiotoxicity through restoration of autophagy in affected cardiomyocytes.
Cardiotoxicity
Sunitinib-induced cardiotoxicity is mediated by off-target inhibition of AMP-activated protein kinase.
Cardiotoxicity
Use of human stem cell derived cardiomyocytes to examine sunitinib mediated cardiotoxicity and electrophysiological alterations.
Cardiovascular Diseases
AMP-activated protein kinase, stress responses and cardiovascular diseases.
Cardiovascular Diseases
AMP-activated protein kinase: a stress-responsive kinase with implications for cardiovascular disease.
Cardiovascular Diseases
AMPK activation enhances the anti-atherogenic effects of high density lipoproteins in apoE(-/-) mice.
Cardiovascular Diseases
AMPK Activators as a Drug for Diabetes, Cancer and Cardiovascular Disease.
Cardiovascular Diseases
AMPK as a Therapeutic Target for Treating Metabolic Diseases.
Cardiovascular Diseases
AMPK?2 deficiency exacerbates long-term PM2.5 exposure-induced lung injury and cardiac dysfunction.
Cardiovascular Diseases
An Integrated Pharmacokinetic Study of an Acanthopanax senticosus Extract Preparation by Combination of Virtual Screening, Systems Pharmacology, and Multi-Component Pharmacokinetics in Rats.
Cardiovascular Diseases
Computer-aided drug design for AMP-activated protein kinase activators.
Cardiovascular Diseases
Diabetic Cardiovascular Disease - AMP-Activated Protein Kinase (AMPK) as a Therapeutic Target.
Cardiovascular Diseases
Estrogenic compound attenuates angiotensin II-induced vascular smooth muscle cell proliferation through interaction between LKB1 and estrogen receptor ?.
Cardiovascular Diseases
Evaluating the impact of AMPK activation, a target of metformin, on risk of cardiovascular diseases and cancer in the UK Biobank: a Mendelian randomisation study.
Cardiovascular Diseases
Intervention Mechanisms of Xinmailong Injection, a Periplaneta Americana Extract, on Cardiovascular Disease: A Systematic Review of Basic Researches.
Cardiovascular Diseases
LB03.05: THE ANTI-CONTRACTILE EFFECTS OF PVAT ARE MODULATED BY AGE. THE ROLE OF NITRIC OXIDE.
Cardiovascular Diseases
Mutation in the ?2-Subunit of AMP-Activated Protein Kinase Stimulates Cardiomyocyte Proliferation and Hypertrophy Independent of Glycogen Storage.
Cardiovascular Diseases
Prolonged AMP-activated protein kinase induction impairs vascular functions.
Cardiovascular Diseases
Targeting AMP-Activated Protein Kinase in Aging-Related Cardiovascular Diseases.
Cardiovascular Diseases
TGFB-INHB/activin signaling regulates age-dependent autophagy and cardiac health through inhibition of MTORC2.
Cardiovascular Diseases
The Role of RIPK1 and RIPK3 in Cardiovascular Disease.
Cardiovascular Diseases
Xanthone glucoside 2-?-D-glucopyranosyl-1,3,6,7-tetrahydroxy-9H-xanthen-9-one binds to the ATP-binding pocket of glycogen synthase kinase 3? and inhibits its activity: implications in prostate cancer and associated cardiovascular disease risk.
Cardiovascular Diseases
Y-27632 Increases Sensitivity of PANC-1 Cells to EGCG in Regulating Cell Proliferation and Migration.
Carotid Artery Thrombosis
Preventive and therapeutic effect of brozopine on stroke in Dahl Salt-sensitive hypertensive rats.
Central Nervous System Diseases
Ammonium Increases TRPC1 Expression Via Cav-1/PTEN/AKT/GSK3? Pathway.
Central Nervous System Diseases
AMP-Activated Protein Kinase Suppresses Autoimmune Central Nervous System Disease by Regulating M1-Type Macrophage-Th17 Axis.
Central Nervous System Diseases
Inhibition of calcium dependent protein kinase 1 (CDPK1) by pyrazolopyrimidine analogs decreases establishment and reoccurrence of central nervous system disease by Toxoplasma gondii.
Cerebellar Ataxia
TTBK2 kinase: linking primary cilia and cerebellar ataxias.
Cerebral Hemorrhage
Mitochondrial Uncouplers Confer Protection by Activating AMP-Activated Protein Kinase to Inhibit Neuroinflammation Following Intracerebral Hemorrhage.
Cerebral Infarction
Hydroxybutyrate promotes the recovery from cerebral infarction by activating Amp-activated protein kinase signaling.
Cerebral Infarction
[Effect of electroacupuncture on neurological function and Wnt signaling pathway in ischemic brain tissue of cerebral infarction rats].
cgmp-dependent protein kinase deficiency
Phosphorylation of GSK-3beta by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes.
Cholangiocarcinoma
Metformin potentiates the anticancer activities of gemcitabine and cisplatin against cholangiocarcinoma cells in vitro and in vivo.
Cholangiocarcinoma
Metformin sensitizes cholangiocarcinoma cell to cisplatin-induced cytotoxicity through oxidative stress mediated mitochondrial pathway.
Cholangiocarcinoma
Nicotine Promotes Cholangiocarcinoma Growth in Xenograft Mice.
Cholangiocarcinoma
Receptor-interacting protein kinase 1 is a key mediator in TLR3 ligand and Smac mimetic-induced cell death and suppresses TLR3 ligand-promoted invasion in cholangiocarcinoma.
Cholangiocarcinoma
Receptor-Interacting Protein Kinase 1 Promotes Cholangiocarcinoma Proliferation And Lymphangiogenesis Through The Activation Protein 1 Pathway.
Cholangiocarcinoma
Salinomycin enhances doxorubicin sensitivity through reversing the epithelial-mesenchymal transition of cholangiocarcinoma cells by regulating ARK5.
Cholera
Adiponectin inhibits palmitate-induced apoptosis through suppression of reactive oxygen species in endothelial cells: involvement of cAMP/protein kinase A and AMP-activated protein kinase.
Cholera
Basal transcriptional activity and cyclic adenosine 3',5'-monophosphate responsiveness of the human cytochrome P450scc promoter transfected into MA-10 Leydig cells.
Cholera
Follicle-stimulating hormone increases concentrations of messenger ribonucleic acid encoding cytochrome P450 cholesterol side-chain cleavage enzyme in primary cultures of porcine granulosa cells.
Cholera
Glycogen synthase kinases-3beta controls differentiation of malignant glioma cells.
Cholera
Regulation of progesterone receptor gene expression in MCF-7 breast cancer cells: a comparison of the effects of cyclic adenosine 3',5'-monophosphate, estradiol, insulin-like growth factor-I, and serum factors.
Cholera
Regulation of steroidogenesis in jc-410, a stable cell line of porcine granulosa origin.
Cholera
Regulation of steroidogenesis in NCI-H295 cells: a cellular model of the human fetal adrenal.
Cholestasis
Alpha-naphthylisothiocyanate impairs bile acid homeostasis through AMPK-FXR pathways in rat primary hepatocytes.
Cholestasis
Picroside II alleviates liver injury induced by alpha-naphthylisothiocyanate through AMPK-FXR pathway.
Cholestasis
Role of AMP-activated protein kinase ?1 in 17?-ethinylestradiol-induced cholestasis in rats.
Chondrosarcoma
AMP-activated protein kinase activation mediates CCL3-induced cell migration and matrix metalloproteinase-2 expression in human chondrosarcoma.
Chondrosarcoma
Endothelin-1 promotes epithelial-mesenchymal transition in human chondrosarcoma cells by repressing miR-300.
Chondrosarcoma
mTORC1 inhibition and ECM-cell adhesion-independent drug resistance via PI3K-AKT and PI3K-RAS-MAPK feedback loops.
Choriocarcinoma
Regulation of proteins in the cholesterol side-chain cleavage system in JEG-3 and Y-1 cells.
Choroidal Neovascularization
Longitudinal phenotypic study of late-onset retinal degeneration due to a founder variant c.562C>A p.(Pro188Thr) in the C1QTNF5 gene.
Choroidal Neovascularization
Resveratrol prevents the development of choroidal neovascularization by modulating AMP-activated protein kinase in macrophages and other cell types.
Chronic Traumatic Encephalopathy
Endoplasmic reticulum stress implicated in chronic traumatic encephalopathy.
Colitis
Broccoli-Derived Nanoparticle Inhibits Mouse Colitis by Activating Dendritic Cell AMP-Activated Protein Kinase.
Colitis
Increased expression of yes-associated protein/YAP and transcriptional coactivator with PDZ-binding motif/TAZ activates intestinal fibroblasts to promote intestinal obstruction in Crohn's disease.
Colitis
Metformin inhibits inflammatory signals in the gut by controlling AMPK and p38 MAP kinase activation.
Colitis
NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-?B-Dependent and -Independent Functions.
Colitis
Preclinical Development of FA5, a Novel AMP-Activated Protein Kinase (AMPK) Activator as an Innovative Drug for the Management of Bowel Inflammation.
Colitis
Using Network Pharmacology for Systematic Understanding of Geniposide in Ameliorating Inflammatory Responses in Colitis Through Suppression of NLRP3 Inflammasome in Macrophage by AMPK/Sirt1 Dependent Signaling.
Colitis, Ulcerative
A randomised, placebo-controlled study of RIPK1 inhibitor GSK2982772 in patients with active ulcerative colitis.
Colitis, Ulcerative
How autophagy controls the intestinal epithelial barrier.
Colitis, Ulcerative
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Colitis, Ulcerative
Quyu Shengxin Decoction Alleviates DSS-Induced Ulcerative Colitis in Mice by Suppressing RIP1/RIP3/NLRP3 Signalling.
Colonic Neoplasms
20(S)-Ginsenoside Rg3-induced apoptosis in HT-29 colon cancer cells is associated with AMPK signaling pathway.
Colonic Neoplasms
5-Aminoimidazole-4-carboxamide riboside sensitizes TRAIL- and TNF{alpha}-induced cytotoxicity in colon cancer cells through AMP-activated protein kinase signaling.
Colonic Neoplasms
A novel AMPK activator reduces glucose uptake and inhibits tumor progression in a mouse xenograft model of colorectal cancer.
Colonic Neoplasms
Activation of AMP-activated protein kinase (AMPK) mediates plumbagin-induced apoptosis and growth inhibition in cultured human colon cancer cells.
Colonic Neoplasms
Addition of 2-deoxyglucose enhances growth inhibition but reverses acidification in colon cancer cells treated with phenformin.
Colonic Neoplasms
Adenine Inhibits the Growth of Colon Cancer Cells via AMP-Activated Protein Kinase Mediated Autophagy.
Colonic Neoplasms
Adiponectin Represses Colon Cancer Cell Proliferation via AdipoR1- and -R2-Mediated AMPK Activation.
Colonic Neoplasms
Aglycon of rhizochalin from the Rhizochalina incrustata induces apoptosis via activation of AMP-activated protein kinase in HT-29 colon cancer cells.
Colonic Neoplasms
Anthocyanins are novel AMPK?1 stimulators that suppress tumor growth by inhibiting mTOR phosphorylation.
Colonic Neoplasms
Compound K Induces Apoptosis via CAMK-IV/AMPK Pathways in HT-29 Colon Cancer Cells.
Colonic Neoplasms
Correlation of GOLPH3 Gene with Wnt Signaling Pathway in Human Colon Cancer Cells.
Colonic Neoplasms
Exopolysaccharides isolated from Rhizopus nigricans induced colon cancer cell apoptosis in vitro and in vivo via activating the AMPK pathway.
Colonic Neoplasms
Glycogen Synthase Kinase 3? Inhibitor (2'Z,3'E)-6-Bromo-indirubin- 3'-Oxime Enhances Drug Resistance to 5-Fluorouracil Chemotherapy in Colon Cancer Cells.
Colonic Neoplasms
Idelalisib induces PUMA-dependent apoptosis in colon cancer cells.
Colonic Neoplasms
Identification of an annonaceous acetogenin mimetic, AA005, as an AMPK activator and autophagy inducer in colon cancer cells.
Colonic Neoplasms
Induction of AMPK activation by N,N'-diarylurea FND-4b decreases growth and increases apoptosis in triple negative and estrogen-receptor positive breast cancers.
Colonic Neoplasms
Inhibition of colon cancer growth by docosahexaenoic acid involves autocrine production of TNF?.
Colonic Neoplasms
Inhibition of GSK-3 beta activity attenuates proliferation of human colon cancer cells in rodents.
Colonic Neoplasms
Kazinol C from Broussonetia kazinoki activates AMP-activated protein kinase to induce antitumorigenic effects in HT-29 colon cancer cells.
Colonic Neoplasms
Kidney bean husk extracts exert antitumor effect by inducing apoptosis involving AMP-activated protein kinase signaling pathway.
Colonic Neoplasms
Knockdown of PFTAIRE Protein Kinase 1 (PFTK1) Inhibits Proliferation, Invasion, and EMT in Colon Cancer Cells.
Colonic Neoplasms
Lithium chloride increases sensitivity to photon irradiation treatment in primary mesenchymal colon cancer cells.
Colonic Neoplasms
Magnolol-Induced Apoptosis in HCT-116 Colon Cancer Cells Is Associated with the AMP-Activated Protein Kinase Signaling Pathway.
Colonic Neoplasms
Pro-apoptotic and migration-suppressing potential of EGCG, and the involvement of AMPK in the p53-mediated modulation of VEGF and MMP-9 expression.
Colonic Neoplasms
Role of AMP-activated protein kinase in cross-talk between apoptosis and autophagy in human colon cancer.
Colonic Neoplasms
Selenium regulates cyclooxygenase-2 and extracellular signal-regulated kinase signaling pathways by activating AMP-activated protein kinase in colon cancer cells.
Colonic Neoplasms
Serine-arginine protein kinase 1 (SRPK1) inhibition as a potential novel targeted therapeutic strategy in prostate cancer.
Colonic Neoplasms
SRPK2 promotes the growth and migration of the colon cancer cells.
Colonic Neoplasms
Sulindac sulfide inhibits epidermal growth factor-induced phosphorylation of extracellular-regulated kinase 1/2 and Bad in human colon cancer cells.
Colonic Neoplasms
The apical (hPepT1) and basolateral peptide transport systems of Caco-2 cells are regulated by AMP-activated protein kinase.
Colonic Neoplasms
Widdrol induces apoptosis via activation of AMP-activated protein kinase in colon cancer cells.
Colorectal Neoplasms
Activation of AMP-Activated Protein Kinase ? and Extracelluar Signal-Regulated Kinase Mediates CB-PIC-Induced Apoptosis in Hypoxic SW620 Colorectal Cancer Cells.
Colorectal Neoplasms
AdipoRon: a possible drug for colorectal cancer prevention?
Colorectal Neoplasms
AMP-activated protein kinase (AMPK)/Ulk1-dependent autophagic pathway contributes to C6 ceramide-induced cytotoxic effects in cultured colorectal cancer HT-29 cells.
Colorectal Neoplasms
Aqueous Oldenlandia diffusa extracts inhibits colorectal cancer cells via activating AMP-activated protein kinase signalings.
Colorectal Neoplasms
ARK5 is transcriptionally regulated by the Large-MAF family and mediates IGF-1-induced cell invasion in multiple myeloma: ARK5 as a new molecular determinant of malignant multiple myeloma.
Colorectal Neoplasms
Aspirin Inhibits mTOR Signaling, Activates AMP-Activated Protein Kinase, and Induces Autophagy in Colorectal Cancer Cells.
Colorectal Neoplasms
Aspirin Targets SIRT1 and AMPK to Induce Senescence of Colorectal Carcinoma Cells.
Colorectal Neoplasms
Bortezomib induces protective autophagy through AMP-activated protein kinase activation in cultured pancreatic and colorectal cancer cells.
Colorectal Neoplasms
Cinnamaldehyde derivative (CB-PIC) sensitizes chemo-resistant cancer cells to drug-induced apoptosis via suppression of MDR1 and its upstream STAT3 and AKT signalling.
Colorectal Neoplasms
Colorectal cancer cells require glycogen synthase kinase-3? for sustaining mitosis via translocated promoter region (TPR)-dynein interaction.
Colorectal Neoplasms
Cooperation of SRPK2, Numb and p53 in the malignant biology and chemosensitivity of colorectal cancer.
Colorectal Neoplasms
Corrigendum to "Activation of AMP-Activated Protein Kinase and Extracelluar Signal-Regulated Kinase Mediates CB-PIC-Induced Apoptosis in Hypoxic SW620 Colorectal Cancer Cells".
Colorectal Neoplasms
Design and Synthesis of Tetrahydroisoquinoline Derivatives as AntiAngiogenesis and Anti-Cancer Agents.
Colorectal Neoplasms
Downregulation of rho-associated protein kinase 1 by miR-124 in colorectal cancer.
Colorectal Neoplasms
Expression of 3-phosphoinositide-dependent protein kinase 1 in colorectal cancer as a potential therapeutic target.
Colorectal Neoplasms
Glycogen synthase kinase 3? inhibition synergizes with PARP inhibitors through the induction of homologous recombination deficiency in colorectal cancer.
Colorectal Neoplasms
GSK-3? inhibitor 6-bromo-indirubin-3'-oxime promotes both adhesive activity and drug resistance in colorectal cancer cells.
Colorectal Neoplasms
GSK3? phosphorylation of the KLF6 tumor suppressor promotes its transactivation of p21.
Colorectal Neoplasms
How autophagy controls the intestinal epithelial barrier.
Colorectal Neoplasms
Human ?? T cell sensing of AMPK-dependent metabolic tumor reprogramming through TCR recognition of EphA2.
Colorectal Neoplasms
MicroRNA-23a promotes colorectal cancer cell migration and proliferation by targeting at MARK1.
Colorectal Neoplasms
MiR-199a-5p Inhibits the Growth and Metastasis of Colorectal Cancer Cells by Targeting ROCK1.
Colorectal Neoplasms
P21-activated protein kinase 1 induces colorectal cancer metastasis involving ERK activation and phosphorylation of FAK at Ser-910.
Colorectal Neoplasms
Prognostic significance of AMP-activated protein kinase expression and modifying effect of MAPK3/1 in colorectal cancer.
Colorectal Neoplasms
Pyrazole-4-Carboxamide (YW2065): A Therapeutic Candidate for Colorectal Cancer via Dual Activities of Wnt/?-Catenin Signaling Inhibition and AMP-Activated Protein Kinase (AMPK) Activation.
Colorectal Neoplasms
Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling.
Colorectal Neoplasms
RNF6 promotes colorectal cancer invasion and migration via the Wnt/?-catenin pathway by inhibiting GSK3? activity.
Colorectal Neoplasms
The orphan receptor TR3 suppresses intestinal tumorigenesis in mice by downregulating Wnt signalling.
Colorectal Neoplasms
Zinc finger protein 746 promotes colorectal cancer progression via c-Myc stability mediated by glycogen synthase kinase 3? and F-box and WD repeat domain-containing 7.
Complex Regional Pain Syndromes
Early Treatment With Metformin in a Mice Model of Complex Regional Pain Syndrome Reduces Pain and Edema.
Confusion
Disruption of anchoring junctions in the testes of experimental varicocele rats.
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Metformin-stimulated mannose transport in dermal fibroblasts.
Coronary Artery Disease
Hypermetabolic macrophages in rheumatoid arthritis and coronary artery disease due to glycogen synthase kinase 3b inactivation.
Coronary Artery Disease
Mitochondrial reactive oxygen species enhance AMP-activated protein kinase activation in the endothelium of patients with coronary artery disease and diabetes.
COVID-19
Network Analysis and Transcriptome Profiling Identify Autophagic and Mitochondrial Dysfunctions in SARS-CoV-2 Infection.
Crohn Disease
How autophagy controls the intestinal epithelial barrier.
Crohn Disease
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Cryptosporidiosis
5-Aminopyrazole-4-Carboxamide-Based Compounds Prevent the Growth of Cryptosporidium parvum.
Cryptosporidiosis
7 H-Pyrrolo[2,3- d]pyrimidin-4-amine-Based Inhibitors of Calcium-Dependent Protein Kinase 1 Have Distinct Inhibitory and Oral Pharmacokinetic Characteristics Compared with 1 H-Pyrazolo[3,4- d]pyrimidin-4-amine-Based Inhibitors.
Cryptosporidiosis
Bumped-Kinase Inhibitors for Therapy of Cryptosporidiosis.
Cryptosporidiosis
Pyrrolopyrimidine Bumped Kinase Inhibitors for the Treatment of Cryptosporidiosis.
Cushing Syndrome
AMP-activated protein kinase mediates glucocorticoid-induced metabolic changes: a novel mechanism in Cushing's syndrome.
Cushing Syndrome
Effects of excess corticosterone on LKB1 and AMPK signaling in rat skeletal muscle.
Cystic Fibrosis
A comprehensive review of therapeutic approaches available for the treatment of cholera.
Cystic Fibrosis
A Randomized Clinical Trial of Metformin to Treat Autosomal Dominant Polycystic Kidney Disease.
Cystic Fibrosis
Abnormal n-6 fatty acid metabolism in cystic fibrosis is caused by activation of AMP-activated protein kinase.
Cystic Fibrosis
Abnormal unsaturated fatty acid metabolism in cystic fibrosis: biochemical mechanisms and clinical implications.
Cystic Fibrosis
Effects of Long-Term Exercise on Liver Cyst in Polycystic Liver Disease Model Rats.
Cystic Fibrosis
Expression of miR?542?3p in osteosarcoma with miRNA microarray data, and its potential signaling pathways.
Cystic Fibrosis
How autophagy controls the intestinal epithelial barrier.
Cystic Fibrosis
Hypoxia Inhibits Colonic Ion Transport via Activation of AMP Kinase.
Cystic Fibrosis
Inhibition of cystic fibrosis transmembrane conductance regulator by novel interaction with the metabolic sensor AMP-activated protein kinase.
Cystic Fibrosis
Involvement of AMP-activated Protein Kinase (AMPK) in Regulation of Cell Membrane Potential in a Gastric Cancer Cell Line.
Cystic Fibrosis
Regulation of channel gating by AMP-activated protein kinase modulates cystic fibrosis transmembrane conductance regulator activity in lung submucosal cells.
Cystic Fibrosis
Role of Binding and Nucleoside Diphosphate Kinase A in the Regulation of the Cystic Fibrosis Transmembrane Conductance Regulator by AMP-Activated Protein Kinase.
Cystic Fibrosis
Serum- and glucocorticoid-induced protein kinase 1 (SGK1) increases the cystic fibrosis transmembrane conductance regulator (CFTR) in airway epithelial cells by phosphorylating Shank2E protein.
Cysts
A Systematic Review of In vitro and In vivo Activities of Anti-Toxoplasma Drugs and Compounds (2006-2016).
Cysts
Chronic effects of maternal tobacco-smoke exposure and/or ?-lipoic acid treatment on reproductive parameters in female rat offspring.
Cysts
JNK signaling prevents biliary cyst formation through a CASPASE-8-dependent function of RIPK1 during aging.
Cysts
Metformin slows liver cyst formation and fibrosis in experimental model of polycystic liver disease.
Cysts
Pranlukast inhibits renal epithelial cyst progression via activation of AMP-activated protein kinase.
Cysts
Targeting AMP-activated protein kinase (AMPK) for treatment of autosomal dominant polycystic kidney disease.
Cytomegalovirus Infections
Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection.
Dehydration
The Craterostigma plantagineum glycine-rich protein CpGRP1 interacts with a cell wall-associated protein kinase 1 (CpWAK1) and accumulates in leaf cell walls during dehydration.
Dementia
Association of GSK3B with Alzheimer disease and frontotemporal dementia.
Dementia
Highlighting the protective or degenerative role of AMPK activators in dementia experimental models.
Dementia
Subtype and regional regulation of prion biomarkers in sporadic Creutzfeldt-Jakob disease.
Dementia
Wnt-pathway activation during the early stage of neurodegeneration in FTDP-17 mice.
Demyelinating Diseases
Conditional depletion of GSK3b protects oligodendrocytes from apoptosis and lessens demyelination in the acute cuprizone model.
Demyelinating Diseases
Inactive GSK3? is disturbed in the spinal cord during experimental autoimmune encephalomyelitis, but rescued by stem cell therapy.
Dengue
Direct Activation of Adenosine Monophosphate-Activated Protein Kinase (AMPK) by PF-06409577 Inhibits Flavivirus Infection through Modification of Host Cell Lipid Metabolism.
Dengue
Glycogen synthase kinase 3ß participates in late stages of Dengue virus-2 infection.
Diabetes Complications
Coumarins as potential antidiabetic agents.
Diabetes Mellitus
(Z)-2-(3-Chlorobenzylidene)-3,4-dihydro-N-(2-methoxyethyl)-3-oxo-2H-benzo[b][1,4]oxazine-6-carboxamide as GSK-3? inhibitor: Identification by virtual screening and its validation in enzyme- and cell-based assay.
Diabetes Mellitus
A novel polymorphism in protein kinase AMP-activated catalytic subunit alpha 2 (PRKAA2) is associated with type 2 diabetes in the Han Chinese population.
Diabetes Mellitus
Activation of AMPK by berberine induces hepatic lipid accumulation by upregulation of fatty acid translocase CD36 in mice.
Diabetes Mellitus
Adult neural stem cell dysfunction in the subventricular zone of the lateral ventricle leads to diabetic olfactory defects.
Diabetes Mellitus
Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective.
Diabetes Mellitus
Betaine ameliorates impaired steroidogenesis and apoptosis in mice granulosa cells induced by high glucose concentration.
Diabetes Mellitus
Bioactive compounds in plant materials for the prevention of diabetesand obesity.
Diabetes Mellitus
Deletion of Myeloid GSK3? Attenuates Atherosclerosis and Promotes an M2 Macrophage Phenotype.
Diabetes Mellitus
High-density lipoprotein modulates glucose metabolism in patients with type 2 diabetes mellitus.
Diabetes Mellitus
In Silico Computations Of Selective Phytochemicals As Potential Inhibitors Against Major Biological Targets Of Diabetes Mellitus.
Diabetes Mellitus
Naturally occurring R225W mutation of the gene encoding AMP-activated protein kinase (AMPK)gamma(3) results in increased oxidative capacity and glucose uptake in human primary myotubes.
Diabetes Mellitus
Novel Small-Molecule AMP-Activated Protein Kinase Allosteric Activator with Beneficial Effects in db/db Mice.
Diabetes Mellitus
Panax ginseng improves glucose metabolism in streptozotocin-induced diabetic rats through 5' adenosine monophosphate kinase up-regulation.
Diabetes Mellitus
Perivascular fat, AMP-activated protein kinase and vascular diseases.
Diabetes Mellitus
Restoration of ?-Adrenergic Signaling and Activity of Akt-Kinase and AMP-Activated Protein Kinase with Metformin in the Myocardium of Diabetic Rats.
Diabetes Mellitus
Strong association of serum GSK-3?/BDNF ratio with mild cognitive impairment in elderly type 2 diabetic patients.
Diabetes Mellitus
Synthesis and biological evaluation of 3-substituted 2-oxindole derivatives as new glycogen synthase kinase 3? inhibitors.
Diabetes Mellitus
The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.
Diabetes Mellitus
The influence of AMPK subunit alpha 2 (PRKAA2) genetic polymorphisms with susceptibility with type 2 diabetes mellitus and diabetic nephropathy in Chinese population.
Diabetes Mellitus, Type 1
Hypothalamic AMP-activated Protein Kinase activation with AICAR amplifies counterregulatory responses to hypoglycemia in a rodent model of Type 1 diabetes.
Diabetes Mellitus, Type 2
?-guanidinopropionic acid and metformin differentially impact autophagy, mitochondria and cellular morphology in developing C2C12 muscle cells.
Diabetes Mellitus, Type 2
A Highly Sensitive FRET Biosensor for AMPK Exhibits Heterogeneous AMPK Responses among Cells and Organs.
Diabetes Mellitus, Type 2
A novel polymorphism in protein kinase AMP-activated catalytic subunit alpha 2 (PRKAA2) is associated with type 2 diabetes in the Han Chinese population.
Diabetes Mellitus, Type 2
A-769662 inhibits adipocyte glucose uptake in an AMPK-independent manner.
Diabetes Mellitus, Type 2
Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR.
Diabetes Mellitus, Type 2
Acute metformin preconditioning confers neuroprotection against focal cerebral ischemia by pre-activation of AMPK-dependent autophagy.
Diabetes Mellitus, Type 2
Adipose-derived mesenchymal stem cells ameliorate hyperglycemia through regulating hepatic glucose metabolism in type 2 diabetic rats.
Diabetes Mellitus, Type 2
AMP-activated protein kinase (AMPK) is activated in muscle of subjects with type 2 diabetes during exercise.
Diabetes Mellitus, Type 2
AMP-activated protein kinase and type 2 diabetes.
Diabetes Mellitus, Type 2
AMP-activated protein kinase is activated in adipose tissue of individuals with type 2 diabetes treated with metformin: a randomised glycaemia-controlled crossover study.
Diabetes Mellitus, Type 2
AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes.
Diabetes Mellitus, Type 2
AMP-activated protein kinase: a new beta-cell glucose sensor?: Regulation by amino acids and calcium ions.
Diabetes Mellitus, Type 2
AMP-activated protein kinase: possible target for treatment of type 2 diabetes.
Diabetes Mellitus, Type 2
AMPK activation by A-769662 and 991 does not affect catecholamine-induced lipolysis in human adipocytes.
Diabetes Mellitus, Type 2
AMPK as a Therapeutic Target for Treating Metabolic Diseases.
Diabetes Mellitus, Type 2
Analysis of microRNA expression profile induced by AICAR in mouse hepatocytes.
Diabetes Mellitus, Type 2
Autophagy anomalies in the diabetic myocardium.
Diabetes Mellitus, Type 2
Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective.
Diabetes Mellitus, Type 2
Berberine suppresses proinflammatory responses through AMPK activation in macrophages.
Diabetes Mellitus, Type 2
Bioactive compounds in plant materials for the prevention of diabetesand obesity.
Diabetes Mellitus, Type 2
Blackcurrant Extract Ameliorates Hyperglycemia in Type 2 Diabetic Mice in Association with Increased Basal Secretion of Glucagon-Like Peptide-1 and Activation of AMP-Activated Protein Kinase.
Diabetes Mellitus, Type 2
Chromosomal mapping and mutational analysis of the coding region of the glycogen synthase kinase-3alpha and beta isoforms in patients with NIDDM.
Diabetes Mellitus, Type 2
Cloning of a human insulin-stimulated protein kinase (ISPK-1) gene and analysis of coding regions and mRNA levels of the ISPK-1 and the protein phosphatase-1 genes in muscle from NIDDM patients.
Diabetes Mellitus, Type 2
Combretastatin A-4 activates AMP-activated protein kinase and improves glucose metabolism in db/db mice.
Diabetes Mellitus, Type 2
Conformational heterogeneity of the allosteric drug and metabolite (ADaM) site in AMP-activated protein kinase (AMPK).
Diabetes Mellitus, Type 2
Discovery and translation of a target engagement marker for AMP-activated protein kinase (AMPK).
Diabetes Mellitus, Type 2
Exendin-4 stimulates autophagy in pancreatic ?-cells via the RAPGEF/EPAC-Ca2+-PPP3/calcineurin-TFEB axis.
Diabetes Mellitus, Type 2
Fluvastatin activates sirtuin 6 to regulate sterol regulatory element-binding proteins and AMP-activated protein kinase in HepG2 cells.
Diabetes Mellitus, Type 2
Ganoderma lucidum Extract Reduces Insulin Resistance by Enhancing AMPK Activation in High-Fat Diet-Induced Obese Mice.
Diabetes Mellitus, Type 2
Genetic deletion of soluble 5'-nucleotidase II reduces body weight gain and insulin resistance induced by a high-fat diet.
Diabetes Mellitus, Type 2
Glucoraphanin: a broccoli sprout extract that ameliorates obesity-induced inflammation and insulin resistance.
Diabetes Mellitus, Type 2
Haplotype Structures and Large-Scale Association Testing of the 5' AMP-Activated Protein Kinase Genes PRKAA2, PRKAB1, and PRKAB1 With Type 2 Diabetes.
Diabetes Mellitus, Type 2
Hepatocyte nuclear factor-4alpha involved in type 1 maturity-onset diabetes of the young is a novel target of AMP-activated protein kinase.
Diabetes Mellitus, Type 2
High-density lipoprotein modulates glucose metabolism in patients with type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Hypothalamic AMP-Activated Protein Kinase Regulates Biphasic Insulin Secretion from Pancreatic ? Cells during Fasting and in Type 2 Diabetes.
Diabetes Mellitus, Type 2
Insulin-like growth factor-1 activates AMPK to augment mitochondrial function and correct neuronal metabolism in sensory neurons in type 1 diabetes.
Diabetes Mellitus, Type 2
Isoalantolactone derivative promotes glucose utilization in skeletal muscle cells and increases energy expenditure in db/db mice via activating AMPK-dependent signaling.
Diabetes Mellitus, Type 2
Loss of a neural AMP-activated kinase mimics the effects of elevated serotonin on fat, movement, and hormonal secretions.
Diabetes Mellitus, Type 2
Low molecular weight fucoidan improves endoplasmic reticulum stress-reduced insulin sensitivity through AMP-activated protein kinase activation in L6 myotubes and restores lipid homeostasis in a mouse model of type 2 diabetes.
Diabetes Mellitus, Type 2
Metformin affects the circadian clock and metabolic rhythms in a tissue-specific manner.
Diabetes Mellitus, Type 2
Metformin antinociceptive effect in models of nociceptive and neuropathic pain is partially mediated by activation of opioidergic mechanisms.
Diabetes Mellitus, Type 2
Metformin attenuates autoimmune disease of the neuromotor system in animal models of myasthenia gravis.
Diabetes Mellitus, Type 2
Metformin attenuates ovarian cancer cell growth in an AMP- kinase dispensable manner.
Diabetes Mellitus, Type 2
Metformin enhances the differentiation and mineralization of osteoblastic MC3T3-E1 cells via AMP kinase activation as well as eNOS and BMP-2 expression.
Diabetes Mellitus, Type 2
Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with type 2 diabetes.
Diabetes Mellitus, Type 2
Metformin inhibits development of diabetic retinopathy through inducing alternative splicing of VEGF-A.
Diabetes Mellitus, Type 2
Metformin inhibits development of diabetic retinopathy through microRNA-497a-5p.
Diabetes Mellitus, Type 2
Metformin prevents vascular prostanoid release alterations induced by a high-fat diet in rats.
Diabetes Mellitus, Type 2
Metformin reduces saturated fatty acid-induced lipid accumulation and inflammatory response by restoration of autophagic flux in endothelial cells.
Diabetes Mellitus, Type 2
Metformin reduces TRPC6 expression through AMPK activation and modulates cytoskeleton dynamics in podocytes under diabetic conditions.
Diabetes Mellitus, Type 2
Metformin, but not leptin, regulates AMP-activated protein kinase in pancreatic islets: impact on glucose-stimulated insulin secretion.
Diabetes Mellitus, Type 2
Molecular Mechanism of Nucleotide-Dependent Allosteric Regulation in AMP-Activated Protein Kinase.
Diabetes Mellitus, Type 2
Molecular mechanisms of estrogen receptors' suppression of lipogenesis in pancreatic ?-cells.
Diabetes Mellitus, Type 2
mTOR Inhibitor Therapy and Metabolic Consequences: Where Do We Stand?
Diabetes Mellitus, Type 2
mTORC1 directly inhibits AMPK to promote cell proliferation under nutrient stress.
Diabetes Mellitus, Type 2
Naturally occurring R225W mutation of the gene encoding AMP-activated protein kinase (AMPK)gamma(3) results in increased oxidative capacity and glucose uptake in human primary myotubes.
Diabetes Mellitus, Type 2
Network Pharmacology-Based Dissection of the Anti-diabetic Mechanism of Lobelia chinensis.
Diabetes Mellitus, Type 2
Novel benzothiazinones (BTOs) as allosteric modulator or substrate competitive inhibitor of glycogen synthase kinase 3? (GSK-3?) with cellular activity of promoting glucose uptake.
Diabetes Mellitus, Type 2
Novel Small-Molecule AMP-Activated Protein Kinase Allosteric Activator with Beneficial Effects in db/db Mice.
Diabetes Mellitus, Type 2
Partial hepatic resistance to IL-6-induced inflammation develops in type 2 diabetic mice, while the anti-inflammatory effect of AMPK is maintained.
Diabetes Mellitus, Type 2
PCNA and JNK1-Stat3 pathways respectively promotes and inhibits diabetes-associated centrosome amplification by targeting at the ROCK1/14-3-3? complex in human colon cancer HCT116 cells.
Diabetes Mellitus, Type 2
Perivascular fat, AMP-activated protein kinase and vascular diseases.
Diabetes Mellitus, Type 2
Phosphorylation and Inactivation of Glycogen Synthase Kinase 3? (GSK3?) by Dual-specificity Tyrosine Phosphorylation-regulated Kinase 1A (Dyrk1A).
Diabetes Mellitus, Type 2
Production and Crystallization of Full-Length Human AMP-Activated Protein Kinase (?1?1?1).
Diabetes Mellitus, Type 2
Prolonged AMP-activated protein kinase induction impairs vascular functions.
Diabetes Mellitus, Type 2
Purinergic System Signaling in Metainflammation-Associated Osteoarthritis.
Diabetes Mellitus, Type 2
Restoration of ?-Adrenergic Signaling and Activity of Akt-Kinase and AMP-Activated Protein Kinase with Metformin in the Myocardium of Diabetic Rats.
Diabetes Mellitus, Type 2
Resveratrol ameliorates diabetes-related metabolic changes via activation of AMP-activated protein kinase and its downstream targets in db/db mice.
Diabetes Mellitus, Type 2
Role of AMP--activated protein kinase in the control of glucose homeostasis.
Diabetes Mellitus, Type 2
Role of AMP-activated protein kinase in the metabolic syndrome and in heart disease.
Diabetes Mellitus, Type 2
Secreted Wnt6 mediates diabetes-associated centrosome amplification via its receptor FZD4.
Diabetes Mellitus, Type 2
Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin.
Diabetes Mellitus, Type 2
Small molecule drug A-769662 and AMP synergistically activate naive AMPK independent of upstream kinase signaling.
Diabetes Mellitus, Type 2
Strong association of serum GSK-3?/BDNF ratio with mild cognitive impairment in elderly type 2 diabetic patients.
Diabetes Mellitus, Type 2
Structural basis for compound C inhibition of the human AMP-activated protein kinase ?2 subunit kinase domain.
Diabetes Mellitus, Type 2
Targeting GSK-3: a promising approach for cancer therapy?
Diabetes Mellitus, Type 2
Targeting skeletal muscle AMP-activated protein kinase to treat type 2 diabetes.
Diabetes Mellitus, Type 2
Targeting the AMP-activated protein kinase for the treatment of type 2 diabetes.
Diabetes Mellitus, Type 2
The AMP-activated protein kinase: role in regulation of skeletal muscle metabolism and insulin sensitivity.
Diabetes Mellitus, Type 2
The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism.
Diabetes Mellitus, Type 2
The antidiabetic effect of ginsenoside Rb2 via activation of AMPK.
Diabetes Mellitus, Type 2
The effects of troglitazone on AMPK in HepG2 cells.
Diabetes Mellitus, Type 2
The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.
Diabetes Mellitus, Type 2
The influence of AMPK subunit alpha 2 (PRKAA2) genetic polymorphisms with susceptibility with type 2 diabetes mellitus and diabetic nephropathy in Chinese population.
Diabetes Mellitus, Type 2
The rise and fall of insulin signaling in Alzheimer's disease.
Diabetes Mellitus, Type 2
The TRPC6-AMPK Pathway is Involved in Insulin-Dependent Cytoskeleton Reorganization and Glucose Uptake in Cultured Rat Podocytes.
Diabetes Mellitus, Type 2
Upregulated NLRP3 inflammasome activation in patients with type 2 diabetes.
Diabetic Angiopathies
Diabetic Cardiovascular Disease - AMP-Activated Protein Kinase (AMPK) as a Therapeutic Target.
Diabetic Cardiomyopathies
AMP-activated protein kinase modulates cardiac autophagy in diabetic cardiomyopathy.
Diabetic Cardiomyopathies
An overview of the crosstalk between inflammatory processes and metabolic dysregulation during diabetic cardiomyopathy.
Diabetic Cardiomyopathies
Cinacalcet as a surrogate therapy for diabetic cardiomyopathy in rats through AMPK-mediated promotion of mitochondrial and autophagic function.
Diabetic Cardiomyopathies
Dissociation of Bcl-2-Beclin1 Complex by Activated AMPK Enhances Cardiac Autophagy and Protects Against Cardiomyocyte Apoptosis in Diabetes.
Diabetic Cardiomyopathies
Hyperglycemia-Driven Inhibition of AMP-Activated Protein Kinase ?2 Induces Diabetic Cardiomyopathy by Promoting Mitochondria-Associated Endoplasmic Reticulum Membranes in vivo.
Diabetic Cardiomyopathies
Role of AMP-activated protein kinase on cardio-metabolic abnormalities in the development of diabetic cardiomyopathy: A molecular landscape.
Diabetic Cardiomyopathies
Sitagliptin attenuates myocardial apoptosis via activating LKB-1/AMPK/Akt pathway and suppressing the activity of GSK-3? and p38?/MAPK in a rat model of diabetic cardiomyopathy.
Diabetic Nephropathies
Absence of the ?1 subunit of AMP-activated protein kinase reduces myofibroblast infiltration of the kidneys in early diabetes.
Diabetic Nephropathies
AMPK signalling: Implications for podocyte biology in diabetic nephropathy.
Diabetic Nephropathies
AMPK?, hs-CRP and Fc?R in diabetic nephropathy and drug intervention.
Diabetic Nephropathies
Anthocyanin-rich Seoritae extract ameliorates renal lipotoxicity via activation of AMP-activated protein kinase in diabetic mice.
Diabetic Nephropathies
Epidermal Growth Factor Receptor Inhibition Slows Progression of Diabetic Nephropathy in Association With a Decrease in Endoplasmic Reticulum Stress and an Increase in Autophagy.
Diabetic Nephropathies
Glomerular angiotensinogen is induced in mesangial cells in diabetic rats via reactive oxygen species-ERK/JNK pathways.
Diabetic Nephropathies
Glycogen synthase kinase 3? hyperactivity in urinary exfoliated cells predicts progression of diabetic kidney disease.
Diabetic Nephropathies
Resveratrol retards progression of diabetic nephropathy through modulations of oxidative stress, proinflammatory cytokines, and AMP-activated protein kinase.
Diabetic Nephropathies
The Adiponectin Receptor Agonist AdipoRon Ameliorates Diabetic Nephropathy in a Model of Type 2 Diabetes.
Diabetic Nephropathies
[Dracorhodin perchlorate inhibit high glucose induce serum and glucocorticoid induced protein kinase 1 and fibronectin expression in human mesangial cells]
Diabetic Neuropathies
Dose-related cytoprotective effect of alpha-lipoic acid on hydrogen peroxide-induced oxidative stress to pancreatic beta cells.
