Information on EC 2.7.11.26 - tau-protein kinase

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The expected taxonomic range for this enzyme is: Eukaryota

EC NUMBER
COMMENTARY hide
2.7.11.26
-
RECOMMENDED NAME
GeneOntology No.
tau-protein kinase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + tau-protein = ADP + O-phospho-tau-protein
show the reaction diagram
-
-
-
-
ATP + [tau-protein] = ADP + O-phospho-[tau-protein]
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:[tau-protein] O-phosphotransferase
Activated by tubulin. Involved in the formation of paired helical filaments, which are the main fibrous component of all fibrillary lesions in brain and are associated with Alzheimer's disease.
CAS REGISTRY NUMBER
COMMENTARY hide
111694-09-8
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
strains Guofu x Nongfong and P1
-
-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain LG13
-
-
Manually annotated by BRENDA team
strain LG13
-
-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
Mus musculus C57BL/6Njcl
C57BL/6Njcl mice
-
-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
Rattus norvegicus Sprague-Dawley
Sprague-Dawley
-
-
Manually annotated by BRENDA team
Wistar
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-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + alpha-casein
ADP + alpha-casein phosphate
show the reaction diagram
ATP + alpha-synuclein
ADP + phosphorylated alpha-synuclein
show the reaction diagram
-
-
-
-
?
ATP + amyloid precursor protein
ADP + phosphorylated amyloid precursor protein
show the reaction diagram
-
-
-
-
?
ATP + axin
ADP + phosphorylated axin
show the reaction diagram
ATP + beta-casein
ADP + beta-casein phosphate
show the reaction diagram
-
isoenzyme TPKII
-
-
?
ATP + beta-catenin
ADP + beta-catenin phosphate
show the reaction diagram
ATP + beta-catenin
ADP + phosphorylated beta-catenin
show the reaction diagram
ATP + beta-tubulin
ADP + beta-tubulin phosphate
show the reaction diagram
-
isoenzyme tau-tubulin kinase
-
-
?
ATP + c-Jun
ADP + phosphorylated c-Jun
show the reaction diagram
-
substrate of isoform GSK-3alpha
-
-
?
ATP + c-Myc
ADP + phosphorylated c-Myc
show the reaction diagram
-
-
-
-
?
ATP + cAMP response element-binding protein
ADP + phosphorylated cAMP response element-binding protein
show the reaction diagram
-
-
-
-
?
ATP + casein
ADP + phosphorylated casein
show the reaction diagram
ATP + coronavirus nucleocapsid protein
ADP + phosphorylated coronavirus nucleocapsid protein
show the reaction diagram
-
phosphorylation sites are at Ser177, Ser181, Ser184, Ser185, Ser187, Ser189, Ser191, Ser203, and Ser207
-
-
?
ATP + cyclin D
ADP + phosphorylated cyclin D
show the reaction diagram
-
-
-
-
?
ATP + cyclin D1
ADP + phosphorylated cyclin D1
show the reaction diagram
-
-
-
-
?
ATP + cyclin E
ADP + phosphorylated cyclin E
show the reaction diagram
-
-
-
-
?
ATP + DIWKKFELLPTPPLSPSRRSG
ADP + DIWKKFELLP(P)TPPL(P)SPSRRSG
show the reaction diagram
-
c-Myc
-
?
ATP + DIWKKFELVPSPPTSPPWGL
ADP + DIWKKFELVP(P)SPPT(P)SPPWGL
show the reaction diagram
-
L-myc
-
?
ATP + EEPQTVPEMPGETPPLSPIDMESQER
ADP + EEPQTVPEMPGE(P)TPPL(P)SPIDMESQER
show the reaction diagram
-
c-Jun
-
?
ATP + eIF2B peptide
ADP + phosphorylated eIF2B peptide
show the reaction diagram
ATP + FITC-GSRSRTPSLP
ADP + FITC-GSRSRTP-phosphoserine-LP
show the reaction diagram
-
synthetic fluorescence-labeled peptide substrate derived from residues 207-216 of tau protein, phosphorylation of S214 by SGK1
-
-
?
