Activating Compound | Comment | Organism | Structure |
---|---|---|---|
soluble beta-amyloid oligomers | activate GSK-3beta mediated tau phosphorylation and increase toxicity, reduced content of soluble, not insoluble, amyloid oligomers reduces the tau phosphorylation activity, specific antibodies can inhibit the activation, overview | Mus musculus | |
soluble beta-amyloid oligomers | activate GSK-3beta mediated tau phosphorylation and increase toxicity, reduced content of soluble, not insoluble, amyloid oligomers reduces the tau phosphorylation activity, specific antibodies can inhibit the activation, overview | Homo sapiens |
Application | Comment | Organism |
---|---|---|
pharmacology | anti-bodies highly specific for toxic amyloid oligomer subspecies may reduce toxicity via reduction of GSK-3beta amount in Alzheimer's disease therapeutic strategy | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Mus musculus | |
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [tau-protein] | Mus musculus | tau phosphorylation by GSK-3beta is involved in development of neurodegenerative Alzheimer's disease, the tau phosphorylation activity by GSK-3beta is further increased by soluble toxic beta-amyloid oligomers, overview | ADP + O-phospho-[tau-protein] | - |
? | |
ATP + [tau-protein] | Homo sapiens | tau phosphorylation by GSK-3beta is involved in development of neurodegenerative Alzheimer's disease, the tau phosphorylation activity by GSK-3beta is further increased by soluble toxic beta-amyloid oligomers, overview | ADP + O-phospho-[tau-protein] | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
transgenic APP TG2576 mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neuron | - |
Mus musculus | - |
SH-SY5Y cell | neuroblastoma cell line | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [tau-protein] | - |
Mus musculus | ADP + O-phospho-[tau-protein] | - |
? | |
ATP + [tau-protein] | - |
Homo sapiens | ADP + O-phospho-[tau-protein] | - |
? | |
ATP + [tau-protein] | tau phosphorylation by GSK-3beta is involved in development of neurodegenerative Alzheimer's disease, the tau phosphorylation activity by GSK-3beta is further increased by soluble toxic beta-amyloid oligomers, overview | Mus musculus | ADP + O-phospho-[tau-protein] | - |
? | |
ATP + [tau-protein] | tau phosphorylation by GSK-3beta is involved in development of neurodegenerative Alzheimer's disease, the tau phosphorylation activity by GSK-3beta is further increased by soluble toxic beta-amyloid oligomers, overview | Homo sapiens | ADP + O-phospho-[tau-protein] | - |
? |
Synonyms | Comment | Organism |
---|---|---|
glycogen synthase kinase-3beta | - |
Mus musculus |
glycogen synthase kinase-3beta | - |
Homo sapiens |
GSK-3beta | - |
Mus musculus |
GSK-3beta | - |
Homo sapiens |
tau kinase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus | |
ATP | - |
Homo sapiens |