Diabetic Retinopathy
Metformin inhibits development of diabetic retinopathy through inducing alternative splicing of VEGF-A.
Disorders of Sex Development
Sex differences in autophagy-mediated diseases: toward precision medicine.
DNA Virus Infections
The regulation of p53 by phosphorylation: a model for how distinct signals integrate into the p53 pathway.
Down Syndrome
Effects of a Tripeptide on Mitogen-Activated Protein Kinase and Glycogen Synthase Kinase Activation in a Cell Line Derived from the Foetal Hippocampus of a Trisomy 16 Mouse: an Animal Model of Down Syndrome.
Down Syndrome
Physiology and pathology of tau protein kinases in relation to Alzheimer's disease.
Dwarfism
GSK-3? and GSK-3? Proteins Are Involved in Early Stages of Chondrocyte Differentiation with Functional Redundancy through RelA Protein Phosphorylation.
Dyskinesias
Effects of 5-HT1A receptor stimulation on striatal and cortical M1 pERK induction by l-DOPA and a D1 receptor agonist in a rat model of Parkinson's disease.
Dyskinesias
Mitogen- and stress-activated protein kinase 1 is required for specific signaling responses in dopamine-denervated mouse striatum, but is not necessary for L-DOPA-induced dyskinesia.
Dyslipidemias
Berberine suppresses proinflammatory responses through AMPK activation in macrophages.
Dyslipidemias
Emodin, a Naturally Occurring Anthraquinone Derivative, Ameliorates Dyslipidemia by Activating AMP-Activated Protein Kinase in High-Fat-Diet-Fed Rats.
Dyslipidemias
Ganoderma lucidum Extract Reduces Insulin Resistance by Enhancing AMPK Activation in High-Fat Diet-Induced Obese Mice.
Dyslipidemias
Krill Oil Supplementation Improves Dyslipidemia and Lowers Body Weight in Mice Fed a High-Fat Diet Through Activation of AMP-Activated Protein Kinase.
Dyslipidemias
Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient mice.
Encephalitis
GSK3? inhibition protects the immature brain from hypoxic-ischaemic insult via reduced STAT3 signalling.
Encephalomyelitis
AMP-activated protein kinase signaling protects oligodendrocytes that restore central nervous system functions in an experimental autoimmune encephalomyelitis model.
Encephalomyelitis
Combination therapy of lovastatin and AMP-activated protein kinase activator improves mitochondrial and peroxisomal functions and clinical disease in experimental autoimmune encephalomyelitis model.
Encephalomyelitis
Selective inhibition of Sarcocystis neurona calcium-dependent protein kinase 1 for equine protozoal myeloencephalitis therapy.
Encephalomyelitis, Autoimmune, Experimental
AMP-activated protein kinase signaling protects oligodendrocytes that restore central nervous system functions in an experimental autoimmune encephalomyelitis model.
Encephalomyelitis, Autoimmune, Experimental
Combination therapy of lovastatin and AMP-activated protein kinase activator improves mitochondrial and peroxisomal functions and clinical disease in experimental autoimmune encephalomyelitis model.
Endometrial Hyperplasia
Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective.
Endometrial Hyperplasia
Autophagy in the physiological endometrium and cancer.
Endometrial Neoplasms
Autophagy in the physiological endometrium and cancer.
Endometrial Neoplasms
Concomitant activation of AKT with extracellular-regulated kinase 1/2 occurs independently of PTEN or PIK3CA mutations in endometrial cancer and may be associated with favorable prognosiss.
Endometrial Neoplasms
Glycogen synthase kinase 3? inhibition as a therapeutic approach in the treatment of endometrial cancer.
Endometrial Neoplasms
Insulin-Like Growth Factor 1/Mammalian Target of Rapamycin and AMP-Activated Protein Kinase Signaling Involved in the Effects of Metformin in the Human Endometrial Cancer.
Endometrial Neoplasms
Metformin inhibits estrogen-dependent endometrial cancer cell growth by activating the AMPK-FOXO1 signal pathway.
Endometrial Neoplasms
MiR-486-5p Act as a Biomarker in Endometrial Carcinoma: Promotes Cell Proliferation, Migration, Invasion by Targeting MARK1.
Endometrial Neoplasms
[Effect of AMPK/mTOR/S6K1 pathways and the insulin-sensitizing effect for adiponectin in endometrial cancer cells].
Endometriosis
Tetraspanin 1 promotes endometriosis leading to ovarian clear cell carcinoma.
Endotoxemia
Isoorientin Inhibits Inflammation in Macrophages and Endotoxemia Mice by Regulating Glycogen Synthase Kinase 3?.
Endotoxemia
Protective Role of Peroxisome Proliferator-Activated Receptor-{beta}/{delta} in Septic Shock.
Eosinophilia
Markers of tyrosine kinase activity in eosinophilic esophagitis: a pilot study of the FIP1L1-PDGFR? fusion gene, pERK 1/2, and pSTAT5.
Epilepsy
Metabolic Aspects of Adenosine Functions in the Brain.
Epilepsy
Uncovering the Pharmacological Mechanism of Chaibei Zhixian Decoction on Epilepsy by Network Pharmacology Analysis.
Epilepsy
Up-regulation of serum- and glucocorticoid-induced protein kinase 1 in the brain tissue of human and experimental epilepsy.
Esophageal Neoplasms
Itraconazole-induced inhibition on human esophageal cancer cell growth requires AMPK activation.
Esophageal Neoplasms
Silencing of PDK1 gene expression by RNA interference suppresses growth of esophageal cancer.
Esophageal Neoplasms
The Role of Glycogen Synthase Kinase 3-? in Immunity and Cell Cycle: Implications in Esophageal Cancer.
Esophageal Neoplasms
[Expressions of TAK1 and TAB1 in esophageal cancer and their correlation with prognosis].
Esophageal Squamous Cell Carcinoma
Potential therapeutic effect of targeting glycogen synthase kinase 3? in esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
[Expression and its clinical significance of AMP-activated protein kinase in esophageal squamous cell carcinoma].
Fatty Liver
?-Terpineol induces fatty liver in mice mediated by the AMP-activated kinase and sterol response element binding protein pathway.
Fatty Liver
AMP-activated protein kinase activation and NADPH oxidase inhibition by inorganic nitrate and nitrite prevent liver steatosis.
Fatty Liver
AMPK as a Therapeutic Target for Treating Metabolic Diseases.
Fatty Liver
AMPK Re-Activation Suppresses Hepatic Steatosis but its Downregulation Does Not Promote Fatty Liver Development.
Fatty Liver
Bai-Hu-Jia-Ren-Shen-Tang Decoction Reduces Fatty Liver by Activating AMP-Activated Protein Kinase In Vitro and In Vivo.
Fatty Liver
Baicalin Attenuates High Fat Diet-Induced Obesity and Liver Dysfunction: Dose-Response and Potential Role of CaMKK?/AMPK/ACC Pathway.
Fatty Liver
Comparison of the main components and bioactivity of Rhus verniciflua Stokes extracts by different detoxification processing methods.
Fatty Liver
Crocin ameliorates hepatic steatosis through activation of AMPK signaling in db/db mice.
Fatty Liver
Dietary ?-lactalbumin induced fatty liver by enhancing nuclear liver X receptor ??/sterol regulatory element-binding protein-1c/PPAR? expression and minimising PPAR?/carnitine palmitoyltransferase-1 expression and AMP-activated protein kinase ? phosphorylation associated with atherogenic dyslipidaemia, insulin resistance and oxidative stress in Balb/c mice.
Fatty Liver
Effects of fatty liver hemorrhagic syndrome on the AMP-activated protein kinase signaling pathway in laying hens.
Fatty Liver
Female mice are more susceptible to non-alcoholic fatty liver disease: sex-specific regulation of the hepatic AMP-activated protein kinase - plasminogen activator inhibitor 1-cascade but not the hepatic endotoxin response.
Fatty Liver
Fenretinide ameliorates insulin resistance and Fatty liver in obese mice.
Fatty Liver
Formation of Fructose-Mediated Advanced Glycation End Products and Their Roles in Metabolic and Inflammatory Diseases.
Fatty Liver
Ginsenoside Rb1 reduces fatty liver by activating AMP-activated protein kinase in obese rats.
Fatty Liver
Glucoraphanin: a broccoli sprout extract that ameliorates obesity-induced inflammation and insulin resistance.
Fatty Liver
Inhibition of receptor-interacting protein kinase 1 improves experimental non-alcoholic fatty liver disease.
Fatty Liver
Liver-specific Gene Inactivation of the Transcription Factor ATF4 Alleviates Alcoholic Liver Steatosis in Mice.
Fatty Liver
Lupin protein isolate improves insulin sensitivity and steatohepatitis in vivo and modulates the expression of the Fasn, Gys2, and Gsk3b genes.
Fatty Liver
Mirtazapine Reduces Adipocyte Hypertrophy and Increases Glucose Transporter Expression in Obese Mice.
Fatty Liver
Momordica cochinchinensis Aril Ameliorates Diet-Induced Metabolic Dysfunction and Non-Alcoholic Fatty Liver by Modulating Gut Microbiota.
Fatty Liver
Nordihydroguaiaretic acid protects against high-fat diet-induced fatty liver by activating AMP-activated protein kinase in obese mice.
Fatty Liver
Peroxiredoxin 5 ameliorates obesity-induced non-alcoholic fatty liver disease through the regulation of oxidative stress and AMP-activated protein kinase signaling.
Fatty Liver
Protective effect of oligomeric proanthocyanidins against alcohol-induced liver steatosis and injury in mice.
Fatty Liver
Protective effect of resveratrol derivatives on high-fat diet induced fatty liver by activating AMP-activated protein kinase.
Fatty Liver
Regulation of hepatic lipin-1 by ethanol: role of AMP-activated protein kinase/sterol regulatory element-binding protein 1 signaling in mice.
Fatty Liver
Resveratrol improves non-alcoholic fatty liver disease by activating AMP-activated protein kinase.
Fatty Liver
Salidroside activates the AMP-activated protein kinase pathway to suppress non-alcoholic steatohepatitis.
Fatty Liver
Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver.
Fatty Liver
Signal Transduction and Molecular Regulation in Fatty Liver Disease.
Fatty Liver
Thiazolidinediones improve hepatic fibrosis by activating the adenosine monophosphate-activated protein kinase (ampk) signaling pathway in rats with non-alcoholic steatohepatitis.
Fatty Liver
Transcriptomic Analysis of Porcine Granulosa Cells Overexpressing Retinol Binding Protein 4.
Fetal Alcohol Spectrum Disorders
Impaired ILK Function Is Associated with Deficits in Hippocampal Based Memory and Synaptic Plasticity in a FASD Rat Model.
Fetal Alcohol Spectrum Disorders
Maternal separation stress reduced prenatal-ethanol-induced increase in exploratory behaviour and extracellular signal-regulated kinase activity.
Fetal Alcohol Spectrum Disorders
Prenatal alcohol exposure leads to enhanced serine 9 phosphorylation of glycogen synthase kinase-3? (GSK-3?) in the hippocampal dentate gyrus of adult mouse.
Fetal Diseases
AMP-activated protein kinase mediates effects of oxidative stress on embryo gene expression in a mouse model of diabetic embryopathy.
Fetal Growth Retardation
AMP-activated protein kinase activator AICAR attenuates hypoxia-induced murine fetal growth restriction in part by improving uterine artery blood flow.
Fibrosarcoma
Glycogen synthase kinase 3? as a potential therapeutic target in synovial sarcoma and fibrosarcoma.
Follicular Cyst
Chronic effects of maternal tobacco-smoke exposure and/or ?-lipoic acid treatment on reproductive parameters in female rat offspring.
Fragile X Syndrome
Loss of neuronal GSK3? reduces dendritic spine stability and attenuates excitatory synaptic transmission via ?-catenin.
Fragile X Syndrome
Selective inhibition of glycogen synthase kinase 3? corrects pathophysiology in a mouse model of fragile X syndrome.
Frontotemporal Dementia
Accelerated neurodegeneration and neuroinflammation in transgenic mice expressing P301L tau mutant and tau-tubulin kinase 1.
Frontotemporal Dementia
Association of GSK3B with Alzheimer disease and frontotemporal dementia.
Frontotemporal Dementia
C9orf72 ALS-FTD: recent evidence for dysregulation of the autophagy-lysosome pathway at multiple levels.
Frontotemporal Dementia
Delta-secretase (AEP) mediates tau-splicing imbalance and accelerates cognitive decline in tauopathies.
Frontotemporal Dementia
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Frontotemporal Dementia
The tau tubulin kinases TTBK1/2 promote accumulation of pathological TDP-43.
Frontotemporal Lobar Degeneration
Adult onset pan-neuronal human tau tubulin kinase 1 expression causes severe cerebellar neurodegeneration in mice.
Gallbladder Neoplasms
AICAR activates ER stress-dependent apoptosis in gallbladder cancer cells.
Gallbladder Neoplasms
Cordycepin down-regulates multiple drug resistant (MDR)/HIF-1? through regulating AMPK/mTORC1 signaling in GBC-SD gallbladder cancer cells.
Gastrointestinal Neoplasms
Correlation of DAPK1 methylation and the risk of gastrointestinal cancer: A systematic review and meta-analysis.
Gastroparesis
Mechanism of AMPK-mediated apoptosis of rat gastric smooth muscle cells under high glucose condition.
Genetic Diseases, Inborn
CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations.
Glaucoma
Protective effect of RIPK1-inhibitory compound in in vivo models for retinal degenerative disease.
Glioblastoma
?-Mangostin, a dietary xanthone, induces autophagic cell death by activating the AMP-activated protein kinase pathway in glioblastoma cells.
Glioblastoma
Activation of AMP-activated protein kinase by temozolomide contributes to apoptosis in glioblastoma cells via p53 activation and mTORC1 inhibition.
Glioblastoma
Biological basis and clinical study of glycogen synthase kinase- 3?-targeted therapy by drug repositioning for glioblastoma.
Glioblastoma
Effects of Glycogen Synthase Kinase Inhibitor on Glioblastoma Multiforme Cell Line via Apoptosis and Cell Signaling Pathways.
Glioblastoma
Evaluation of Combination Treatment Effect With TRAIL-secreting Mesenchymal Stem Cells and Compound C Against Glioblastoma.
Glioblastoma
Glycogen synthase kinase 3? inhibition sensitizes human glioblastoma cells to temozolomide by affecting O6-methylguanine DNA methyltransferase promoter methylation via c-Myc signaling.
Glioblastoma
Glycogen Synthase Kinase 3? Sustains Invasion of Glioblastoma via the Focal Adhesion Kinase, Rac1, and c-Jun N-Terminal Kinase-Mediated Pathway.
Glioblastoma
GSK3? regulates Bcl2L12 and Bcl2L12A anti-apoptosis signaling in glioblastoma and is inhibited by LiCl.
Glioblastoma
Hispidulin potently inhibits human glioblastoma multiforme cells through activation of AMP-activated protein kinase (AMPK).
Glioblastoma
The PEA-15/PED protein protects glioblastoma cells from glucose deprivation-induced apoptosis via the ERK/MAP kinase pathway.
Glioblastoma
Tight regulation between cell survival and programmed cell death in GBM stem-like cells by EGFR/GSK3b/PP2A signaling.
Glioblastoma
Yes and PI3K bind CD95 to signal invasion of glioblastoma.
Glioma
A kinome-wide shRNA screen uncovers vaccinia-related kinase 3 (VRK3) as an essential gene for diffuse intrinsic pontine glioma survival.
Glioma
Activation of AMP-activated protein kinase by kainic acid mediates brain-derived neurotrophic factor expression through a NF-kappaB dependent mechanism in C6 glioma cells.
Glioma
AMP-activated protein kinase-dependent and -independent mechanisms underlying in vitro antiglioma action of compound C.
Glioma
Circular RNA TTBK2 regulates cell proliferation, invasion and ferroptosis via miR-761/ITGB8 axis in glioma.
Glioma
Circular RNA TTBK2?promotes the development of human glioma cells via miR-520b/EZH2 axis.
Glioma
Clk1-regulated aerobic glycolysis is involved in glioma chemoresistance.
Glioma
Glycogen synthase kinases-3beta controls differentiation of malignant glioma cells.
Glioma
GSK621 Targets Glioma Cells via Activating AMP-Activated Protein Kinase Signalings.
Glioma
High expression of mitogen-activated and stress-activated protein kinase 1 indicates poor prognosis in patients with glioma.
Glioma
Knockdown of circ-TTBK2 Inhibits Glioma Progression by Regulating miR-1283 and CHD1.
Glioma
Knockdown of Rho-associated protein kinase 1 suppresses proliferation and invasion of glioma cells.
Glioma
miR?143 acts as a novel Big mitogen?activated protein kinase 1 suppressor and may inhibit invasion of glioma.
Glioma
Morphological analysis of CDC2 and glycogen synthase kinase 3? phosphorylation as markers of g2???m transition in glioma.
Glioma
p53 modulates the AMPK inhibitor compound C induced apoptosis in human skin cancer cells.
Glioma
Pyruvate kinase M2 is a target of the tumor-suppressive microRNA-326 and regulates the survival of glioma cells.
Glioma
Reversibility of glioma stem cells' phenotypes explains their complex in vitro and in vivo behavior. Discovery of a novel neurosphere-specific enzyme, cGMP-dependent protein kinase 1, using the genomic landscape of human glioma stem cells.
Glioma
Serum ROCK1 mRNA is of great diagnostic value for glioma patients.
Glioma
The prognostic value of DAPK1 hypermethylation in gliomas: A site-specific analysis.
Glioma
TTBK2 circular RNA promotes glioma malignancy by regulating miR-217/HNF1?/Derlin-1 pathway.
Glucose Intolerance
Aging impairs insulin-stimulated glucose uptake in rat skeletal muscle via suppressing AMPKalpha.
Glucose Intolerance
Continued postnatal administration of resveratrol prevents diet-induced metabolic syndrome in rat offspring born growth restricted.
Glucose Intolerance
Exogenous thyroxine improves glucose intolerance in insulin-resistant rats.
Glucose Intolerance
Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption.
Glucose Metabolism Disorders
Adipose-derived mesenchymal stem cells ameliorate hyperglycemia through regulating hepatic glucose metabolism in type 2 diabetic rats.
Glycogen Storage Disease
Fatal congenital heart glycogenosis caused by a recurrent activating R531Q mutation in the gamma 2-subunit of AMP-activated protein kinase (PRKAG2), not by phosphorylase kinase deficiency.
Glycogen Storage Disease
Fatal infantile cardiac glycogenosis with phosphorylase kinase deficiency and a mutation in the gamma2-subunit of AMP-activated protein kinase.
Glycogen Storage Disease
PRKAG2 cardiac syndrome: familial ventricular preexcitation, conduction system disease, and cardiac hypertrophy.
Glycogen Storage Disease Type IIb
A PRKAG2 mutation causes biphasic changes in myocardial AMPK activity and does not protect against ischemia.
Glycogen Storage Disease Type IIb
Familial hypertrophic cardiomyopathy: clinical features, molecular genetics and molecular genetic testing.
Glycogen Storage Disease Type IIb
SGLT1, a novel cardiac glucose transporter, mediates increased glucose uptake in PRKAG2 cardiomyopathy.
Growth Hormone-Secreting Pituitary Adenoma
Effects of metformin on cell growth and AMPK activity in pituitary adenoma cell cultures, focusing on the interaction with adenylyl cyclase activating signals.
Head and Neck Neoplasms
Gain-of-function mutant p53 promotes cell growth and cancer cell metabolism via inhibition of AMPK activation.
Hearing Loss
AMP-activated protein kinase in BK-channel regulation and protection against hearing loss following acoustic overstimulation.
Hearing Loss, Noise-Induced
Noise-Induced Loss of Hair Cells and Cochlear Synaptopathy Are Mediated by the Activation of AMPK.
Heart Diseases
New Challenges and Strategies for Cardiac Disease: Autophagy, mTOR, and AMP-Activated Protein Kinase.
Heart Diseases
Recent Insights into the Biological Functions of Sestrins in Health and Disease.
Heart Diseases
Regulation of AMP-activated protein kinase activity by G-protein coupled receptors: Potential utility in treatment of diabetes and heart disease.
Heart Diseases
Role of AMP-activated protein kinase in the metabolic syndrome and in heart disease.
Heart Diseases
Role of cAMP in modulating relaxation kinetics and the force-frequency relation in mitral regurgitation heart failure.
Heart Failure
Activated glycogen synthase-3 beta suppresses cardiac hypertrophy in vivo.
Heart Failure
Activation of AMP-activated protein kinase by metformin improves left ventricular function and survival in heart failure.
Heart Failure
Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis.
Heart Failure
AMPK activation, a preventive therapeutic target in the transition from cardiac injury to heart failure.
Heart Failure
AMPK blunts chronic heart failure by inhibiting autophagy.
Heart Failure
Cardioprotective Effects of Sirtuin-1 and Its Downstream Effectors: Potential Role in Mediating the Heart Failure Benefits of SGLT2 (Sodium-Glucose Cotransporter 2) Inhibitors.
Heart Failure
Fenofibrate Reverses Dysfunction of EPCs Caused by Chronic Heart Failure.
Heart Failure
Heart Failure Associated with Sunitinib: Lessons Learned from Animal Models.
Heart Failure
Loss of glycogen synthase kinase 3 isoforms during murine oocyte growth induces offspring cardiac dysfunction.
Heart Failure
Metformin improves cardiac function in rats via activation of AMP-activated protein kinase.
Heart Failure
Metformin Prevents Progression of Heart Failure in Dogs. Role of AMP-Activated Protein Kinase.
Heart Failure
Metformin Protects Against Systolic Overload-Induced Heart Failure Independent of AMP-Activated Protein Kinase ?2.
Heart Failure
Resveratrol, an activator of SIRT1, upregulates AMPK and improves cardiac function in heart failure.
Heart Failure
Targeting fatty acid metabolism in heart failure: is it a suitable therapeutic approach?
Heart Failure
The cardioprotective effects of carvedilol on ischemia and reperfusion injury by AMPK signaling pathway.
Heart Failure
The Cardioprotective Signaling Activity of Activated Protein C in Heart Failure and Ischemic Heart Diseases.
Heart Failure
The effects of ginsenoside Rb1 on fatty acid ?-oxidation, mediated by AMPK, in the failing heart.
Hematologic Neoplasms
AICA-riboside (acadesine), an activator of AMP-activated protein kinase with potential for application in hematologic malignancies.
Hepatitis
Fenofibrate and PBA prevent fatty acid-induced loss of adiponectin receptor and pAMPK in human hepatoma cells and in hepatitis C virus-induced steatosis.
Hepatitis
RIPK1 protects hepatocytes from Kupffer cells-mediated TNF-induced apoptosis in mouse models of PAMP-induced hepatitis.
Hepatitis
Sibiriline, a new small chemical inhibitor of receptor-interacting protein kinase 1, prevents immune-dependent hepatitis.
Hepatitis B
Activation of AMPK/MnSOD signaling mediates anti-apoptotic effect of hepatitis B virus in hepatoma cells.
Hepatitis B
Hepatitis B vaccine induces apoptotic death in Hepa1-6 cells.
Hepatitis B
Identification of SRPK1 and SRPK2 as the major cellular protein kinases phosphorylating hepatitis B virus core protein.
Hepatitis B
Suppression of hepatitis B virus replication by SRPK1 and SRPK2 via a pathway independent of the phosphorylation of the viral core protein.
Hepatitis C
2-octynoic acid inhibits hepatitis C virus infection through activation of AMP-activated protein kinase.
Hepatitis C
Enhanced hepatitis C virus genome replication and lipid accumulation mediated by inhibition of AMP-activated protein kinase.
Hepatitis C
Glycogen Synthase Kinase 3? Enhances Hepatitis C Virus Replication by Supporting miR-122.
Hepatitis C
Glycogen synthase kinase 3? inhibitors prevent hepatitis C virus release/assembly through perturbation of lipid metabolism.
Holoprosencephaly
CORTECON: a temporal transcriptome analysis of in vitro human cerebral cortex development from human embryonic stem cells.
Hookworm Infections
Myeloid-Restricted AMPK?1 Promotes Host Immunity and Protects against IL-12/23p40-Dependent Lung Injury during Hookworm Infection.
Huntington Disease
A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers.
Huntington Disease
AMPK-dependent phosphorylation is required for transcriptional activation of TFEB and TFE3.
Huntington Disease
Impairment of PGC-1alpha expression, neuropathology and hepatic steatosis in a transgenic mouse model of Huntington's disease following chronic energy deprivation.
Huntington Disease
Integrative bioinformatics approaches for identifying potential biomarkers and pathways involved in non-obstructive azoospermia.
Huntington Disease
Metabolic Aspects of Adenosine Functions in the Brain.
Huntington Disease
Metformin treatment reduces motor and neuropsychiatric phenotypes in the zQ175 mouse model of Huntington disease.
Huntington Disease
Mutant HTT (huntingtin) impairs mitophagy in a cellular model of Huntington disease.
Huntington Disease
Mutant huntingtin and glycogen synthase kinase 3-beta accumulate in neuronal lipid rafts of a presymptomatic knock-in mouse model of Huntington's disease.
Huntington Disease
trans-(-)-?-Viniferin increases mitochondrial sirtuin 3 (SIRT3), activates AMP-activated protein kinase (AMPK), and protects cells in models of Huntington Disease.
Huntington Disease
Transcriptomic Analysis of Porcine Granulosa Cells Overexpressing Retinol Binding Protein 4.
Hyperalgesia
AMP-activated protein kinase (AMPK) activator drugs reduce mechanical allodynia in a mouse model of low back pain.
Hyperalgesia
Glycogen synthase kinase-3? contributes to remifentanil-induced postoperative hyperalgesia via regulating N-methyl-D-aspartate receptor trafficking.
Hyperalgesia
Indirect AMP-Activated Protein Kinase Activators Prevent Incision-Induced Hyperalgesia and Block Hyperalgesic Priming, Whereas Positive Allosteric Modulators Block Only Priming in Mice.
Hyperalgesia
Pharmacological modulation of secondary mediator systems--cyclic AMP and cyclic GMP--on inflammatory hyperalgesia.
Hyperalgesia
[Effects of infection and stress on transient receptor potential vanilloid receptor 1 and extracellular-regulated kinase in spinal cord of mast cell deficient rats].
Hypercholesterolemia
Fluvastatin activates sirtuin 6 to regulate sterol regulatory element-binding proteins and AMP-activated protein kinase in HepG2 cells.
Hypercholesterolemia
Glycogen synthase kinase 3? inhibition enhanced proliferation, migration and functional re-endothelialization of endothelial progenitor cells in hypercholesterolemia microenvironment.
Hypercholesterolemia
Policosanol Attenuates Cholesterol Synthesis via AMPK Activation in Hypercholesterolemic Rats.
Hyperglycemia
Ampelopsin protects endothelial cells from hyperglycemia-induced oxidative damage by inducing autophagy via the AMPK signaling pathway.
Hyperglycemia
Angelica gigas Ameliorates Hyperglycemia and Hepatic Steatosis in C57BL/KsJ-db/db Mice via Activation of AMP-Activated Protein Kinase Signaling Pathway.
Hyperglycemia
Black soybean seed coat extract ameliorates hyperglycemia and insulin sensitivity via the activation of AMP-activated protein kinase in diabetic mice.
Hyperglycemia
Blackcurrant Extract Ameliorates Hyperglycemia in Type 2 Diabetic Mice in Association with Increased Basal Secretion of Glucagon-Like Peptide-1 and Activation of AMP-Activated Protein Kinase.
Hyperglycemia
Diabetes and cancer: the mechanistic implications of epidemiological analyses from the Hong Kong Diabetes Registry.
Hyperglycemia
Diabetes, insulin and cancer risk.
Hyperglycemia
Dietary anthocyanin-rich bilberry extract ameliorates hyperglycemia and insulin sensitivity via activation of AMP-activated protein kinase in diabetic mice.
Hyperglycemia
Effect of Hyperglycemia on Human Monocyte Activation.
Hyperglycemia
Effects of PPAR-gamma knock-down and hyperglycemia on insulin signaling in vascular smooth muscle cells from hypertensive rats.
Hyperglycemia
Extracellular nucleotides and adenosine independently activate AMP-activated protein kinase in endothelial cells: involvement of P2 receptors and adenosine transporters.
Hyperglycemia
Hyperglycemia and insulin resistance: possible mechanisms.
Hyperglycemia
Hyperglycemia- and hyperinsulinemia-induced alteration of adiponectin receptor expression and adiponectin effects in L6 myoblasts.
Hyperglycemia
Large enhancement of skeletal muscle cell glucose uptake and suppression of hepatocyte glucose-6-phosphatase activity by weak uncouplers of oxidative phosphorylation.
Hyperglycemia
Loss of CLOCK under high glucose upregulates ROCK1-mediated endothelial to mesenchymal transition and aggravates plaque vulnerability.
Hyperglycemia
North American Wild Rice-Attenuated Hyperglycemia in High-Fat-Induced Obese Mice: Involvement of AMP-Activated Protein Kinase.
Hyperglycemia
O-GlcNAcylation in Hyperglycemic Pregnancies: Impact on Placental Function.
Hyperglycemia
Pre-germinated brown rice extract ameliorates high-fat diet-induced metabolic syndrome.
Hyperglycemia
Rhizoma Anemarrhenae extract ameliorates hyperglycemia and insulin resistance via activation of AMP-activated protein kinase in diabetic rodents.
Hyperglycemia
The cacao procyanidin extract-caused anti-hyperglycemic effect was changed by the administration timings.
Hyperglycemia
The heme oxygenase system abates hyperglycemia in Zucker diabetic fatty rats by potentiating insulin-sensitizing pathways.
Hyperglycemia
The role of aberrant mitochondrial bioenergetics in diabetic neuropathy.
Hyperglycemia
X-3, a mangiferin derivative, stimulates AMP-activated protein kinase and reduces hyperglycemia and obesity in db/db mice.
Hyperinsulinism
Effects of endurance exercise training on insulin signaling in human skeletal muscle: interactions at the level of phosphatidylinositol 3-kinase, Akt, and AS160.
Hyperinsulinism
Evidence That Chromium Modulates Cellular Cholesterol Homeostasis and ABCA1 Functionality Impaired by Hyperinsulinemia.
Hyperinsulinism
Hyperglycemia- and hyperinsulinemia-induced alteration of adiponectin receptor expression and adiponectin effects in L6 myoblasts.
Hyperinsulinism
Hyperinsulinemia enhances interleukin-17-induced inflammation to promote prostate cancer development in obese mice through inhibiting glycogen synthase kinase 3-mediated phosphorylation and degradation of interleukin-17 receptor.
Hyperinsulinism
Regulation of glycogen synthase kinase-3 in human skeletal muscle: effects of food intake and bicycle exercise.
Hyperinsulinism
The rise and fall of insulin signaling in Alzheimer's disease.
Hyperinsulinism
Tiliroside, a glycosidic flavonoid, ameliorates obesity-induced metabolic disorders via activation of adiponectin signaling followed by enhancement of fatty acid oxidation in liver and skeletal muscle in obese-diabetic mice.
Hyperlipidemias
(-)-Epicatechin-3-O-?-D-allopyranoside from Davallia formosana, Prevents Diabetes and Hyperlipidemia by Regulation of Glucose Transporter 4 and AMP-Activated Protein Kinase Phosphorylation in High-Fat-Fed Mice.
Hyperlipidemias
AMPK activation with glabridin ameliorates adiposity and lipid dysregulation in obesity.
Hyperlipidemias
Baicalin Attenuates High Fat Diet-Induced Obesity and Liver Dysfunction: Dose-Response and Potential Role of CaMKK?/AMPK/ACC Pathway.
Hyperlipidemias
Cordycepin activates AMP-activated protein kinase (AMPK) via interaction with the ?1 subunit.
Hyperlipidemias
Cordycepin prevents hyperlipidemia in hamsters fed a high-fat diet via activation of AMP-activated protein kinase.
Hyperlipidemias
Effect of a single bout of aerobic exercise on high-fat meal-induced inflammation.
Hyperlipidemias
Effects of Bofu-Tsusho-San on diabetes and hyperlipidemia associated with AMP-activated protein kinase and glucose transporter 4 in high-fat-fed mice.
Hyperlipidemias
Effects of Huatan Jiangzhuo decoction on diet-induced hyperlipidemia and gene expressions in rats.
Hyperlipidemias
Ergostatrien-3?-ol from Antrodia camphorata Inhibits Diabetes and Hyperlipidemia in High-Fat-Diet Treated Mice via Regulation of Hepatic Related Genes, Glucose Transporter 4, and AMP-Activated Protein Kinase Phosphorylation.
Hyperlipidemias
Pharmacological Effects of 1'-Acetoxychavicol Acetate, a Major Constituent in the Rhizomes of Alpinia galanga and Alpinia conchigera.
Hyperlipidemias
Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient mice.
Hyperlipidemias
Protection against high-fat diet-induced obesity in Helz2-deficient male mice due to enhanced expression of hepatic leptin receptor.
Hyperlipidemias
Tiliroside, a glycosidic flavonoid, ameliorates obesity-induced metabolic disorders via activation of adiponectin signaling followed by enhancement of fatty acid oxidation in liver and skeletal muscle in obese-diabetic mice.
Hyperlipidemias
Tormentic acid, a major component of suspension cells of Eriobotrya japonica, suppresses high-fat diet-induced diabetes and hyperlipidemia by glucose transporter 4 and AMP-activated protein kinase phosphorylation.
Hypersensitivity
AMPK activation regulates P-body dynamics in mouse sensory neurons in vitro and in vivo.
Hypersensitivity
Antihyperalgesia effect of AMP-activated protein kinase (AMPK) activators in a mouse model of postoperative pain.
Hypersensitivity
Autophagy genes in myeloid cells counteract IFN?-induced TNF-mediated cell death and fatal TNF-induced shock.
Hypersensitivity
Inactivation of MARK4, an AMP-activated protein kinase (AMPK)-related kinase, leads to insulin hypersensitivity and resistance to diet-induced obesity.
Hypersensitivity
Inflammatory Role of ROS-Sensitive AMP-Activated Protein Kinase in the Hypersensitivity of Lung Vagal C Fibers Induced by Intermittent Hypoxia in Rats.
Hypersensitivity
Presynaptically localized cyclic GMP-dependent protein kinase 1 is a key determinant of spinal synaptic potentiation and pain hypersensitivity.
Hypertension
Activation of AMP-activated protein kinase by metformin ablates angiotensin II-induced endoplasmic reticulum stress and hypertension in mice in vivo.
Hypertension
Activation of SIRT1 Attenuates Klotho Deficiency-Induced Arterial Stiffness and Hypertension by Enhancing AMP-Activated Protein Kinase Activity.
Hypertension
AMP-Activated Protein Kinase as a Reprogramming Strategy for Hypertension and Kidney Disease of Developmental Origin.
Hypertension
AMPK attenuates ventricular remodeling and dysfunction following aortic banding in mice via the Sirt3/Oxidative stress pathway.
Hypertension
Anomalous AMPK-regulated angiotensin AT1R expression and SIRT1-mediated mitochondrial biogenesis at RVLM in hypertension programming of offspring to maternal high fructose exposure.
Hypertension
Dietary iron restriction prevents hypertensive cardiovascular remodeling in Dahl salt-sensitive rats.
Hypertension
Highly purified eicosapentaenoic acid ameliorates cardiac injury and adipose tissue inflammation in a rat model of metabolic syndrome.
Hypertension
Maternal melatonin or agomelatine therapy prevents programmed hypertension in male offspring of mother exposed to continuous light.
Hypertension
Pioglitazone attenuates cardiac hypertrophy in rats with salt-sensitive hypertension: role of activation of AMP-activated protein kinase and inhibition of Akt.
Hypertension
Resveratrol prevents combined prenatal NG-nitro-L-arginine-methyl ester (L-NAME) treatment plus postnatal high-fat diet induced programmed hypertension in adult rat offspring: interplay between nutrient-sensing signals, oxidative stress and gut microbiota.
Hypertension
Resveratrol prevents the combined maternal plus postweaning high-fat-diets-induced hypertension in male offspring.
Hypertension
Retracted: Resveratrol inhibits oesophageal adenocarcinoma cell proliferation via AMP-activated protein kinase signaling
Hypertension
Roles of Dietary Bioactive Peptides in Redox Balance and Metabolic Disorders.
Hypertension
Severe Arterial Hypertension from Cullin 3 Mutations Is Caused by Both Renal and Vascular Effects.
Hypertension
Whether AICAR in Pregnancy or Lactation Prevents Hypertension Programmed by High Saturated Fat Diet: A Pilot Study.
Hypertension
[Investigating the role of ceramide metabolism-associated CERS5 (LASS5) gene in atherosclerosis pathogenesis in endothelial cells].
Hypertension, Portal
Endothelin-1 in portal hypertension: The intricate role of hepatic stellate cells.
Hypertension, Pulmonary
AMP-activated protein kinase inhibits Kv 1.5 channel currents of pulmonary arterial myocytes in response to hypoxia and inhibition of mitochondrial oxidative phosphorylation.
Hypertension, Pulmonary
Metformin Reverses Development of Pulmonary Hypertension via Aromatase Inhibition.
Hypertension, Pulmonary
Protective Roles of Endothelial AMP-Activated Protein Kinase Against Hypoxia-Induced Pulmonary Hypertension in Mice.
Hypertension, Pulmonary
Regulatory effect of AMP-activated protein kinase on pulmonary hypertension induced by chronic hypoxia in rats: in vivo and in vitro studies.
Hyperthyroidism
Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance.
Hyperthyroidism
Redox status and pro-survival/pro-apoptotic protein expression in the early cardiac hypertrophy induced by experimental hyperthyroidism.
Hyperthyroidism
The influence of thyroid state on hypothalamic AMP-activated protein kinase pathways in broilers.
Hyperthyroidism
Thyroid hormone effects on LKB1, MO25, phospho-AMPK, phospho-CREB, and PGC-1alpha in rat muscle.
Hyperthyroidism
Thyroid states regulate subcellular glucose phosphorylation activity in male mice.
Hypertrophy, Left Ventricular
Glycogen storage diseases presenting as hypertrophic cardiomyopathy.
Hypertrophy, Left Ventricular
Human ?2-AMPK Mutations.
Hypertrophy, Left Ventricular
Pioglitazone attenuates cardiac hypertrophy in rats with salt-sensitive hypertension: role of activation of AMP-activated protein kinase and inhibition of Akt.
Hypertrophy, Left Ventricular
Transgenic mice overexpressing mutant PRKAG2 define the cause of Wolff-Parkinson-White syndrome in glycogen storage cardiomyopathy.
Hypoglycemia
Activation of AMP-Activated Protein Kinase Within the Ventromedial Hypothalamus Amplifies Counterregulatory Hormone Responses in Rats With Defective Counterregulation.
Hypoglycemia
Ca2+/calmodulin-dependent protein kinase kinase is not involved in hypothalamic AMP-activated protein kinase activation by neuroglucopenia.
Hypoglycemia
Hypothalamic AMP-activated Protein Kinase activation with AICAR amplifies counterregulatory responses to hypoglycemia in a rodent model of Type 1 diabetes.
Hypoglycemia
Key role for AMP-activated protein kinase in the ventromedial hypothalamus in regulating counterregulatory hormone responses to acute hypoglycemia.
Hypoglycemia
Lactogenic and somatogenic hormones regulate the expression of neuropeptide Y and cocaine- and amphetamine-regulated transcript in rat insulinoma (INS-1) cells: interactions with glucose and glucocorticoids.
Hypoglycemia
Phenformin as an Anticancer Agent: Challenges and Prospects.
Hypoglycemia
Potential role for AMP-activated protein kinase in hypoglycemia sensing in the ventromedial hypothalamus.
Hypoglycemia
Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver.
Hypopigmentation
Baicalin-induced Akt activation decreases melanogenesis through downregulation of microphthalmia-associated transcription factor and tyrosinase.
Hypotension
Effect of maternal nutrient restriction from early to midgestation on cardiac function and metabolism after adolescent-onset obesity.
Hypothyroidism
Mitochondrial and energetic cardiac phenotype in hypothyroid rat. Relevance to heart failure.
Immune System Diseases
Recent Insights into the Biological Functions of Sestrins in Health and Disease.
Infarction, Middle Cerebral Artery
Cortical spreading depression preconditioning mediates neuroprotection against ischemic stroke by inducing AMP-activated protein kinase-dependent autophagy in a rat cerebral ischemic/reperfusion injury model.
Infections
A hypothesis: adiponectin mediates anti-atherosclerosis via adventitia-AMPK-iNOS pathway.
Infections
Activation of GLUT1 by metabolic and osmotic stress: potential involvement of AMP-activated protein kinase (AMPK).
Infections
Adenovirus-mediated gene transfer of RasN17 inhibits specific CCK actions on pancreatic acinar cells.
Infections
Alterations of Gut Microbiome and Metabolite Profiling in Mice Infected by Schistosoma japonicum.
Infections
AMP-Activated Protein Kinase and Host Defense against Infection.
Infections
ASK1 regulates influenza virus infection-induced apoptotic cell death.
Infections
Bacterial Muramyl Dipeptide (MDP) Restricts Human Cytomegalovirus Replication via an IFN-?-Dependent Pathway.
Infections
BECN1-dependent CASP2 incomplete autophagy induction by binding to rabies virus phosphoprotein.
Infections
Candida albicans induces cyclo-oxygenase 2 expression and prostaglandin E2 production in synovial fibroblasts through an extracellular-regulated kinase 1/2 dependent pathway.
Infections
Chromatin-Remodeling Factor SPOC1 Acts as a Cellular Restriction Factor against Human Cytomegalovirus by Repressing the Major Immediate Early Promoter.
Infections
Co-administration of interleukins 7 and 15 with DNA vaccine improves protective immunity against Toxoplasma gondii.
Infections
Coronavirus Disease (COVID)-19 and Diabetic Kidney Disease.
Infections
Development of a murine vertical transmission model for Toxoplasma gondii oocyst infection and studies on the efficacy of bumped kinase inhibitor (BKI)-1294 and the naphthoquinone buparvaquone against congenital toxoplasmosis.
Infections
Differential Metabolic Reprogramming by Zika Virus Promotes Cell Death in Human versus Mosquito Cells.
Infections
Direct Activation of Adenosine Monophosphate-Activated Protein Kinase (AMPK) by PF-06409577 Inhibits Flavivirus Infection through Modification of Host Cell Lipid Metabolism.
Infections
Effects of Varicella-Zoster Virus on Cell Cycle Regulatory Pathways.
Infections
Formyl peptide receptor 2 plays a deleterious role during influenza A virus infections.
Infections
Glycogen Synthase Kinase 3? Modulates the Inflammatory Response Activated by Bacteria, Viruses, and Parasites.