ATP + FXVEXTPXCFSRXSSLSSLS
ADP + ?
show the reaction diagram
-
-
-
-
?
ATP + glycogen synthase
ADP + glycogen synthase phosphate
show the reaction diagram
-
-
-
-
?
ATP + glycogen synthase
ADP + phosphorylated glycogen synthase
show the reaction diagram
-
-
-
-
ATP + H-Arg-Arg-Arg-Ala-Ala-Glu-Glu-Leu-Asp-Ser-Arg-Ala-Gly-pSer-Pro-Gln-Leu-OH
ADP + ?
show the reaction diagram
-
-
-
-
?
ATP + heat shock factor-1
ADP + phosphorylated heat shock factor-1
show the reaction diagram
-
-
-
-
?
ATP + histone H1
ADP + histone H1 phosphate
show the reaction diagram
ATP + histone H2a
ADP + histone H2a phosphate
show the reaction diagram
-
isoenzyme TPKII
-
-
?
ATP + histone H2b
ADP + histone H2b phosphate
show the reaction diagram
-
isoenzyme TPKII
-
-
?
ATP + histone H3
ADP + histone H3 phosphate
show the reaction diagram
-
isoenzyme TPKII
-
-
?
ATP + JHMV-N protein
ADP + phosphorylated JHMV-N protein
show the reaction diagram
-
phosphorylation sites are at Ser197, Ser201, Ser-205, and Ser-209
-
-
?
ATP + Jun
ADP + phosphorylated Jun
show the reaction diagram
-
-
-
-
?
ATP + KAUSSPTVSRKTD
ADP + KAUSSPTVSRKTD phosphate
show the reaction diagram
-
synthetic peptide p25/F3
-
-
?
ATP + KRREILSRRPpSYR
ADP + ?
show the reaction diagram
-
KRREILSRRPpSYR is selectively phosphorylated by GSK-3 and therefore acts as a competitive inhibitor of other GSK-3 substrates
-
-
?
ATP + LLNASGSTSTPAPSRTASFSESR
ADP + LLNASGSTS(P)TPAP(P)SRTASFSESR
show the reaction diagram
-
ATP-citrate lyase
-
?
ATP + MADSRPKPANKTPPK
ADP + MADSRPKPANKTPPK phosphate
show the reaction diagram
-
synthetic peptide F5f
-
-
?
ATP + mammalian histone H1
ADP + phosphorylated mammalian histone H1
show the reaction diagram
ATP + MAP2
ADP + MAP2 phosphate
show the reaction diagram
ATP + MARSRPK
ADP + MARSRPK phosphate
show the reaction diagram
-
synthetic peptide F5h
-
-
?
ATP + Myc
ADP + phosphorylated Myc
show the reaction diagram
-
-
-
-
?
ATP + myelin basic protein
ADP + phosphorylated myelin basic protein
show the reaction diagram
ATP + nuclear factor-kappaB
ADP + phosphorylated nuclear factor-kappaB
show the reaction diagram
-
-
-
-
?
ATP + p53
ADP + p53 phosphate
show the reaction diagram
-
-
-
-
?
ATP + p53
ADP + phosphorylated p53
show the reaction diagram
ATP + PANKTPPKSPGEPAKDPAAK
ADP + PANKTPPKSPGEPAKDPAAK phosphate
show the reaction diagram
-
synthetic peptide p25/F5a
-
-
?
ATP + phospho-glycogen synthase peptide-2
ADP + phosphorylated phospho-glycogen synthase peptide-2
show the reaction diagram
-
GSK3 substrate
-
-
-
ATP + protein
ADP + phosphoprotein
show the reaction diagram
-
autophosphorylation at Tyr and Ser
-
-
-
ATP + protein PHF-1
ADP + protein PHF-1 phosphate
show the reaction diagram
-
-
-
-
?
