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Literature summary for 2.7.11.26 extracted from

  • Koh, S.H.; Kim, S.H.; Kim, H.T.
    Role of glycogen synthase kinase-3 in L-DOPA-induced neurotoxicity (2009), Expert. Opin. Drug Metab. Toxicol., 5, 1359-1368.
    View publication on PubMed
Search for more literature for 2.7.11.26

Activating Compound

Activating Compound Comment Organism Structure
L-Dopa activates GSK-3beta at high dose Homo sapiens
additional information activation of GSK-3beta is absolutely dependent on the presence of alpha-synuclein Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + beta-catenin
-
 Homo sapiens ADP + phosphorylated beta-catenin
-
 ?
ATP + cAMP response element-binding protein
-
 Homo sapiens ADP + phosphorylated cAMP response element-binding protein
-
 ?
ATP + heat shock factor-1
-
 Homo sapiens ADP + phosphorylated heat shock factor-1
-
 ?
ATP + Jun
-
 Homo sapiens ADP + phosphorylated Jun
-
 ?
ATP + Myc
-
 Homo sapiens ADP + phosphorylated Myc
-
 ?
ATP + protein tau
-
 Homo sapiens ADP + protein tau phosphate
-
 ?

Synonyms

Synonyms Comment Organism
glycogen synthase kinase-3
-
 Homo sapiens
GSK-3alpha isoform Homo sapiens
GSK-3beta isoform Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function increased GSK-3 correlates with increased cell death, GSK-3 plays a very important role in L-DOPA neurotoxicity, as well as in neurodegeneration Homo sapiens