Infections
Glycogen synthase kinase 3ß participates in late stages of Dengue virus-2 infection.
Infections
Glycolysis Is an Intrinsic Factor for Optimal Replication of a Norovirus.
Infections
Hepatitis C virus inhibits AKT-tuberous sclerosis complex (TSC), the mechanistic target of rapamycin (MTOR) pathway, through endoplasmic reticulum stress to induce autophagy.
Infections
Human Cytomegalovirus Induces the Expression of the AMPKa2 Subunit to Drive Glycolytic Activation and Support Productive Viral Infection.
Infections
Human papillomavirus type 16 infection activates the host serine arginine protein kinase 1 (SRPK1) - splicing factor axis.
Infections
Identification of SRPK1 and SRPK2 as the major cellular protein kinases phosphorylating hepatitis B virus core protein.
Infections
Inhibition of focal adhesion kinase expression or activity disrupts epidermal growth factor-stimulated signaling promoting the migration of invasive human carcinoma cells.
Infections
Inhibition of GSK-3beta enhances reovirus-induced apoptosis in colon cancer cells.
Infections
Metabolic energy sensors as targets for designing host-directed therapies for tuberculosis.
Infections
Metarhizium anisopliae s.l. modulation of lipid metabolism during tick infection is independent of AMPK and ERK pathways.
Infections
Methamphetamine enhances HIV-1 infectivity in monocyte derived dendritic cells.
Infections
Mimic Phosphorylation of a ?C1 Protein Encoded by TYLCCNB Impairs Its Functions as a Viral Suppressor of RNA Silencing and a Symptom Determinant.
Infections
MIR144* inhibits antimicrobial responses against Mycobacterium tuberculosis in human monocytes and macrophages by targeting the autophagy protein DRAM2.
Infections
Neospora caninum: Differential Proteome of Multinucleated Complexes Induced by the Bumped Kinase Inhibitor BKI-1294.
Infections
Optimizing Small Molecule Inhibitors of Calcium-Dependent Protein Kinase 1 to Prevent Infection by Toxoplasma gondii.
Infections
Overexpression of miR?214 promotes the progression of human osteosarcoma by regulating the Wnt/??catenin signaling pathway.
Infections
Oxidative Stress Attenuates Lipid Synthesis and Increases Mitochondrial Fatty Acid Oxidation in Hepatoma Cells Infected with Hepatitis C Virus.
Infections
PDPK1 regulates autophagosome biogenesis by binding to PIK3C3.
Infections
Plasmodium Infection Induces Dyslipidemia and a Hepatic Lipogenic State in the Host through the Inhibition of the AMPK-ACC Pathway.
Infections
Porphyromonas gingivalis (W83) Infection Induces Alzheimer's Disease-Like Pathophysiology in Obese and Diabetic Mice.
Infections
Rhabdovirus Infection Is Dependent on Serine/Threonine Kinase AP2-Associated Kinase 1.
Infections
Rice black-streaked dwarf virus P10 promotes phosphorylation of GAPDH (glyceraldehyde-3-phosphate dehydrogenase) to induce autophagy in Laodelphax striatellus.
Infections
Rosiglitazone stimulates nitric oxide synthesis in human aortic endothelial cells via AMP-activated protein kinase.
Infections
The effect of human immunodeficiency virus-1 on monocyte-derived dendritic cell maturation and function.
Infections
Varicella-zoster virus ORF12 protein activates the phosphatidylinositol 3-kinase/Akt pathway to regulate cell cycle progression.
Infections
[Effects of infection and stress on transient receptor potential vanilloid receptor 1 and extracellular-regulated kinase in spinal cord of mast cell deficient rats].
Infertility
AMPK regulates germline stem cell quiescence and integrity through an endogenous small RNA pathway.
Infertility, Male
Targeted Disruption of Glycogen Synthase Kinase 3a (Gsk3a) in Mice Affects Sperm Motility Resulting in Male Infertility.
Inflammatory Bowel Diseases
How autophagy controls the intestinal epithelial barrier.
Inflammatory Bowel Diseases
Metformin inhibits inflammatory signals in the gut by controlling AMPK and p38 MAP kinase activation.
Inflammatory Bowel Diseases
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Influenza, Human
Immunomodulatory therapy for severe influenza.
Influenza, Human
Peroxisome proliferator-activated receptor and AMP-activated protein kinase agonists protect against lethal influenza virus challenge in mice.
Influenza, Human
VaximmutorDB: A Web-Based Vaccine Immune Factor Database and Its Application for Understanding Vaccine-Induced Immune Mechanisms.
Influenza, Human
ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways.
Insulin Resistance
(Healthy) ageing: focus on iodothyronines.
Insulin Resistance
14-Deoxy-11,12-Didehydroandrographolide Ameliorates Glucose Intolerance Enhancing the LKB1/AMPK[Formula: see text]/TBC1D1/GLUT4 Signaling Pathway and Inducing GLUT4 Expression in Myotubes and Skeletal Muscle of Obese Mice.
Insulin Resistance
A cell-based screening identifies compounds from the stem of Momordica charantia that overcome insulin resistance and activate AMP-activated protein kinase.
Insulin Resistance
A newly synthetic chromium complex-chromium (D-phenylalanine)3 activates AMP-activated protein kinase and stimulates glucose transport.
Insulin Resistance
A? exacerbates ?-synuclein-induced neurotoxicity through impaired insulin signaling in ?-synuclein-overexpressed human SK-N-MC neuronal cells.
Insulin Resistance
Abelmoschus esculentus subfractions attenuate beta amyloid-induced neuron apoptosis by regulating DPP-4 with improving insulin resistance signals.
Insulin Resistance
Ablation of 3-phosphoinositide-dependent protein kinase 1 (PDK1) in vascular endothelial cells enhances insulin sensitivity by reducing visceral fat and suppressing angiogenesis.
Insulin Resistance
Ablation of AMP-activated protein kinase alpha2 activity exacerbates insulin resistance induced by high-fat feeding of mice.
Insulin Resistance
Abnormalities in brain structure and behavior in GSK-3alpha mutant mice.
Insulin Resistance
Activation of AMPK by Medicinal Plants and Natural Products: Its Role in Type 2 Diabetes Mellitus.
Insulin Resistance
Activation of Muscular TrkB by its Small Molecular Agonist 7,8-Dihydroxyflavone Sex-Dependently Regulates Energy Metabolism in Diet-Induced Obese Mice.
Insulin Resistance
Adiponectin and Cognitive Decline.
Insulin Resistance
Adiponectin and the cardiovascular system: from risk to disease.
Insulin Resistance
Adiponectin induced AMP-activated protein kinase impairment mediates insulin resistance in Bama mini-pig fed high-fat and high-sucrose diet.
Insulin Resistance
Adiponectin Reduces Embryonic Loss Rate and Ameliorates Trophoblast Apoptosis in Early Pregnancy of Mice with Polycystic Ovary Syndrome by Affecting the AMPK/PI3K/Akt/FoxO3a Signaling Pathway.
Insulin Resistance
Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake.
Insulin Resistance
Administration of kynurenic acid reduces hyperlipidemia-induced inflammation and insulin resistance in skeletal muscle and adipocytes.
Insulin Resistance
Aged garlic extract suppresses the increase of plasma glycated albumin level and enhances the AMP-activated protein kinase in adipose tissue in TSOD mice.
Insulin Resistance
Alpha-lipoic acid increases cardiac glucose oxidation independent of AMP-activated protein kinase in isolated working rat hearts.
Insulin Resistance
AMP-activated protein kinase (AMPK)?2 plays a role in determining the cellular fate of glucose in insulin-resistant mouse skeletal muscle.
Insulin Resistance
AMP-Activated Protein Kinase ?1 Protects Against Diet-Induced Insulin Resistance and Obesity.
Insulin Resistance
AMP-activated protein kinase ?1 protects against diet-induced insulin resistance and obesity. Diabetes 2012;61:3114-3125.
Insulin Resistance
AMP-activated protein kinase ?2 subunit is required for the preservation of hepatic insulin sensitivity by n-3 polyunsaturated fatty acids.
Insulin Resistance
AMP-activated protein kinase and muscle insulin resistance.
Insulin Resistance
AMP-activated protein kinase, fatty acid metabolism, and insulin sensitivity.
Insulin Resistance
AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol.
Insulin Resistance
AMP-activated protein kinase-mediated expression of heat shock protein beta 1 enhanced insulin sensitivity in the skeletal muscle.
Insulin Resistance
AMPK activity and isoform protein expression are similar in muscle of obese subjects with and without type 2 diabetes.
Insulin Resistance
AMPK as a Therapeutic Target for Treating Metabolic Diseases.
Insulin Resistance
AMPK-?2 is involved in exercise training-induced adaptations in insulin-stimulated metabolism in skeletal muscle following high-fat diet.
Insulin Resistance
AMPK?2 is an essential signal in the regulation of insulin-stimulated fatty acid uptake in control-fed and high fat-fed mice.
Insulin Resistance
An integrated and unifying hypothesis for the metabolic basis of sporadic Alzheimer's disease.
Insulin Resistance
Anti-diabetic effects of a coptis chinensis containing new traditional chinese medicine formula in type 2 diabetic rats.
Insulin Resistance
Ascofuranone prevents ER stress-induced insulin resistance via activation of AMP-activated protein kinase in L6 myotube cells.
Insulin Resistance
Aspalathin-Enriched Green Rooibos Extract Reduces Hepatic Insulin Resistance by Modulating PI3K/AKT and AMPK Pathways.
Insulin Resistance
Attenuation of Free Fatty Acid-Induced Muscle Insulin Resistance by Rosemary Extract.
Insulin Resistance
Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective.
Insulin Resistance
BAIBA attenuates insulin resistance and inflammation induced by palmitate or a high fat diet via an AMPK-PPAR?-dependent pathway in mice.
Insulin Resistance
Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action.
Insulin Resistance
Berberine inhibits PTP1B activity and mimics insulin action.
Insulin Resistance
Black soybean seed coat extract ameliorates hyperglycemia and insulin sensitivity via the activation of AMP-activated protein kinase in diabetic mice.
Insulin Resistance
Brain adipocytokine action and metabolic regulation.
Insulin Resistance
Ca2+/calmodulin-dependent protein kinase kinase is involved in AMP-activated protein kinase activation by alpha-lipoic acid in C2C12 myotubes.
Insulin Resistance
Chronic ethanol feeding impairs AMPK and MEF2 expression and is associated with GLUT4 decrease in rat myocardium.
Insulin Resistance
Ciliary neurotrophic factor stimulates muscle glucose uptake by a PI3-kinase-dependent pathway that is impaired with obesity.
Insulin Resistance
cis-9,trans-11-Conjugated Linoleic Acid Activates AMP-Activated Protein Kinase in Attenuation of Insulin Resistance in C(2)C(12) Myotubes.
Insulin Resistance
Clinically confirmed DEL-1 as a myokine attenuates lipid-induced inflammation and insulin resistance in 3T3-L1 adipocytes via AMPK/HO-1- pathway.
Insulin Resistance
CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK.
Insulin Resistance
Cocoa-rich diet ameliorates hepatic insulin resistance by modulating insulin signaling and glucose homeostasis in Zucker diabetic fatty rats.
Insulin Resistance
Combretastatin A-4 activates AMP-activated protein kinase and improves glucose metabolism in db/db mice.
Insulin Resistance
Compound C inhibits macrophage chemotaxis through an AMPK-independent mechanism.
Insulin Resistance
Continued postnatal administration of resveratrol prevents diet-induced metabolic syndrome in rat offspring born growth restricted.
Insulin Resistance
CtBP2 ameliorates palmitate-induced insulin resistance in HepG2 cells through ROS mediated JNK pathway.
Insulin Resistance
Decreased AMP-activated protein kinase activity is associated with increased inflammation in visceral adipose tissue and with whole-body insulin resistance in morbidly obese humans.
Insulin Resistance
Depression-like behaviors in mice subjected to co-treatment of high-fat diet and corticosterone are ameliorated by AICAR and exercise.
Insulin Resistance
DhHP-6 ameliorates hepatic oxidative stress and insulin resistance in type 2 diabetes mellitus through the PI3K/AKT and AMPK pathway.
Insulin Resistance
Diabetes, insulin and cancer risk.
Insulin Resistance
Dietary ?-lactalbumin induced fatty liver by enhancing nuclear liver X receptor ??/sterol regulatory element-binding protein-1c/PPAR? expression and minimising PPAR?/carnitine palmitoyltransferase-1 expression and AMP-activated protein kinase ? phosphorylation associated with atherogenic dyslipidaemia, insulin resistance and oxidative stress in Balb/c mice.
Insulin Resistance
Dietary anthocyanin-rich bilberry extract ameliorates hyperglycemia and insulin sensitivity via activation of AMP-activated protein kinase in diabetic mice.
Insulin Resistance
Dietary intake of green tea polyphenols regulates insulin sensitivity with an increase in AMP-activated protein kinase ? content and changes in mitochondrial respiratory complexes.
Insulin Resistance
Dietary Iron Deficiency Modulates Adipocyte Iron Homeostasis, Adaptive Thermogenesis, and Obesity in C57BL/6 Mice.
Insulin Resistance
Dietary polyunsaturated fatty acids enhance hepatic AMP-activated protein kinase activity in rats.
Insulin Resistance
Dihydromyricetin prevents obesity-induced slow-twitch-fiber reduction partially via FLCN/FNIP1/AMPK pathway.
Insulin Resistance
Distinct Time Course of the Decrease in Hepatic AMP-Activated Protein Kinase and Akt Phosphorylation in Mice Fed a High Fat Diet.
Insulin Resistance
Does regular ethanol consumption promote insulin sensitivity and leanness by stimulating AMP-activated protein kinase?
Insulin Resistance
Downregulation of AMPK accompanies leucine- and glucose-induced increases in protein synthesis and insulin resistance in rat skeletal muscle.
Insulin Resistance
Dysregulated Autophagy Mediates Sarcopenic Obesity and Its Complications via AMPK and PGC1? Signaling Pathways: Potential Involvement of Gut Dysbiosis as a Pathological Link.
Insulin Resistance
Effects of angiotensin II receptor blockade on glucose metabolism via AMP-activated protein kinase in insulin-resistant hypertensive rats.
Insulin Resistance
Effects of individual branched-chain amino acids deprivation on insulin sensitivity and glucose metabolism in mice.
Insulin Resistance
Effects of intravenous AICAR (5-aminoimidazole-4-carboximide riboside) administration on insulin signaling and resistance in premature baboons, Papio sp.
Insulin Resistance
Efficacy and Mechanisms of Oleuropein in Mitigating Diabetes and Diabetes Complications.
Insulin Resistance
Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation.
Insulin Resistance
Enhanced skeletal muscle insulin sensitivity after acute resistance-type exercise is upregulated by rapamycin-sensitive mTOR complex 1 inhibition.
Insulin Resistance
Erratum to: 'Inhibition of myostatin protects against diet-induced obesity by enhancing fatty acid oxidation and promoting a brown adipose phenotype in mice' and 'Myostatin-deficient mice exhibit reduced insulin resistance through activating the AMP-activated protein kinase signalling pathway'.
Insulin Resistance
Eugenol ameliorates insulin resistance, oxidative stress and inflammation in high fat-diet/streptozotocin-induced diabetic rat.
Insulin Resistance
Exercise Training Improves Whole Body Insulin Resistance via Adiponectin Receptor 1.
Insulin Resistance
Exercise training-induced improvements in insulin action.
Insulin Resistance
Exercise-induced increase in muscle insulin sensitivity.
Insulin Resistance
Fibronectin Type III Domain Containing 4 attenuates hyperlipidemia-induced insulin resistance via suppression of inflammation and ER stress through HO-1 expression in adipocytes.
Insulin Resistance
Fish oil supplementation inhibits endoplasmic reticulum stress and improves insulin resistance: involvement of AMP-activated protein kinase.
Insulin Resistance
Ganoderma lucidum Extract Reduces Insulin Resistance by Enhancing AMPK Activation in High-Fat Diet-Induced Obese Mice.
Insulin Resistance
Ginsenoside Rb1 increases insulin sensitivity by activating AMP-activated protein kinase in male rats.
Insulin Resistance
Glimepiride enhances intrinsic peroxisome proliferator-activated receptor-gamma activity in 3T3-L1 adipocytes.
Insulin Resistance
Globular adiponectin resistance develops independently of impaired insulin-stimulated glucose transport in soleus muscle from high-fat-fed rats.
Insulin Resistance
Glycogen synthase kinase 3alpha-specific regulation of murine hepatic glycogen metabolism.
Insulin Resistance
Grape seed extract supplementation prevents high-fructose diet-induced insulin resistance in rats by improving insulin and adiponectin signalling pathways.
Insulin Resistance
Green tea polyphenol extract regulates the expression of genes involved in glucose uptake and insulin signaling in rats fed a high fructose diet.
Insulin Resistance
Heat shock transcription factor 1 is a key determinant of HCC development by regulating hepatic steatosis and metabolic syndrome.
Insulin Resistance
Hepatic serum- and glucocorticoid-regulated protein kinase 1 (SGK1) regulates insulin sensitivity in mice via extracellular-signal-regulated kinase 1/2 (ERK1/2).
Insulin Resistance
Identification of Potential Biomarkers for Psoriasis by DNA Methylation and Gene Expression Datasets.
Insulin Resistance
Increased malonyl-CoA and diacylglycerol content and reduced AMPK activity accompany insulin resistance induced by glucose infusion in muscle and liver of rats.
Insulin Resistance
Increased oxidative stress and anaerobic energy release, but blunted Thr172-AMPK? phosphorylation, in response to sprint exercise in severe acute hypoxia in humans.
Insulin Resistance
Inflammation in obesity is the common link between defects in fatty acid metabolism and insulin resistance.
Insulin Resistance
Inhibition of arachidonic acid and iron-induced mitochondrial dysfunction and apoptosis by oltipraz and novel 1,2-dithiole-3-thione congeners.
Insulin Resistance
Inhibition of C1-Ten PTPase activity reduces insulin resistance through IRS-1 and AMPK pathways.
Insulin Resistance
Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption.
Insulin Resistance
Inhibition of ERK1/2 Restores GSK3? Activity and Protein Synthesis Levels in a Model of Tuberous Sclerosis.
Insulin Resistance
Inhibition of the mTOR/p70S6K pathway is not involved in the insulin-sensitizing effect of AMPK on cardiac glucose uptake.
Insulin Resistance
Insulin resistance and fuel homeostasis: the role of AMP-activated protein kinase.
Insulin Resistance
Insulin Resistance Exacerbates Alzheimer Disease via Multiple Mechanisms.
Insulin Resistance
Insulin signalling in the heart.
Insulin Resistance
Interleukin-18 Activates Skeletal Muscle AMPK and Reduces Weight Gain and Insulin Resistance in Mice.
Insulin Resistance
Lipocalin-2: a role in hepatic gluconeogenesis via AMP-activated protein kinase (AMPK).
Insulin Resistance
Liraglutide enhances insulin sensitivity by activating AMP-activated protein kinase in male Wistar rats.
Insulin Resistance
Long-term moderate ethanol consumption restores insulin sensitivity in high-fat-fed rats by increasing SLC2A4 (GLUT4) in the adipose tissue by AMP-activated protein kinase activation.
Insulin Resistance
Low molecular weight fucoidan improves endoplasmic reticulum stress-reduced insulin sensitivity through AMP-activated protein kinase activation in L6 myotubes and restores lipid homeostasis in a mouse model of type 2 diabetes.
Insulin Resistance
LRP6 Knockdown Ameliorates Insulin Resistance via Modulation of Autophagy by Regulating GSK3? Signaling in Human LO2 Hepatocytes.
Insulin Resistance
Lupin protein isolate improves insulin sensitivity and steatohepatitis in vivo and modulates the expression of the Fasn, Gys2, and Gsk3b genes.
Insulin Resistance
Malonyl-CoA and AMP-activated protein kinase (AMPK): possible links between insulin resistance in muscle and early endothelial cell damage in diabetes.
Insulin Resistance
Metformin ameliorates IL-6-induced hepatic insulin resistance via induction of orphan nuclear receptor small heterodimer partner (SHP) in mouse models.
Insulin Resistance
Metformin attenuates the exacerbation of the allergic eosinophilic inflammation in high fat-diet-induced obesity in mice.
Insulin Resistance
METRNL attenuates lipid-induced inflammation and insulin resistance via AMPK or PPAR?-dependent pathways in skeletal muscle of mice.
Insulin Resistance
Mevastatin promotes neuronal survival against A?-induced neurotoxicity through AMPK activation.
Insulin Resistance
Mitochondrial inhibitor as a new class of insulin sensitizer.
Insulin Resistance
Mitochondrial oxidative stress causes insulin resistance without disrupting oxidative phosphorylation.
Insulin Resistance
Mulberry (Morus alba L.) Fruit Extract Containing Anthocyanins Improves Glycemic Control and Insulin Sensitivity via Activation of AMP-Activated Protein Kinase in Diabetic C57BL/Ksj-db/db Mice.
Insulin Resistance
Myostatin-deficient mice exhibit reduced insulin resistance through activating the AMP-activated protein kinase signalling pathway.
Insulin Resistance
Nardostachys jatamansi DC Extract Alleviates Insulin Resistance and Regulates Glucose Metabolism in C57BL/KsJ-db/db Mice Through the AMP-Activated Protein Kinase Signaling Pathway.
Insulin Resistance
Network Pharmacology-Based Dissection of the Anti-diabetic Mechanism of Lobelia chinensis.
Insulin Resistance
Network Pharmacology-Based Strategy to Investigate the Pharmacological Mechanisms of Ginkgo biloba Extract for Aging.
Insulin Resistance
Novel benzothiazinones (BTOs) as allosteric modulator or substrate competitive inhibitor of glycogen synthase kinase 3? (GSK-3?) with cellular activity of promoting glucose uptake.
Insulin Resistance
Nutrient Excess and AMPK Downregulation in Incubated Skeletal Muscle and Muscle of Glucose Infused Rats.
Insulin Resistance
Obese mice lacking inducible nitric oxide synthase are sensitized to the metabolic actions of peroxisome proliferator-activated receptor-gamma agonism.
Insulin Resistance
Oleate prevents saturated-fatty-acid-induced ER stress, inflammation and insulin resistance in skeletal muscle cells through an AMPK-dependent mechanism.
Insulin Resistance
Overexpression of AMP-activated protein kinase or protein kinase D prevents lipid-induced insulin resistance in cardiomyocytes.
Insulin Resistance
Paeoniflorin suppresses lipid accumulation and alleviates insulin resistance by regulating the Rho kinase/IRS-1 pathway in palmitate-induced HepG2Cells.
Insulin Resistance
PCBP2 regulates hepatic insulin sensitivity via HIF-1? and STAT3 pathway in HepG2 cells.
Insulin Resistance
Pentamethylquercetin generates beneficial effects in monosodium glutamate-induced obese mice and C2C12 myotubes by activating AMP-activated protein kinase.
Insulin Resistance
Pinusolide improves high glucose-induced insulin resistance via activation of AMP-activated protein kinase.
Insulin Resistance
Pioglitazone ameliorates insulin resistance and diabetes by both adiponectin-dependent and -independent pathways.
Insulin Resistance
PKD1 Inhibits AMPK?2 through Phosphorylation of Serine 491 and Impairs Insulin Signaling in Skeletal Muscle Cells.
Insulin Resistance
Plant Extracts for Type 2 Diabetes: From Traditional Medicine to Modern Drug Discovery.
Insulin Resistance
Porphyromonas gingivalis (W83) Infection Induces Alzheimer's Disease-Like Pathophysiology in Obese and Diabetic Mice.
Insulin Resistance
Postcontraction insulin sensitivity: relationship with contraction protocol, glycogen concentration, and 5' AMP-activated protein kinase phosphorylation.
Insulin Resistance
Prediabetes and Alzheimer's Disease.
Insulin Resistance
Preoperative Oral Carbohydrate Reduces Postoperative Insulin Resistance by Activating AMP-Activated Protein Kinase after Colorectal Surgery.
Insulin Resistance
Prevention of high-fat diet-induced muscular lipid accumulation in rats by alpha lipoic acid is not mediated by AMPK activation.
Insulin Resistance
Prior treatment with the AMPK activator AICAR induces subsequently enhanced glucose uptake in isolated skeletal muscles from 24 month-old rats.
Insulin Resistance
Probucol Ameliorates the Development of Nonalcoholic Steatohepatitis in Rats Fed High-Fat Diets.
Insulin Resistance
Protectin DX ameliorates palmitate- or high-fat diet-induced insulin resistance and inflammation through an AMPK-PPAR?-dependent pathway in mice.
Insulin Resistance
Protectin DX ameliorates palmitate-induced hepatic insulin resistance through AMPK/SIRT1-mediated modulation of fetuin-A and SeP expression.
Insulin Resistance
Protection against high-fat diet-induced obesity in Helz2-deficient male mice due to enhanced expression of hepatic leptin receptor.
Insulin Resistance
Protective effect of esculin on streptozotocin-induced diabetic renal damage in mice.
Insulin Resistance
Raspberry alleviates obesity-induced inflammation and insulin resistance in skeletal muscle through activation of AMP-activated protein kinase (AMPK) ?1.
Insulin Resistance
Reduced AMP-activated protein kinase activity in mouse skeletal muscle does not exacerbate the development of insulin resistance with obesity.
Insulin Resistance
Reduced Insulin Resistance Contributes to the Beneficial Effect of Protein Tyrosine Phosphatase-1B Deletion in a Mouse Model of Sepsis.
Insulin Resistance
Reduced skeletal muscle AMPK and mitochondrial markers do not promote age-induced insulin resistance.
Insulin Resistance
Resistin's, obesity and insulin resistance: the continuing disconnect between rodents and humans.
Insulin Resistance
Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network.
Insulin Resistance
Resveratrol improves health and survival of mice on a high-calorie diet.
Insulin Resistance
Rhizoma Anemarrhenae extract ameliorates hyperglycemia and insulin resistance via activation of AMP-activated protein kinase in diabetic rodents.
Insulin Resistance
Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.
Insulin Resistance
Rimonabant ameliorates insulin resistance via both adiponectin-dependent and adiponectin-independent pathways.
Insulin Resistance
Role of AMP-Activated Protein Kinase for Regulating Post-exercise Insulin Sensitivity.
Insulin Resistance
Role of glycogen synthase kinase-3 alpha in insulin action in cultured human skeletal muscle cells.
Insulin Resistance
Role of Phosphorylated AMP-Activated Protein Kinase (AMPK) in Myocardial Insulin Resistance After Myocardial Ischemia-Reperfusion During Cardiopulmonary Bypass Surgery in Dogs.
Insulin Resistance
Roles and Tissue Source of Adiponectin Involved in Lifestyle Modifications.
Insulin Resistance
Rosiglitazone reduces fatty acid translocase and increases AMPK in skeletal muscle in aged rats: a possible mechanism to prevent high-fat-induced insulin resistance.
Insulin Resistance
Salidroside alleviates diabetic neuropathic pain through regulation of the AMPK-NLRP3 inflammasome axis.
Insulin Resistance
Salidroside Attenuates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease via AMPK-Dependent TXNIP/NLRP3 Pathway.
Insulin Resistance
Serum Is Not Necessary for Prior Pharmacological Activation of AMPK to Increase Insulin Sensitivity of Mouse Skeletal Muscle.
Insulin Resistance
Sex Differences in MicroRNA Expression and Cardiometabolic Risk Factors in Hispanic Adolescents with Obesity.
Insulin Resistance
Skeletal muscle AMP-activated protein kinase ?1(H151R) overexpression enhances whole body energy homeostasis and insulin sensitivity.
Insulin Resistance
Skeletal muscle of stroke-prone spontaneously hypertensive rats exhibits reduced insulin-stimulated glucose transport and elevated levels of caveolin and flotillin.
Insulin Resistance
Suppression of Rho-kinase 1 is responsible for insulin regulation of the AMPK/SREBP-1c pathway in skeletal muscle cells exposed to palmitate.
Insulin Resistance
Suppression of the mTORC1/STAT3/Notch1 pathway by activated AMPK prevents hepatic insulin resistance induced by excess amino acids.
Insulin Resistance
Tanshinone IIA improves endoplasmic reticulum stress-induced insulin resistance through AMP-activated protein kinase.
Insulin Resistance
Targeting AMP-activated protein kinase in adipocytes to modulate obesity-related adipokine production associated with insulin resistance and breast cancer cell proliferation.
Insulin Resistance
The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity.
Insulin Resistance
The AMP-activated protein kinase: role in regulation of skeletal muscle metabolism and insulin sensitivity.
Insulin Resistance
The autophagy protein Becn1 improves insulin sensitivity by promoting adiponectin secretion via exocyst binding.
Insulin Resistance
The Eeffect of Metformin Combined with Calcium-Vitamin D3 Against Diet-Induced Nonalcoholic Fatty Liver Disease.
Insulin Resistance
The emerging role of HDL in glucose metabolism.
Insulin Resistance
The PIKE homolog Centaurin gamma regulates developmental timing in Drosophila.
Insulin Resistance
The role of intramuscular lipid in insulin resistance.
Insulin Resistance
The total phenolic fraction of Anemarrhena asphodeloides inhibits inflammation and reduces insulin resistance in adipocytes via regulation of AMP-kinase activity.
Insulin Resistance
Therapeutic potential of dithiolethiones for hepatic diseases.
Insulin Resistance
Therapy with resveratrol attenuates obesity-associated allergic airway inflammation in mice.
Insulin Resistance
Thiazolidinediones can rapidly activate AMP-activated protein kinase in mammalian tissues.
Insulin Resistance
Timing Matters: Circadian Effects on Energy Homeostasis and Alzheimer's Disease.
Insulin Resistance
Tissue-specific role of glycogen synthase kinase 3beta in glucose homeostasis and insulin action.
Insulin Resistance
Triterpenoid saponins from Stauntonia chinensis ameliorate insulin resistance via the AMP-activated protein kinase and IR/IRS-1/PI3K/Akt pathways in insulin-resistant HepG2 cells.
Insulin Resistance
VASP increases hepatic fatty acid oxidation by activating AMPK in mice.
Insulin Resistance
[Molecular targets for new drug discovery to treat type 2 diabetes and obesity]
Insulin Resistance
[Progress of Research on Mechanism of Acupuncture for Diabetes Mellitus].
Insulinoma
AMP-Activated Protein Kinase and Pancreatic/Duodenal Homeobox-1 Involved in Insulin Secretion under High Leucine Exposure in Rat Insulinoma beta-cells.
Insulinoma
AMP-activated protein kinase and pancreatic/duodenal homeobox-1 involved in insulin secretion under high leucine exposure in rat insulinoma beta-cells.
Insulinoma
The imidazoline compound RX871024 promotes insulinoma cell death independent of AMP-activated protein kinase inhibition.
Intervertebral Disc Displacement
AMP-Activated Protein Kinase Activation in Dorsal Root Ganglion Suppresses mTOR/p70S6K Signaling and Alleviates Painful Radiculopathies in Lumbar Disc Herniation Rat Model.
Intestinal Diseases
Activation of AMPK by chitosan oligosaccharide in intestinal epithelial cells: Mechanism of action and potential applications in intestinal disorders.
Intestinal Diseases
AMP-activated protein kinase: a therapeutic target in intestinal diseases.
Iron Deficiencies
Dietary Iron Deficiency Modulates Adipocyte Iron Homeostasis, Adaptive Thermogenesis, and Obesity in C57BL/6 Mice.
Iron Deficiencies
Iron deficiency attenuates protein synthesis stimulated by branched-chain amino acids and insulin in myotubes.
Iron Deficiencies
Iron deficiency causes a shift in AMP-activated protein kinase (AMPK) subunit composition in rat skeletal muscle.
Iron Deficiencies
Iron Deficiency Reprograms Phosphorylation Signaling and Reduces O-GlcNAc Pathways in Neuronal Cells.
Iron Overload
Enhanced phosphatidylinositol 3-kinase (PI3K)/Akt signaling has pleiotropic targets in hippocampal neurons exposed to iron-induced oxidative stress.
Iron Overload
Secoisolariciresinol diglucoside abrogates oxidative stress-induced damage in cardiac iron overload condition.
Ischemic Stroke
A Dual AMPK/Nrf2 Activator Reduces Brain Inflammation After Stroke by Enhancing Microglia M2 Polarization.
Ischemic Stroke
AMPK-regulated miRNA-210-3p is activated during ischaemic neuronal injury and modulates PI3K-p70S6K signalling.
Ischemic Stroke
Inhibition of microglial receptor-interacting protein kinase 1 ameliorates neuroinflammation following cerebral ischaemic stroke.
Ischemic Stroke
Metformin limits apoptosis in primary rat cortical astrocytes subjected to oxygen and glucose deprivation.
Ischemic Stroke
Metformin prevents stroke damage in non-diabetic female mice with chronic kidney disease.
Ischemic Stroke
Nicotinamide Mononucleotide Adenylyltransferase 1 Protects Neural Cells Against Ischemic Injury in Primary Cultured Neuronal Cells and Mouse Brain with Ischemic Stroke Through AMP-Activated Protein Kinase Activation.
Ischemic Stroke
PDK1 Determines Collagen-Dependent Platelet Ca2+ Signaling and Is Critical to Development of Ischemic Stroke In Vivo.
Keratitis
The Regulating Role of SB216763 in Pseudomonas aeruginosa Keratitis.
Ketosis
Diet-Induced Ketosis Protects Against Focal Cerebral Ischemia in Mouse.
Kidney Calculi
Melatonin inhibits oxalate-induced endoplasmic reticulum stress and apoptosis in HK-2 cells by activating the AMPK pathway.
Kidney Diseases
AMP-activated protein kinase activation ameliorates eicosanoid dysregulation in high-fat-induced kidney disease in mice.
Kidney Diseases
AMP-Activated Protein Kinase as a Reprogramming Strategy for Hypertension and Kidney Disease of Developmental Origin.
Kidney Diseases
Correlation between PKB/Akt, GSK-3? expression and tubular epithelial-mesenchymal transition in renal allografts with chronic active antibody-mediated rejection.
Kidney Diseases
Glycogen synthase kinase 3? hyperactivity in urinary exfoliated cells predicts progression of diabetic kidney disease.
Kidney Diseases
Glycogen synthase kinase 3beta: a novel marker and modulator of inflammatory injury in chronic renal allograft disease.
Kidney Diseases
Metformin: the updated protective property in kidney disease.
Kidney Diseases
Methionine restriction delays senescence and suppresses the senescence-associated secretory phenotype in the kidney through endogenous hydrogen sulfide.
Kidney Diseases
Recent Insights into the Biological Functions of Sestrins in Health and Disease.
Kidney Failure, Chronic
Apparent Correlations Between AMPK Expression and Brain Inflammatory Response and Neurological Function Factors in Rats with Chronic Renal Failure.
Kidney Failure, Chronic
Podocytes maintain high basal levels of autophagy independent of mtor signaling.
Kidney Neoplasms
Fluvastatin potentiates anticancer activity of vorinostat in renal cancer cells.
Kidney Neoplasms
Molecular pathways: Fumarate hydratase-deficient kidney cancer--targeting the Warburg effect in cancer.
Lafora Disease
Laforin, a dual specificity protein phosphatase involved in Lafora disease, is phosphorylated at Ser25 by AMP-activated protein kinase.
Lafora Disease
The laforin-malin complex, involved in Lafora disease, promotes the incorporation of K63-linked ubiquitin chains into AMP-activated protein kinase beta subunits.
Laryngeal Neoplasms
MiR-632 promotes laryngeal carcinoma cell proliferation, migration and invasion through negative regulation of GSK3?.
Leiomyoma
All-trans-retinoic acid mediates changes in PI3K and retinoic acid signaling proteins of leiomyomas.
Leiomyoma
Changes related to phosphatidylinositol 3-kinase/Akt signaling in leiomyomas: possible involvement of glycogen synthase kinase 3alpha and cyclin D2 in the pathophysiology.
Leiomyoma
The antidiabetic drug metformin inhibits uterine leiomyoma cell proliferation via an AMP-activated protein kinase signaling pathway.
Leishmaniasis
Evaluating the Role of Host AMPK in Leishmania Burden.
Leukemia
AMP-activated protein kinase mediates T cell activation-induced expression of FasL and COX-2 via protein kinase C theta-dependent pathway in human Jurkat T leukemia cells.
Leukemia
Betulin, a Newly Characterized Compound in Acacia auriculiformis Bark, Is a Multi-Target Protein Kinase Inhibitor.
Leukemia
BRAF Inhibitors in Thyroid Cancer: Clinical Impact, Mechanisms of Resistance and Future Perspectives.
Leukemia
Combined SRPK and AKT pharmacological inhibition is synergistic in T-cell acute lymphoblastic leukemia cells.
Leukemia
Discovery of Novel Benzothiazepinones as Irreversible Covalent Glycogen Synthase Kinase 3? Inhibitors for the Treatment of Acute Promyelocytic Leukemia.
Leukemia
Galectin-3 mediates bone marrow microenvironment-induced drug resistance in acute leukemia cells via Wnt/ß-catenin signaling pathway.
Leukemia
Generation of integration-free and region-specific neural progenitors from primate fibroblasts.
Leukemia
Highly Expressed Antisense Noncoding RNA in the INK4 Locus Promotes Growth and Invasion of Renal Clear Carcinoma Cells via the ?-Catenin Pathway.
Leukemia
Identification of novel lipid droplet factors that regulate lipophagy and cholesterol efflux in macrophage foam cells.
Leukemia
Increased galectin-3 facilitates leukemia cell survival from apoptotic stimuli.
Leukemia
Indirubin-3-Oxime Effectively Prevents 6OHDA-Induced Neurotoxicity in PC12 Cells via Activating MEF2D Through the Inhibition of GSK3?.
Leukemia
Induction of apoptosis by esculetin in human leukemia U937 cells: Roles of Bcl-2 and extracellular-regulated kinase signaling.
Leukemia
Inhibition of AMP-activated protein kinase pathway sensitizes human leukemia K562 cells to nontoxic concentration of doxorubicin.
Leukemia
Isolation and analysis of candidate myeloid tumor suppressor genes from a commonly deleted segment of 7q22.
Leukemia
Loss of aryl hydrocarbon receptor promotes gene changes associated with premature hematopoietic stem cell exhaustion and development of a myeloproliferative disorder in aging mice.
Leukemia
Metformin Sensitizes Leukemia Cells to Vincristine via Activation of AMP-activated Protein Kinase.
Leukemia
MicroRNA-124 represses wound healing by targeting SERP1 and inhibiting the Wnt/?-catenin pathway.
Leukemia
Pinosylvin enhances leukemia cell death via down-regulation of AMPK? expression.
Leukemia
Potential Antileukemia Effect and Structural Analyses of SRPK Inhibition by N-(2-(Piperidin-1-yl)-5-(Trifluoromethyl)Phenyl)Isonicotinamide (SRPIN340).
Leukemia
RhoA as a mediator of clinically relevant androgen action in prostate cancer cells.
Leukemia
Serine/arginine protein-specific kinase 2 promotes leukemia cell proliferation by phosphorylating acinus and regulating cyclin A1.
Leukemia
Small-Molecule Induction of Canine Embryonic Stem Cells Toward Naïve Pluripotency.
Leukemia
Suppression of glycogen synthase kinase activity is not sufficient for leukemia enhancer factor-1 activation.
Leukemia
Targeting 6-phosphogluconate dehydrogenase in the oxidative PPP sensitizes leukemia cells to antimalarial agent dihydroartemisinin.
Leukemia
The role of autophagy in targeted therapy for acute myeloid leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Adenine causes cell cycle arrest and autophagy of chronic myelogenous leukemia K562 cells via AMP-activated protein kinase signaling.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
GCA links TRAF6-ULK1-dependent autophagy activation in resistant chronic myeloid leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
PIM-1 kinase inhibitor SMI-4a exerts antitumor effects in chronic myeloid leukemia cells by enhancing the activity of glycogen synthase kinase 3?.
Leukemia, Myeloid
Activated Ca2+/calmodulin-dependent protein kinase IIgamma is a critical regulator of myeloid leukemia cell proliferation.
Leukemia, Myeloid, Acute
AMP-activated protein kinase links acetyl-CoA homeostasis to BRD4 recruitment in acute myeloid leukemia.
Leukemia, Myeloid, Acute
Co-activation of AMPK and mTORC1 as a new therapeutic option for acute myeloid leukemia.
Leukemia, Myeloid, Acute
Combination therapy with 5-amino-4-imidazolecarboxamide riboside and arsenic trioxide in acute myeloid leukemia cells involving AMPK/TSC2/mTOR pathway.
Leukemia, Myeloid, Acute
Discovery of novel glycogen synthase kinase-3? inhibitors: Structure-based virtual screening, preliminary SAR and biological evaluation for treatment of acute myeloid leukemia.
Leukemia, Myeloid, Acute
FBW7 Inhibits Myeloid Differentiation in Acute Myeloid Leukemia via GSK3-Dependent Ubiquitination of PU.1.
Leukemia, Myeloid, Acute
GSK3? suppression inhibits MCL1 protein synthesis in human acute myeloid leukemia cells.
Leukemia, Myeloid, Acute
MEK inhibitor CI-1040 induces apoptosis in acute myeloid leukemia cells in vitro.
Leukemia, Myeloid, Acute
Proteolytic systems and AMP-activated protein kinase are critical targets of acute myeloid leukemia therapeutic approaches.
Leukemia, Myeloid, Acute
Role of mTORC1-S6K1 signaling pathway in regulation of hematopoietic stem cell and acute myeloid leukemia.
Leukemia, Myeloid, Acute
Serine/arginine protein-specific kinase 2 promotes leukemia cell proliferation by phosphorylating acinus and regulating cyclin A1.
Leukemia, Myeloid, Acute
The role of autophagy in targeted therapy for acute myeloid leukemia.
Leukemia, Promyelocytic, Acute
Discovery of Novel Benzothiazepinones as Irreversible Covalent Glycogen Synthase Kinase 3? Inhibitors for the Treatment of Acute Promyelocytic Leukemia.
Leukemia, Promyelocytic, Acute
The role of autophagy in targeted therapy for acute myeloid leukemia.
Leukemia, T-Cell
Identification of novel lipid droplet factors that regulate lipophagy and cholesterol efflux in macrophage foam cells.
Leukemia, T-Cell
Inhibition of cyclin-dependent kinase 5 but not of glycogen synthase kinase 3-? prevents neurite retraction and tau hyperphosphorylation caused by secretable products of human T-cell leukemia virus type I-infected lymphocytes.
Leukemia-Lymphoma, Adult T-Cell
Nucleotide sequence analysis of HTLV-I isolate from a Korean patient with HAM/TSP.
Leukodystrophy, Globoid Cell
Expression of Ripk1 and DAM genes correlates with severity and progression of Krabbe disease.
Lipid Metabolism Disorders
The effects of chronic lead exposure on the liver of female Japanese quail (Coturnix japonica): Histopathological damages, oxidative stress and AMP-activated protein kinase based lipid metabolism disorder.
Lipodystrophy
Identification of Potential Biomarkers for Psoriasis by DNA Methylation and Gene Expression Datasets.
Liver Cirrhosis
AMP-activated protein kinase activator, HL156A reduces thioacetamide-induced liver fibrosis in mice and inhibits the activation of cultured hepatic stellate cells and macrophages.
Liver Cirrhosis
Curcumol induces RIPK1/RIPK3 complex-dependent necroptosis via JNK1/2-ROS signaling in hepatic stellate cells.
Liver Cirrhosis
Effects of probiotics on intestinal flora, inflammation and degree of liver cirrhosis in rats with liver cirrhosis by regulating Wnt/?-catenin signaling pathway.
Liver Cirrhosis
Hepatoprotective effects of berberine on liver fibrosis via activation of AMP-activated protein kinase.
Liver Diseases
Activating AMP-activated Protein Kinase Mediates Fibroblast Growth Factor 1 Protection from Nonalcoholic Fatty Liver Disease in Mice.
Liver Diseases
AMPK as a Therapeutic Target for Treating Metabolic Diseases.
Liver Diseases
Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective.
Liver Diseases
Betulinic acid inhibits high-fat diet-induced obesity and improves energy balance by activating AMPK.
Liver Diseases
Calcium and vitamin D3 combinations improve fatty liver disease through AMPK-independent mechanisms.
Liver Diseases
Female mice are more susceptible to non-alcoholic fatty liver disease: sex-specific regulation of the hepatic AMP-activated protein kinase - plasminogen activator inhibitor 1-cascade but not the hepatic endotoxin response.
Liver Diseases
From overnutrition to liver injury: AMP-activated protein kinase in nonalcoholic fatty liver diseases.
Liver Diseases
Genetic Liver-Specific AMPK Activation Protects against Diet-Induced Obesity and NAFLD.
Liver Diseases
Glucoraphanin: a broccoli sprout extract that ameliorates obesity-induced inflammation and insulin resistance.
Liver Diseases
Hepatoprotective Effects of Soybean Embryo by Enhancing Adiponectin-Mediated AMP-Activated Protein Kinase ? Pathway in High-Fat and High-Cholesterol Diet-Induced Nonalcoholic Fatty Liver Disease.
Liver Diseases
Inhibition of receptor-interacting protein kinase 1 improves experimental non-alcoholic fatty liver disease.
Liver Diseases
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
Liver Diseases
Nutrient sensor-mediated programmed nonalcoholic fatty liver disease in low birthweight offspring.
Liver Diseases
Oxyresveratrol ameliorates nonalcoholic fatty liver disease by regulating hepatic lipogenesis and fatty acid oxidation through liver kinase B1 and AMP-activated protein kinase.
Liver Diseases
Peroxiredoxin 5 ameliorates obesity-induced non-alcoholic fatty liver disease through the regulation of oxidative stress and AMP-activated protein kinase signaling.
Liver Diseases
Plant sterol ester of ?-linolenic acid ameliorates high-fat diet-induced nonalcoholic fatty liver disease in mice: association with regulating mitochondrial dysfunction and oxidative stress via activating AMPK signaling.
Liver Diseases
Resveratrol improves non-alcoholic fatty liver disease by activating AMP-activated protein kinase.
Liver Diseases
Signal Transduction and Molecular Regulation in Fatty Liver Disease.
Liver Diseases
The emerging role of AMP-activated protein kinase in cholestatic liver diseases.
Liver Diseases
The role of lipid metabolism in the pathogenesis of alcoholic and nonalcoholic hepatic steatosis.
Liver Diseases
Transcriptomic Analysis of Porcine Granulosa Cells Overexpressing Retinol Binding Protein 4.
Liver Diseases
TXNIP/VDUP1 attenuates steatohepatitis via autophagy and fatty acid oxidation.
Liver Diseases, Alcoholic
AMPK protects against alcohol-induced liver injury through UQCRC2 to up-regulate mitophagy.
Liver Diseases, Alcoholic
Inhibition of cereblon by fenofibrate ameliorates alcoholic liver disease by enhancing AMPK.
Liver Diseases, Alcoholic
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
Liver Diseases, Alcoholic
The role of lipid metabolism in the pathogenesis of alcoholic and nonalcoholic hepatic steatosis.
Liver Failure
Cannabinoids ameliorate cerebral dysfunction following liver failure via AMP-activated protein kinase.
Liver Failure, Acute
Endoplasmic Reticulum Stress-Activated Glycogen Synthase Kinase 3? Aggravates Liver Inflammation and Hepatotoxicity in Mice with Acute Liver Failure.
Liver Failure, Acute
Inhibition of glycogen synthase kinase 3? promotes autophagy to protect mice from acute liver failure mediated by peroxisome proliferator-activated receptor ?.
Liver Failure, Acute
Oxidative stress promotes D-GalN/LPS-induced acute hepatotoxicity by increasing glycogen synthase kinase 3? activity.
Liver Failure, Acute
[Protective effect of glycogen synthase kinase 3? inhibition via peroxisome proliferator-activated receptor alpha activation in mice with acute liver failure].
Liver Failure, Acute
[Role of endoplasmic reticulum stress-mediated glycogen synthase kinase 3? activity in pathogenesis of acute liver failure in mice].
Liver Neoplasms
Activation of AMP-activated Protein Kinase and Phosphorylation of Glycogen Synthase Kinase3 ? Mediate Ursolic Acid Induced Apoptosis in HepG2 Liver Cancer Cells.
Liver Neoplasms
Adiponectin accounts for gender differences in hepatocellular carcinoma incidence.
Liver Neoplasms
Anticancer Effect of ERM210 on Liver Cancer Cells Through ROS/Mitochondria-dependent Apoptosis Signaling Pathways.
Liver Neoplasms
HCAR1/MCT1 Regulates Tumor Ferroptosis through the Lactate-Mediated AMPK-SCD1 Activity and Its Therapeutic Implications.
Liver Neoplasms
MET Inhibitors Promote Liver Tumor Evasion of the Immune Response by Stabilizing PDL1.
Liver Neoplasms
Metformin Resensitizes Sorafenib-Resistant HCC Cells Through AMPK-Dependent Autophagy Activation.
Lung Diseases
Recent Insights into the Biological Functions of Sestrins in Health and Disease.
Lung Injury
AMP-activated protein kinase and Glycogen Synthase Kinase 3? modulate the severity of sepsis-induced lung injury.
Lung Injury
AMP-activated protein kinase deficiency reduces ozone-induced lung injury and oxidative stress in mice.
Lung Injury
Decreased AMP-activated protein kinase (AMPK) function and protective effect of metformin in neonatal rat pups exposed to hyperoxia lung injury.
Lung Injury
Genipin attenuates hyperoxia-induced lung injury and pulmonary hypertension via targeting glycogen synthase kinase-3 ? in neonatal rats.
Lung Injury
Inhibition of AMP-Activated Protein Kinase Accentuates Lipopolysaccharide-Induced Lung Endothelial Barrier Dysfunction and Lung Injury in Vivo.
Lung Injury
Inhibition of necroptosis attenuates lung injury and improves survival in neonatal sepsis.
Lung Injury
Metformin protects against PM2.5-induced lung injury and cardiac dysfunction independent of AMP-activated protein kinase ?2.
Lung Injury
Myeloid-Restricted AMPK?1 Promotes Host Immunity and Protects against IL-12/23p40-Dependent Lung Injury during Hookworm Infection.
Lung Neoplasms
Activation of AMP-activated protein kinase sensitizes lung cancer cells and H1299 xenografts to erlotinib.
Lung Neoplasms
AMP-activated protein kinase (AMPK) activation is involved in chrysin-induced growth inhibition and apoptosis in cultured A549 lung cancer cells.
Lung Neoplasms
AMP-activated Protein Kinase (AMPK) Control of mTORC1 Is p53- and TSC2-independent in Pemetrexed-treated Carcinoma Cells.
Lung Neoplasms
AMP-activated protein kinase ?1 serves a carcinogenic role via regulation of vascular endothelial growth factor expression in patients with non-small cell lung cancer.
Lung Neoplasms
AMPK-Mediated Lysosome Biogenesis in Lung Cancer Growth.
Lung Neoplasms
Anticancer effects of epigallocatechin-3-gallate nanoemulsion on lung cancer cells through the activation of AMP-activated protein kinase signaling pathway.
Lung Neoplasms
Circular RNA circHIPK3 modulates autophagy via MIR124-3p-STAT3-PRKAA/AMPK? signaling in STK11 mutant lung cancer.
Lung Neoplasms
Cytotoxicity and Proteomics Analyses of OSU03013 in Lung Cancer.
Lung Neoplasms
Downregulation of SRPK2 promotes cell cycle arrest though E2F1 in non-small cell lung cancer.
Lung Neoplasms
Fibulin-3 suppresses Wnt/?-catenin signaling and lung cancer invasion.
Lung Neoplasms
Implication of AMP-activated protein kinase and Akt-regulated survivin in lung cancer chemopreventive activities of deguelin.
Lung Neoplasms
Induction of cytoprotective autophagy by morusin via AMP-activated protein kinase activation in human non-small cell lung cancer cells.
Lung Neoplasms
LCAL1 enhances lung cancer survival via inhibiting AMPK-related antitumor functions.
Lung Neoplasms
LKB1 promotes metabolic flexibility in response to energy stress.
Lung Neoplasms
Metformin prevents tobacco carcinogen--induced lung tumorigenesis.
Lung Neoplasms
Microarray data re-annotation reveals specific lncRNAs and their potential functions in non-small cell lung cancer subtypes.
Lung Neoplasms
miR-135a inhibits malignant proliferation and diffusion of non-small cell lung cancer cells by down-regulating ROCK1 protein.
Lung Neoplasms
MiR-98 inhibits cell proliferation and invasion of non-small cell carcinoma lung cancer by targeting PAK1.
Lung Neoplasms
PCNA and GSK3? interact with each other to regulate H1299 lung adenocarcinoma cells apoptosis.
Lung Neoplasms
Phenolic compound ellagic acid inhibits mitochondrial respiration and tumor growth in lung cancer.
Lung Neoplasms
Repression of phosphoinositide-dependent protein kinase 1 expression by ciglitazone via Egr-1 represents a new approach for inhibition of lung cancer cell growth.
Lung Neoplasms
Targeting 3-phosphoinositide-dependent protein kinase 1 by N-acetyl-cysteine through activation of peroxisome proliferators activated receptor alpha in human lung cancer cells, the role of p53 and p65.
Lung Neoplasms
The impact of phosphorylated AMP-activated protein kinase expression on lung cancer survival.
Lung Neoplasms
The influence of circular RNAs on autophagy and disease progression.
Lung Neoplasms
The relationship between energy status and AMP-activated protein kinase in human H460 lung cancer cells.
Lung Neoplasms
TMEM158 and FBLP1 as novel marker genes of cisplatin sensitivity in non-small cell lung cancer cells.
Lung Neoplasms
Up-regulation of SRPK1 in non-small cell lung cancer promotes the growth and migration of cancer cells.
Lung Neoplasms
[Effect of DAPK1 gene transfection on high-metastasis non-small lung cancer cell PGCl3]
Lung Neoplasms
[Effects of nm23-H1 point mutation on activity of GSK-3? in human high-metastatic large cell lung cancer cell line L9981.]
Lung Neoplasms
[Transfection of tumor metastasis suppressor gene nm23-H1 can up-regulate the activity of GSK-3? in human high-metastasis large cell lung cancer cell line L9981.]
Lupus Erythematosus, Systemic
Immunometabolic Pathways and Its Therapeutic Implication in Autoimmune Diseases.
Lupus Erythematosus, Systemic
[AMPK over-expression inhibits proliferation, matrix synthesis and inflammation response of glomerular mesangial cells in pristine-induced lupus mice].
Lupus Nephritis
Lupus nephritis: Glycogen synthase kinase 3? promotes renal damage through activation of NLRP3 inflammasome in lupus-prone mice.
Lymphoma
Akt GSK-3 pathway as a target in genistein-induced inhibition of TRAMP prostate cancer progression toward a poorly differentiated phenotype.
Lymphoma
Eaf2 protects human lens epithelial cells against oxidative stress?induced apoptosis by Wnt signaling.
Lymphoma
Lymphotoxin alfa and receptor-interacting protein kinase 1 gene polymorphisms may correlate with prognosis in patients with diffuse large B cell lymphoma treated with R-CHOP.
Lymphoma
Neuroprotective Effects of Acetyl-L-Carnitine Against Oxygen-Glucose Deprivation-Induced Neural Stem Cell Death.
Lymphoma
Phosphoinositide-dependent protein kinase 1 is a potential novel therapeutic target in mantle cell lymphoma.
Lymphoma
Songorine suppresses cell growth and metastasis in epithelial ovarian cancer via the Bcl?2/Bax and GSK3?/??catenin signaling pathways.
Lymphoma, B-Cell
Apoptotic effect of lambertianic acid through AMPK/FOXM1 signaling in MDA-MB231 breast cancer cells.
Lymphoma, B-Cell
Betaine ameliorates impaired steroidogenesis and apoptosis in mice granulosa cells induced by high glucose concentration.
Lymphoma, B-Cell
Coenzyme Q10 protects neural stem cells against hypoxia by enhancing survival signals.
Lymphoma, B-Cell
Concerted outcome of metformin and low dose of radiation in modulation of cisplatin induced uremic encephalopathy via renal and neural preservation.
Lymphoma, B-Cell
ER?36 gene silencing promotes tau protein phosphorylation, inhibits cell proliferation, and induces apoptosis in human neuroblastoma SH-SY5Y cells.
Lymphoma, B-Cell
Lymphotoxin alfa and receptor-interacting protein kinase 1 gene polymorphisms may correlate with prognosis in patients with diffuse large B cell lymphoma treated with R-CHOP.
Lymphoma, B-Cell
Modulation of Autophagy by Sorafenib: Effects on Treatment Response.
Lymphoma, B-Cell
Neuroprotective Effects of Acetyl-L-Carnitine Against Oxygen-Glucose Deprivation-Induced Neural Stem Cell Death.
Lymphoma, B-Cell
Phosphatase and Tensin Homolog Deleted on Chromosome Ten Knockdown Attenuates Cognitive Deficits by Inhibiting Neuroinflammation in a Mouse Model of Perioperative Neurocognitive Disorder.
Lymphoma, B-Cell
Phosphoinositide-dependent protein kinase 1 is a potential novel therapeutic target in mantle cell lymphoma.
Lymphoma, B-Cell
Vascular Endothelial Growth Factor Isoform-B Stimulates Neurovascular Repair After Ischemic Stroke by Promoting the Function of Pericytes via Vascular Endothelial Growth Factor Receptor-1.
Lymphoma, Follicular
Phosphoinositide-dependent protein kinase 1 is a potential novel therapeutic target in mantle cell lymphoma.
Lymphoma, Large B-Cell, Diffuse
Lymphotoxin alfa and receptor-interacting protein kinase 1 gene polymorphisms may correlate with prognosis in patients with diffuse large B cell lymphoma treated with R-CHOP.
Lymphoma, Large B-Cell, Diffuse
Phosphoinositide-dependent protein kinase 1 is a potential novel therapeutic target in mantle cell lymphoma.
Lymphoma, Mantle-Cell
Phosphoinositide-dependent protein kinase 1 is a potential novel therapeutic target in mantle cell lymphoma.
Lymphoma, Non-Hodgkin
Association of AMP-activated Protein Kinase with Risk and Progression of Non-Hodgkin Lymphoma.
Lymphoma, T-Cell
Akt GSK-3 pathway as a target in genistein-induced inhibition of TRAMP prostate cancer progression toward a poorly differentiated phenotype.
Lysosomal Storage Diseases
Contractile activity attenuates autophagy suppression and reverses mitochondrial defects in skeletal muscle cells.
Macular Degeneration
Angiotensin II-induced MMP-2 activity and MMP-14 and basigin protein expression are mediated via the angiotensin II receptor type 1-mitogen-activated protein kinase 1 pathway in retinal pigment epithelium implications for age-related macular degeneration.
Macular Degeneration
Longitudinal phenotypic study of late-onset retinal degeneration due to a founder variant c.562C>A p.(Pro188Thr) in the C1QTNF5 gene.
Macular Degeneration
Protective effect of RIPK1-inhibitory compound in in vivo models for retinal degenerative disease.
Malaria
Calcium dependent protein kinase 1 and calcium fluxes in the malaria parasite.
Malaria, Cerebral
AMP-activated protein kinase (AMPK) is decreased in the mouse brain during experimental cerebral malaria.
Mania
Sigma 1 Receptor Antagonists Inhibit Manic-Like Behaviors in Two Congenital Strains of Mice.
Mania
The impact of glycogen synthase kinase 3? gene on psychotic mania in bipolar disorder patients.
Mania
The interaction of GSK3B and FXR1 genotypes may influence the mania and depression dimensions in mood disorders.
Massive Hepatic Necrosis
AMP-activated protein kinase agonist N
Medulloblastoma
AMP-Activated Protein Kinase Directly Phosphorylates and Destabilizes Hedgehog Pathway Transcription Factor GLI1 in Medulloblastoma.
Medulloblastoma
Small-molecule inhibitors of phosphatidylinositol 3-kinase/Akt signaling inhibit Wnt/beta-catenin pathway cross-talk and suppress medulloblastoma growth.
Melanoma
3-Methyladenine prevents energy stress-induced necrotic death of melanoma cells through autophagy-independent mechanisms.
Melanoma
A derivative of 2-aminothiazole inhibits melanogenesis in B16 mouse melanoma cells via glycogen synthase kinase 3? phosphorylation.
Melanoma
A novel adamantyl benzylbenzamide derivative, AP736, inhibits melanogenesis in B16F10 mouse melanoma cells via glycogen synthase kinase 3? phosphorylation.
Melanoma
Absence of mutations of the BRAF gene and constitutive activation of extracellular-regulated kinase in malignant melanomas of the uvea.
Melanoma
ACTN4 regulates the stability of RIPK1 in melanoma.
Melanoma
AMPK activation by GSK621 inhibits human melanoma cells in vitro and in vivo.
Melanoma
AMPK promotes tolerance to Ras pathway inhibition by activating autophagy.
Melanoma
Compound 13, an ?1-selective small molecule activator of AMPK, potently inhibits melanoma cell proliferation.
Melanoma
Compound C Inhibits B16-F1 Tumor Growth in a Syngeneic Mouse Model Via the Blockage of Cell Cycle Progression and Angiogenesis.
Melanoma
Encorafenib (LGX818), a potent BRAF inhibitor, induces senescence accompanied by autophagy in BRAFV600E melanoma cells.
Melanoma
GSK3? Inhibition Blocks Melanoma Cell/Host Interactions by Downregulating N-Cadherin Expression and Decreasing FAK Phosphorylation.
Melanoma
Honokiol affects melanoma cell growth by targeting the AMP-activated protein kinase signaling pathway.
Melanoma
Identification of glycogen synthase kinase 3? as a therapeutic target in melanoma.
Melanoma
Inhibition of retinoic acid receptor ? signaling confers glycolytic dependence and sensitization to dichloroacetate in melanoma cells.
Melanoma
Insulin-like growth factor I-stimulated melanoma cell migration requires phosphoinositide 3-kinase but not extracellular-regulated kinase activation.
Melanoma
Involvement of ER stress and activation of apoptotic pathways in fisetin induced cytotoxicity in human melanoma.
Melanoma
Knockdown of MAGEA6 Activates AMP-Activated Protein Kinase (AMPK) Signaling to Inhibit Human Renal Cell Carcinoma Cells.
Melanoma
LncRNA HAND2-AS1 overexpression inhibits cancer cell proliferation in melanoma by downregulating ROCK1.
Melanoma
MAGEA6 promotes human glioma cell survival via targeting AMPK?1.
Melanoma
Metformin accelerates the growth of BRAF V600E-driven melanoma by upregulating VEGF-A.
Melanoma
miR-1273g silences MAGEA3/6 to inhibit human colorectal cancer cell growth via activation of AMPK signaling.
Melanoma
MiR-769 promoted cell proliferation in human melanoma by suppressing GSK3B expression.
Melanoma
Mps1 is associated with the BRAFV600E mutation and predicts poor outcome in patients with colorectal cancer.
Melanoma
Phosphoproteomic analysis of basal and therapy-induced adaptive signaling networks in BRAF and NRAS mutant melanoma.
Melanoma
Proteome Analysis of USP7 Substrates Revealed Its Role in Melanoma Through PI3K/Akt/FOXO and AMPK Pathways.
Melanoma
Tuberous sclerosis complex inactivation disrupts melanogenesis via mTORC1 activation.
Melanoma, Experimental
Activation of AMP-activated protein kinase is involved in vincristine-induced cell apoptosis in B16 melanoma cell.
Melanoma, Experimental
Relapse of Nephrotic Syndrome after Adrenocorticotropic Hormone-Induced Remission: Implications of Adrenocorticotropic Hormone Antibodies.
MELAS Syndrome
Critical role of AMP-activated protein kinase in the balance between mitophagy and mitochondrial biogenesis in MELAS disease.
Memory Disorders
Cotinine improves visual recognition memory and decreases cortical Tau phosphorylation in the Tg6799 mice.
Memory Disorders
Delta-secretase (AEP) mediates tau-splicing imbalance and accelerates cognitive decline in tauopathies.
Memory Disorders
Experimental induction of type 2 diabetes in aging-accelerated mice triggered Alzheimer-like pathology and memory deficits.
Memory Disorders
GSK-3 is essential in the pathogenesis of Alzheimer's disease.
Memory Disorders
Ludwigia octovalvis extract improves glycemic control and memory performance in diabetic mice.
Memory Disorders
Resveratrol Attenuates Obesity-Associated Peripheral and Central Inflammation and Improves Memory Deficit in Mice Fed a High-Fat Diet.
Mesothelioma
Ras pathway activation in malignant mesothelioma.
Metabolic Diseases
(Healthy) ageing: focus on iodothyronines.
Metabolic Diseases
3-Caffeoyl, 4-dihydrocaffeoylquinic acid from Salicornia herbacea attenuates high glucose-induced hepatic lipogenesis in human HepG2 cells through activation of the liver kinase B1 and silent information regulator T1/AMPK-dependent pathway.
Metabolic Diseases
A 5' AMP-Activated Protein Kinase Enzyme Activator, Compound 59, Induces Autophagy and Apoptosis in Human Oral Squamous Cell Carcinoma.
Metabolic Diseases
Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models.
Metabolic Diseases
Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice.
Metabolic Diseases
Berberine activates AMPK to suppress proteolytic processing, nuclear translocation and target DNA binding of SREBP-1c in 3T3-L1 adipocytes.
Metabolic Diseases
Cetylpyridinium chloride is a potent AMP-activated kinase (AMPK) inducer and has therapeutic potential in cancer.
Metabolic Diseases
Characterization of the CaMKK?-AMPK signaling complex.
Metabolic Diseases
Conformational heterogeneity of the allosteric drug and metabolite (ADaM) site in AMP-activated protein kinase (AMPK).
Metabolic Diseases
Cordycepin Ameliorates Nonalcoholic Steatohepatitis by Activation of the AMP-Activated Protein Kinase Signaling Pathway.
Metabolic Diseases
Detection of AMP-activated protein kinase ?1 by isoelectric focusing in sera of patients with metabolic diseases.
Metabolic Diseases
Exercise-induced myokines in health and metabolic diseases.
Metabolic Diseases
Fluvastatin activates sirtuin 6 to regulate sterol regulatory element-binding proteins and AMP-activated protein kinase in HepG2 cells.
Metabolic Diseases
Genetic Liver-Specific AMPK Activation Protects against Diet-Induced Obesity and NAFLD.
Metabolic Diseases
Knockdown of Human AMPK Using the CRISPR/Cas9 Genome-Editing System.
Metabolic Diseases
Metformin: the updated protective property in kidney disease.
Metabolic Diseases
Petasin activates AMP-activated protein kinase and modulates glucose metabolism.
Metabolic Diseases
Pharmacological Targeting of AMP-Activated Protein Kinase and Opportunities for Computer-Aided Drug Design.
Metabolic Diseases
Salt-Inducible Kinase 3 Promotes Vascular Smooth Muscle Cell Proliferation and Arterial Restenosis by Regulating AKT and PKA-CREB Signaling.
Metabolic Diseases
Small molecule drug A-769662 and AMP synergistically activate naive AMPK independent of upstream kinase signaling.
Metabolic Diseases
Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states.
Metabolic Diseases
The effects of troglitazone on AMPK in HepG2 cells.
Metabolic Diseases
The emerging role of AMP-activated protein kinase in cholestatic liver diseases.
Metabolic Diseases
Unraveling the actions of AMP-activated protein kinase in metabolic diseases: Systemic to molecular insights.
Metabolic Syndrome
Activation of AMPK by berberine induces hepatic lipid accumulation by upregulation of fatty acid translocase CD36 in mice.
Metabolic Syndrome
AMP-activated protein kinase (AMPK) activation by benzofurans and coumestans isolated from Erythrina abyssinica.
Metabolic Syndrome
AMP-activated protein kinase (AMPK) activators from Myristica fragrans (nutmeg) and their anti-obesity effect.
Metabolic Syndrome
AMP-activated protein kinase and the metabolic syndrome.
Metabolic Syndrome
AMP-independent activator of AMPK for treatment of mitochondrial disorders.
Metabolic Syndrome
AMPK: a key regulator of energy balance in the single cell and the whole organism.
Metabolic Syndrome
Antidiabetes and antiobesity effect of cryptotanshinone via activation of AMP-activated protein kinase.
Metabolic Syndrome
Calpain inhibition modulates glycogen synthase kinase 3? pathways in ischemic myocardium: A proteomic and mechanistic analysis.
Metabolic Syndrome
Correction to: HMGCoA reductase inhibition reverses myocardial fibrosis and diastolic dysfunction through AMP-activated protein kinase activation in a mouse model of metabolic syndrome.
Metabolic Syndrome
Corrigendum to: HMGCoA reductase inhibition reverses myocardial fibrosis and diastolic dysfunction through AMP-activated protein kinase activation in a mouse model of metabolic syndrome.
Metabolic Syndrome
Dietary Aloe Reduces Adipogenesis via the Activation of AMPK and Suppresses Obesity-related Inflammation in Obese Mice.
Metabolic Syndrome
Drug repurposing in alternative medicine: herbal digestive Sochehwan exerts multifaceted effects against metabolic syndrome.
Metabolic Syndrome
Emerging Role of Metabolic Signaling in Synovial Joint Remodeling and Osteoarthritis.
Metabolic Syndrome
Glycogen Synthase Kinase 3? Inhibition Improves Myocardial Angiogenesis and Perfusion in a Swine Model of Metabolic Syndrome.
Metabolic Syndrome
Glycogen synthase kinase 3? inhibition reduces mitochondrial oxidative stress in chronic myocardial ischemia.
Metabolic Syndrome
HMGCoA reductase inhibition reverses myocardial fibrosis and diastolic dysfunction through AMP-activated protein kinase activation in a mouse model of metabolic syndrome.
Metabolic Syndrome
Icariin enhances AMP-activated protein kinase and prevents high fructose and high salt-induced metabolic syndrome in rats.
Metabolic Syndrome
Interleukin-6 regulation of AMP-activated protein kinase. Potential role in the systemic response to exercise and prevention of the metabolic syndrome.
Metabolic Syndrome
Long-Term Impact of Neonatal Intake of Oleanolic Acid on the Expression of AMP-Activated Protein Kinase, Adiponectin and Inflammatory Cytokines in Rats Fed with a High Fructose Diet.
Metabolic Syndrome
Mechanisms of body weight reduction and metabolic syndrome alleviation by tea.
Metabolic Syndrome
Metformin prevents vascular prostanoid release alterations induced by a high-fat diet in rats.
Metabolic Syndrome
Naringin ameliorates metabolic syndrome by activating AMP-activated protein kinase in mice fed a high-fat diet.
Metabolic Syndrome
Nootkatone, a characteristic constituent of grapefruit, stimulates energy metabolism and prevents diet-induced obesity by activating AMPK.
Metabolic Syndrome
Novel Small-Molecule AMP-Activated Protein Kinase Allosteric Activator with Beneficial Effects in db/db Mice.
Metabolic Syndrome
Novel small-molecule AMPK activator orally exerts beneficial effects on diabetic db/db mice.
Metabolic Syndrome
Protection against the Metabolic Syndrome by Guar Gum-Derived Short-Chain Fatty Acids Depends on Peroxisome Proliferator-Activated Receptor ? and Glucagon-Like Peptide-1.
Metabolic Syndrome
Purification and Characterization of Truncated Human AMPK alpha2beta2gamma3 Heterotrimer from Baculovirus-Infected Insect Cells.
Metabolic Syndrome
Role of AMP-activated protein kinase in the metabolic syndrome and in heart disease.
Metabolic Syndrome
SIRT3-AMP-Activated Protein Kinase Activation by Nitrite and Metformin Improves Hyperglycemia and Normalizes Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction.
Metabolic Syndrome
Structural basis for compound C inhibition of the human AMP-activated protein kinase ?2 subunit kinase domain.
Microphthalmos
WIPI1 Coordinates Melanogenic Gene Transcription and Melanosome Formation via TORC1 Inhibition.
Mitochondrial Diseases
Diverse cytopathologies in mitochondrial disease are caused by AMP-activated protein kinase signaling.
Mitochondrial Diseases
Legionella pneumophila multiplication is enhanced by chronic AMPK signalling in mitochondrially diseased Dictyostelium cells.
Mitochondrial Diseases
Ndufaf5 deficiency in the Dictyostelium model: new roles in autophagy and development.
Mitochondrial Diseases
Role of AMPK-mediated adaptive responses in human cells with mitochondrial dysfunction to oxidative stress.
Motor Neuron Disease
Reduced activity of AMP-activated protein kinase protects against genetic models of motor neuron disease.
Mouth Neoplasms
Reversion-inducing cysteine-rich protein with Kazal motifs and its regulation by glycogen synthase kinase 3 signaling in oral cancer.
Mouth Neoplasms
The dietary phytochemical 3,3'-diindolylmethane induces G2/M arrest and apoptosis in oral squamous cell carcinoma by modulating Akt-NF-?B, MAPK, and p53 signaling.
Movement Disorders
The crystal structure of the catalytic domain of tau tubulin kinase 2 in complex with a small-molecule inhibitor.
Movement Disorders
TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development.
Multiple Myeloma
Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells.
Multiple Myeloma
Reactive Oxygen Species-Mediated Activation of AMP-Activated Protein Kinase and c-Jun N-terminal Kinase Plays a Critical Role in Beta-Sitosterol-Induced Apoptosis in Multiple Myeloma U266 cells.
Multiple Sclerosis
Inactive GSK3? is disturbed in the spinal cord during experimental autoimmune encephalomyelitis, but rescued by stem cell therapy.
Multiple Sclerosis
Potential involvement of glycogen synthase kinase (GSK)-3? in a rat model of multiple sclerosis: evidenced by lithium treatment.
Multiple Sclerosis
RIPK1 activation mediates neuroinflammation and disease progression in multiple sclerosis.
Multiple System Atrophy
Increased prefrontal cortex interleukin-2 protein levels and shift in the peripheral T cell population in progressive supranuclear palsy patients.
Muscular Atrophy
Advanced glycation end-products induce skeletal muscle atrophy and dysfunction in diabetic mice via a RAGE-mediated, AMPK-down-regulated, Akt pathway.
Muscular Atrophy
AMP-activated protein kinase agonists increase mRNA content of the muscle-specific ubiquitin ligases MAFbx and MuRF1 in C2C12 cells.
Muscular Atrophy
Asparagine reduces the mRNA expression of muscle atrophy markers via regulating protein kinase B (Akt), AMP-activated protein kinase ?, toll-like receptor 4 and nucleotide-binding oligomerisation domain protein signalling in weaning piglets after lipopolysaccharide challenge.
Muscular Atrophy
Effect of Deer Antler Extract on Muscle Differentiation and 5-Aminoimidazole-4-Carboxamide Ribonucleoside (AICAR)-Induced Muscle Atrophy in C2C12 Cells.
Muscular Atrophy
Insulin prevents and reverts simvastatin-induced toxicity in C2C12 skeletal muscle cells.
Muscular Atrophy
Protein arginine methyltransferase expression, localization, and activity during disuse-induced skeletal muscle plasticity.
Muscular Atrophy
Pseudomonas aeruginosa Quorum Sensing Molecule Alters Skeletal Muscle Protein Homeostasis by Perturbing the Antioxidant Defense System.
Muscular Atrophy
[High frequency electrical stimulation of sciatic nerve enhances skeletal muscle autophagy in mice].
Muscular Diseases
Biochemical and genetic evaluation of the role of AMP-activated protein kinase in polysaccharide storage myopathy in Quarter Horses.
Muscular Disorders, Atrophic
PGC-1?-Targeted Therapeutic Approaches to Enhance Muscle Recovery in Aging.
Muscular Dystrophies, Limb-Girdle
Myostatin inhibition promotes fast fibre hypertrophy but causes loss of AMP-activated protein kinase signalling and poor exercise tolerance in a model of limb-girdle muscular dystrophy R1/2A.
Muscular Dystrophy, Duchenne
AMP-activated protein kinase at the nexus of therapeutic skeletal muscle plasticity in Duchenne muscular dystrophy.
Muscular Dystrophy, Duchenne
Effect of a long-term treatment with metformin in dystrophic mdx mice: A reconsideration of its potential clinical interest in Duchenne muscular dystrophy.
Muscular Dystrophy, Duchenne
Metformin increases peroxisome proliferator-activated receptor ? Co-activator-1? and utrophin a expression in dystrophic skeletal muscle.
Myasthenia Gravis
A dual altered peptide ligand inhibits myasthenia gravis associated responses by inducing phosphorylated extracellular-regulated kinase 1,2 that upregulates CD4+CD25+Foxp3+ cells.
Myelodysplastic Syndromes
The role of autophagy in targeted therapy for acute myeloid leukemia.
Myocardial Infarction
AMP-activated protein kinase sparks the fire of cardioprotection against myocardial ischemia and cardiac ageing.
Myocardial Infarction
Chronic treatment with metformin suppresses toll-like receptor 4 signaling and attenuates left ventricular dysfunction following myocardial infarction.
Myocardial Infarction
Dapagliflozin attenuates arrhythmic vulnerabilities by regulating connexin43 expression via the AMPK pathway in post-infarcted rat hearts.
Myocardial Infarction
Disruption of TAB1/p38? Interaction Using a Cell-permeable Peptide Limits Myocardial Ischemia/Reperfusion Injury.
Myocardial Infarction
Inhibition of glycogen synthase kinase enhances isoflurane-induced protection against myocardial infarction during early reperfusion in vivo.
Myocardial Infarction
Letter to the editor regarding article, "Role of glycogen synthase kinase following myocardial infarction and ischemia-reperfusion".
Myocardial Infarction
Loss of Adult Cardiac Myocyte GSK-3 Leads to Mitotic Catastrophe Resulting in Fatal Dilated Cardiomyopathy.
Myocardial Infarction
Metformin attenuates myocardial remodeling and neutrophil recruitment after myocardial infarction in rat.
Myocardial Infarction
MMP9 inhibition increases autophagic flux in chronic heart failure.
Myocardial Infarction
Overexpression of protein phosphatase 2A in a murine model of chronic myocardial infarction leads to increased adverse remodeling but restores the regulation of ?-catenin by glycogen synthase kinase 3?
Myocardial Infarction
Protective Effects of Erythropoietin on Myocardial Infarction in Rats: The Role of AMP-Activated Protein Kinase Signaling Pathway.
Myocardial Infarction
Role of glycogen synthase kinase following myocardial infarction and ischemia-reperfusion.
Myocardial Infarction
Sevoflurane postconditioning reduces myocardial ischemia reperfusion injury-induced necroptosis by up-regulation of OGT-mediated O-GlcNAcylated RIPK3.
Myocardial Infarction
The potential effects of anti-diabetic medications on myocardial ischemia-reperfusion injury.
Myocardial Ischemia
Activated protein C: a potential cardioprotective factor against ischemic injury during ischemia/reperfusion.
Myocardial Ischemia
Activated protein C modulates cardiac metabolism and augments autophagy in the ischemic heart.
Myocardial Ischemia
Activation of cardiac AMPK-FGF21 feed-forward loop in acute myocardial infarction: Role of adrenergic overdrive and lipolysis byproducts.
Myocardial Ischemia
Acute metformin therapy confers cardioprotection against myocardial infarction via AMPK-eNOS-mediated signaling.
Myocardial Ischemia
AMP-activated protein kinase sparks the fire of cardioprotection against myocardial ischemia and cardiac ageing.
Myocardial Ischemia
Calpain inhibition modulates glycogen synthase kinase 3? pathways in ischemic myocardium: A proteomic and mechanistic analysis.
Myocardial Ischemia
Cardioprotective actions of Notch1 against myocardial infarction via LKB1-dependent AMPK signaling pathway.
Myocardial Ischemia
Dual mechanisms regulating AMPK kinase action in the ischemic heart.
Myocardial Ischemia
Fisetin Confers Cardioprotection against Myocardial Ischemia Reperfusion Injury by Suppressing Mitochondrial Oxidative Stress and Mitochondrial Dysfunction and Inhibiting Glycogen Synthase Kinase 3? Activity.
Myocardial Ischemia
Glycogen synthase kinase 3? inhibition reduces mitochondrial oxidative stress in chronic myocardial ischemia.
Myocardial Ischemia
Hydrogen sulfide protects against myocardial ischemia and reperfusion injury by activating AMP-activated protein kinase to restore autophagic flux.
Myocardial Ischemia
RNA sequencing revealing the role of AMP-activated protein kinase signaling in mice myocardial ischemia reperfusion injury.
Myocardial Ischemia
The Cardioprotective Signaling Activity of Activated Protein C in Heart Failure and Ischemic Heart Diseases.
Myocardial Ischemia
The relationship between p38 mitogen-activated protein kinase and AMP-activated protein kinase during myocardial ischemia.
Myocardial Ischemia
Translocation of myocardial GLUT-4 and increased glucose uptake through activation of AMPK by AICAR.
Myocardial Ischemia
Vagal stimulation mimics preconditioning and postconditioning of ischemic myocardium in mice by activating different protection mechanisms.
Myocardial Ischemia
[Effect of electroacupuncture preconditioning of "Neiguan"(PC6) on myocardial LKB1/AMPK/PFK2 pathway in myocardial ischemia rats].
Myocardial Ischemia
[Electroacupuncture for myocardial ischemia injury in rats via AMPK-HDAC5-HIF-1? signaling].
Myocardial Stunning
Ischemic preconditioning activates AMPK in a PKC-dependent manner and induces GLUT4 up-regulation in the late phase of cardioprotection.
Myotonic Dystrophy
Irreversible Activation of Rho-activated Kinases Resulted from Evolution of Proteolytic Sites within Disordered Regions in Coiled-coil Domain.
Nasal Polyps
Critical link between glycogen synthase kinase 3? and forkhead box P3 in patients with chronic rhinosinusitis with nasal polyps.
Nasopharyngeal Carcinoma
Clinicopathological significance of ROCK1 and PIK3CA expression in nasopharyngeal carcinoma.
Nasopharyngeal Carcinoma
CRISPR/Cas9-mediated double knockout of SRPK1 and SRPK2 in a nasopharyngeal carcinoma cell line.
Nasopharyngeal Carcinoma
Epstein-Barr virus associated modulation of Wnt pathway is not dependent on latent membrane protein-1.
Nasopharyngeal Carcinoma
Expression of mismatch repair gene PMS2 in nasopharyngeal carcinoma and regulation by glycogen synthase kinase-3? in vivo and in vitro.
Neonatal Sepsis
Inhibition of necroptosis attenuates lung injury and improves survival in neonatal sepsis.
Neoplasm Metastasis
Alzheimer's drug Memantine inhibits metastasis and p-Erk protein expression on 4T1 breast cancer cells.
Neoplasm Metastasis
AMPK Inhibits the Stimulatory Effects of TGF-? on Smad2/3 Activity, Cell Migration, and Epithelial-to-Mesenchymal Transition.
Neoplasm Metastasis
AMPK-Independent LKB1 Activity Is Required for Efficient Epithelial Ovarian Cancer Metastasis.
Neoplasm Metastasis
An AMPK-independent signaling pathway downstream of the LKB1 tumor suppressor controls Snail1 and metastatic potential.
Neoplasm Metastasis
An Inhibitor of GSK3B and HDACs Kills Pancreatic Cancer Cells and Slows Pancreatic Tumor Growth and Metastasis in Mice.
Neoplasm Metastasis
Association of axon guidance factor Semaphorin 3A with poor outcome in pancreatic cancer.
Neoplasm Metastasis
Augmented AMPK activity inhibits cell migration by phosphorylating the novel substrate Pdlim5.
Neoplasm Metastasis
Berberine inhibits human colon cancer cell migration via AMP-activated protein kinase-mediated downregulation of integrin ?1 signaling.
Neoplasm Metastasis
Berberine inhibits Wilms' tumor cell progression through upregulation of Wilms' tumor gene on the X chromosome.
Neoplasm Metastasis
CLDN3 inhibits cancer aggressiveness via Wnt-EMT signaling and is a potential prognostic biomarker for hepatocellular carcinoma.
Neoplasm Metastasis
Collapsing the Metabolic PON2zi Scheme in Pancreatic Ductal Adenocarcinoma.
Neoplasm Metastasis
Correction to Identification of 5-(2,3-Dihydro-1 H-indol-5-yl)-7 H-pyrrolo[2,3- d]pyrimidin-4-amine Derivatives as a New Class of Receptor-Interacting Protein Kinase 1 (RIPK1) Inhibitors, Which Showed Potent Activity in a Tumor Metastasis Model.
Neoplasm Metastasis
Cysteine-rich intestinal protein 1 silencing alleviates the migration and invasive capability enhancement induced by excessive zinc supplementation in colorectal cancer cells.
Neoplasm Metastasis
Downregulation of DAPK1 promotes the stemness of cancer stem cells and EMT process by activating ZEB1 in colorectal cancer.
Neoplasm Metastasis
Enhanced expression of SRPK2 contributes to aggressive progression and metastasis in prostate cancer.
Neoplasm Metastasis
FBXO22 Possesses Both Protumorigenic and Antimetastatic Roles in Breast Cancer Progression.
Neoplasm Metastasis
Glycogen synthase kinase 3? promotes osteosarcoma invasion and migration via regulating PTEN and phosphorylation of focal adhesion kinase.
Neoplasm Metastasis
Honokiol: A Review of Its Anticancer Potential and Mechanisms.
Neoplasm Metastasis
Identification of 5-(2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Derivatives as a New Class of Receptor-Interacting Protein Kinase 1 (RIPK1) Inhibitors, Which Showed Potent Activity in a Tumor Metastasis Model.
Neoplasm Metastasis
Indirubin Derivative 6BIO Suppresses Metastasis.
Neoplasm Metastasis
Interleukin 1?-mediated HOXC10 Overexpression Promotes Hepatocellular Carcinoma Metastasis by Upregulating PDPK1 and VASP.
Neoplasm Metastasis
Long non-coding RNA MALAT1 for promoting metastasis and proliferation by acting as a ceRNA of miR-144-3p in osteosarcoma cells.
Neoplasm Metastasis
Long non-coding RNA NEAT1 promoted ovarian cancer cells' metastasis through regulation of miR-382-3p/ROCK1 axial.
Neoplasm Metastasis
MiR-199a-5p Inhibits the Growth and Metastasis of Colorectal Cancer Cells by Targeting ROCK1.
Neoplasm Metastasis
miR-200c/141 Regulates Breast Cancer Stem Cell Heterogeneity via Targeting HIPK1/?-Catenin Axis.
Neoplasm Metastasis
Overexpression of novel lncRNA NLIPMT inhibits metastasis by reducing phosphorylated glycogen synthase kinase 3? in breast cancer.
Neoplasm Metastasis
P21-activated protein kinase 1 induces colorectal cancer metastasis involving ERK activation and phosphorylation of FAK at Ser-910.
Neoplasm Metastasis
P21-activated protein kinase 1 is overexpressed in gastric cancer and induces cancer metastasis.
Neoplasm Metastasis
Recent advances in the role of AMP-activated protein kinase in metabolic reprogramming of metastatic cancer cells: targeting cellular bioenergetics and biosynthetic pathways for anti-tumor treatment.
Neoplasm Metastasis
Resistin promotes tumor metastasis by down-regulation of miR-519d through the AMPK/p38 signaling pathway in human chondrosarcoma cells.
Neoplasm Metastasis
RIPK1 is a negative mediator in Aquaporin 1-driven triple-negative breast carcinoma progression and metastasis.
Neoplasm Metastasis
Shikonin inhibits triple-negative breast cancer-cell metastasis by reversing the epithelial-to-mesenchymal transition via glycogen synthase kinase 3?-regulated suppression of ?-catenin signaling.
Neoplasm Metastasis
SUZ12 is involved in progression of non-small cell lung cancer by promoting cell proliferation and metastasis.
Neoplasm Metastasis
Targeting of TGF-?-activated protein kinase 1 inhibits chemokine (C-C motif) receptor 7 expression, tumor growth and metastasis in breast cancer.
Neoplasm Metastasis
The Wnt/?-catenin pathway drives increased cyclin D1 levels in lymph node metastasis in papillary thyroid cancer.
Neoplasm Metastasis
TRAF6 inhibits colorectal cancer metastasis through regulating selective autophagic CTNNB1/?-catenin degradation and is targeted for GSK3B/GSK3?-mediated phosphorylation and degradation.
Neoplasm Metastasis
[Effects of nm23-H1 point mutation on activity of GSK-3? in human high-metastatic large cell lung cancer cell line L9981.]
Neoplasm Metastasis
[Transfection of tumor metastasis suppressor gene nm23-H1 can up-regulate the activity of GSK-3? in human high-metastasis large cell lung cancer cell line L9981.]
Neoplasms
(+)-Naloxone blocks Toll-like receptor 4 to ameliorate deleterious effects of stress on male mouse behaviors.
Neoplasms
(Z)-2-(3-Chlorobenzylidene)-3,4-dihydro-N-(2-methoxyethyl)-3-oxo-2H-benzo[b][1,4]oxazine-6-carboxamide as GSK-3? inhibitor: Identification by virtual screening and its validation in enzyme- and cell-based assay.
Neoplasms
14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK.
Neoplasms
3-O-acetylrubianol C (3AR-C) induces RIPK1-dependent programmed cell death by selective inhibition of IKK?.
Neoplasms
4-O-methylascochlorin, methylated derivative of ascochlorin, stabilizes HIF-1? via AMPK activation.
Neoplasms
5-Aminoimidazole-4-carboxamide riboside sensitizes TRAIL- and TNF{alpha}-induced cytotoxicity in colon cancer cells through AMP-activated protein kinase signaling.
Neoplasms
5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP-activated protein kinase.
Neoplasms
6-mercaptopurine promotes energetic failure in proliferating T cells.
Neoplasms
6-Shogaol induces cell cycle arrest and apoptosis in human hepatoma cells through pleiotropic mechanisms.
Neoplasms
?-catenin Helices in the Cytoplasm of Sporadic and FAP Duodenal Adenomas.
Neoplasms
?-SMA-Cre-mediated excision of PDK1 reveals an essential role of PDK1 in regulating morphology of cardiomyocyte and tumor progression in tissue microenvironment.
Neoplasms
A 5' AMP-Activated Protein Kinase Enzyme Activator, Compound 59, Induces Autophagy and Apoptosis in Human Oral Squamous Cell Carcinoma.
Neoplasms
A critical role for p53 in the control of NF-kappaB-dependent gene expression in TLR4-stimulated dendritic cells exposed to Genistein.
Neoplasms
A dipeptidyl peptidase-IV inhibitor improves hepatic steatosis and insulin resistance by AMPK-dependent and JNK-dependent inhibition of LECT2 expression.
Neoplasms
A high-fat diet increases angiogenesis, solid tumor growth, and lung metastasis of CT26 colon cancer cells in obesity-resistant BALB/c mice.
Neoplasms
A kinome-wide shRNA screen uncovers vaccinia-related kinase 3 (VRK3) as an essential gene for diffuse intrinsic pontine glioma survival.
Neoplasms
A miR-135b-TAZ positive feedback loop promotes epithelial-mesenchymal transition (EMT) and tumorigenesis in osteosarcoma.
Neoplasms
A new protocol for predicting novel GSK-3? ATP competitive inhibitors.
Neoplasms
A noncatalytic domain of glycogen synthase kinase-3 (GSK-3) is essential for activity.
Neoplasms
A novel inhibitor of the PI3K/Akt pathway based on the structure of inositol 1,3,4,5,6-pentakisphosphate.
Neoplasms
A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis.
Neoplasms
A novel therapeutic approach to colorectal cancer in diabetes: role of metformin and rapamycin.
Neoplasms
A nuclear shift of GSK3? protein is an independent prognostic factor in prostate cancer.
Neoplasms
A randomised, placebo-controlled study of RIPK1 inhibitor GSK2982772 in patients with active ulcerative colitis.
Neoplasms
A single amino acid substitution confers B-cell clonogenic activity to the HIV-1 matrix protein p17.
Neoplasms
Aberrant glycogen synthase kinase 3? in the development of pancreatic cancer.
Neoplasms
Aberrant glycogen synthase kinase 3? is involved in pancreatic cancer cell invasion and resistance to therapy.
Neoplasms
Ablation of ?,?-carotene-9',10'-oxygenase 2 remodels the hypothalamic metabolome leading to metabolic disorders in mice.
Neoplasms
Ablation of ATG4B Suppressed Autophagy and Activated AMPK for Cell Cycle Arrest in Cancer Cells.
Neoplasms
Activation of AMP-Activated Protein Kinase Attenuates Tumor Necrosis Factor-?-Induced Lipolysis via Protection of Perilipin in 3T3-L1 Adipocytes.
Neoplasms
Activation of AMP-activated protein kinase by 3,3'-Diindolylmethane (DIM) is associated with human prostate cancer cell death in vitro and in vivo.
Neoplasms
Activation of AMP-activated protein kinase by MAPO1 and FLCN induces apoptosis triggered by alkylated base mismatch in DNA.
Neoplasms
Activation of ERK1/2 occurs independently of KRAS or BRAF status in endometrial cancer and is associated with favorable prognosis.
Neoplasms
Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO.
Neoplasms
Activation of the ROCK1/MMP-9 pathway is associated with the invasion and poor prognosis in papillary thyroid carcinoma.
Neoplasms
Activation of TNF-alpha transcription utilizes distinct MAP kinase pathways in different macrophage populations.
Neoplasms
Adenosine activates AMPK to phosphorylate Bcl-XL responsible for mitochondrial damage and DIABLO release in HuH-7 cells.
Neoplasms
Adiponectin receptor agonist AdipoRon induces apoptotic cell death and suppresses proliferation in human ovarian cancer cells.
Neoplasms
Adiponectin signals in prostate cancer cells through Akt to activate the mammalian target of rapamycin pathway.
Neoplasms
Adiponectin upregulates ferritin heavy chain in skeletal muscle cells.
Neoplasms
Adzuki bean ameliorates hepatic lipogenesis and proinflammatory mediator expression in mice fed a high-cholesterol and high-fat diet to induce nonalcoholic fatty liver disease.
Neoplasms
AICAR induces AMPK-independent programmed necrosis in prostate cancer cells.
Neoplasms
AICAR Induces Apoptosis and Inhibits Migration and Invasion in Prostate Cancer Cells Through an AMPK/mTOR-Dependent Pathway.
Neoplasms
AICAR inhibits cancer cell growth and triggers cell-type distinct effects on OXPHOS biogenesis, oxidative stress and Akt activation.
Neoplasms
Akt GSK-3 pathway as a target in genistein-induced inhibition of TRAMP prostate cancer progression toward a poorly differentiated phenotype.
Neoplasms
Akt-dependent and -independent mechanisms of mTOR regulation in cancer.
Neoplasms
Alisol A 24-Acetate Prevents Hepatic Steatosis and Metabolic Disorders in HepG2 Cells.
Neoplasms
Alteration of the ?-catenin pathway in spiradenoma.
Neoplasms
AMP-activated kinase (AMPK) regulates activity of HER2 and EGFR in breast cancer.
Neoplasms
AMP-activated protein kinase (AMPK) beyond metabolism: A novel genomic stress sensor participating in the DNA damage response pathway.
Neoplasms
AMP-activated protein kinase (AMPK) in the rock crab, Cancer irroratus: an early indicator of temperature stress.
Neoplasms
AMP-activated protein kinase ?1 serves a carcinogenic role via regulation of vascular endothelial growth factor expression in patients with non-small cell lung cancer.
Neoplasms
AMP-activated Protein Kinase ?2 Protects against Liver Injury from Metastasized Tumors via Reduced Glucose Deprivation-induced Oxidative Stress.
Neoplasms
AMP-activated protein kinase activators, cancer regression, and survival.
Neoplasms
AMP-activated protein kinase activity is required for vanadate-induced hypoxia-inducible factor 1alpha expression in DU145 cells.
Neoplasms
AMP-activated protein kinase and cancer.
Neoplasms
AMP-activated protein kinase and human cancer: cancer metabolism revisited.
Neoplasms
AMP-activated protein kinase determines apoptotic sensitivity of cancer cells to ginsenoside-Rh2.
Neoplasms
AMP-activated protein kinase is dispensable for maintaining ATP levels and for survival following inhibition of glycolysis, but promotes tumour engraftment of Ras-transformed fibroblasts.
Neoplasms
AMP-activated protein kinase is required for the macropinocytic internalization of ebolavirus.
Neoplasms
AMP-activated protein kinase promotes epithelial-mesenchymal transition in cancer cells through Twist1 upregulation.
Neoplasms
AMP-activated protein kinase regulates cancer cell growth and metabolism via nuclear and mitochondria events.
Neoplasms
AMP-activated protein kinase selectively inhibited by the type II inhibitor SBI-0206965.
Neoplasms
AMP-Activated Protein Kinase Signalling in Cancer and Cardiac Hypertrophy.
Neoplasms
AMP-activated protein kinase: a cellular energy sensor with a key role in metabolic disorders and in cancer.
Neoplasms
AMP-activated protein kinase: a target for old drugs against diabetes and cancer.
Neoplasms
AMPK ?1 Downregulates ROS Levels Through Regulating Trx Leading to Dysfunction of Apoptosis in Non-Small Cell Lung Cancer.
Neoplasms
AMPK activation by AICAR sensitizes prostate cancer cells to radiotherapy.
Neoplasms
AMPK Activators as a Drug for Diabetes, Cancer and Cardiovascular Disease.
Neoplasms
AMPK Causes Cell Cycle Arrest in LKB1-Deficient Cells via Activation of CAMKK2.
Neoplasms
AMPK expression patterns are significantly associated with poor prognosis in breast cancer patients.
Neoplasms
AMPK Inhibits the Stimulatory Effects of TGF-? on Smad2/3 Activity, Cell Migration, and Epithelial-to-Mesenchymal Transition.
Neoplasms
AMPK Promotes Aberrant PGC1? Expression To Support Human Colon Tumor Cell Survival.
Neoplasms
AMPK Promotes p53 Acetylation via Phosphorylation and Inactivation of SIRT1 in Liver Cancer Cells.
Neoplasms
AMPK promotes the survival of colorectal cancer stem cells.
Neoplasms
AMPK promotes tolerance to Ras pathway inhibition by activating autophagy.
Neoplasms
AMPK-dependent phosphorylation is required for transcriptional activation of TFEB and TFE3.
Neoplasms
AMPK-related kinase 5 (ARK5) enhances gemcitabine resistance in pancreatic carcinoma by inducing epithelial-mesenchymal transition.
Neoplasms
AMPK: energy sensor and survival mechanism in the ischemic heart.
Neoplasms
An ent-kaurane diterpenoid from Croton tonkinensis induces apoptosis by regulating AMP-activated protein kinase in SK-HEP1 human hepatocellular carcinoma cells.
Neoplasms
An Inhibitor of GSK3B and HDACs Kills Pancreatic Cancer Cells and Slows Pancreatic Tumor Growth and Metastasis in Mice.
Neoplasms
An SGLT2 inhibitor modulates SHH expression by activating AMPK to inhibit the migration and induce the apoptosis of cervical carcinoma cells.
Neoplasms
Analysis of the effect of rutin on GSK-3? and TNF-? expression in lung cancer.
Neoplasms
Anthocyanins are novel AMPK?1 stimulators that suppress tumor growth by inhibiting mTOR phosphorylation.
Neoplasms
Anti-tumor effect of luteolin is accompanied by AMP-activated protein kinase and nuclear factor-?B modulation in HepG2 hepatocarcinoma cells.
Neoplasms
Anticancer targets and mechanisms of calycosin to treat nasopharyngeal carcinoma.
Neoplasms
Antitumorigenic Effect of Memantine via Interfering Glutamate Metabolism in Mouse 4T1 Breast Tumor Model.
Neoplasms
Apoptotic effect of quercetin on HT-29 colon cancer cells via the AMPK signaling pathway.
Neoplasms
ARK5 is transcriptionally regulated by the Large-MAF family and mediates IGF-1-induced cell invasion in multiple myeloma: ARK5 as a new molecular determinant of malignant multiple myeloma.
Neoplasms
ARK5 promotes doxorubicin resistance in hepatocellular carcinoma via epithelial-mesenchymal transition.
Neoplasms
Aspartate ?-hydroxylase modulates cellular senescence through glycogen synthase kinase 3? in hepatocellular carcinoma.
Neoplasms
ATG2B and GSKIP: 2 new genes predisposing to myeloid malignancies.
Neoplasms
Augmented AMPK activity inhibits cell migration by phosphorylating the novel substrate Pdlim5.
Neoplasms
Autophagy genes in myeloid cells counteract IFN?-induced TNF-mediated cell death and fatal TNF-induced shock.
Neoplasms
Autophagy in the physiological endometrium and cancer.
Neoplasms
Berberine and cinnamaldehyde together prevent lung carcinogenesis.
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Berberine enhances antidiabetic effects and attenuates untoward effects of canagliflozin in streptozotocin-induced diabetic mice.
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Berberine inhibits human colon cancer cell migration via AMP-activated protein kinase-mediated downregulation of integrin ?1 signaling.
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Berberine inhibits Wilms' tumor cell progression through upregulation of Wilms' tumor gene on the X chromosome.
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Berberine Represses ?-Catenin Translation Involving 4E-BPs in Hepatocellular Carcinoma Cells.
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Berberine-induced AMPK activation inhibits the metastatic potential of melanoma cells via reduction of ERK activity and COX-2 protein expression.
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Betaine ameliorates impaired steroidogenesis and apoptosis in mice granulosa cells induced by high glucose concentration.
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Bifunctional mechanisms of autophagy and apoptosis regulations in melanoma from Bacillus subtilis natto fermentation extract.
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Bioactive compounds in plant materials for the prevention of diabetesand obesity.
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Bioinformatics Based Therapeutic Effects of Sinomenium Acutum.
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Bone marrow-derived mesenchymal stem cells attenuate severe acute pancreatitis via regulation of microRNA-9 to inhibit necroptosis in rats.
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BRAF Inhibitors in Thyroid Cancer: Clinical Impact, Mechanisms of Resistance and Future Perspectives.
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BRAF(V600E) inhibition stimulates AMP-activated protein kinase-mediated autophagy in colorectal cancer cells.
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Breast tumor-associated osteoblast-derived CXCL5 increases cancer progression by ERK/MSK1/Elk-1/Snail signaling pathway.
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c-Jun N-terminal kinases differentially regulate TNF- and TLRs-mediated necroptosis through their kinase-dependent and -independent activities.
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c-Jun N-terminal protein kinase 1 (JNK1), but not JNK2, is essential for tumor necrosis factor alpha-induced c-Jun kinase activation and apoptosis.
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C-terminal phosphorylation of LKB1 is not required for regulation of AMP-activated protein kinase, BRSK1, BRSK2, or cell cycle arrest.
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C1q tumor necrosis factor alpha-related protein isoform 5 is increased in mitochondrial DNA-depleted myocytes and activates AMP-activated protein kinase.
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C6 ceramide dramatically increases vincristine sensitivity both in vivo and in vitro, involving AMP-activated protein kinase-p53 signaling.
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Caffeic acid derivatives inhibit the growth of colon cancer: involvement of the PI3-K/Akt and AMPK signaling pathways.
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Cancer's sweet tooth: the Janus effect of glucose metabolism in tumorigenesis.
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Capillary electrophoresis as a novel technique for screening natural flavonoids as kinase inhibitors.
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Cardioprotective Effect of Echinatin Against Ischemia/Reperfusion Injury: Involvement of Hippo/Yes-Associated Protein Signaling.
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CCNE1 amplification is associated with poor prognosis in patients with triple negative breast cancer.
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Cell death induced by dorsomorphin in adult T-cell leukemia/lymphoma is AMPK-independent.
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Cellular energy stress induces AMPK-mediated regulation of glioblastoma cell proliferation by PIKE-A phosphorylation.
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Cetylpyridinium chloride is a potent AMP-activated kinase (AMPK) inducer and has therapeutic potential in cancer.
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Characterisation of mesenchymal colon tumour-derived cells in tumourspheres as a model for colorectal cancer progression.
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Characterization of the CaMKK?-AMPK signaling complex.
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Chronic AMPK activation via loss of FLCN induces functional beige adipose tissue through PGC-1?/ERR?.
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Circadian gating of epithelial-to-mesenchymal transition in breast cancer cells via melatonin-regulation of GSK3?.
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Circular RNA circMTO1 acts as an antitumor factor in rectal cancer cell lines by downregulation of miR-19b-3p.
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Citrus flavonoid naringenin reduces mammary tumor cell viability, adipose mass, and adipose inflammation in obese ovariectomized mice.
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Clinical and functional significance of CHK1-S, an alternatively spliced isoform of the CHK1 gene, in hepatocellular carcinoma.
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Colorectal cancer cells require glycogen synthase kinase-3? for sustaining mitosis via translocated promoter region (TPR)-dynein interaction.
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Comparison of the effects of metformin on MDA-MB-231 breast cancer cells in a monolayer culture and in tumor spheroids as a function of nutrient concentrations.
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Competitive Control of Independent Programs of Tumor Necrosis Factor Receptor-Induced Cell Death by TRADD and RIP1.
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Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade.
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Compound C induces protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway.
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Compound K Induces Apoptosis via CAMK-IV/AMPK Pathways in HT-29 Colon Cancer Cells.
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Computer-aided drug design for AMP-activated protein kinase activators.
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Concomitant activation of AKT with extracellular-regulated kinase 1/2 occurs independently of PTEN or PIK3CA mutations in endometrial cancer and may be associated with favorable prognosiss.
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Conjugated linoleic acid-induced apoptosis in mouse mammary tumor cells is mediated by both G protein coupled receptor-dependent activation of the AMP-activated protein kinase pathway and by oxidative stress.
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Control of Glycolytic Flux by AMP-Activated Protein Kinase in Tumor Cells Adapted to Low pH.
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Cooperation of SRPK2, Numb and p53 in the malignant biology and chemosensitivity of colorectal cancer.
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Cordycepin inhibits lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF)-? production via activating amp-activated protein kinase (AMPK) signaling.
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Correction to Identification of 5-(2,3-Dihydro-1 H-indol-5-yl)-7 H-pyrrolo[2,3- d]pyrimidin-4-amine Derivatives as a New Class of Receptor-Interacting Protein Kinase 1 (RIPK1) Inhibitors, Which Showed Potent Activity in a Tumor Metastasis Model.
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CRISPR/Cas9-mediated double knockout of SRPK1 and SRPK2 in a nasopharyngeal carcinoma cell line.
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Critical roles of AMP-activated protein kinase in constitutive tolerance of cancer cells to nutrient deprivation and tumor formation.
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Cucurbitacin E induces apoptosis of human prostate cancer cells via cofilin-1 and mTORC1.
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Curcumin exerts antidifferentiation effect through AMPKalpha-PPAR-gamma in 3T3-L1 adipocytes and antiproliferatory effect through AMPKalpha-COX-2 in cancer cells.
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Current strategies exploiting NK-cell therapy to treat haematologic malignancies.
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CUX1-Transcriptional Master Regulator of Tumor Progression in Pancreatic Neuroendocrine Tumors.
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Cyclin-dependent kinase 1-mediated AMPK phosphorylation regulates chromosome alignment and mitotic progression.
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DC120, a novel and potent inhibitor of AKT kinase, induces tumor cell apoptosis and suppresses tumor growth.
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Decreased expression levels of Nurr1 are associated with chronic inflammation in patients with type 2 diabetes.
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Decreased expression of DUSP4 is associated with liver and lung metastases in colorectal cancer.
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Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction.
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Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization.
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Deletion of Myeloid GSK3? Attenuates Atherosclerosis and Promotes an M2 Macrophage Phenotype.
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Diabetes, insulin and cancer risk.
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Differential control of Yorkie activity by LKB1/AMPK and the Hippo/Warts cascade in the central nervous system.
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Differential crosstalk between the AMPK and PI3K/Akt pathways in breast cancer cells of differing genotypes: Leptin inhibits the effectiveness of AMPK activation.
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Differential effects of AMPK agonists on cell growth and metabolism.
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Differential expression of DUSP2 in left- and right-sided colon cancer is associated with poor prognosis in colorectal cancer.
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Differential modulation of AMPK signaling pathways by low or high levels of exogenous reactive oxygen species in colon cancer cells.
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Differential regulation of AMP-activated protein kinase in healthy and cancer cells explains why V-ATPase inhibition selectively kills cancer cells.
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Differentiated macrophages acquire a pro-inflammatory and cell death-resistant phenotype due to increasing XIAP and p38-mediated inhibition of RipK1.
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Discovery of a Small-Molecule Bromodomain-Containing Protein 4 (BRD4) Inhibitor That Induces AMP-Activated Protein Kinase-Modulated Autophagy-Associated Cell Death in Breast Cancer.
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Distinct expression and activity of GSK-3? and GSK-3? in prostate cancer.
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DNA-dependent protein kinase regulates lysosomal AMP-dependent protein kinase activation and autophagy.
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Down-regulation and clinical significance of miR-7-2-3p in papillary thyroid carcinoma with multiple detecting methods.
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Downregulation of DAPK1 promotes the stemness of cancer stem cells and EMT process by activating ZEB1 in colorectal cancer.
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Downregulation of SRPK2 promotes cell cycle arrest though E2F1 in non-small cell lung cancer.
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Dual targeting of GSK3B and HDACs reduces tumor growth and improves survival in an ovarian cancer mouse model.
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Dysfunctional AMPK activity, signalling through mTOR and survival in response to energetic stress in LKB1-deficient lung cancer.
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E-type prostanoid receptor 4 drives resolution of intestinal inflammation by blocking epithelial necroptosis.
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Effect of Atorvastatin on Wound Healing in Rats.
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Effect of Lactobacillus fermentum TKSN041 on improving streptozotocin-induced type 2 diabetes in rats.
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Effect of Methanolic Extract of Dandelion Roots on Cancer Cell Lines and AMP-Activated Protein Kinase Pathway.
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Effects of cotreatment of 12-O-tetradecanoylphorbol-13-acetate and H2O2 on apoptotic regulation via AMP-activated protein kinase-cyclooxygenase-2 signals.
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Effects of metformin and pioglitazone combination on apoptosis and AMPK/mTOR signaling pathway in human anaplastic thyroid cancer cells.
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Effects of Nigella sativa oil and thymoquinone against bisphenol A-induced metabolic disorder in rats.
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Effects of the epidermal growth factor receptor inhibitor OSI-774, Tarceva, on downstream signaling pathways and apoptosis in human pancreatic adenocarcinoma.
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Elevated SRPK1 lessens apoptosis in breast cancer cells through RBM4-regulated splicing events.
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Eliminating animal facility light-at-night contamination and its effect on circadian regulation of rodent physiology, tumor growth, and metabolism: a challenge in the relocation of a cancer research laboratory.
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Enantiospecific formal total synthesis of the tumor and GSK-3 beta inhibiting alkaloid, (-)-agelastatin A.
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Endothelin-1 in portal hypertension: The intricate role of hepatic stellate cells.
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Energy homeostasis and cancer prevention: the AMP-activated protein kinase.
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Energy restriction affect liver development in Hu sheep ram lambs through Hippo signaling pathway.
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Enhanced expression of SRPK2 contributes to aggressive progression and metastasis in prostate cancer.
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Enhanced TLR4 Expression on Colon Cancer Cells After Chemotherapy Promotes Cell Survival and Epithelial-Mesenchymal Transition Through Phosphorylation of GSK3?.
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EPA and DHA attenuate deoxynivalenol-induced intestinal porcine epithelial cell injury and protect barrier function integrity by inhibiting necroptosis signaling pathway.
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Epithelial-mesenchymal transition-converted tumor cells can induce T-cell apoptosis through upregulation of programmed death ligand 1 expression in esophageal squamous cell carcinoma.
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Evaluating the impact of AMPK activation, a target of metformin, on risk of cardiovascular diseases and cancer in the UK Biobank: a Mendelian randomisation study.
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Everolimus, an mTOR pathway inhibitor, is highly successful on ovarian hyperstimulation syndrome by reducing ovarian weight and progesterone levels: a preclinical experimental randomized controlled study.
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Evidence for a new binding mode to GSK-3: Allosteric regulation by the marine compound palinurin.
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Exosomes of Mesenchymal Stem Cells as a Proper Vehicle for Transfecting miR-145 into the Breast Cancer Cell Line and Its Effect on Metastasis.
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Expression of 3-phosphoinositide-dependent protein kinase 1 in colorectal cancer as a potential therapeutic target.
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Expression of Phosphorylated AMP-Activated Protein Kinase Predicts Response to Transarterial Chemoembolization in Postoperative Cases of Hepatocellular Carcinoma.
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FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells.
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Fatty acid synthase inhibition activates AMP-activated protein kinase in SKOV3 human ovarian cancer cells.
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FBW7 Inhibits Myeloid Differentiation in Acute Myeloid Leukemia via GSK3-Dependent Ubiquitination of PU.1.
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Fish Oil Alleviates Activation of Hypothalamic-Pituitary-Adrenal Axis Associated with Inhibition of TLR4 and NOD Signaling Pathways in Weaned Piglets after a Lipopolysaccharide Challenge.
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FLI1 Exonic Circular RNAs as a Novel Oncogenic Driver to Promote Tumor Metastasis in Small Cell Lung Cancer.
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Fluid flow-induced activation of subcellular AMPK and its interaction with FAK and Src.
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Fyn-phosphorylated PIKE-A binds and inhibits AMPK signaling, blocking its tumor suppressive activity.
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Gain-of-function mutant p53 promotes the oncogenic potential of head and neck squamous cell carcinoma cells by targeting the transcription factors FOXO3a and FOXM1.
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Gene Expression of the Tumour Suppressor LKB1 Is Mediated by Sp1, NF-Y and FOXO Transcription Factors.
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Genotoxic Damage Activates the AMPK-?1 Isoform in the Nucleus via Ca
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Ginkgolic acid suppresses the development of pancreatic cancer by inhibiting pathways driving lipogenesis.
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Ginseng saponin metabolite induces apoptosis in MCF-7 breast cancer cells through the modulation of AMP-activated protein kinase.
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Glucoraphanin: a broccoli sprout extract that ameliorates obesity-induced inflammation and insulin resistance.
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Glucose deprivation increases mRNA stability of vascular endothelial growth factor through activation of AMP-activated protein kinase in DU145 prostate carcinoma.
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Glucose metabolism and cancer.
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Glucosylceramide synthase inhibitor PDMP sensitizes chronic myeloid leukemia T315I mutant to Bcr-Abl inhibitor and cooperatively induces glycogen synthase kinase-3-regulated apoptosis.
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GLUT12 expression and regulation in murine small intestine and human Caco-2 cells.
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Glycogen synthase kinase 3 regulates cell death and survival signaling in tumor cells under redox stress.
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Glycogen synthase kinase 3? and cyclin D1 expression in cervical carcinogenesis.
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Glycogen synthase kinase 3? as a potential therapeutic target in synovial sarcoma and fibrosarcoma.
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Glycogen Synthase Kinase 3? in Cancer Biology and Treatment.
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Glycogen synthase kinase 3? inhibition sensitizes human glioblastoma cells to temozolomide by affecting O6-methylguanine DNA methyltransferase promoter methylation via c-Myc signaling.
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Glycogen synthase kinase 3? inhibitors induce apoptosis in ovarian cancer cells and inhibit in-vivo tumor growth.
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Glycogen synthase kinase-3 beta regulates NF-kappa B1/p105 stability.
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Glycogen synthase kinase-3 in insulin and Wnt signalling: a double-edged sword?
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Glycogen Synthase Kinase-3 Inhibition Sensitizes Pancreatic Cancer Cells to Chemotherapy by Abrogating the TopBP1/ATR-Mediated DNA Damage Response.
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Glycogen synthase kinase-3? is a pivotal mediator of cancer invasion and resistance to therapy.
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Glycogen synthase kinase-3? participates in acquired resistance to gemcitabine in pancreatic cancer.
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Glycolytic phenotype and AMP kinase modify the pathologic response of tumor xenografts to VEGF neutralization.
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GSK-3 beta targets Cdc25A for ubiquitin-mediated proteolysis, and GSK-3 beta inactivation correlates with Cdc25A overproduction in human cancers.
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GSK3? and CREB3 gene expression profiling in benign and malignant salivary gland tumors.
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Heat shock transcription factor 1 is a key determinant of HCC development by regulating hepatic steatosis and metabolic syndrome.
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Herpes simplex virus suppresses necroptosis in human cells.
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Hexane Insoluble Fraction from Purple Rice Extract Retards Carcinogenesis and Castration-Resistant Cancer Growth of Prostate Through Suppression of Androgen Receptor Mediated Cell Proliferation and Metabolism.
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High-Dose Metformin Plus Temozolomide Shows Increased Anti-tumor Effects in Glioblastoma In Vitro and In Vivo Compared with Monotherapy.
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Honokiol affects melanoma cell growth by targeting the AMP-activated protein kinase signaling pathway.
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Hormone-activated nuclear receptors inhibit the stimulation of the JNK and ERK signalling pathways in endothelial cells.
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How autophagy controls the intestinal epithelial barrier.
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How does intestinal-type intraductal papillary mucinous neoplasm emerge? CDX2 plays a critical role in the process of intestinal differentiation and progression.
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Human ?? T cell sensing of AMPK-dependent metabolic tumor reprogramming through TCR recognition of EphA2.
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Hypoglycemic effect of whole grain diet in C57BL/KsJ-db/db mice by activating PI3K/Akt and AMPK pathways.
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Identification of 5-(2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Derivatives as a New Class of Receptor-Interacting Protein Kinase 1 (RIPK1) Inhibitors, Which Showed Potent Activity in a Tumor Metastasis Model.
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Identification of curcumin targets in neuroinflammatory pathways: molecular docking scores with GSK-3?, p38 MAPK, COX, ICE and TACE enzymes.
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Identification of Driver Genes Regulating the T-Cell-Infiltrating Levels in Hepatocellular Carcinoma.
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Identification of dual kinase inhibitors of CK2 and GSK3?: combined qualitative and quantitative pharmacophore modeling approach.
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Identification of microRNAs and their Endonucleolytic Cleavaged target mRNAs in colorectal cancer.
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IGF1R as druggable target mediating PI3K-? inhibitor resistance in a murine model of chronic lymphocytic leukemia.
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Immune-mediated antitumor effect by type 2 diabetes drug, metformin.
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Inactivation of AMPK alters gene expression and promotes growth of prostate cancer cells.
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Increased lipogenesis in cancer cells: new players, novel targets.
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Induction of AMPK activation by N,N'-diarylurea FND-4b decreases growth and increases apoptosis in triple negative and estrogen-receptor positive breast cancers.
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Induction of Apoptosis by a Combination of 2-Deoxyglucose and Metformin in Esophageal Squamous Cell Carcinoma by Targeting Cancer Cell Metabolism.
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Inhibition of AMP-activated protein kinase sensitizes cancer cells to cisplatin-induced apoptosis via hyper-induction of p53.
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Inhibition of AMPK-related kinase 5 (ARK5) enhances cisplatin cytotoxicity in non-small cell lung cancer cells through regulation of epithelial-mesenchymal transition.
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Inhibition of tumor cell proliferation by type IV collagen requires increased levels of cAMP.
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Inhibition of tumor necrosis factor alpha-stimulated monocyte adhesion to human aortic endothelial cells by AMP-activated protein kinase.
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Integrated genomic and transcriptomic analysis of human brain metastases identifies alterations of potential clinical significance.
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Integrated molecular signaling involving mitochondrial dysfunction and alteration of cell metabolism induced by tyrosine kinase inhibitors in cancer.
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Integrative analysis of miRNA-mRNA expression profiles in esophageal fibrosis after ESD.
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Intermediate domain of receptor-interacting protein kinase 1 (RIPK1) determines the switch between necroptosis and RIPK1 kinase-dependent apoptosis.
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Intravenous Statin Administration During Myocardial Infarction Compared With Oral Post-Infarct Administration.
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Involvement of AMP-activated protein kinase and Death Receptor 5 in TRAIL-Berberine-induced apoptosis of cancer cells.
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Ionizing radiation regulates the expression of AMP-activated protein kinase (AMPK) in epithelial cancer cells: Modulation of cellular signals regulating cell cycle and survival.
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IPA-3 inhibits the growth of liver cancer cells by suppressing PAK1 and NF-?B activation.
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Keratinocyte autophagy enables the activation of keratinocytes and fibroblasts and facilitates wound healing.
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Knockdown of Human AMPK Using the CRISPR/Cas9 Genome-Editing System.
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Knockdown of Serine-Arginine Protein Kinase 1 Inhibits the Growth and Migration in Renal Cell Carcinoma Cells.
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Leptin-promoted cilia assembly is critical for normal energy balance.
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Lithium suppresses astrogliogenesis by neural stem and progenitor cells by inhibiting STAT3 pathway independently of glycogen synthase kinase 3 beta.
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LKB1 and AMPK and the cancer-metabolism link - ten years after.
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LKB1 and AMPK differentially regulate pancreatic ?-cell identity.
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LKB1 and AMPK?1 are required in pancreatic alpha cells for the normal regulation of glucagon secretion and responses to hypoglycemia.
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LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.
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LKB1 is necessary for Akt-mediated phosphorylation of proapoptotic proteins.
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LKB1 promotes metabolic flexibility in response to energy stress.
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Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells.
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LKB1: a sweet side to Peutz-Jeghers syndrome?
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LncRNA HAND2-AS1 overexpression inhibits cancer cell proliferation in melanoma by downregulating ROCK1.
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LncRNA MACC1-AS1 Promotes Lung Adenocarcinoma Cell Proliferation by Downregulating PTEN.
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lncRNA NBR2 modulates cancer cell sensitivity to phenformin through GLUT1.
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Local alignment vectors reveal cancer cell-induced ECM fiber remodeling dynamics.
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Long Noncoding RNA LOC441178 Reduces the Invasion and Migration of Squamous Carcinoma Cells by Targeting ROCK1.
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Long noncoding RNA MORT overexpression inhibits cancer cell proliferation in oral squamous cell carcinoma by downregulating ROCK1.
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Long noncoding RNA POU3F3 promotes cancer cell proliferation in prostate carcinoma by upregulating rho-associated protein kinase 1.
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Long-term artificial selection reveals a role of TCTP in autophagy in mammalian cells.
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Longitudinal phenotypic study of late-onset retinal degeneration due to a founder variant c.562C>A p.(Pro188Thr) in the C1QTNF5 gene.
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Loss of AMPK?2 Impairs Hedgehog-Driven Medulloblastoma Tumorigenesis.
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m5C RNA Methylation Primarily Affects the ErbB and PI3K-Akt Signaling Pathways in Gastrointestinal Cancer.
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Macrophage-Associated PGK1 Phosphorylation Promotes Aerobic Glycolysis and Tumorigenesis.
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MAGEA6 promotes human glioma cell survival via targeting AMPK?1.
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Magnolol-Induced Apoptosis in HCT-116 Colon Cancer Cells Is Associated with the AMP-Activated Protein Kinase Signaling Pathway.
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MARK1 is a Novel Target for miR-125a-5p: Implications for Cell Migration in Cervical Tumor Cells.
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Mechanism of sphingosine-1-phosphate induced cardioprotection against I/R injury in diabetic rat heart: Possible involvement of glycogen synthase kinase 3? and mitochondrial permeability transition pore.
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MEK inhibition suppresses cell invasion and migration in ovarian cancers with activation of ERK1/2.
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MET Inhibitors Promote Liver Tumor Evasion of the Immune Response by Stabilizing PDL1.
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Metabolic changes associated with metformin potentiates Bcl-2 inhibitor, Venetoclax, and CDK9 inhibitor, BAY1143572 and reduces viability of lymphoma cells.
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Metformin and AICAR regulate NANOG expression via the JNK pathway in HepG2 cells independently of AMPK.
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Metformin and Ara-a Effectively Suppress Brain Cancer by Targeting Cancer Stem/Progenitor Cells.
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Metformin and berberine, two versatile drugs in treatment of common metabolic diseases.
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Metformin and Cancer Glucose Metabolism: At the Bench or at the Bedside?
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Metformin Augments Panobinostat's Anti-Bladder Cancer Activity by Activating AMP-Activated Protein Kinase.
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Metformin displays anti-myeloma activity and synergistic effect with dexamethasone in in vitro and in vivo xenograft models.
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Metformin Dysregulates the Unfolded Protein Response and the WNT/?-Catenin Pathway in Endometrial Cancer Cells through an AMPK-Independent Mechanism.
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Metformin Induces Apoptosis and Inhibits Proliferation through the AMP-Activated Protein Kinase and Insulin-like Growth Factor 1 Receptor Pathways in the Bile Duct Cancer Cells.
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Metformin induces g1 cell cycle arrest and inhibits cell proliferation in nasopharyngeal carcinoma cells.
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Metformin inhibits estrogen-dependent endometrial cancer cell growth by activating the AMPK-FOXO1 signal pathway.
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Metformin Inhibits Progression of Head and Neck Squamous Cell Carcinoma by Acting Directly on Carcinoma-Initiating Cells.
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Metformin is synthetically lethal with glucose withdrawal in cancer cells.
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Metformin Prevents the Development of Chronic Heart Failure in the SHHF Rat Model.
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Metformin targets multiple signaling pathways in cancer.
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Metformin, insulin, breast cancer and more...
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Methylselenol, a selenium metabolite, induces cell cycle arrest in G1 phase and apoptosis via the extracellular-regulated kinase 1/2 pathway and other cancer signaling genes.
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Microarray data re-annotation reveals specific lncRNAs and their potential functions in non-small cell lung cancer subtypes.
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MicroRNA-144 acts as a tumor suppressor by targeting Rho-associated coiled-coil containing protein kinase 1 in osteosarcoma cells.
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MicroRNA-217 functions as a tumor suppressor in cervical cancer cells through targeting Rho-associated protein kinase 1.
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MicroRNA-335 and its target Rock1 synergistically influence tumor progression and prognosis in osteosarcoma.
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MicroRNA-mediated upregulation of integrin-linked kinase promotes Src-induced tumor progression.
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MIF/CD74 axis is a target for novel therapies in colon carcinomatosis.
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MiR-126 functions as a tumor suppressor by targeting SRPK1 in human gastric cancer.
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miR-1273g silences MAGEA3/6 to inhibit human colorectal cancer cell growth via activation of AMPK signaling.
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MiR-199a-5p Inhibits the Growth and Metastasis of Colorectal Cancer Cells by Targeting ROCK1.
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miR-200c/141 Regulates Breast Cancer Stem Cell Heterogeneity via Targeting HIPK1/?-Catenin Axis.
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MiR-486-5p Act as a Biomarker in Endometrial Carcinoma: Promotes Cell Proliferation, Migration, Invasion by Targeting MARK1.
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MiR-506 suppresses cell proliferation and tumor growth by targeting Rho-associated protein kinase 1 in hepatocellular carcinoma.
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MiR-769 promoted cell proliferation in human melanoma by suppressing GSK3B expression.
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miR?124 inhibits cell growth through targeting IQGAP1 in colorectal cancer.
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Misregulation of polo-like protein kinase 1, P53 and P21WAF1 in epithelial ovarian cancer suggests poor prognosis.
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Mitochondrial DNA Maintenance Is Regulated in Human Hepatoma Cells by Glycogen Synthase Kinase 3? and p53 in Response to Tumor Necrosis Factor ?.
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Modulation of Cancer Cell Autophagic Responses by Graphene-Based Nanomaterials: Molecular Mechanisms and Therapeutic Implications.
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Modulation of deoxycytidine kinase (dCK) and glycogen synthase kinase (GSK-3?) by anti-CD20 (rituximab) and 2-chlorodeoxyadenosine (2-CdA) in human lymphoid malignancies.
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Molecular Determinants of Thyroid Nodules with Indeterminate Cytology and RAS Mutations.
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Molecular docking based screening analysis of GSK3B.
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Molecular Mechanism of Nucleotide-Dependent Allosteric Regulation in AMP-Activated Protein Kinase.
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Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor.
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MSK1 promotes cell proliferation and metastasis in uveal melanoma by phosphorylating CREB.
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Mst1 overexpression combined with Yap knockdown augments thyroid carcinoma apoptosis via promoting MIEF1-related mitochondrial fission and activating the JNK pathway.
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mTORC1 directly inhibits AMPK to promote cell proliferation under nutrient stress.
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Multiple implications of 3-phosphoinositide-dependent protein kinase 1 in human cancer.
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Mutation in the ?2-Subunit of AMP-Activated Protein Kinase Stimulates Cardiomyocyte Proliferation and Hypertrophy Independent of Glycogen Storage.
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Mutational analysis of the CTNNB1 (beta-catenin) gene in human endometrial cancer: frequent mutations at codon 34 that cause nuclear accumulation.
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Mutations of the beta-catenin gene in endometrial carcinomas.
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Myeloid cell-derived LL-37 promotes lung cancer growth by activating Wnt/?-catenin signaling.
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n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
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Narrative review of the influence of diabetes mellitus and hyperglycemia on colorectal cancer risk and oncological outcomes.
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NDRG2 overexpression enhances glucose deprivation-mediated apoptosis in breast cancer cells via inhibition of the LKB1-AMPK pathway.
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Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases.
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Negative regulation of AMP-activated protein kinase (AMPK) activity by MIF family members in NSCLC.
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NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis.
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New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
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New perspective for an old antidiabetic drug: metformin as anticancer agent.
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NFE2L2/NRF2 Activity Is Linked to Mitochondria and AMP-Activated Protein Kinase Signaling in Cancers Through miR-181c/Mitochondria-Encoded Cytochrome c Oxidase Regulation.
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Nicotine Promotes Cholangiocarcinoma Growth in Xenograft Mice.
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Nootkatone, an AMPK activator derived from grapefruit, inhibits KRAS downstream pathway and sensitizes non-small-cell lung cancer A549 cells to adriamycin.
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Novel Anti-Angiogenic and Anti-Tumour Activities of the N-Terminal Domain of NOEY2 via Binding to VEGFR-2 in Ovarian Cancer.
Neoplasms
Novel epigallocatechin gallate (EGCG) analogs activate AMP-activated protein kinase pathway and target cancer stem cells.
Neoplasms
Novel mutations and role of the LKB1 gene as a tumor suppressor in renal cell carcinoma.
Neoplasms
Novel synthetic baicalein derivatives caused apoptosis and activated AMP-activated protein kinase in human tumor cells.
Neoplasms
Oleanolic acid induces metabolic adaptation in cancer cells by activating the AMP-activated protein kinase pathway.
Neoplasms
Oncogenic activity and cellular functionality of melanoma associated antigen A3.
Neoplasms
Over-expressions of AMPK subunits in ovarian carcinomas with significant clinical implications.
Neoplasms
Overexpression of ROCK1 promotes cancer cell proliferation and is associated with poor prognosis in human urothelial bladder cancer.
Neoplasms
P21-activated protein kinase 1 is overexpressed in gastric cancer and induces cancer metastasis.
Neoplasms
p38 mitogen-activated protein kinase controls NF-kappaB transcriptional activation and tumor necrosis factor alpha production through RelA phosphorylation mediated by mitogen- and stress-activated protein kinase 1 in response to Borrelia burgdorferi antigens.
Neoplasms
Pancreatic lkb1 deletion leads to acinar polarity defects and cystic neoplasms.
Neoplasms
Paradoxical activation of AMPK by glucose drives selective EP300 activity in colorectal cancer.
Neoplasms
Parkin, PINK1 and DJ1 as possible modulators of mTOR pathway in ganglioglioma.
Neoplasms
Past strategies and future directions for identifying AMP-activated protein kinase (AMPK) modulators.
Neoplasms
Paternal malnutrition programs breast cancer risk and tumor metabolism in offspring.
Neoplasms
Pathway pathology: histological differences between ErbB/Ras and Wnt pathway transgenic mammary tumors.
Neoplasms
PDK1 induces JunB, EMT, cell migration and invasion in human gallbladder cancer.
Neoplasms
Perspectives of adenosine monophosphate activated kinase (AMPK) signalling pathway in thyroid cancer.
Neoplasms
Pharmacological Effects of 1'-Acetoxychavicol Acetate, a Major Constituent in the Rhizomes of Alpinia galanga and Alpinia conchigera.
Neoplasms
Phenformin as an Anticancer Agent: Challenges and Prospects.
Neoplasms
Phillyrin lowers body weight in obese mice via the modulation of PPAR/-ANGPTL 4 pathway.
Neoplasms
Phosphatase and Tensin Homolog Deleted on Chromosome Ten Knockdown Attenuates Cognitive Deficits by Inhibiting Neuroinflammation in a Mouse Model of Perioperative Neurocognitive Disorder.
Neoplasms
Phosphatidylinositol ether lipid analogues induce AMP-activated protein kinase-dependent death in LKB1-mutant non small cell lung cancer cells.
Neoplasms
Phosphoinositide-dependent protein kinase 1 is a potential novel therapeutic target in mantle cell lymphoma.
Neoplasms
Phosphorylation and Inactivation of Glycogen Synthase Kinase 3? (GSK3?) by Dual-specificity Tyrosine Phosphorylation-regulated Kinase 1A (Dyrk1A).
Neoplasms
Phytomodulatory proteins promote inhibition of hepatic glucose production and favor glycemic control via the AMPK pathway.
Neoplasms
PI3K, Rac1 and pPAK1 are overexpressed in extramammary Paget's disease.
Neoplasms
PLEKHO2 inhibits TNF?-induced cell death by suppressing RIPK1 activation.
Neoplasms
Possible link between NO concentrations and COX-2 expression in systems treated with soy-isoflavones.
Neoplasms
Potential Antileukemia Effect and Structural Analyses of SRPK Inhibition by N-(2-(Piperidin-1-yl)-5-(Trifluoromethyl)Phenyl)Isonicotinamide (SRPIN340).
Neoplasms
Potential antitumor mechanisms of phenothiazine drugs.
Neoplasms
Potential biomarkers and therapeutic targets in cervical cancer: Insights from the meta-analysis of transcriptomics data within network biomedicine perspective.
Neoplasms
Potential therapeutic effect of targeting glycogen synthase kinase 3? in esophageal squamous cell carcinoma.
Neoplasms
Production and Crystallization of Full-Length Human AMP-Activated Protein Kinase (?1?1?1).
Neoplasms
Prognostic significance of AMP-activated protein kinase expression and modifying effect of MAPK3/1 in colorectal cancer.
Neoplasms
Prognostic Significance of AMP-Dependent Kinase Alpha Expression in Cervical Cancer.
Neoplasms
Prognostic Significance of AMPK Activation and Therapeutic Effects of Metformin in Hepatocellular Carcinoma.
Neoplasms
Prognostic significance of AMPK activation in advanced stage colorectal cancer treated with chemotherapy plus bevacizumab.
Neoplasms
Prognostic values of ERK1/2 and p-ERK1/2 expressions for poor survival in non-small cell lung cancer.
Neoplasms
Proliferative and androgenic effects of indirubin derivatives in LNCaP human prostate cancer cells at sub-apoptotic concentrations.
Neoplasms
Proline dehydrogenase (oxidase), a mitochondrial tumor suppressor, and autophagy under the hypoxia microenvironment.
Neoplasms
Prolyl isomerase Pin1 in metabolic reprogramming of cancer cells.
Neoplasms
Prospective Evaluation of Effect of Metformin on Activation of AMP-activated Protein Kinase (AMPK) and Disease Control in a Sub-group Analysis of Patients with GI Malignancies.
Neoplasms
Protective effect of Lycium barbarum polysaccharides against high-fat diet-induced renal injury and lipid deposition in rat kidneys.
Neoplasms
Protective vascular and myocardial effects of adiponectin.
Neoplasms
Protein activation dynamics in cells and tumor micro arrays assessed by time resolved förster resonance energy transfer.
Neoplasms
Protein kinase-a directed antisense therapy of tumor growth in vivo : the antisense effects outlast antisense survival.
Neoplasms
Proteomic and phosphoproteomic alterations in benign, premalignant and tumor human breast epithelial cells and xenograft lesions: biomarkers of progression.
Neoplasms
Purification of p53/55 kinase from nuclear ribonucleoproteins of Namalwa cells.
Neoplasms
Putative Mechanisms Responsible for the Antihyperglycemic Action of Lactobacillus paracasei HII01 in Experimental Type 2 Diabetic Rats.
Neoplasms
Pyruvate kinase M knockdown-induced signaling via AMP-activated protein kinase promotes mitochondrial biogenesis, autophagy, and cancer cell survival.
Neoplasms
Qiyusanlong decoction suppresses lung cancer in mice via Wnt/?-catenin pathway.
Neoplasms
Ramping up the signal: promoting endurance training adaptation in skeletal muscle by nutritional manipulation.
Neoplasms
RBMY, a novel inhibitor of glycogen synthase kinase 3?, increases tumor stemness and predicts poor prognosis of hepatocellular carcinoma.
Neoplasms
Recent advances in the role of AMP-activated protein kinase in metabolic reprogramming of metastatic cancer cells: targeting cellular bioenergetics and biosynthetic pathways for anti-tumor treatment.
Neoplasms
Reciprocal expression of p-AMPKa and p-S6 is strongly associated with the prognosis of gastric cancer.
Neoplasms
Reciprocal Regulation between Primary Cilia and mTORC1.
Neoplasms
Reconstruction of Purine Metabolism in Bacillus subtilis to Obtain the Strain Producer of AICAR: A New Drug with a Wide Range of Therapeutic Applications.
Neoplasms
Reduced expression of p21-activated protein kinase 1 correlates with poor histological differentiation in pancreatic cancer.
Neoplasms
Regulation and function of autophagy in pancreatic cancer.
Neoplasms
Regulation of the C-X-C chemokine, mob-1, gene expression in primary rat hepatocytes.
Neoplasms
Requirements of LEFTY and Nodal overexpression for tumor cell survival under hypoxia in glioblastoma.
Neoplasms
Resveratrol enhances prostate cancer cell response to ionizing radiation. Modulation of the AMPK, Akt and mTOR pathways.
Neoplasms
Resveratrol inhibits necroptosis by mediating the TNF-?/RIP1/RIP3/MLKL pathway in myocardial hypoxia/reoxygenation injury.
Neoplasms
Retracted: Resveratrol inhibits oesophageal adenocarcinoma cell proliferation via AMP-activated protein kinase signaling
Neoplasms
Revealing the effect of 6-gingerol, 6-shogaol and curcumin on mPGES-1, GSK-3? and ?-catenin pathway in A549 cell line.
Neoplasms
Reversing the warburg effect as a treatment for glioblastoma.
Neoplasms
Reversion-inducing cysteine-rich protein with Kazal motifs and its regulation by glycogen synthase kinase 3 signaling in oral cancer.
Neoplasms
RIPK1 binds to vitamin D receptor and decreases vitamin D-induced growth suppression.
Neoplasms
ROCK1 Inhibition Promotes the Self-Renewal of a Novel Mouse Mammary Cancer Stem Cell.
Neoplasms
ROCK1 promotes migration and invasion of non?small?cell lung cancer cells through the PTEN/PI3K/FAK pathway.
Neoplasms
Role of AMP-Activated Protein Kinase in Cancer Therapy.
Neoplasms
Role of AMPK and PPAR? in the anti-skin cancer effects of ursolic acid.
Neoplasms
Role of heparanase 2 (Hpa2) in gastric cancer.
Neoplasms
Role of MicroRNAs in carcinogenesis that potential for biomarker of endometrial cancer.
Neoplasms
Role of the LKB1/AMPK pathway in tumor invasion and metastasis of cancer cells (Review).
Neoplasms
ROS/KRAS/AMPK Signaling Contributes to Gemcitabine-Induced Stem-like Cell Properties in Pancreatic Cancer.
Neoplasms
S-Adenosylmethionine and methylthioadenosine inhibit ?-catenin signaling by multiple mechanisms in liver and colon cancer.
Neoplasms
Salinomycin suppresses LRP6 expression and inhibits both Wnt/?-catenin and mTORC1 signaling in breast and prostate cancer cells.
Neoplasms
Serine arginine protein kinase 1 (SRPK1): a moonlighting protein with theranostic ability in cancer prevention.
Neoplasms
Serine-Arginine Protein Kinase 1 (SRPK1) as a Prognostic Factor and Potential Therapeutic Target in Cancer: Current Evidence and Future Perspectives.
Neoplasms
Serine-arginine protein kinase 1 (SRPK1), a determinant of angiogenesis, is upregulated in prostate cancer and correlates with disease stage and invasion.
Neoplasms
Serine-arginine protein kinase 1 is associated with hepatocellular carcinoma progression and poor patient survival.
Neoplasms
Serine-arginine protein kinase 1 promotes a cancer stem cell-like phenotype through activation of Wnt/?-catenin signalling in NSCLC.
Neoplasms
Serine/arginine protein-specific kinase 2 promotes the development and progression of pancreatic cancer by downregulating Numb and p53.
Neoplasms
Serine/threonine protein phosphatase 5 is a potential therapeutic target in cholangiocarcinoma.
Neoplasms
Sestrin2 Modulates AMPK Subunit Expression and Its Response to Ionizing Radiation in Breast Cancer Cells.
Neoplasms
Signal pathway profiling of ovarian cancer from human tissue specimens using reverse-phase protein microarrays.
Neoplasms
Small Molecule Inhibition of GSK-3 Specifically Inhibits the Transcription of Inhibitory Co-receptor LAG-3 for Enhanced Anti-tumor Immunity.
Neoplasms
sMEK1 inhibits endothelial cell proliferation by attenuating VEGFR-2-dependent-Akt/eNOS/HIF-1? signaling pathways.
Neoplasms
SORBS1 serves a metastatic role via suppression of AHNAK in colorectal cancer cell lines.
Neoplasms
Spatial alterations of De Novo purine biosynthetic enzymes by Akt-independent PDK1 signaling pathways.
Neoplasms
SRPK2 Acts Downstream of MTORC1 to Promote
Neoplasms
SRPK2 promotes the growth and migration of the colon cancer cells.
Neoplasms
Structural Basis for MARK1 Kinase Autoinhibition by Its KA1 Domain.
Neoplasms
Structural basis of AMPK regulation by adenine nucleotides and glycogen.
Neoplasms
Study and Experimental Validation of the Functional Components and Mechanisms of Hemerocallis citrina Baroni in the Treatment of Lactation Deficiency.
Neoplasms
Substituted oxindol-3-ylidenes as AMP-activated protein kinase (AMPK) inhibitors.
Neoplasms
Subunit composition of AMPK trimers present in the cytokinetic apparatus: Implications for drug target identification.
Neoplasms
Sulindac sulfide inhibits epidermal growth factor-induced phosphorylation of extracellular-regulated kinase 1/2 and Bad in human colon cancer cells.
Neoplasms
Synergic chemoprevention with dietary carbohydrate restriction and supplementation of AMPK-activating phytochemicals: the role of SIRT1.
Neoplasms
Synthesis and biological evaluation of 3-substituted 2-oxindole derivatives as new glycogen synthase kinase 3? inhibitors.
Neoplasms
Systematic module approach identifies altered genes and pathways in four types of ovarian cancer.
Neoplasms
TAK1-TAB2 Signaling Contributes to Bone Destruction by Breast Carcinoma Cells.
Neoplasms
TallyHO obese female mice experience poor reproductive outcomes and abnormal blastocyst metabolism that is reversed by metformin.
Neoplasms
Tanshinone I regulates autophagic signaling via the activation of AMP-activated protein kinase in cancer cells.
Neoplasms
Targeting AMPK signaling in combating ovarian cancers: opportunities and challenges.
Neoplasms
Targeting AMPK Signaling Pathway to Overcome Drug Resistance for Cancer Therapy.
Neoplasms
Targeting of lipid metabolism with a metabolic inhibitor cocktail eradicates peritoneal metastases in ovarian cancer cells.
Neoplasms
Targeting of TGF-?-activated protein kinase 1 inhibits chemokine (C-C motif) receptor 7 expression, tumor growth and metastasis in breast cancer.
Neoplasms
Targeting PDK1 in cancer.
Neoplasms
Targeting the AMP-Activated Protein Kinase for Cancer Prevention and Therapy.
Neoplasms
Targeting the RNA splicing machinery as a novel treatment strategy for pancreatic carcinoma.
Neoplasms
TGF?-activated kinase 1 (TAK1)-binding proteins (TAB) 2 and 3 negatively regulate autophagy.
Neoplasms
The activated nerve growth factor receptor p-TrkA is selectively expressed in advanced-stage ovarian carcinoma.
Neoplasms
The AMP-activated protein kinase (AMPK) and cancer: Many faces of a metabolic regulator.
Neoplasms
The ATM protein kinase and cellular redox signaling: beyond the DNA damage response.
Neoplasms
The Critical Role of SRPK1 in EMT of Human Glioblastoma in the Spinal Cord.
Neoplasms
The crucial role of SRPK1 in IGF-1-induced EMT of human gastric cancer.
Neoplasms
The death-inducing activity of RIPK1 is regulated by the pH environment.
Neoplasms
The disaccharide trehalose inhibits proinflammatory phenotype activation in macrophages and prevents mortality in experimental septic shock.
Neoplasms
The discovery of novel benzothiazinones as highly selective non-ATP competitive glycogen synthase kinase 3? inhibitors for the treatment of ovarian cancer.
Neoplasms
The E3 Ubiquitin-Protein Ligase RNF4 Promotes TNF-?-Induced Cell Death Triggered by RIPK1.
Neoplasms
The effects of adiponectin and metformin on prostate and colon neoplasia involve activation of AMP-activated protein kinase.
Neoplasms
The energy sensing LKB1-AMPK?1 pathway regulates IGF1 secretion and consequent activation of the IGF1R-PKB pathway in primary hepatocytes.
Neoplasms
The Energy Status of Astrocytes Is the Achilles' Heel of eIF2B-Leukodystrophy.
Neoplasms
The evolving roles of canonical WNT signaling in stem cells and tumorigenesis: implications in targeted cancer therapies.
Neoplasms
The Function of PPAR?/AMPK/SIRT-1 Pathway in Inflammatory Response of Human Articular Chondrocytes Stimulated by Advanced Glycation End Products.
Neoplasms
The glycogen synthase kinase (GSK) 3beta represses RNA polymerase I transcription.
Neoplasms
The influence of circular RNAs on autophagy and disease progression.
Neoplasms
The Interplay of AMP-Activated Protein Kinase and Androgen Receptor in Prostate Cancer Cells.
Neoplasms
The LKB1/AMPK polarity pathway.
Neoplasms
The MST4-MOB4 complex disrupts the MST1-MOB1 complex in the Hippo-YAP pathway and plays a pro-oncogenic role in pancreatic cancer.
Neoplasms
The ORF3 Protein of Genotype 1 Hepatitis E Virus Suppresses TLR3-induced NF-?B Signaling via TRADD and RIP1.
Neoplasms
The presence of wild type p53 in hematological cancers improves the efficacy of combinational therapy targeting metabolism.
Neoplasms
The prognostic value of DAPK1 hypermethylation in gliomas: A site-specific analysis.
Neoplasms
The protective mechanism underlying total flavones of Dracocephalum (TFD) effects on rat cerebral ischemia reperfusion injury.
Neoplasms
The Proteome of Primary Prostate Cancer.
Neoplasms
The response to PAK1 inhibitor IPA3 distinguishes between cancer cells with mutations in BRAF and Ras oncogenes.
Neoplasms
The ribonucleoside AICAr induces differentiation of myeloid leukemia by activating the ATR/Chk1 kinase via pyrimidine depletion.
Neoplasms
The RNA-Binding Protein PCBP1 Functions as a Tumor Suppressor in Prostate Cancer by Inhibiting Mitogen Activated Protein Kinase 1.
Neoplasms
The role of autophagy in targeted therapy for acute myeloid leukemia.
Neoplasms
The Role of Heparin Cofactor ? in the Regulation of Insulin Sensitivity and Maintenance of Glucose Homeostasis in Humans and Mice.
Neoplasms
The role of targeting kinase activity by natural products in cancer chemoprevention and chemotherapy (Review).
Neoplasms
The serine/threonine kinase LKB1 controls thymocyte survival through regulation of AMPK activation and Bcl-XL expression.
Neoplasms
The synergistic effect of 1'-acetoxychavicol acetate and sodium butyrate on the death of human hepatocellular carcinoma cells.
Neoplasms
The tumor antigen repertoire identified in tumor-bearing neu transgenic mice predicts human tumor antigens.
Neoplasms
The Wnt/?-catenin pathway drives increased cyclin D1 levels in lymph node metastasis in papillary thyroid cancer.
Neoplasms
Thiamin deficiency induces impaired fish gill immune responses, tight junction protein expression and antioxidant capacity: Roles of the NF-?B, TOR, p38 MAPK and Nrf2 signaling molecules.
Neoplasms
Thioridazine inhibits angiogenesis and tumor growth by targeting the VEGFR-2/PI3K/mTOR pathway in ovarian cancer xenografts.
Neoplasms
Thymoquinone ameliorates obesity-induced metabolic dysfunction, improves reproductive efficiency exhibiting a dose-organ relationship.
Neoplasms
TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1.
Neoplasms
TNF-induced necroptosis initiates early autophagy events via RIPK3-dependent AMPK activation, but inhibits late autophagy.
Neoplasms
Tozasertib Analogues as Inhibitors of Necroptotic Cell Death.
Neoplasms
Transcriptional profiling of genes at the human common fragile site FRA1H in tumor-derived cell lines.
Neoplasms
Transformation of mammary epithelial cells by 3-phosphoinositide-dependent protein kinase-1 (PDK1) is associated with the induction of protein kinase Calpha.
Neoplasms
Transient Receptor Potential Melastatin 8 (TRPM8) Channel Regulates Proliferation and Migration of Breast Cancer Cells by Activating the AMPK-ULK1 Pathway to Enhance Basal Autophagy.
Neoplasms
Treadmill exercise produces neuroprotective effects in a murine model of Parkinson's disease by regulating the TLR2/MyD88/NF-?B signaling pathway.
Neoplasms
TTBK2 circular RNA promotes glioma malignancy by regulating miR-217/HNF1?/Derlin-1 pathway.
Neoplasms
Tumor necrosis factor alpha-induced desumoylation and cytoplasmic translocation of homeodomain-interacting protein kinase 1 are critical for apoptosis signal-regulating kinase 1-JNK/p38 activation.
Neoplasms
Tumor necrosis factor-? induces increased lung vascular permeability: A role for GSK3?/?.
Neoplasms
Tumor Necrosis Factor-? Promotes Phosphoinositide 3-Kinase Enhancer A and AMP-Activated Protein Kinase Interaction to Suppress Lipid Oxidation in Skeletal Muscle.
Neoplasms
Tumor necrosis factor-alpha induces interleukin-6 production via extracellular-regulated kinase 1 activation in breast cancer cells.
Neoplasms
Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-Troglitazone-induced Apoptosis in Prostate Cancer Cells Involve AMP-activated Protein Kinase.
Neoplasms
Tumor-Associated Macrophages Enhance Tumor Hypoxia and Aerobic Glycolysis.
Neoplasms
Tumour Microenvironment: Roles of the Aryl Hydrocarbon Receptor, O-GlcNAcylation, Acetyl-CoA and Melatonergic Pathway in Regulating Dynamic Metabolic Interactions across Cell Types-Tumour Microenvironment and Metabolism.
Neoplasms
Tuning of apoptosis-mediator gene transcription in HepG2 human hepatoma cells through an adenosine signal.
Neoplasms
TXNIP/VDUP1 attenuates steatohepatitis via autophagy and fatty acid oxidation.
Neoplasms
Type 2 diabetes is associated with altered NF-?B DNA binding activity, JNK phosphorylation, and AMPK phosphorylation in skeletal muscle after LPS.
Neoplasms
Tyrosine Kinase SYK Licenses MyD88 Adaptor Protein to Instigate IL-1?-Mediated Inflammatory Disease.
Neoplasms
Upregulation of GPNCA is associated with poor prognosis through enhancement of tumor growth via regulating GSK3B.
Neoplasms
Upregulation of Na-coupled glucose transporter SGLT1 by Tau tubulin kinase 2.
Neoplasms
Variation in genes coding for AMP-activated protein kinase (AMPK) and breast cancer risk in the European Prospective Investigation on Cancer (EPIC).
Neoplasms
Verotoxin-2 Activates Mitogen-Activated Protein Kinases in Bovine Adherent Peripheral Blood Mononuclear Cells.
Neoplasms
Weight control and cancer preventive mechanisms: role of insulin growth factor-1-mediated signaling pathways.
Neoplasms
Widdrol induces apoptosis via activation of AMP-activated protein kinase in colon cancer cells.
Neoplasms
Withdrawal: Inhibition of AMP-activated protein kinase sensitizes cancer cells to cisplatin-induced apoptosis via hyper-induction of p53.
Neoplasms
Y-27632 Increases Sensitivity of PANC-1 Cells to EGCG in Regulating Cell Proliferation and Migration.
Neoplasms
ZBP1 not RIPK1 mediates tumor necroptosis in breast cancer.
Neoplasms
[Establishment of a mice model with liver-specific AMP-activated protein kinase gene knockout].
Neoplasms
[Expression and significance of p-AKT, p-GSK3? and ?-catenin in epithelial carcinoma of ovary].
Neoplasms
[Retracted] MicroRNA?144 acts as a tumor suppressor by targeting Rho?associated coiled?coil containing protein kinase 1 in osteosarcoma cells.
Neoplasms
[Transfection of tumor metastasis suppressor gene nm23-H1 can up-regulate the activity of GSK-3? in human high-metastasis large cell lung cancer cell line L9981.]
Nephrosis
Podocytes maintain high basal levels of autophagy independent of mtor signaling.
Nervous System Diseases
GSK3b, a centre-staged kinase in neuropsychiatric disorders, modulates long term memory by inhibitory phosphorylation at Ser-9.
Nervous System Diseases
The Ever-Changing Morphology of Hippocampal Granule Neurons in Physiology and Pathology.
Nervous System Diseases
The functional variant rs334558 of GSK3B is associated with remission in patients with depressive disorders.
Neuralgia
Gene therapy by lentivirus-mediated RNA interference targeting extracellular-regulated kinase alleviates neuropathic pain in vivo.
Neuralgia
Glycogen synthase kinase 3-specific inhibitor AR-A014418 decreases neuropathic pain in mice: evidence for the mechanisms of action.
Neuralgia
Obesity increases neuropathic pain via the AMPK-ERK-NOX4 pathway in rats.
Neuralgia
Redox-guided axonal regrowth requires cyclic GMP dependent protein kinase 1: Implication for neuropathic pain.
Neuroblastoma
All-trans retinoic acid induces COX-2 and prostaglandin E2 synthesis in SH-SY5Y human neuroblastoma cells: involvement of retinoic acid receptors and extracellular-regulated kinase 1/2.
Neuroblastoma
AMP-activated protein kinase inhibits MPP+-induced oxidative stress and apoptotic death of SH-SY5Y cells through sequential stimulation of Akt and autophagy.
Neuroblastoma
Autophagy-dependent and -independent involvement of AMP-activated protein kinase in 6-hydroxydopamine toxicity to SH-SY5Y neuroblastoma cells.
Neuroblastoma
Berberine modulates amyloid-? peptide generation by activating AMP-activated protein kinase.
Neuroblastoma
Bupivacaine Induces Reactive Oxygen Species Production via Activation of the AMP-Activated Protein Kinase-Dependent Pathway.
Neuroblastoma
Coordinated activation of AMP-activated protein kinase, extracellular signal-regulated kinase, and autophagy regulates phorbol myristate acetate-induced differentiation of SH-SY5Y neuroblastoma cells.
Neuroblastoma
Estrogen induces a rapid secretion of amyloid beta precursor protein via the mitogen-activated protein kinase pathway.
Neuroblastoma
Involvement of AMP-activated protein kinase in mediating pyrrolo-1,5-benzoxazepine-induced apoptosis in neuroblastoma cells.
Neuroblastoma
Involvement of store-operated Ca(2+) entry in activation of AMP-activated protein kinase and stimulation of glucose uptake by M3 muscarinic acetylcholine receptors in human neuroblastoma cells.
Neuroblastoma
LIN28B regulates transcription and potentiates MYCN-induced neuroblastoma through binding to ZNF143 at target gene promotors.
Neuroblastoma
Lithium chloride and staurosporine potentiate the accumulation of phosphorylated glycogen synthase kinase 3?/Tyr216, resulting in glycogen synthase kinase 3? activation in SH-SY5Y human neuroblastoma cell lines.
Neuroblastoma
Proapoptotic stimuli induce nuclear accumulation of glycogen synthase kinase-3 beta.
Neuroblastoma
Requirement of AMPK activation for neuronal metabolic-enhancing effects of antidepressant paroxetine.
Neuroblastoma
Role of extracellular-regulated kinase and c-jun NH(2)-terminal kinase in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurofilament phosphorylation.
Neuroblastoma
The interrelationship between selective tau phosphorylation and microtubule association.
Neuroblastoma
The neuron-specific isoform of glycogen synthase kinase-3beta is required for axon growth.
Neuroblastoma
Valproic acid enhances protein L-isoaspartyl methyltransferase expression by stimulating extracellular signal-regulated kinase signaling pathway.
Neurodegenerative Diseases
A 24-residue peptide (p5), derived from p35, the Cdk5 neuronal activator, specifically inhibits Cdk5-p25 hyperactivity and tau hyperphosphorylation.
Neurodegenerative Diseases
A Bibenzyl Component Moscatilin Mitigates Glycation-Mediated Damages in an SH-SY5Y Cell Model of Neurodegenerative Diseases through AMPK Activation and RAGE/NF-?B Pathway Suppression.
Neurodegenerative Diseases
Acute inhibition of the CNS-specific kinase TTBK1 significantly lowers tau phosphorylation at several disease relevant sites.
Neurodegenerative Diseases
Adult onset pan-neuronal human tau tubulin kinase 1 expression causes severe cerebellar neurodegeneration in mice.
Neurodegenerative Diseases
aFGF Promotes Neurite Growth by Regulating GSK3?-CRMP2 Signaling Pathway in Cortical Neurons Damaged by Amyloid-?.
Neurodegenerative Diseases
AMPK: Potential Therapeutic Target for Alzheimer's disease.
Neurodegenerative Diseases
An impedimetric microelectrode-based array sensor for label-free detection of tau hyperphosphorylation in human cells.
Neurodegenerative Diseases
Association study of the GSK-3B gene with tardive dyskinesia in European Caucasians.
Neurodegenerative Diseases
C9orf72 ALS-FTD: recent evidence for dysregulation of the autophagy-lysosome pathway at multiple levels.
Neurodegenerative Diseases
Capillary electrophoresis as a novel technique for screening natural flavonoids as kinase inhibitors.
Neurodegenerative Diseases
Cdk5: a multifaceted kinase in neurodegenerative diseases.
Neurodegenerative Diseases
Cholesterol derivatives induce dephosphorylation of the histone deacetylases Rpd3/HDAC1 to upregulate autophagy.
Neurodegenerative Diseases
Conditional GSK3? deletion in parvalbumin-expressing interneurons potentiates excitatory synaptic function and learning in adult mice.
Neurodegenerative Diseases
Delayed treatment of 6-Bromoindirubin-3'-oxime stimulates neurogenesis and functional recovery after focal ischemic stroke in mice.
Neurodegenerative Diseases
Exploring the Multifaceted Therapeutic Potential of Withaferin A and Its Derivatives.
Neurodegenerative Diseases
Highlighting the protective or degenerative role of AMPK activators in dementia experimental models.
Neurodegenerative Diseases
Identification and Mechanistic Characterization of a Peptide Inhibitor of Glycogen Synthase Kinase (GSK3?) Derived from the Disrupted in Schizophrenia 1 (DISC1) Protein.
Neurodegenerative Diseases
Identification of human tau-tubulin kinase 1 inhibitors: an integrated e-pharmacophore-based virtual screening and molecular dynamics simulation.
Neurodegenerative Diseases
Increased prefrontal cortex interleukin-2 protein levels and shift in the peripheral T cell population in progressive supranuclear palsy patients.
Neurodegenerative Diseases
Inhibition of glycogen synthase kinase-3 suppresses the onset of symptoms and disease progression of G93A-SOD1 mouse model of ALS.
Neurodegenerative Diseases
Isoform-specific dysregulation of AMP-activated protein kinase signaling in a non-human primate model of Alzheimer's disease.
Neurodegenerative Diseases
Kinase inhibitor scaffolds against neurodegenerative diseases from a Southern Australian ascidian, Didemnum sp.
Neurodegenerative Diseases
Lithium Inhibits GSK3? and Augments GluN2A Receptor Expression in the Prefrontal Cortex.
Neurodegenerative Diseases
Lithium Use During Pregnancy in a Patient With Bipolar Disorder and Multiple Sclerosis.
Neurodegenerative Diseases
Metabolic Aspects of Adenosine Functions in the Brain.
Neurodegenerative Diseases
Monosodium glutamate neurotoxicity increases beta amyloid in the rat hippocampus: a potential role for cyclic AMP protein kinase.
Neurodegenerative Diseases
Neuronal AMP-activated protein kinase hyper-activation induces synaptic loss by an autophagy-mediated process.
Neurodegenerative Diseases
Pharmacological Effects of 1'-Acetoxychavicol Acetate, a Major Constituent in the Rhizomes of Alpinia galanga and Alpinia conchigera.
Neurodegenerative Diseases
Pharmacological Interventions to Ameliorate Neuropathological Symptoms in a Mouse Model of Lafora Disease.
Neurodegenerative Diseases
Pharmacophore Modeling, Ensemble Docking, Virtual Screening, and Biological Evaluation on Glycogen Synthase Kinase-3?.
Neurodegenerative Diseases
Potential Enzymatic Targets in Alzheimer's: A Comprehensive Review.
Neurodegenerative Diseases
PROTACs suppression of GSK-3?, a crucial kinase in neurodegenerative diseases.
Neurodegenerative Diseases
Resveratrol:New Avenues For A Natural Compound In Neuroprotection.
Neurodegenerative Diseases
RIPK1 inhibitor ameliorates the MPP+/MPTP-induced Parkinson's disease through the ASK1/JNK signalling pathway.
Neurodegenerative Diseases
Structure-based design of benzo[e]isoindole-1,3-dione derivatives as selective GSK-3? inhibitors to activate Wnt/?-catenin pathway.
Neurodegenerative Diseases
Targeting autophagy in disease: established and new strategies.
Neurodegenerative Diseases
Tau Tubulin Kinase 1 (TTBK1), a new player in the fight against neurodegenerative diseases.
Neurodegenerative Diseases
Tau tubulin kinases in proteinopathy.
Neurodegenerative Diseases
The crystal structure of the catalytic domain of tau tubulin kinase 2 in complex with a small-molecule inhibitor.
Neurodegenerative Diseases
TTBK2 and primary cilia are essential for the connectivity and survival of cerebellar Purkinje neurons.
Neuroectodermal Tumors, Primitive
The regulatory role of aberrant Phosphatase and Tensin Homologue and Liver Kinase B1 on AKT/mTOR/c-Myc axis in pancreatic neuroendocrine tumors.
Neurofibromatoses
Heat shock factor 1 (HSF1)-targeted anticancer therapeutics: overview of current preclinical progress.
Neurofibromatosis 1
Heat shock factor 1 (HSF1)-targeted anticancer therapeutics: overview of current preclinical progress.
Neuroinflammatory Diseases
Accelerated neurodegeneration and neuroinflammation in transgenic mice expressing P301L tau mutant and tau-tubulin kinase 1.
Neuroinflammatory Diseases
CaMKK?-Dependent Activation of AMP-Activated Protein Kinase Is Critical to Suppressive Effects of Hydrogen Sulfide on Neuroinflammation.
Neuroinflammatory Diseases
Curcumin Prevents Neuroinflammation by Inducing Microglia to Transform into the M2-phenotype via CaMKK?-dependent Activation of the AMP-Activated Protein Kinase Signal Pathway.
Neuroinflammatory Diseases
Emerging neuroprotective effect of metformin in Parkinson's disease: A molecular crosstalk.
Neuroinflammatory Diseases
Inactive GSK3? is disturbed in the spinal cord during experimental autoimmune encephalomyelitis, but rescued by stem cell therapy.
Neuroinflammatory Diseases
Inflammatory, regulatory, and autophagy co-expression modules and hub genes underlie the peripheral immune response to human intracerebral hemorrhage.
Neuroinflammatory Diseases
Inhibition of Gsk3b Reduces Nfkb1 Signaling and Rescues Synaptic Activity to Improve the Rett Syndrome Phenotype in Mecp2-Knockout Mice.
Neuroinflammatory Diseases
Inhibition of microglial receptor-interacting protein kinase 1 ameliorates neuroinflammation following cerebral ischaemic stroke.
Neuroinflammatory Diseases
Interplay between Peripheral and Central Inflammation in Obesity-Promoted Disorders: The Impact on Synaptic Mitochondrial Functions.
Neuroinflammatory Diseases
Intracellular Signaling Cascades in Bipolar Disorder.
Neuroinflammatory Diseases
Involvement of AMP-activated protein kinase in neuroinflammation and neurodegeneration in the adult and developing brain.
Neuroinflammatory Diseases
LISPRO mitigates ?-amyloid and associated pathologies in Alzheimer's mice.
Neuroinflammatory Diseases
Lithium ameliorates rat spinal cord injury by suppressing glycogen synthase kinase-3? and activating heme oxygenase-1.
Neuroinflammatory Diseases
miR-98 and let-7g* protect the blood-brain barrier under neuroinflammatory conditions.
Neuroinflammatory Diseases
Mitochondrial Uncouplers Confer Protection by Activating AMP-Activated Protein Kinase to Inhibit Neuroinflammation Following Intracerebral Hemorrhage.
Neuroinflammatory Diseases
Oleocanthal-Rich Extra-Virgin Olive Oil Restores the Blood-Brain Barrier Function through NLRP3 Inflammasome Inhibition Simultaneously with Autophagy Induction in TgSwDI Mice.
Neuroinflammatory Diseases
Pharmacotherapy of Alzheimer's Disease: Seeking Clarity in a Time of Uncertainty.
Neuroinflammatory Diseases
Potential involvement of glycogen synthase kinase (GSK)-3? in a rat model of multiple sclerosis: evidenced by lithium treatment.
Neuroinflammatory Diseases
PQM130, a Novel Feruloyl-Donepezil Hybrid Compound, Effectively Ameliorates the Cognitive Impairments and Pathology in a Mouse Model of Alzheimer's Disease.
Neuroinflammatory Diseases
Salvianolic acid B protects against MPP+-induced neuronal injury via repressing oxidative stress and restoring mitochondrial function.
Neuroinflammatory Diseases
Silencing of TREM2 exacerbates tau pathology, neurodegenerative changes, and spatial learning deficits in P301S tau transgenic mice.
Neuroinflammatory Diseases
Tau-tubulin kinase.
Neuroinflammatory Diseases
TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice.
Neurologic Manifestations
Metformin Improves Neurologic Outcome Via AMP-Activated Protein Kinase-Mediated Autophagy Activation in a Rat Model of Cardiac Arrest and Resuscitation.
Newcastle Disease
Autophagy in farm animals: current knowledge and future challenges.
Niemann-Pick Disease, Type C
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Niemann-Pick Diseases
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Non-alcoholic Fatty Liver Disease
Activating AMP-activated Protein Kinase Mediates Fibroblast Growth Factor 1 Protection from Nonalcoholic Fatty Liver Disease in Mice.
Non-alcoholic Fatty Liver Disease
AMPK as a Therapeutic Target for Treating Metabolic Diseases.
Non-alcoholic Fatty Liver Disease
Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective.
Non-alcoholic Fatty Liver Disease
Betulinic acid inhibits high-fat diet-induced obesity and improves energy balance by activating AMPK.
Non-alcoholic Fatty Liver Disease
Calcium and vitamin D3 combinations improve fatty liver disease through AMPK-independent mechanisms.
Non-alcoholic Fatty Liver Disease
Cilostazol Improves HFD-Induced Hepatic Steatosis by Upregulating Hepatic STAMP2 Expression through AMPK.
Non-alcoholic Fatty Liver Disease
Cordycepin Ameliorates Nonalcoholic Steatohepatitis by Activation of the AMP-Activated Protein Kinase Signaling Pathway.
Non-alcoholic Fatty Liver Disease
Demethyleneberberine attenuates non-alcoholic fatty liver disease with activation of AMPK and inhibition of oxidative stress.
Non-alcoholic Fatty Liver Disease
Emerging molecular targets for the treatment of nonalcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
Female mice are more susceptible to non-alcoholic fatty liver disease: sex-specific regulation of the hepatic AMP-activated protein kinase - plasminogen activator inhibitor 1-cascade but not the hepatic endotoxin response.
Non-alcoholic Fatty Liver Disease
Free radical biology for medicine: learning from nonalcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
From overnutrition to liver injury: AMP-activated protein kinase in nonalcoholic fatty liver diseases.
Non-alcoholic Fatty Liver Disease
Gastrodin Ameliorates Oxidative Stress and Proinflammatory Response in Nonalcoholic Fatty Liver Disease through the AMPK/Nrf2 Pathway.
Non-alcoholic Fatty Liver Disease
Genetic Liver-Specific AMPK Activation Protects against Diet-Induced Obesity and NAFLD.
Non-alcoholic Fatty Liver Disease
Glucoraphanin: a broccoli sprout extract that ameliorates obesity-induced inflammation and insulin resistance.
Non-alcoholic Fatty Liver Disease
Hepatoprotective Effects of Soybean Embryo by Enhancing Adiponectin-Mediated AMP-Activated Protein Kinase ? Pathway in High-Fat and High-Cholesterol Diet-Induced Nonalcoholic Fatty Liver Disease.
Non-alcoholic Fatty Liver Disease
High-altitude chronic hypoxia ameliorates obesity-induced non-alcoholic fatty liver disease in mice by regulating mitochondrial and AMPK signaling.
Non-alcoholic Fatty Liver Disease
Inhibition of receptor-interacting protein kinase 1 improves experimental non-alcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
Liraglutide reduces fatty degeneration in hepatic cells via the AMPK/SREBP1 pathway.
Non-alcoholic Fatty Liver Disease
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
Non-alcoholic Fatty Liver Disease
New insight into the mechanisms of ectopic fat deposition improvement after bariatric surgery.
Non-alcoholic Fatty Liver Disease
Nutrient sensor-mediated programmed nonalcoholic fatty liver disease in low birthweight offspring.
Non-alcoholic Fatty Liver Disease
Oxyresveratrol ameliorates nonalcoholic fatty liver disease by regulating hepatic lipogenesis and fatty acid oxidation through liver kinase B1 and AMP-activated protein kinase.
Non-alcoholic Fatty Liver Disease
Peroxiredoxin 5 ameliorates obesity-induced non-alcoholic fatty liver disease through the regulation of oxidative stress and AMP-activated protein kinase signaling.
Non-alcoholic Fatty Liver Disease
Pilose antler peptide attenuates high-fat-diet-induced liver injury.
Non-alcoholic Fatty Liver Disease
Plant sterol ester of ?-linolenic acid ameliorates high-fat diet-induced nonalcoholic fatty liver disease in mice: association with regulating mitochondrial dysfunction and oxidative stress via activating AMPK signaling.
Non-alcoholic Fatty Liver Disease
Research progress in use of traditional Chinese medicine monomer for treatment of non-alcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
Resveratrol improves non-alcoholic fatty liver disease by activating AMP-activated protein kinase.
Non-alcoholic Fatty Liver Disease
Salsalate (Salicylate) Uncouples Mitochondria, Improves Glucose Homeostasis, and Reduces Liver Lipids Independent of AMPK ?1.
Non-alcoholic Fatty Liver Disease
SREBP-1c, regulated by the insulin and AMPK signaling pathways, plays a role in nonalcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
Targeting arginase-II protects mice from high-fat-diet-induced hepatic steatosis through suppression of macrophage inflammation.
Non-alcoholic Fatty Liver Disease
The role of lipid metabolism in the pathogenesis of alcoholic and nonalcoholic hepatic steatosis.
Non-alcoholic Fatty Liver Disease
Transcriptomic Analysis of Porcine Granulosa Cells Overexpressing Retinol Binding Protein 4.
Non-alcoholic Fatty Liver Disease
Treatment of Non-Alcoholic Fatty Liver Disease (NAFLD): Role of AMPK.
Non-alcoholic Fatty Liver Disease
TXNIP/VDUP1 attenuates steatohepatitis via autophagy and fatty acid oxidation.
Non-alcoholic Fatty Liver Disease
Ursodeoxycholic acid alleviates nonalcoholic fatty liver disease by inhibiting apoptosis and improving autophagy via activating AMPK.
Obesity
(Healthy) ageing: focus on iodothyronines.
Obesity
?-guanidinopropionic acid and metformin differentially impact autophagy, mitochondria and cellular morphology in developing C2C12 muscle cells.
Obesity
Activation of AMPK by berberine induces hepatic lipid accumulation by upregulation of fatty acid translocase CD36 in mice.
Obesity
Acute leptin exposure reduces megalin expression and upregulates TGF?1 in cultured renal proximal tubule cells.
Obesity
Adiponectin alleviates exacerbation of airway inflammation and oxidative stress in obesity-related asthma mice partly through AMPK signaling pathway.
Obesity
AICAR inhibits adipocyte differentiation in 3T3L1 and restores metabolic alterations in diet-induced obesity mice model.
Obesity
alpha-Lipoic acid regulates AMP-activated protein kinase and inhibits insulin secretion from beta cells.
Obesity
AMP-activated protein kinase (AMPK) activation by benzofurans and coumestans isolated from Erythrina abyssinica.
Obesity
AMP-activated protein kinase (AMPK) activators from Myristica fragrans (nutmeg) and their anti-obesity effect.
Obesity
AMP-Activated Protein Kinase ?1 Protects Against Diet-Induced Insulin Resistance and Obesity.
Obesity
AMP-activated protein kinase ?1 protects against diet-induced insulin resistance and obesity. Diabetes 2012;61:3114-3125.
Obesity
AMP-activated protein kinase in obesity: metabolic node and beyond--introduction.
Obesity
AMP-activated protein kinase mediates myogenin expression and myogenesis via histone deacetylase 5.
Obesity
AMPK activation with glabridin ameliorates adiposity and lipid dysregulation in obesity.
Obesity
AMPK as a Therapeutic Target for Treating Metabolic Diseases.
Obesity
AMPK: a key regulator of energy balance in the single cell and the whole organism.
Obesity
AMPK?1 deficiency suppresses brown adipogenesis in favor of fibrogenesis during brown adipose tissue development.
Obesity
AMPK?1 regulates Idh2 transcription through H2B O-GlcNAcylation during brown adipogenesis.
Obesity
Anti-obesity effects of Spirulina maxima in high fat diet induced obese rats via the activation of AMPK pathway and SIRT1.
Obesity
Bacillus licheniformis Zhengchangsheng® Inhibits Obesity by Regulating the AMP-Activated Protein Kinase Signaling Pathway.
Obesity
Berberine suppresses proinflammatory responses through AMPK activation in macrophages.
Obesity
Betulinic acid inhibits high-fat diet-induced obesity and improves energy balance by activating AMPK.
Obesity
Bioenergy sensing in the brain: the role of AMP-activated protein kinase in neuronal metabolism, development and neurological diseases.
Obesity
Black tea affects obesity by reducing nutrient intake and activating AMP-activated protein kinase in mice.
Obesity
Boesenbergia pandurata Attenuates Diet-Induced Obesity by Activating AMP-Activated Protein Kinase and Regulating Lipid Metabolism.
Obesity
CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations.
Obesity
Chronic Activation of ?2 AMPK Induces Obesity and Reduces ? Cell Function.
Obesity
Crystal structure of the heterotrimer core of Saccharomyces cerevisiae AMPK homologue SNF1.
Obesity
Crystal structure of the protein kinase domain of yeast AMP-activated protein kinase Snf1.
Obesity
Deficiency of phosphoinositide 3-kinase enhancer protects mice from diet-induced obesity and insulin resistance.
Obesity
Diet-induced obesity suppresses sevoflurane preconditioning against myocardial ischemia-reperfusion injury: role of AMP-activated protein kinase pathway.
Obesity
Dietary Silk Peptide Prevents High-Fat Diet-Induced Obesity and Promotes Adipose Browning by Activating AMP-Activated Protein Kinase in Mice.
Obesity
Emodin protects against high-fat diet-induced obesity via regulation of AMP-activated protein kinase pathways in white adipose tissue.
Obesity
Epithelial sodium channels in endothelial cells mediate diet-induced endothelium stiffness and impaired vascular relaxation in obese female mice.
Obesity
Erratum to: 'Inhibition of myostatin protects against diet-induced obesity by enhancing fatty acid oxidation and promoting a brown adipose phenotype in mice' and 'Myostatin-deficient mice exhibit reduced insulin resistance through activating the AMP-activated protein kinase signalling pathway'.
Obesity
Glomerular-specific protein kinase C-?-induced insulin receptor substrate-1 dysfunction and insulin resistance in rat models of diabetes and obesity.
Obesity
Heat-processed Gynostemma pentaphyllum extract improves obesity in ob/ob mice by activating AMP-activated protein kinase
Obesity
Heat-processed Gynostemma pentaphyllum extract improves obesity in ob/ob mice by activating AMP-activated protein kinase.
Obesity
Inactivation of MARK4, an AMP-activated protein kinase (AMPK)-related kinase, leads to insulin hypersensitivity and resistance to diet-induced obesity.
Obesity
Inflammation in obesity is the common link between defects in fatty acid metabolism and insulin resistance.
Obesity
Inhibitory Effects of Chung Hun Wha Dam Tang (CHWDT) on High-Fat Diet-Induced Obesity via AMP-Activated Protein Kinase Activation.
Obesity
Lack of starvation-induced activation of AMP-activated protein kinase in the hypothalamus of the Lou/C rats resistant to obesity.
Obesity
m6A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells.
Obesity
Mechanisms of Body Weight Reduction by Black Tea Polyphenols.
Obesity
Metabolaid® Combination of Lemon Verbena and Hibiscus Flower Extract Prevents High-Fat Diet-Induced Obesity through AMP-Activated Protein Kinase Activation.
Obesity
Metformin reduces TRPC6 expression through AMPK activation and modulates cytoskeleton dynamics in podocytes under diabetic conditions.
Obesity
Minireview: weapons of lean body mass destruction: the role of ectopic lipids in the metabolic syndrome.
Obesity
Molecular Mechanism of Nucleotide-Dependent Allosteric Regulation in AMP-Activated Protein Kinase.
Obesity
Naproxen and cromolyn as new glycogen synthase kinase 3? inhibitors for amelioration of diabetes and obesity: an investigation by docking simulation and subsequent in vitro/in vivo biochemical evaluation.
Obesity
Nicotine in combination with a high-fat diet causes intramyocellular mitochondrial abnormalities in male mice.
Obesity
Nootkatone, a characteristic constituent of grapefruit, stimulates energy metabolism and prevents diet-induced obesity by activating AMPK.
Obesity
Obesity: the role of hypothalamic AMP-activated protein kinase in body weight regulation.
Obesity
Pathogenesis of diabesity-induced kidney disease: role of kidney nutrient sensing.
Obesity
Perivascular fat, AMP-activated protein kinase and vascular diseases.
Obesity
Petalonia binghamiae extract and its constituent fucoxanthin ameliorate high-fat diet-induced obesity by activating AMP-activated protein kinase.
Obesity
Pharmacological Effects of 1'-Acetoxychavicol Acetate, a Major Constituent in the Rhizomes of Alpinia galanga and Alpinia conchigera.
Obesity
Phosphorylation and Inactivation of Glycogen Synthase Kinase 3? (GSK3?) by Dual-specificity Tyrosine Phosphorylation-regulated Kinase 1A (Dyrk1A).
Obesity
PI3K/AKT, MAPK and AMPK signalling: protein kinases in glucose homeostasis.
Obesity
Piperidine alkaloids from Piperretrofractum Vahl. protect against high-fat diet-induced obesity by regulating lipid metabolism and activating AMP-activated protein kinase.
Obesity
Platycodin D, a novel activator of AMP-activated protein kinase, attenuates obesity in db/db mice via regulation of adipogenesis and thermogenesis.
Obesity
Possible involvement of AMP-activated protein kinase in obesity resistance induced by respiratory uncoupling in white fat.
Obesity
Production and Crystallization of Full-Length Human AMP-Activated Protein Kinase (?1?1?1).
Obesity
Punicalagin, an active component in pomegranate, ameliorates cardiac mitochondrial impairment in obese rats via AMPK activation.
Obesity
Purinergic System Signaling in Metainflammation-Associated Osteoarthritis.
Obesity
Reduced AMP-activated protein kinase activity in mouse skeletal muscle does not exacerbate the development of insulin resistance with obesity.
Obesity
Resveratrol improves muscle regeneration in obese mice through enhancing mitochondrial biogenesis.
Obesity
Role of AMP-activated Protein Kinase and Adiponectin during Development of Hepatic Steatosis in High-fat Diet-induced Obesity in Rats.
Obesity
Role of AMP-activated protein kinase in the metabolic syndrome and in heart disease.
Obesity
Roles of Dietary Bioactive Peptides in Redox Balance and Metabolic Disorders.
Obesity
Small molecule antagonizes autoinhibition and activates AMP-activated protein kinase in cells.
Obesity
Small molecule drug A-769662 and AMP synergistically activate naive AMPK independent of upstream kinase signaling.
Obesity
Stimulation of brown adipose tissue by polyphenols in extra virgin olive oil.
Obesity
Structural basis for compound C inhibition of the human AMP-activated protein kinase ?2 subunit kinase domain.
Obesity
Structural basis of AMPK regulation by adenine nucleotides and glycogen.
Obesity
Targeted therapies of the LKB1/AMPK pathway for the treatment of insulin resistance.
Obesity
The AMP-activated protein kinase: role in regulation of skeletal muscle metabolism and insulin sensitivity.
Obesity
The herbal composition GGEx18 from Laminaria japonica, Rheum palmatum, and Ephedra sinica reduces obesity via skeletal muscle AMPK and PPAR?.
Obesity
The role of AMP-activated protein kinase in obesity.
Obesity
The role of hypothalamic AMP-activated protein kinase in ovariectomy-induced obesity in rats.
Obesity
The role of vitamin D in asthma.
Obesity
The small-molecule activators of AMPK, RSVA314 and RSVA405, inhibit adipogenesis.
Obesity
The TRPC6-AMPK Pathway is Involved in Insulin-Dependent Cytoskeleton Reorganization and Glucose Uptake in Cultured Rat Podocytes.
Obesity
Therapeutic potential of panduratin A, LKB1-dependent AMP-activated protein kinase stimulator, with activation of peroxisome proliferatoractivated receptor ?/? for the treatment of obesity.
Obesity
Therapeutic promises of Chlorogenic acid with special emphasis on its anti-obesity property.
Obesity
Thr55 phosphorylation of p21 by MPK38/MELK ameliorates defects in glucose, lipid, and energy metabolism in diet-induced obese mice.
Obesity
Transcriptomic and metabolic analyses reveal salvage pathways in creatine-deficient AGAT(-/-) mice.
Obesity
Ubiquitin C-terminal hydrolase-L3-knockout mice are resistant to diet-induced obesity and show increased activation of AMP-activated protein kinase in skeletal muscle.
Obesity
Viola mandshurica ethanolic extract prevents high-fat-diet-induced obesity in mice by activating AMP-activated protein kinase.
Obesity
X-3, a mangiferin derivative, stimulates AMP-activated protein kinase and reduces hyperglycemia and obesity in db/db mice.
Obesity
[Effect of electroacupuncture combined with treadmill exercise on body weight and expression of PGC-1?? Irisin and AMPK in skeletal muscle of diet-induced obesity rats].
Obesity
[Energy homeostasis regulated by an adipocyte-derived hormone--mechanism of leptin resistance and role of hypothalamic melanocortin signaling]
Obesity, Abdominal
Effects of excess corticosterone on LKB1 and AMPK signaling in rat skeletal muscle.
Obesity, Abdominal
Pentamethylquercetin generates beneficial effects in monosodium glutamate-induced obese mice and C2C12 myotubes by activating AMP-activated protein kinase.
Obesity, Maternal
AMP-activated protein kinase signalling pathways are down regulated and skeletal muscle development impaired in fetuses of obese, over-nourished sheep.
Obesity, Maternal
Exercise prevents the adverse effects of maternal obesity on placental vascularization and fetal growth.
Obesity, Maternal
Maternal Obesity, Inflammation, and Fetal Skeletal Muscle Development.
Obesity, Morbid
The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.
Optic Atrophy
AKT-GSK3? Signaling Pathway Regulates Mitochondrial Dysfunction-Associated OPA1 Cleavage Contributing to Osteoblast Apoptosis: Preventative Effects of Hydroxytyrosol.
Optic Nerve Injuries
Genetic inhibition of CRMP2 phosphorylation delays Wallerian degeneration after optic nerve injury.
Osteoarthritis
A dysfunctional TRPV4-GSK3? pathway prevents osteoarthritic chondrocytes from sensing changes in extracellular matrix viscoelasticity.
Osteoarthritis
Homocysteine causes dysfunction of chondrocytes and oxidative stress through repression of SIRT1/AMPK pathway: A possible link between hyperhomocysteinemia and osteoarthritis.
Osteoarthritis
Modulation of matrix metabolism by ATP-citrate lyase in articular chondrocytes.
Osteoblastoma
microRNA-135b expression silences Ppm1e to provoke AMPK activation and inhibit osteoblastoma cell proliferation.
Osteochondritis Dissecans
Autophagy in farm animals: current knowledge and future challenges.
Osteonecrosis
MiR-155-5p regulates mesenchymal stem cell osteogenesis and proliferation via targeting GSK3B in steroid-associated osteonecrosis.
Osteosarcoma
Capsaicin induces apoptosis in human osteosarcoma cells through AMPK-dependent and AMPK-independent signaling pathways.
Osteosarcoma
Dihydromyricetin Activates AMP-Activated Protein Kinase and P38MAPK Exerting Antitumor Potential in Osteosarcoma.
Osteosarcoma
Glycogen synthase kinase 3? promotes osteosarcoma invasion and migration via regulating PTEN and phosphorylation of focal adhesion kinase.
Osteosarcoma
Hypoxia promotes drug resistance in osteosarcoma cells via activating AMP-activated protein kinase (AMPK) signaling.
Osteosarcoma
Identification of two potential glycogen synthase kinase 3? inhibitors for the treatment of osteosarcoma.
Osteosarcoma
LncRNA-zinc finger protein 281 downregulates rho-associated coiled-coil containing protein kinase 1 by upregulating miR-144 in osteosarcoma.
Osteosarcoma
Long non-coding RNA MALAT1 for promoting metastasis and proliferation by acting as a ceRNA of miR-144-3p in osteosarcoma cells.
Osteosarcoma
Long noncoding RNA DANCR, working as a competitive endogenous RNA, promotes ROCK1-mediated proliferation and metastasis via decoying of miR-335-5p and miR-1972 in osteosarcoma.
Osteosarcoma
MicroRNA-144 acts as a tumor suppressor by targeting Rho-associated coiled-coil containing protein kinase 1 in osteosarcoma cells.
Osteosarcoma
MicroRNA-335 and its target Rock1 synergistically influence tumor progression and prognosis in osteosarcoma.
Osteosarcoma
ROCK1 as a potential therapeutic target in osteosarcoma.
Osteosarcoma
Structure-function relationship of parathyroid hormone: activation of phospholipase-C, protein kinase-A and -C in osteosarcoma cells.
Osteosarcoma
The ?5/focal adhesion kinase/glycogen synthase kinase 3? integrin pathway in high-grade osteosarcoma: a protein expression profile predictive of response to neoadjuvant chemotherapy.
Osteosarcoma
Tideglusib suppresses stem-cell-like features and progression of osteosarcoma by inhibiting GSK-3?/NOTCH1 signaling.
Osteosarcoma
[Retracted] MicroRNA?144 acts as a tumor suppressor by targeting Rho?associated coiled?coil containing protein kinase 1 in osteosarcoma cells.
Ovarian Hyperstimulation Syndrome
Everolimus, an mTOR pathway inhibitor, is highly successful on ovarian hyperstimulation syndrome by reducing ovarian weight and progesterone levels: a preclinical experimental randomized controlled study.
Ovarian Neoplasms
Activation of AMP-activated Protein Kinase by Metformin Induces Protein Acetylation in Prostate and Ovarian Cancer Cells.
Ovarian Neoplasms
Activation of AMP-activated protein kinase is essential for lysophosphatidic acid-induced cell migration in ovarian cancer cells.
Ovarian Neoplasms
Beta-arrestin links endothelin A receptor to beta-catenin signaling to induce ovarian cancer cell invasion and metastasis.
Ovarian Neoplasms
Co-administration of perifosine with paclitaxel synergistically induces apoptosis in ovarian cancer cells: More than just AKT inhibition.
Ovarian Neoplasms
Dual targeting of GSK3B and HDACs reduces tumor growth and improves survival in an ovarian cancer mouse model.
Ovarian Neoplasms
Elevated expression of the serine-arginine protein kinase 1 gene in ovarian cancer and its role in Cisplatin cytotoxicity in vitro.
Ovarian Neoplasms
Fatty acid synthase inhibition activates AMP-activated protein kinase in SKOV3 human ovarian cancer cells.
Ovarian Neoplasms
Glycogen synthase kinase 3? inhibitors induce apoptosis in ovarian cancer cells and inhibit in-vivo tumor growth.
Ovarian Neoplasms
Gonadotropin-releasing hormone-II increases membrane type I metalloproteinase production via beta-catenin signaling in ovarian cancer cells.
Ovarian Neoplasms
Lithium chloride and inhibition of glycogen synthase kinase 3? as a potential therapy for serous ovarian cancer.
Ovarian Neoplasms
Loss of TAB3 expression by shRNA exhibits suppressive bioactivity and increased chemical sensitivity of ovarian cancer cell lines via the NF-?B pathway.
Ovarian Neoplasms
Systematic module approach identifies altered genes and pathways in four types of ovarian cancer.
Ovarian Neoplasms
The discovery of novel benzothiazinones as highly selective non-ATP competitive glycogen synthase kinase 3? inhibitors for the treatment of ovarian cancer.
Ovarian Neoplasms
[Partial isoform-specific expression and function of AMPK in ovarian carcinoma].
Overnutrition
From overnutrition to liver injury: AMP-activated protein kinase in nonalcoholic fatty liver diseases.
Overnutrition
Negative regulation of AMPK signaling by high glucose via E3 ubiquitin ligase MG53.
Overweight
Cardiovascular effects of antidiabetic agents: focus on blood pressure effects of incretin-based therapies.
Overweight
Impact of pre-exercise feeding status on metabolic adaptations to endurance-type exercise training.
Paget Disease, Extramammary
PI3K, Rac1 and pPAK1 are overexpressed in extramammary Paget's disease.
Pancreatic Neoplasms
Aberrant glycogen synthase kinase 3? in the development of pancreatic cancer.
Pancreatic Neoplasms
Aberrant glycogen synthase kinase 3? is involved in pancreatic cancer cell invasion and resistance to therapy.
Pancreatic Neoplasms
An Inhibitor of GSK3B and HDACs Kills Pancreatic Cancer Cells and Slows Pancreatic Tumor Growth and Metastasis in Mice.
Pancreatic Neoplasms
Angiotensin II type 2 receptor blockade inhibits fatty acid synthase production through activation of AMP-activated protein kinase in pancreatic cancer cells.
Pancreatic Neoplasms
Association of axon guidance factor Semaphorin 3A with poor outcome in pancreatic cancer.
Pancreatic Neoplasms
Belinostat-induced apoptosis and growth inhibition in pancreatic cancer cells involve activation of TAK1-AMPK signaling axis.
Pancreatic Neoplasms
Bitter melon juice-intake modulates glucose metabolism and lactate efflux in tumors in its efficacy against pancreatic cancer.
Pancreatic Neoplasms
Cooperation of SRPK2, Numb and p53 in the malignant biology and chemosensitivity of colorectal cancer.
Pancreatic Neoplasms
Effects of the epidermal growth factor receptor inhibitor OSI-774, Tarceva, on downstream signaling pathways and apoptosis in human pancreatic adenocarcinoma.
Pancreatic Neoplasms
Emerging role of the KRAS-PDK1 axis in pancreatic cancer.
Pancreatic Neoplasms
Expression of CAMK1 and its association with clinicopathologic characteristics in pancreatic cancer.
Pancreatic Neoplasms
Glycogen Synthase Kinase 3? in Pancreatic Cancer and its Implications in Chemotherapy and Radiation Therapy.
Pancreatic Neoplasms
Glycogen synthase kinase 3? inhibition sensitizes pancreatic cancer cells to gemcitabine.
Pancreatic Neoplasms
Glycogen Synthase Kinase-3 Inhibition Sensitizes Pancreatic Cancer Cells to Chemotherapy by Abrogating the TopBP1/ATR-Mediated DNA Damage Response.
Pancreatic Neoplasms
Glycogen synthase kinase-3? participates in acquired resistance to gemcitabine in pancreatic cancer.
Pancreatic Neoplasms
GSK-3? Governs Inflammation-Induced NFATc2 Signaling Hubs to Promote Pancreatic Cancer Progression.
Pancreatic Neoplasms
HOXB5 promotes proliferation, migration, and invasion of pancreatic cancer cell through the activation of the GSK3?/?-catenin pathway.
Pancreatic Neoplasms
MiR-744 increases tumorigenicity of pancreatic cancer by activating Wnt/?-catenin pathway.
Pancreatic Neoplasms
Overexpression of YBX1 Promotes Pancreatic Ductal Adenocarcinoma Growth via the GSK3B/Cyclin D1/Cyclin E1 Pathway.
Pancreatic Neoplasms
Preclinical validation of 3-phosphoinositide-dependent protein kinase 1 inhibition in pancreatic cancer.
Pancreatic Neoplasms
Reduced expression of p21-activated protein kinase 1 correlates with poor histological differentiation in pancreatic cancer.
Pancreatic Neoplasms
Serine/arginine protein-specific kinase 2 promotes the development and progression of pancreatic cancer by downregulating Numb and p53.
Pancreatic Neoplasms
The MST4-MOB4 complex disrupts the MST1-MOB1 complex in the Hippo-YAP pathway and plays a pro-oncogenic role in pancreatic cancer.
Pancreatic Neoplasms
Ultraviolet enhances the sensitivity of pancreatic cancer cells to gemcitabine by activation of 5' AMP-activated protein kinase.
Pancreatic Neoplasms
Upregulated ?-catenin signaling does not affect survival of pancreatic cancer cells during dual inhibition of GSK3B and HDAC.
Pancreatic Neoplasms
UVC irradiation suppresses platelet-derived growth factor-BB-induced migration in human pancreatic cancer cells.
Pancreatitis
Pancreas-specific deletion of protein kinase D attenuates inflammation, necrosis, and severity of acute pancreatitis.
Pancreatitis
Protective Effects of Necrostatin-1 in Acute Pancreatitis: Partial Involvement of Receptor Interacting Protein Kinase 1.
Pancreatitis
Protective effects of SP600125 a new inhibitor of c-jun N-terminal kinase (JNK) and extracellular-regulated kinase (ERK1/2) in an experimental model of cerulein-induced pancreatitis.
Parathyroid Neoplasms
Loss of expression for the Wnt pathway components adenomatous polyposis coli and glycogen synthase kinase 3-beta in parathyroid carcinomas.
Parkinson Disease
(ADP-ribose) polymerase 1 and AMP-activated protein kinase mediate progressive dopaminergic neuronal degeneration in a mouse model of Parkinson's disease.
Parkinson Disease
6-Hydroxydopamine induces secretion of PARK7/DJ-1 via autophagy-based unconventional secretory pathway.
Parkinson Disease
A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers.
Parkinson Disease
AMP-activated protein kinase is activated in Parkinson's disease models mediated by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Parkinson Disease
Effects of miR-199a on autophagy by targeting glycogen synthase kinase 3? to activate PTEN/AKT/mTOR signaling in an MPP+in vitro model of Parkinson's disease.
Parkinson Disease
GSK3B polymorphisms alter transcription and splicing in Parkinson's disease.
Parkinson Disease
Increase of oxidative stress by a novel PINK1 mutation, P209A.
Parkinson Disease
Increased prefrontal cortex interleukin-2 protein levels and shift in the peripheral T cell population in progressive supranuclear palsy patients.
Parkinson Disease
LncRNA MALAT1 targeting miR-124-3p regulates DAPK1 expression contributes to cell apoptosis in Parkinson's Disease.
Parkinson Disease
MAPT rs242562 and GSK3B rs334558 are associated with Parkinson's Disease in central China.
Parkinson Disease
New Targets for Parkinson's Disease: Adhesion G Protein-Coupled Receptor B1 is Downregulated by AMP-Activated Protein Kinase Activation.
Parkinson Disease
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Parkinson Disease
Regulation of PRKN-independent mitophagy.
Parkinson Disease
Role of tau kinases (CDK5R1 and GSK3B) in Parkinson's disease: A study from India.
Parkinson Disease
SNCA, MAPT, and GSK3B in Parkinson disease: a gene-gene interaction study.
Parkinson Disease
The protective role of AMP-activated protein kinase in alpha-synuclein neurotoxicity in vitro.
Parkinson Disease
Transcriptomic Analysis of Porcine Granulosa Cells Overexpressing Retinol Binding Protein 4.
Parkinsonian Disorders
6-Hydroxydopamine induces secretion of PARK7/DJ-1 via autophagy-based unconventional secretory pathway.
Parkinsonian Disorders
Sex differences in autophagy-mediated diseases: toward precision medicine.
Parkinsonian Disorders
Sophora Tomentosa Extract Prevents MPTP-Induced Parkinsonism in C57BL/6 Mice Via the Inhibition of GSK-3? Phosphorylation and Oxidative Stress.
peptide-n4-(n-acetyl-beta-glucosaminyl)asparagine amidase deficiency
A conserved role for AMP-activated protein kinase in NGLY1 deficiency.
Peri-Implantitis
Development of an immunogenomic landscape for the competing endogenous RNAs network of peri-implantitis.
Perinatal Death
Loss of glycogen synthase kinase 3 isoforms during murine oocyte growth induces offspring cardiac dysfunction.
Periodontitis
Increased Innate Lymphoid Cells in Periodontal Tissue of the Murine Model of Periodontitis: The Role of AMP-Activated Protein Kinase and Relevance for the Human Condition.
Peripheral Nerve Injuries
Changes in microtubule-associated protein tau during peripheral nerve injury and regeneration.
Peritoneal Fibrosis
HL156A, a novel AMP-activated protein kinase activator, is protective against peritoneal fibrosis in an in vivo and in vitro model of peritoneal fibrosis.
Peste-des-Petits-Ruminants
Autophagy in farm animals: current knowledge and future challenges.
Peutz-Jeghers Syndrome
A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis.
Phenylketonurias
AMP-activated protein kinase activation in mediating phenylalanine-induced neurotoxicity in experimental models of phenylketonuria.
phosphorylase kinase deficiency
Fatal congenital heart glycogenosis caused by a recurrent activating R531Q mutation in the gamma 2-subunit of AMP-activated protein kinase (PRKAG2), not by phosphorylase kinase deficiency.
phosphorylase kinase deficiency
Fatal infantile cardiac glycogenosis with phosphorylase kinase deficiency and a mutation in the gamma2-subunit of AMP-activated protein kinase.
Pituitary Neoplasms
Estrogen- and xenoestrogen-induced ERK signaling in pituitary tumor cells involves estrogen receptor-? interactions with G protein-?i and caveolin I.
Pituitary Neoplasms
Infrequent mutation of APC, AXIN1, and GSK3B in human pituitary adenomas with abnormal accumulation of CTNNB1.
Pituitary Neoplasms
Interplay between the intracellular energy sensor AMP-activated protein kinase (AMPK) and the estrogen receptor activities in regulating rat pituitary tumor cell (GH3) growth in vitro.
Pituitary Neoplasms
Role of AMP-activated protein kinase activators in antiproliferative multi-drug pituitary tumour therapies: effects of combined treatments with compounds affecting the mTOR-p70S6 kinase axis in cultured pituitary tumour cells.
Pneumonia
AMP-activated Protein Kinase Activation by 5-Aminoimidazole-4-carbox-amide-1-?-D-ribofuranoside (AICAR) Reduces Lipoteichoic Acid-induced Lung Inflammation.
Pneumonia
Glucosamine attenuates cigarette smoke-induced lung inflammation by inhibiting ROS-sensitive inflammatory signaling.
Pneumonia
Inhibition of necroptosis attenuates lung injury and improves survival in neonatal sepsis.
Pneumonia
Novel role of AMP-activated protein kinase signaling in cigarette smoke induction of IL-8 in human lung epithelial cells and lung inflammation in mice.
Pneumonia
Role of AMP-Activated Protein Kinase (AMPK) in Smoking-Induced Lung Inflammation and Emphysema.
Pneumonia
Therapeutic target and molecular mechanism of vitamin C-treated pneumonia: a systematic study of network pharmacology.
Polycystic Kidney Diseases
Baseline Characteristics and Patient-Reported Outcomes of ADPKD Patients in the Multicenter TAME-PKD Clinical Trial.
Polycystic Kidney Diseases
Metformin slows liver cyst formation and fibrosis in experimental model of polycystic liver disease.
Polycystic Kidney Diseases
Salsalate, but not metformin or canagliflozin, slows kidney cyst growth in an adult-onset mouse model of polycystic kidney disease.
Polycystic Kidney Diseases
Targeting AMP-activated protein kinase (AMPK) for treatment of autosomal dominant polycystic kidney disease.
Polycystic Kidney, Autosomal Dominant
Baseline Characteristics and Patient-Reported Outcomes of ADPKD Patients in the Multicenter TAME-PKD Clinical Trial.
Polycystic Kidney, Autosomal Dominant
Renal activation of extracellular signal-regulated kinase in rats with autosomal-dominant polycystic kidney disease.
Polycystic Kidney, Autosomal Dominant
Salsalate, but not metformin or canagliflozin, slows kidney cyst growth in an adult-onset mouse model of polycystic kidney disease.
Polycystic Kidney, Autosomal Dominant
Targeting AMP-activated protein kinase (AMPK) for treatment of autosomal dominant polycystic kidney disease.
Polycystic Ovary Syndrome
Association study of AMP-activated protein kinase subunit genes in polycystic ovary syndrome.
Polycystic Ovary Syndrome
Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective.
Polycystic Ovary Syndrome
Baicalin ameliorates polycystic ovary syndrome through AMP-activated protein kinase.
Polycystic Ovary Syndrome
Prenatal androgenization of female mice programs an increase in firing activity of gonadotropin-releasing hormone (GnRH) neurons that is reversed by metformin treatment in adulthood.
Polycystic Ovary Syndrome
Replication of association of a novel insulin receptor gene polymorphism with polycystic ovary syndrome.
Polycystic Ovary Syndrome
Vitamin D3 regulates steroidogenesis in granulosa cells through AMP-activated protein kinase (AMPK) activation in a mouse model of polycystic ovary syndrome.
Pre-Eclampsia
Death associated protein kinase 1 (DAPK-1) is increased in preeclampsia.
Pre-Eclampsia
Maternal serum AMP-activated protein kinase levels in mild and severe preeclampsia.
Pre-Excitation Syndromes
N488I mutation of the gamma2-subunit results in bidirectional changes in AMP-activated protein kinase activity.
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
GSK3B and MAPT Polymorphisms Are Associated with Grey Matter and Intracranial Volume in Healthy Individuals.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
AMPK inhibition enhances apoptosis in MLL-rearranged pediatric B-acute lymphoblastic leukemia cells.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Combined SRPK and AKT pharmacological inhibition is synergistic in T-cell acute lymphoblastic leukemia cells.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Glycogen Synthase Kinase-3? (GSK-3?) and Nuclear Factor Kappa-B (NFKB) in Childhood Acute Lymphoblastic Leukemia.
Pregnancy Complications
AMP-Activated Protein (AMPK) in Pathophysiology of Pregnancy Complications.
Progeria
Cellular stress and AMPK activation as a common mechanism of action linking the effects of metformin and diverse compounds that alleviate accelerated aging defects in Hutchinson-Gilford progeria syndrome.
Prostatic Neoplasms
Activation of AMP-activated protein kinase by 3,3'-Diindolylmethane (DIM) is associated with human prostate cancer cell death in vitro and in vivo.
Prostatic Neoplasms
Akt GSK-3 pathway as a target in genistein-induced inhibition of TRAMP prostate cancer progression toward a poorly differentiated phenotype.
Prostatic Neoplasms
Alternol exerts prostate-selective antitumor effects through modulations of the AMPK signaling pathway.
Prostatic Neoplasms
AMP-activated protein kinase (AMPK) as a potential therapeutic target independent of PI3K/Akt signaling in prostate cancer.
Prostatic Neoplasms
AMP-activated protein kinase activators can inhibit the growth of prostate cancer cells by multiple mechanisms.
Prostatic Neoplasms
AMP-activated protein kinase promotes human prostate cancer cell growth and survival.
Prostatic Neoplasms
CaM kinase kinase beta-mediated activation of the growth regulatory kinase AMPK is required for androgen-dependent migration of prostate cancer cells.
Prostatic Neoplasms
CCL2 is a negative regulator of AMP-activated protein kinase to sustain mTOR complex-1 activation, survivin expression, and cell survival in human prostate cancer PC3 cells.
Prostatic Neoplasms
Cyclosporin A suppresses prostate cancer cell growth through CaMKK?/AMPK-mediated inhibition of mTORC1 signaling.
Prostatic Neoplasms
Differential roles of ERK and Akt pathways in regulation of EGFR-mediated signaling and motility in prostate cancer cells.
Prostatic Neoplasms
Distinct expression and activity of GSK-3? and GSK-3? in prostate cancer.
Prostatic Neoplasms
Down-regulation of AMP-activated protein kinase sensitizes DU145 carcinoma to Fas-induced apoptosis via c-FLIP degradation.
Prostatic Neoplasms
Enhanced expression of SRPK2 contributes to aggressive progression and metastasis in prostate cancer.
Prostatic Neoplasms
GSK-3? controls autophagy by modulating LKB1-AMPK pathway in prostate cancer cells.
Prostatic Neoplasms
Hexane Insoluble Fraction from Purple Rice Extract Retards Carcinogenesis and Castration-Resistant Cancer Growth of Prostate Through Suppression of Androgen Receptor Mediated Cell Proliferation and Metabolism.
Prostatic Neoplasms
High Serine-arginine Protein Kinase 1 Expression with PTEN Loss Defines Aggressive Phenotype of Prostate Cancer Associated with Lethal Outcome and Decreased Overall Survival.
Prostatic Neoplasms
Hyperinsulinemia enhances interleukin-17-induced inflammation to promote prostate cancer development in obese mice through inhibiting glycogen synthase kinase 3-mediated phosphorylation and degradation of interleukin-17 receptor.
Prostatic Neoplasms
Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1.
Prostatic Neoplasms
Microsecond molecular dynamics simulations and dynamic network analysis provide understanding of the allosteric inactivation of GSK3? induced by the L343R mutation.
Prostatic Neoplasms
Oleanolic acid induces metabolic adaptation in cancer cells by activating the AMP-activated protein kinase pathway.
Prostatic Neoplasms
Phospholipase C? Regulates Prostate Cancer Lipid Metabolism and Proliferation by Targeting AMP-Activated Protein Kinase (AMPK)/Sterol Regulatory Element-Binding Protein 1 (SREBP-1) Signaling Pathway.
Prostatic Neoplasms
Reactive oxygen species stabilize hypoxia-inducible factor-1 alpha protein and stimulate transcriptional activity via AMP-activated protein kinase in DU145 human prostate cancer cells.
Prostatic Neoplasms
Serine-arginine protein kinase 1 (SRPK1) inhibition as a potential novel targeted therapeutic strategy in prostate cancer.
Prostatic Neoplasms
Serine-arginine protein kinase 1 (SRPK1), a determinant of angiogenesis, is upregulated in prostate cancer and correlates with disease stage and invasion.
Prostatic Neoplasms
The antioxidant effects of genistein are associated with AMP-activated protein kinase activation and PTEN induction in prostate cancer cells.
Prostatic Neoplasms
The dark side of glucose transporters in prostate cancer: Are they a new feature to characterize carcinomas?
Prostatic Neoplasms
The Interplay of AMP-Activated Protein Kinase and Androgen Receptor in Prostate Cancer Cells.
Prostatic Neoplasms
The metastasis suppressor CD82/KAI1 represses the TGF-? 1 and Wnt signalings inducing epithelial-to-mesenchymal transition linked to invasiveness of prostate cancer cells.
Prostatic Neoplasms
The PIM1 kinase promotes prostate cancer cell migration and adhesion via multiple signalling pathways.
Prostatic Neoplasms
The RNA-Binding Protein PCBP1 Functions as a Tumor Suppressor in Prostate Cancer by Inhibiting Mitogen Activated Protein Kinase 1.
Prostatic Neoplasms
Transcriptomic analysis reveals inhibition of androgen receptor activity by AMPK in prostate cancer cells.
Prostatic Neoplasms
Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-Troglitazone-induced Apoptosis in Prostate Cancer Cells Involve AMP-activated Protein Kinase.
Prostatic Neoplasms
Ursolic acid activates the apoptosis of prostate cancer via ROCK/PTEN mediated mitochondrial translocation of cofilin-1.
Prostatic Neoplasms
Xanthone glucoside 2-?-D-glucopyranosyl-1,3,6,7-tetrahydroxy-9H-xanthen-9-one binds to the ATP-binding pocket of glycogen synthase kinase 3? and inhibits its activity: implications in prostate cancer and associated cardiovascular disease risk.
Prostatic Neoplasms
Zinc and p53 disrupt mitochondrial binding of HK2 by phosphorylating VDAC1.
protein acetyllysine n-acetyltransferase deficiency
SIRT3 Blocks Aging-Associated Tissue Fibrosis in Mice by Deacetylating and Activating Glycogen Synthase Kinase 3?.
protein acetyllysine n-acetyltransferase deficiency
Sirtuin 3 deficiency exacerbates diabetic cardiomyopathy via necroptosis enhancement and NLRP3 activation.
protein-lysine desuccinylase (nad+) deficiency
SIRT5 deficiency suppresses mitochondrial ATP production and promotes AMPK activation in response to energy stress.
Proteinuria
Activation of mineralocorticoid receptor by ecdysone, an adaptogenic and anabolic ecdysteroid, promotes glomerular injury and proteinuria involving overactive GSK3? pathway signaling.
Proteinuria
Dietary iron restriction prevents hypertensive cardiovascular remodeling in Dahl salt-sensitive rats.
Proteinuria
The ? isoform of GSK3 mediates podocyte autonomous injury in proteinuric glomerulopathy.
Pseudorabies
Pseudorabies virus tegument protein Us2 recruits the mitogen-activated protein kinase extracellular-regulated kinase (ERK) to membranes through interaction with the ERK common docking domain.
Psoriasis
Response to Inhibition of Receptor-Interacting Protein Kinase 1 (RIPK1) in Active Plaque Psoriasis: A Randomized Placebo-Controlled Study.
Pulmonary Disease, Chronic Obstructive
AMP-Activated Protein Kinase (AMPK) at the Crossroads Between CO2 Retention and Skeletal Muscle Dysfunction in Chronic Obstructive Pulmonary Disease (COPD).
Pulmonary Disease, Chronic Obstructive
AMPK protects against alcohol-induced liver injury through UQCRC2 to up-regulate mitophagy.
Pulmonary Disease, Chronic Obstructive
Enhanced ROCK1 dependent contractility in fibroblast from chronic obstructive pulmonary disease patients.
Pulmonary Disease, Chronic Obstructive
Molecular Pathogenesis in Chronic Obstructive Pulmonary Disease and Therapeutic Potential by Targeting AMP-activated Protein Kinase.
Pulmonary Disease, Chronic Obstructive
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Pulmonary Disease, Chronic Obstructive
Triterpene Acids of Loquat Leaf Improve Inflammation in Cigarette Smoking Induced COPD by Regulating AMPK/Nrf2 and NF?B Pathways.
Pulmonary Emphysema
AMP-activated protein kinase reduces inflammatory responses and cellular senescence in pulmonary emphysema.
Pulmonary Fibrosis
Clinical significance of mTOR, ZEB1, ROCK1 expression in lung tissues of pulmonary fibrosis patients.
Radiculopathy
AMP-Activated Protein Kinase Activation in Dorsal Root Ganglion Suppresses mTOR/p70S6K Signaling and Alleviates Painful Radiculopathies in Lumbar Disc Herniation Rat Model.
Rectal Neoplasms
CircTUBGCP3 Contributes to the Malignant Progression of Rectal Cancer.
Rectal Neoplasms
Circular RNA circMTO1 acts as an antitumor factor in rectal cancer cell lines by downregulation of miR-19b-3p.
Rectal Neoplasms
MicroRNA?144 inhibits migration and proliferation in rectal cancer by downregulating ROCK?1.
Relative Energy Deficiency in Sport
MiR-155-5p regulates mesenchymal stem cell osteogenesis and proliferation via targeting GSK3B in steroid-associated osteonecrosis.
Renal Insufficiency, Chronic
AMP-activated Protein Kinase as a Drug Target in Chronic Kidney Disease.
Renal Insufficiency, Chronic
Metformin arrests the progression of established kidney disease in the subtotal nephrectomy model of chronic kidney disease.
Renal Insufficiency, Chronic
Methionine restriction delays senescence and suppresses the senescence-associated secretory phenotype in the kidney through endogenous hydrogen sulfide.
Reperfusion Injury
A novel cardioprotective agent in cardiac transplantation: metformin activation of AMP-activated protein kinase decreases acute ischemia-reperfusion injury and chronic rejection.
Reperfusion Injury
Activated protein C prevents methylglyoxal-induced endoplasmic reticulum stress and cardiomyocyte apoptosis via regulation of the AMP-activated protein kinase signaling pathway.
Reperfusion Injury
AMP-activated protein kinase: An attractive therapeutic target for ischemia-reperfusion injury.
Reperfusion Injury
Amyloid beta-peptide worsens cognitive impairment following cerebral ischemia-reperfusion injury.
Reperfusion Injury
Delayed administration of parecoxib, a specific COX-2 inhibitor, attenuated postischemic neuronal apoptosis by phosphorylation Akt and GSK-3?.
Reperfusion Injury
Diet-induced obesity suppresses sevoflurane preconditioning against myocardial ischemia-reperfusion injury: role of AMP-activated protein kinase pathway.
Reperfusion Injury
Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury.
Reperfusion Injury
Fisetin Confers Cardioprotection against Myocardial Ischemia Reperfusion Injury by Suppressing Mitochondrial Oxidative Stress and Mitochondrial Dysfunction and Inhibiting Glycogen Synthase Kinase 3? Activity.
Reperfusion Injury
FIsetin Preserves Interfibrillar Mitochondria to Protect Against Myocardial Ischemia-Reperfusion Injury.
Reperfusion Injury
Hydrogen sulfide protects against myocardial ischemia and reperfusion injury by activating AMP-activated protein kinase to restore autophagic flux.
Reperfusion Injury
Influence of Fat on Differential Receptor Interacting Serine/Threonine Protein Kinase 1 Activity Leading to Apoptotic Cell Death in Murine Liver Ischemia Reperfusion Injury Through Caspase 8.
Reperfusion Injury
Inhibition of glycogen synthase kinase enhances isoflurane-induced protection against myocardial infarction during early reperfusion in vivo.
Reperfusion Injury
Inhibition of GSK-3? alleviates cerebral ischemia/reperfusion injury in rats by suppressing NLRP3 inflammasome activation through autophagy.
Reperfusion Injury
Macrophage migration inhibitory factor plays an essential role in ischemic preconditioning mediated cardioprotection.
Reperfusion Injury
Mechanical Stretch-Induced Protection against Myocardial Ischemia-Reperfusion Injury Involves AMP-Activated Protein Kinase.
Reperfusion Injury
Metformin-Enhanced Cardiac AMP-Activated Protein Kinase/Atrogin-1 Pathways Inhibit Charged Multivesicular Body Protein 2B Accumulation in Ischemia-Reperfusion Injury.
Reperfusion Injury
Mitogen-activated protein kinase 3/mitogen-activated protein kinase 1 activates apoptosis during testicular ischemia-reperfusion injury in a nuclear factor-kappaB-independent manner.
Reperfusion Injury
Oxycodone inhibits myocardial cell apoptosis after myocardial ischemia-reperfusion injury in rats via RhoA/ROCK1 signaling pathway.
Reperfusion Injury
Protective benefits of AMP-activated protein kinase in hepatic ischemia-reperfusion injury.
Reperfusion Injury
Protective vascular and myocardial effects of adiponectin.
Reperfusion Injury
Pyruvate prevents cardiac dysfunction and AMP-activated protein kinase activation by hydrogen peroxide in isolated rat hearts.
Reperfusion Injury
Remote ischemic preconditioning for kidney protection: GSK3?-centric insights into the mechanism of action.
Reperfusion Injury
RNA sequencing revealing the role of AMP-activated protein kinase signaling in mice myocardial ischemia reperfusion injury.
Reperfusion Injury
Role of glycogen synthase kinase 3? in protective effect of propofol against hepatic ischemia-reperfusion injury.
Reperfusion Injury
Simulated microgravity increases myocardial susceptibility to ischemia-reperfusion injury via a deficiency of AMP-activated protein kinase.
Reperfusion Injury
The outcome of renal ischemia-reperfusion injury is unchanged in AMPK-?1 deficient mice.
Reperfusion Injury
[Hypoglycemic therapy in heart disease patients with type 2 diabetes mellitus].
Respiratory Syncytial Virus Infections
Inhibition of AMP-activated protein kinase in respiratory syncytial virus infection activates lipid metabolism.
Retinal Degeneration
Longitudinal phenotypic study of late-onset retinal degeneration due to a founder variant c.562C>A p.(Pro188Thr) in the C1QTNF5 gene.
Retinal Dystrophies
Longitudinal phenotypic study of late-onset retinal degeneration due to a founder variant c.562C>A p.(Pro188Thr) in the C1QTNF5 gene.
Retinoblastoma
A small-molecule inhibitor of glucose transporter 1 downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivo.
Retinoblastoma
AMP-activated protein kinase phosphorylates retinoblastoma protein to control mammalian brain development.
Retinoblastoma
Dehydroglyasperin D Inhibits the Proliferation of HT-29 Human Colorectal Cancer Cells Through Direct Interaction With Phosphatidylinositol 3-kinase.
Retinoblastoma
Identification of novel lipid droplet factors that regulate lipophagy and cholesterol efflux in macrophage foam cells.
Retinoblastoma
Lactoferrin increases (172Thr)AMPK phosphorylation and insulin-induced (p473Ser)AKT while impairing adipocyte differentiation.
Retinoblastoma
Ligand-regulated peptides: a general approach for modulating protein-peptide interactions with small molecules.
Rett Syndrome
Inhibition of Gsk3b Reduces Nfkb1 Signaling and Rescues Synaptic Activity to Improve the Rett Syndrome Phenotype in Mecp2-Knockout Mice.
Rhabdomyosarcoma
Oxidant-mediated Akt Activation in Human RPE Cells.
Rhabdomyosarcoma, Alveolar
Glycogen synthase kinase 3? represses MYOGENIN function in alveolar rhabdomyosarcoma.
Rhabdomyosarcoma, Embryonal
AMP-activated protein kinase regulates the expression of monocarboxylate transporter 4 in skeletal muscle.
Sarcoma
BRAF Inhibitors in Thyroid Cancer: Clinical Impact, Mechanisms of Resistance and Future Perspectives.
Sarcoma
Electrochemical investigations into kinase-catalyzed transformations of tau protein.
Sarcoma
Electrochemical investigations into Tau protein phosphorylations.
Sarcoma
Identification of novel lipid droplet factors that regulate lipophagy and cholesterol efflux in macrophage foam cells.
Sarcoma, Synovial
Glycogen synthase kinase 3? as a potential therapeutic target in synovial sarcoma and fibrosarcoma.
Seizures
Analysis of resting noise characteristics of three EIT systems in order to compare suitability for time difference imaging with scalp electrodes during epileptic seizures.
Seizures
Inhibition of AKT/GSK3?/CREB Pathway Improves the Responsiveness to AMPA Receptor Antagonists by Regulating GRIA1 Surface Expression in Chronic Epilepsy Rats.
Seizures
Wwox deficiency leads to neurodevelopmental and degenerative neuropathies and glycogen synthase kinase 3?-mediated epileptic seizure activity in mice.
Sepsis
13-Methylberberine reduces HMGB1 release in LPS-activated RAW264.7 cells and increases the survival of septic mice through AMPK/P38 MAPK activation.
Sepsis
Activation of AMPK attenuates lipopolysaccharide-impaired integrity and function of blood-brain barrier in human brain microvascular endothelial cells.
Sepsis
Age-dependent cardiac function during experimental sepsis: effect of pharmacological activation of AMP-activated protein kinase by AICAR.
Sepsis
AMP-activated protein kinase and Glycogen Synthase Kinase 3? modulate the severity of sepsis-induced lung injury.
Sepsis
AMPK regulates immunometabolism in sepsis.
Sepsis
Autophagy and mitochondrial biogenesis impairment contribute to age-dependent liver injury in experimental sepsis: dysregulation of AMP-activated protein kinase pathway.
Sepsis
Burn plus lipopolysaccharide augments endoplasmic reticulum stress and NLRP3 inflammasome activation and reduces PGC-1? in liver.
Sepsis
Cell-specific regulation of iNOS by AMP-activated protein kinase in primary rat hepatocytes.
Sepsis
Differential Regulation of the Autophagy and Proteasome Pathways in Skeletal Muscles in Sepsis.
Sepsis
Geniposide protects against sepsis-induced myocardial dysfunction through AMPK?-dependent pathway.
Sepsis
Ginsenoside Rg3 attenuates sepsis-induced injury and mitochondrial dysfunction in liver via AMPK-mediated autophagy flux.
Sepsis
Inhibition of glycogen synthase kinase (GSK)-3-? improves liver microcirculation and hepatocellular function after hemorrhagic shock.
Sepsis
Inhibition of necroptosis attenuates lung injury and improves survival in neonatal sepsis.
Sepsis
Metformin ameliorates endotoxemia-induced endothelial pro-inflammatory responses via AMPK-dependent mediation of HDAC5 and KLF2.
Sepsis
Stimulation of Brain AMP-Activated Protein Kinase Attenuates Inflammation and Acute Lung Injury in Sepsis.
Sepsis
The Protective Effects of Melatonin Against LPS-Induced Septic Myocardial Injury: A Potential Role of AMPK-Mediated Autophagy.
Severe Acute Respiratory Syndrome
Coronavirus Disease (COVID)-19 and Diabetic Kidney Disease.
Severe Acute Respiratory Syndrome
Phosphorylation of the arginine/serine dipeptide-rich motif of the severe acute respiratory syndrome coronavirus nucleocapsid protein modulates its multimerization, translation inhibitory activity and cellular localization.
Severe Acute Respiratory Syndrome
Targeting autophagy in disease: established and new strategies.
Sick Sinus Syndrome
Transgenic mice overexpressing mutant PRKAG2 define the cause of Wolff-Parkinson-White syndrome in glycogen storage cardiomyopathy.
Skin Diseases
JNK1 Signaling Downstream of the EGFR Pathway Contributes to Aldara®-Induced Skin Inflammation.
Sleep Deprivation
A glycogen synthase kinase 3-beta promoter gene single nucleotide polymorphism is associated with age at onset and response to total sleep deprivation in bipolar depression.
Sleep Deprivation
Gene-gene interaction of glycogen synthase kinase 3-? and serotonin transporter on human antidepressant response to sleep deprivation.
Sleep Deprivation
Long-term response to lithium salts in bipolar illness is influenced by the glycogen synthase kinase 3-beta -50 T/C SNP.
Sleep Initiation and Maintenance Disorders
Glycogen synthase kinase-3? genetic polymorphisms and insomnia in depressed patients: A prospective study.
sphingosine kinase deficiency
SPHK1 deficiency protects mice from acetaminophen-induced ER stress and mitochondrial permeability transition.
Spinal Cord Injuries
Changes in Expression of Receptor-Interacting Protein Kinase 1 in Secondary Neural Tissue Damage Following Spinal Cord Injury.
Spinal Cord Injuries
Lithium ameliorates rat spinal cord injury by suppressing glycogen synthase kinase-3? and activating heme oxygenase-1.
Spinal Cord Injuries
[Effect of lentivirus-mediated small interfering RNA on mitogen- and stress-activated protein kinase 1 in spinal cord injury of rats].
Spinocerebellar Ataxias
A Novel TTBK2 De Novo Mutation in a Danish Family with Early-Onset Spinocerebellar Ataxia.
Spinocerebellar Ataxias
Adult onset pan-neuronal human tau tubulin kinase 1 expression causes severe cerebellar neurodegeneration in mice.
Spinocerebellar Ataxias
Ataxin-1 regulates the cerebellar bioenergetics proteome through the GSK3?-mTOR pathway which is altered in Spinocerebellar ataxia type 1 (SCA1).
Spinocerebellar Ataxias
Mechanisms of Regulation and Diverse Activities of Tau-Tubulin Kinase (TTBK) Isoforms.
Spinocerebellar Ataxias
Mutations in TTBK2, encoding a kinase implicated in tau phosphorylation, segregate with spinocerebellar ataxia type 11.
Spinocerebellar Ataxias
Spinocerebellar ataxia type 11-associated alleles of Ttbk2 dominantly interfere with ciliogenesis and cilium stability.
Spinocerebellar Ataxias
Tau Tubulin Kinase TTBK2 Sensitivity of Glutamate Receptor GluK2.
Spinocerebellar Ataxias
Tau-tubulin kinase.
Spinocerebellar Ataxias
The crystal structure of the catalytic domain of tau tubulin kinase 2 in complex with a small-molecule inhibitor.
Spinocerebellar Ataxias
The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis.
Spinocerebellar Ataxias
TTBK2 and primary cilia are essential for the connectivity and survival of cerebellar Purkinje neurons.
Spinocerebellar Ataxias
TTBK2 kinase: linking primary cilia and cerebellar ataxias.
Spinocerebellar Ataxias
TTBK2: a tau protein kinase beyond tau phosphorylation.
Spinocerebellar Ataxias
Upregulation of Na,Cl(-)-Coupled Betaine/ ?-Amino-Butyric Acid Transporter BGT1 by Tau Tubulin Kinase 2.
Spinocerebellar Degenerations
Mutations in TTBK2, encoding a kinase implicated in tau phosphorylation, segregate with spinocerebellar ataxia type 11.
Squamous Cell Carcinoma of Head and Neck
A 5' AMP-Activated Protein Kinase Enzyme Activator, Compound 59, Induces Autophagy and Apoptosis in Human Oral Squamous Cell Carcinoma.
Squamous Cell Carcinoma of Head and Neck
CD44(high) /ALDH1(high) head and neck squamous cell carcinoma cells exhibit mesenchymal characteristics and GSK3?-dependent cancer stem cell properties.
Squamous Cell Carcinoma of Head and Neck
Differential expression of organic cation transporter OCT-3 in oral premalignant and malignant lesions: potential implications in the antineoplastic effects of metformin.
Squamous Cell Carcinoma of Head and Neck
Dysregulation of splicing proteins in head and neck squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Identification of a Novel Proto-oncogenic Network in Head and Neck Squamous Cell Carcinoma.
Squamous Cell Carcinoma of Head and Neck
Metformin Inhibits Progression of Head and Neck Squamous Cell Carcinoma by Acting Directly on Carcinoma-Initiating Cells.
Squamous Cell Carcinoma of Head and Neck
Metformin prevents the development of oral squamous cell carcinomas from carcinogen-induced premalignant lesions.
Squamous Cell Carcinoma of Head and Neck
Role of the AMPK/ACC Signaling Pathway in TRPP2-Mediated Head and Neck Cancer Cell Proliferation.
Squamous Cell Carcinoma of Head and Neck
[Expression and clinical significance of nuclear factor ?B/B cell lymphoma-2 signal pathway and glycogen synthase kinase 3? in oral squamous cell carcinoma].
Starvation
A role for AMPK in increased insulin action after serum starvation.
Starvation
Activation of mTORC1 under nutrient starvation conditions increases cellular radiosensitivity in human liver cancer cell lines, HepG2 and HuH6.
Starvation
AKT Ser/Thr kinase increases V-ATPase-dependent lysosomal acidification in response to amino acid starvation in mammalian cells.
Starvation
Ambra1 modulates starvation-induced autophagy through AMPK signaling pathway in cardiomyocytes.
Starvation
AMP-activated protein kinase in the grass carp Ctenopharyngodon idellus: Molecular characterization, tissue distribution and mRNA expression in response to overwinter starvation stress.
Starvation
AMP-activated protein kinase protects against anoxia in Drosophila melanogaster.
Starvation
AMP-activated protein kinase supports the NGF-induced viability of human HeLa cells to glucose starvation.
Starvation
AMPK acts as a molecular trigger to coordinate glutamatergic signals and adaptive behaviours during acute starvation.
Starvation
AMPK modulates Hippo pathway activity to regulate energy homeostasis.
Starvation
AMPK-SKP2-CARM1 signalling cascade in transcriptional regulation of autophagy.
Starvation
Antagonistic control of muscle cell size by AMPK and mTORC1.
Starvation
Atg11 is required for initiation of glucose starvation-induced autophagy.
Starvation
Berberine and cinnamaldehyde together prevent lung carcinogenesis.
Starvation
Ca2+/calmodulin-dependent kinase (CaMK) signaling via CaMKI and AMP-activated protein kinase contributes to the regulation of WIPI-1 at the onset of autophagy.
Starvation
CCL2 is a negative regulator of AMP-activated protein kinase to sustain mTOR complex-1 activation, survivin expression, and cell survival in human prostate cancer PC3 cells.
Starvation
Cooperation of two mRNA-binding proteins drives metabolic adaptation to iron deficiency.
Starvation
Critical role of AMPK in redox regulation under glucose starvation.
Starvation
FCS-like zinc finger 6 and 10 repress SnRK1 signalling in Arabidopsis.
Starvation
Functional domains of the alpha1 catalytic subunit of the AMP-activated protein kinase.
Starvation
Genome-wide RNAi Screen for Fat Regulatory Genes in C. elegans Identifies a Proteostasis-AMPK Axis Critical for Starvation Survival.
Starvation
Glucose starvation induces mitochondrial fragmentation depending on the dynamin GTPase Dnm1/Drp1 in fission yeast.
Starvation
H2A Monoubiquitination Links Glucose Availability to Epigenetic Regulation of the Endoplasmic Reticulum Stress Response and Cancer Cell Death.
Starvation
In the Hunger Games, the Winner Takes Everything.
Starvation
Induction of cell-cell detachment during glucose starvation through F-actin conversion by SNARK, the fourth member of the AMP-activated protein kinase catalytic subunit family.
Starvation
Inhibition of protein phosphatase 2A overrides tau protein kinase I/glycogen synthase kinase 3 beta and cyclin-dependent kinase 5 inhibition and results in tau hyperphosphorylation in the hippocampus of starved mouse.
Starvation
Involvement of AMP-activated protein kinase in fat depot-specific metabolic changes during starvation.
Starvation
Kmt5a Controls Hepatic Metabolic Pathways by Facilitating RNA Pol II Release from Promoter-Proximal Regions.
Starvation
Nutrient deprivation induces the Warburg effect through ROS/AMPK-dependent activation of pyruvate dehydrogenase kinase.
Starvation
Paraoxonase 2 Facilitates Pancreatic Cancer Growth and Metastasis by Stimulating GLUT1-Mediated Glucose Transport.
Starvation
Phosphorylation of CEP83 by TTBK2 is necessary for cilia initiation.
Starvation
Prior starvation mitigates acute doxorubicin cardiotoxicity through restoration of autophagy in affected cardiomyocytes.
Starvation
Quantitative phosphoproteomics of protein kinase SnRK1 regulated protein phosphorylation in Arabidopsis under submergence.
Starvation
Regulation of the forkhead transcription factor FKHR (FOXO1a) by glucose starvation and AICAR, an activator of AMP-activated protein kinase.
Starvation
Regulation of the Forkhead Transcription Factor FKHR (FOXO1a) by Glucose Starvation and AICAR, an Activator of AMP-Activated Protein Kinase.
Starvation
Serum starvation: caveat emptor.
Starvation
State transitions in the TORC1 signaling pathway and information processing in Saccharomyces cerevisiae.
Starvation
The E3 Ubiquitin Ligase TRAF6 Intercedes in Starvation-Induced Skeletal Muscle Atrophy through Multiple Mechanisms.
Starvation
The FCS-like zinc finger scaffold of the kinase SnRK1 is formed by the coordinated actions of the FLZ domain and intrinsically disordered regions.
Starvation
Tip60 Phosphorylation at Ser 99 Is Essential for Autophagy Induction in Bombyx mori.
Starvation
TSC2 mediates cellular energy response to control cell growth and survival.
Starvation
ULK1 O-GlcNAcylation Is Crucial for Activating VPS34 via ATG14L during Autophagy Initiation.
stearoyl-coa 9-desaturase deficiency
Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver.
Stomach Neoplasms
Activation of AMP-activated protein kinase on human gastric cancer cells by apoptosis induced by corosolic acid isolated from Weigela subsessilis.
Stomach Neoplasms
Adenosine induces apoptosis in the human gastric cancer cells via an intrinsic pathway relevant to activation of AMP-activated protein kinase.
Stomach Neoplasms
AMPK? modulation in cancer progression: multilayer integrative analysis of the whole transcriptome in Asian gastric cancer.
Stomach Neoplasms
Association between Phosphorylated AMP-Activated Protein Kinase and MAPK3/1 Expression and Prognosis for Patients with Gastric Cancer.
Stomach Neoplasms
AT13148, a first-in-class multi-AGC kinase inhibitor, potently inhibits gastric cancer cells both in vitro and in vivo.
Stomach Neoplasms
Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray.
Stomach Neoplasms
Expression and function of transforming growth factor???activated protein kinase 1 in gastric cancer.
Stomach Neoplasms
Expression Profiling of Stem Cell-Related Genes in Neoadjuvant-Treated Gastric Cancer: A NOTCH2, GSK3B and ?-catenin Gene Signature Predicts Survival.
Stomach Neoplasms
Ginkgolic acid (GA) suppresses gastric cancer growth by inducing apoptosis and suppressing STAT3/JAK2 signaling regulated by ROS.
Stomach Neoplasms
Insulin-like growth factor-I induces epithelial to mesenchymal transition via GSK-3? and ZEB2 in the BGC-823 gastric cancer cell line.
Stomach Neoplasms
Involvement of AMP-activated Protein Kinase (AMPK) in Regulation of Cell Membrane Potential in a Gastric Cancer Cell Line.
Stomach Neoplasms
LncRNA LINC00483?promotes gastric cancer development through regulating MAPK1 expression by sponging miR-490-3p.
Stomach Neoplasms
LncRNA MACC1-AS1 Promotes Lung Adenocarcinoma Cell Proliferation by Downregulating PTEN.
Stomach Neoplasms
MicroRNA-139 inhibits the proliferation, migration and invasion of gastric cancer cells by directly targeting ?-associated protein kinase 1.
Stomach Neoplasms
microRNA-761 regulates glycogen synthase kinase 3? expression and promotes the proliferation and cell cycle of human gastric cancer cells.
Stomach Neoplasms
MiR-126 functions as a tumor suppressor by targeting SRPK1 in human gastric cancer.
Stomach Neoplasms
Modulation of CD8+ memory stem T cell activity and glycogen synthase kinase 3? inhibition enhances anti-tumoral immunity in gastric cancer.
Stomach Neoplasms
Nuclear receptor retinoid-related orphan receptor alpha promotes apoptosis but is reduced in human gastric cancer.
Stomach Neoplasms
p21-activated protein kinase 1 induces the invasion of gastric cancer cells through c-Jun NH2-terminal kinase-mediated activation of matrix metalloproteinase-2.
Stomach Neoplasms
P21-activated protein kinase 1 is overexpressed in gastric cancer and induces cancer metastasis.
Stomach Neoplasms
Perilaldehyde activates AMP-activated protein kinase to suppress the growth of gastric cancer via induction of autophagy.
Stomach Neoplasms
Phosphorylated AMP-activated protein kinase expression associated with prognosis for patients with gastric cancer treated with cisplatin-based adjuvant chemotherapy.
Stomach Neoplasms
PRKAA1 promotes proliferation and inhibits apoptosis of gastric cancer cells through activating JNK1 and Akt pathways.
Stomach Neoplasms
Risk of gastric cancer is associated with PRKAA1 gene polymorphisms in Koreans.
Stomach Neoplasms
ROS-mediated activation of AMPK plays a critical role in sulforaphane-induced apoptosis and mitotic arrest in AGS human gastric cancer cells.
Stomach Neoplasms
Serine-arginine protein kinase 1 (SRPK1) is elevated in gastric cancer and plays oncogenic functions.
Stomach Neoplasms
The aurora kinase A regulates GSK-3beta in gastric cancer cells.
Stroke
Acute metformin preconditioning confers neuroprotection against focal cerebral ischemia by pre-activation of AMPK-dependent autophagy.
Stroke
Age-related changes in AMP-activated protein kinase after stroke.
Stroke
Apelin-13 protects against apoptosis by activating AMP-activated protein kinase pathway in ischemia stroke.
Stroke
Discovery of novel GSK-3? inhibitors with potent in vitro and in vivo activities and excellent brain permeability using combined ligand- and structure-based virtual screening.
Stroke
Exploring putative inhibitors of Death Associated Protein Kinase 1 (DAPK1) via targeting Gly-Glu-Leu (GEL) and Pro-Glu-Asn (PEN) substrate recognition motifs.
Stroke
Heat shock protein 70 and AMP-activated protein kinase contribute to 17-DMAG-dependent protection against heat stroke.
Stroke
Pharmacological inhibition of AMP-activated protein kinase provides neuroprotection in stroke.
Stroke
Preventive and therapeutic effect of brozopine on stroke in Dahl Salt-sensitive hypertensive rats.
Stroke
Targeting GSK-3: a promising approach for cancer therapy?
Tachycardia
Human ?2-AMPK Mutations.
Tachycardia
Transgenic mouse model of ventricular preexcitation and atrioventricular reentrant tachycardia induced by an AMP-activated protein kinase loss-of-function mutation responsible for Wolff-Parkinson-White syndrome.
Tachycardia, Atrioventricular Nodal Reentry
Transgenic mouse model of ventricular preexcitation and atrioventricular reentrant tachycardia induced by an AMP-activated protein kinase loss-of-function mutation responsible for Wolff-Parkinson-White syndrome.
Tardive Dyskinesia
No evidence so far of a major role of AKT1 and GSK3B in the pathogenesis of antipsychotic-induced tardive dyskinesia.
tau-protein kinase deficiency
AMP-activated protein kinase deficiency enhances myocardial ischemia/reperfusion injury but has minimal effect on the antioxidant/antinitrative protection of adiponectin.
tau-protein kinase deficiency
AMP-activated protein kinase deficiency exacerbates aging-induced myocardial contractile dysfunction.
tau-protein kinase deficiency
AMP-activated protein kinase deficiency reduces ozone-induced lung injury and oxidative stress in mice.
tau-protein kinase deficiency
AMP-activated protein kinase deficiency rescues paraquat-induced cardiac contractile dysfunction through an autophagy-dependent mechanism.
Tauopathies
Abeta amyloidosis induces the initial stage of tau accumulation in APP(Sw) mice.
Tauopathies
Delta-secretase (AEP) mediates tau-splicing imbalance and accelerates cognitive decline in tauopathies.
Tauopathies
GSK3alpha exhibits beta-catenin and tau directed kinase activities that are modulated by Wnt.
Tauopathies
Mechanisms of Regulation and Diverse Activities of Tau-Tubulin Kinase (TTBK) Isoforms.
Tauopathies
Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration.
Tauopathies
Randomized placebo-controlled trial of sodium valproate in progressive supranuclear palsy.
Tauopathies
Tau-tubulin kinase 1 enhances prefibrillar tau aggregation and motor neuron degeneration in P301L FTDP-17 tau-mutant mice.
Tauopathies
Tau-tubulin kinase.
Tauopathies
Temsirolimus attenuates tauopathy in vitro and in vivo by targeting tau hyperphosphorylation and autophagic clearance.
Tauopathies
The structural, functional, and dynamic effect of Tau tubulin kinase1 upon a mutation: A neuro-degenerative hotspot.
Teratocarcinoma
A dominant repressor of cyclic adenosine 3',5'-monophosphate (cAMP)-regulated enhancer-binding protein activity inhibits the cAMP-mediated induction of the somatostatin promoter in vivo.
Thalassemia
Killing me softly - suicidal erythrocyte death.
Thalassemia
Mechanisms and Significance of Eryptosis, the Suicidal Death of Erythrocytes.
Thalassemia
Physiology and pathophysiology of eryptosis.
Thrombosis
PDK1 governs thromboxane generation and thrombosis in platelets by regulating activation of Raf1 in the MAPK pathway.
Thrombosis
Preventive and therapeutic effect of brozopine on stroke in Dahl Salt-sensitive hypertensive rats.
Thymoma
AKT inhibition-mediated dephosphorylation of TFE3 promotes overactive autophagy independent of MTORC1 in cadmium-exposed bone mesenchymal stem cells.
Thymoma
Astaxanthin Modulation of Signaling Pathways That Regulate Autophagy.
Thymoma
Differential Regulation of the Autophagy and Proteasome Pathways in Skeletal Muscles in Sepsis.
Thymoma
Erythroblast macrophage protein (Emp): Past, present, and future.
Thymoma
Mammalian target of rapamycin (mTor) mediates tau protein dyshomeostasis: implication for Alzheimer disease.
Thymoma
PI3K/AKT, MAPK and AMPK signalling: protein kinases in glucose homeostasis.
Thymoma
Role of Insulin-like Growth Factor-1 in the Central Regulation of Feeding Behavior in Chicks.
Thymoma
Skeletal muscle-specific Prmt1 deletion causes muscle atrophy via deregulation of the PRMT6-FOXO3 axis.
Thyroid Cancer, Papillary
AMP-activated protein kinase signaling is upregulated in papillary thyroid cancer.
Thyroid Cancer, Papillary
MicroRNA-150 targets Rho-associated protein kinase 1 to inhibit cell proliferation, migration and invasion in papillary thyroid carcinoma.
Thyroid Cancer, Papillary
miR-214 regulates papillary thyroid carcinoma cell proliferation and metastasis by targeting PSMD10.
Thyroid Cancer, Papillary
The Wnt/?-catenin pathway drives increased cyclin D1 levels in lymph node metastasis in papillary thyroid cancer.
Thyroid Neoplasms
Adenosine 5'-monophosphate-activated protein kinase-dependent mTOR pathway is involved in flavokawain B-induced autophagy in thyroid cancer cells.
Thyroid Neoplasms
Expression and Biologic Significance of Adiponectin Receptors in Papillary Thyroid Carcinoma.
Thyroid Neoplasms
Expression of PDK-1 and DMBT1 in the thyroid carcinoma and its clinicopathological significance.
Thyroid Neoplasms
Iodine Promotes Tumorigenesis of Thyroid Cancer by Suppressing Mir-422a and Up-Regulating MAPK1.
Thyroid Neoplasms
The Ca2+-calmodulin-dependent kinase II is activated in papillary thyroid carcinoma (PTC) and mediates cell proliferation stimulated by RET/PTC.
Tonsillitis
Detection of GSK-3? activation index in pediatric chronic tonsillitis is an indicator for chronic recurrent inflammation.
Toxoplasmosis
1NM-PP1 Treatment of Mice Infected with Toxoplasma gondii.
Toxoplasmosis
A Novel Calcium-Dependent Protein Kinase 1 Inhibitor Potently Prevents Toxoplasma gondii Transmission to Foetuses in Mouse.
Toxoplasmosis
Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis.
Toxoplasmosis
Evaluation of protective immunity induced by recombinant calcium-dependent protein kinase 1 (TgCDPK1) protein against acute toxoplasmosis in mice.
Toxoplasmosis
Imidazo[1,2-b]pyridazines targeting Toxoplasma gondii calcium-dependent protein kinase 1 decrease the parasite burden in mice with acute toxoplasmosis.
Toxoplasmosis
Optimizing Pyrazolopyrimidine Inhibitors of Calcium Dependent Protein Kinase 1 for Treatment of Acute and Chronic Toxoplasmosis.
Toxoplasmosis
Perspective on current and emerging drugs in the treatment of acute and chronic toxoplasmosis.
Toxoplasmosis
Protective efficacy of Toxoplasma gondii calcium-dependent protein kinase 1 (TgCDPK1) adjuvated with recombinant IL-15 and IL-21 against experimental toxoplasmosis in mice.
Triple Negative Breast Neoplasms
AMP-activated protein kinase: a potential therapeutic target for triple-negative breast cancer.
Trypanosomiasis, African
Trypanosoma brucei glycogen synthase kinase-3, a target for anti-trypanosomal drug development: a public-private partnership to identify novel leads.
Tuberculosis
Immune Cell Regulatory Pathways Unexplored as Host-Directed Therapeutic Targets for Mycobacterium tuberculosis: An Opportunity to Apply Precision Medicine Innovations to Infectious Diseases.
Tuberculosis
Metabolic energy sensors as targets for designing host-directed therapies for tuberculosis.
Tuberculosis
PP2Ac Modulates AMPK-Mediated Induction of Autophagy in Mycobacterium bovis-Infected Macrophages.
Tuberculosis
Trehalose limits opportunistic mycobacterial survival during HIV co-infection by reversing HIV-mediated autophagy block.
Tuberous Sclerosis
A non-canonical MEK/ERK signaling pathway regulates autophagy via regulating Beclin 1.
Tuberous Sclerosis
AMP-Activated Protein Kinase Inhibits IGF-I Signaling and Protein Synthesis in Vascular Smooth Muscle Cells via Stimulation of Insulin Receptor Substrate 1 S794 and Tuberous Sclerosis 2 S1345 Phosphorylation.
Tuberous Sclerosis
AMP-activated protein kinase signalling pathways are down regulated and skeletal muscle development impaired in fetuses of obese, over-nourished sheep.
Tuberous Sclerosis
AMP-activated protein kinase: a universal regulator of autophagy?
Tuberous Sclerosis
Androgens induce prostate cancer cell proliferation through mammalian target of rapamycin activation and post-transcriptional increases in cyclin D proteins.
Tuberous Sclerosis
Antioxidant catalase rescues against high fat diet-induced cardiac dysfunction via an IKK?-AMPK-dependent regulation of autophagy.
Tuberous Sclerosis
Dexamethasone may inhibit placental growth by blocking glucocorticoid receptors via phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin and reactive oxygen species/AMP-activated protein kinase signalling pathways in human placental JEG-3 cells.
Tuberous Sclerosis
Forkhead box protein O1 negatively regulates skeletal myocyte differentiation through degradation of mammalian target of rapamycin pathway components.
Tuberous Sclerosis
Glucose stimulates protein synthesis in skeletal muscle of neonatal pigs through an AMPK- and mTOR-independent process.
Tuberous Sclerosis
High glucose reduces megalin-mediated albumin endocytosis in renal proximal tubule cells through protein kinase B O-GlcNAcylation.
Tuberous Sclerosis
Hypoxia impairs adaptation of skeletal muscle protein turnover- and AMPK signaling during fasting-induced muscle atrophy.
Tuberous Sclerosis
IL-4 up-regulates cyclooxygenase-1 expression in macrophages.
Tuberous Sclerosis
Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1.
Tuberous Sclerosis
Inhibition of ERK1/2 Restores GSK3? Activity and Protein Synthesis Levels in a Model of Tuberous Sclerosis.
Tuberous Sclerosis
Leucine stimulates protein synthesis in skeletal muscle of neonatal pigs by enhancing mTORC1 activation.
Tuberous Sclerosis
MARCKSL1 exhibits anti-angiogenic effects through suppression of VEGFR-2-dependent Akt/PDK-1/mTOR phosphorylation.
Tuberous Sclerosis
Novel Anti-Angiogenic and Anti-Tumour Activities of the N-Terminal Domain of NOEY2 via Binding to VEGFR-2 in Ovarian Cancer.
Tuberous Sclerosis
NQO1 Deficiency Leads Enhanced Autophagy in Cisplatin-Induced Acute Kidney Injury Through the AMPK/TSC2/mTOR Signaling Pathway.
Tuberous Sclerosis
PDK4 protein promotes tumorigenesis through activation of cAMP-response element-binding protein (CREB)-Ras homolog enriched in brain (RHEB)-mTORC1 signaling cascade.
Tuberous Sclerosis
Podocytes maintain high basal levels of autophagy independent of mtor signaling.
Tuberous Sclerosis
Recent advances in the regulation of the TOR pathway by insulin and nutrients.
Tuberous Sclerosis
Resistin promotes cardiac hypertrophy via AMPK/mTOR and JNK/IRS1 pathways.
Tuberous Sclerosis
Sestrins inhibit mTORC1 kinase activation through the GATOR complex.
Tuberous Sclerosis
Stimulation of muscle protein synthesis by prolonged parenteral infusion of leucine is dependent on amino acid availability in neonatal pigs.
Tuberous Sclerosis
The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.
Tuberous Sclerosis
The mTORC1 Signaling Network Senses Changes in Cellular Purine Nucleotide Levels.
Ureteral Obstruction
1,25-(OH)2D3 ameliorates renal interstitial fibrosis in UUO rats through the AMPK?/mTOR pathway.
Ureteral Obstruction
Impact of AMP-Activated Protein Kinase ?1 Deficiency on Tissue Injury following Unilateral Ureteral Obstruction.
Urinary Bladder Neck Obstruction
AMPK Alters Detrusor Contractility During Emptying in Normal Bladder and Hypertrophied Bladder with Partial Bladder Outlet Obstruction via CaMKK?.
Urinary Bladder Neoplasms
Effects of microRNA-135a on the epithelial-mesenchymal transition, migration and invasion of bladder cancer cells by targeting GSK3? through the Wnt/?-catenin signaling pathway.
Urinary Bladder Neoplasms
Isorhamnetin Induces Cell Cycle Arrest and Apoptosis Via Reactive Oxygen Species-Mediated AMP-Activated Protein Kinase Signaling Pathway Activation in Human Bladder Cancer Cells.
Urinary Bladder Neoplasms
Liposome-Encapsulated Bacillus Calmette-Guérin Cell Wall Skeleton Enhances Antitumor Efficiency for Bladder Cancer In Vitro and In Vivo via Induction of AMP-Activated Protein Kinase.
Urinary Bladder Neoplasms
Metabolic phenotype of bladder cancer.
Urinary Bladder Neoplasms
Overexpression of ROCK1 promotes cancer cell proliferation and is associated with poor prognosis in human urothelial bladder cancer.
Urinary Bladder Neoplasms
PPM-18, an Analog of Vitamin K, Induces Autophagy and Apoptosis in Bladder Cancer Cells Through ROS and AMPK Signaling Pathways.
Urinary Bladder Neoplasms
Ursolic acid-induced AMP-activated protein kinase (AMPK) activation contributes to growth inhibition and apoptosis in human bladder cancer T24 cells.
Uterine Cervical Neoplasms
Activation of AMPK inhibits cervical cancer cell growth through AKT/FOXO3a/FOXM1 signaling cascade.
Uterine Cervical Neoplasms
Clinical Significance of Inactivated Glycogen Synthase Kinase 3? in HPV-Associated Cervical Cancer: Relationship with Wnt/?-Catenin Pathway Activation.
Uterine Cervical Neoplasms
Induction of apoptosis by ethanol extract of Evodia rutaecarpa in HeLa human cervical cancer cells via activation of AMP-activated protein kinase.
Uterine Cervical Neoplasms
Inhibition of BAP31 expression inhibits cervical cancer progression by suppressing metastasis and inducing intrinsic and extrinsic apoptosis.
Uterine Cervical Neoplasms
Inhibition of Cervical Cancer Cell Growth through Activation of Upstream Kinases of AMP-Activated Protein Kinase.
Uterine Cervical Neoplasms
MARK1 is a Novel Target for miR-125a-5p: Implications for Cell Migration in Cervical Tumor Cells.
Uterine Cervical Neoplasms
MicroRNA-217 functions as a tumor suppressor in cervical cancer cells through targeting Rho-associated protein kinase 1.
Uterine Cervical Neoplasms
Potential biomarkers and therapeutic targets in cervical cancer: Insights from the meta-analysis of transcriptomics data within network biomedicine perspective.
Uterine Cervical Neoplasms
Prognostic Significance of AMP-Dependent Kinase Alpha Expression in Cervical Cancer.
Uterine Cervical Neoplasms
RhoC mediates invasion and migration of CaSki cells through the Rho-associated serine-threonine protein kinase 1 signaling pathway.
Uterine Cervical Neoplasms
The role of miR-106p-5p in cervical cancer: from expression to molecular mechanism.
Uterine Cervicitis
Sipi soup inhibits cancer?associated fibroblast activation and the inflammatory process by downregulating long non?coding RNA HIPK1?AS.
Vaccinia
High intracellular Zn2+ ions modulate the VHR, ZAP-70 and ERK activities of LNCaP prostate cancer cells.
Vascular Calcification
Metformin, resveratrol, and exendin-4 inhibit high phosphate-induced vascular calcification via AMPK-RANKL signaling.
Vascular Calcification
[Vascular calcification and anti-aging]
Vascular Diseases
AMP-activated protein kinase and the control of smooth muscle cell hyperproliferation in vascular disease.
Vascular Diseases
AMPK: energy sensor and survival mechanism in the ischemic heart.
Vascular Diseases
Perivascular fat, AMP-activated protein kinase and vascular diseases.
Vascular Diseases
Rottlerin activates AMPK possibly through LKB1 in vascular cells and tissues.
Vascular System Injuries
Activation of NAD(P)H:quinone oxidoreductase 1 prevents arterial restenosis by suppressing vascular smooth muscle cell proliferation.
Virus Diseases
2-octynoic acid inhibits hepatitis C virus infection through activation of AMP-activated protein kinase.
Virus Diseases
Identification of SRPK1 and SRPK2 as the major cellular protein kinases phosphorylating hepatitis B virus core protein.
Virus Diseases
Inhibition of AMP-activated protein kinase in respiratory syncytial virus infection activates lipid metabolism.
Virus Diseases
Mimic Phosphorylation of a ?C1 Protein Encoded by TYLCCNB Impairs Its Functions as a Viral Suppressor of RNA Silencing and a Symptom Determinant.
Virus Diseases
Small Molecule Inhibition of GSK-3 Specifically Inhibits the Transcription of Inhibitory Co-receptor LAG-3 for Enhanced Anti-tumor Immunity.
Vitreoretinopathy, Proliferative
GSK3? inhibits epithelial-mesenchymal transition via the Wnt/?-catenin and PI3K/Akt pathways.
Vulvar Neoplasms
ROCK1 as a novel prognostic marker in vulvar cancer.
Whooping Cough
Apelin Decreases Lipolysis via Gq, Gi, and AMPK-Dependent Mechanisms.
Wilms Tumor
m6A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells.
Wolff-Parkinson-White Syndrome
A pivotal role for endogenous TGF-beta-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway.
Wolff-Parkinson-White Syndrome
AMP-activated protein kinase and familial Wolff-Parkinson-White syndrome: new perspectives on heart development and arrhythmogenesis.
Wolff-Parkinson-White Syndrome
Characterization of the role of gamma2 R531G mutation in AMP-activated protein kinase in cardiac hypertrophy and Wolff-Parkinson-White syndrome.
Wolff-Parkinson-White Syndrome
Familial hypertrophic cardiomyopathy: clinical features, molecular genetics and molecular genetic testing.
Wolff-Parkinson-White Syndrome
Familial Wolff-Parkinson-White Syndrome: a disease of glycogen storage or ion channel dysfunction?
Wolff-Parkinson-White Syndrome
Functional analysis of mutations in the gamma 2 subunit of AMP-activated protein kinase associated with cardiac hypertrophy and Wolff-Parkinson-White syndrome.
Wolff-Parkinson-White Syndrome
Genomics and cardiac arrhythmias.
Wolff-Parkinson-White Syndrome
Transgenic mice overexpressing mutant PRKAG2 define the cause of Wolff-Parkinson-White syndrome in glycogen storage cardiomyopathy.
Wolff-Parkinson-White Syndrome
Transgenic mouse model of ventricular preexcitation and atrioventricular reentrant tachycardia induced by an AMP-activated protein kinase loss-of-function mutation responsible for Wolff-Parkinson-White syndrome.
Xeroderma Pigmentosum
Xeroderma Pigmentosum Group D (XPD) Inhibits the Proliferation Cycle of Vascular Smooth Muscle Cell (VSMC) by Activating Glycogen Synthase Kinase 3? (GSK3?).
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