ATP + protein PHF-1 (Ser396/404)
ADP + protein PHF-1 (Ser396/404) phosphate
show the reaction diagram
-
-
-
-
?
ATP + protein tau
ADP + protein tau phosphate
show the reaction diagram
ATP + protein tau-1
ADP + protein tau-1 phosphate
show the reaction diagram
-
-
-
-
?
ATP + pyruvate dehydrogenase
ADP + pyruvate dehydrogenase phosphate
show the reaction diagram
-
PDH is phosphorylated and inactivated in vitro and also in betaA-treated hippocampal cultures, resulting in mitochondrial dysfunction which will contribute to neuronal death
-
-
?
ATP + RADSRPK
ADP + RADSRPK phosphate
show the reaction diagram
-
synthetic peptide F5g
-
-
?
ATP + RKRSRAE
ADP + RKRSRAE phosphate
show the reaction diagram
-
synthetic peptide 8659
-
-
?
ATP + RKRSRKE
ADP + RKRSRKE phosphate
show the reaction diagram
-
synthetic peptide 8655
-
-
?
ATP + RRREEETEEE
ADP + RRREEETEEE phosphate
show the reaction diagram
-
synthetic peptide CKII substrate
-
-
?
ATP + RRRPASVPPSPSLSRHSpSHQRR
ADP + ?
show the reaction diagram
-
-
-
-
?
ATP + RSRSRSRSRSRSPPPVSK
ADP + phosphorylated RSRSRSRSRSRSPPPVSK
show the reaction diagram
-
SC35-derived peptide 180-197, recombinant GSK-3beta
-
-
?
ATP + SC35
ADP + phosphorylated SC35
show the reaction diagram
ATP + SPPLSPIDMETQER
ADP + (P)SPPLSPIDME(P)TQER
show the reaction diagram
-
JunD
-
?
ATP + SPVVSGDT(P)SPR
ADP + ?
show the reaction diagram
-
-
-
-
-
ATP + tau protein
ADP + phosphorylated tau protein
show the reaction diagram
ATP + TPPKSPSAAK
ADP + TPPK(P)SPSAAK
show the reaction diagram
-
protein tau
-
?
ATP + YRRAAVPPSPSLSRHSSPHQSpEDEEE
ADP + ?
show the reaction diagram
ATP + [FRAT-2 protein]
ADP + phosphorylated [FRAT-2 protein]
show the reaction diagram
-
i.e. frequently rearranged in advanced T-cell lymphoma protein 2, phosphorylation by GSK3beta
-
-
?
ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
show the reaction diagram
glycogen synthase + ATP
phosphorylated glycogen synthase + ADP
show the reaction diagram
protein tau + ATP
phosphorylated protein tau + ADP
show the reaction diagram
-
the microtubule-associated protein tau is the principal component of the paired helical filaments - PHFs - found in the brains of patients with Alzheimer disease, and PHF-tau is hyperphosphorylated
-
-
?
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + amyloid precursor protein
ADP + phosphorylated amyloid precursor protein
show the reaction diagram
-
-
-
-
?
ATP + beta-catenin
ADP + phosphorylated beta-catenin
show the reaction diagram
-
-
-
-
?
ATP + c-Myc
ADP + phosphorylated c-Myc
show the reaction diagram
-
-
-
-
?
ATP + cyclin D
ADP + phosphorylated cyclin D
show the reaction diagram
-
-
-
-
?
ATP + cyclin E
ADP + phosphorylated cyclin E
show the reaction diagram
-
-
-
-
?
ATP + glycogen synthase
ADP + glycogen synthase phosphate
show the reaction diagram
-
-
-
-
?
ATP + nuclear factor-kappaB
ADP + phosphorylated nuclear factor-kappaB
show the reaction diagram
-
-
-
-
?
ATP + p53
ADP + phosphorylated p53
show the reaction diagram
-
-
-
-
?
ATP + protein tau
ADP + protein tau phosphate
show the reaction diagram
ATP + SC35
ADP + phosphorylated SC35
show the reaction diagram
-
substrate prephosphorylated SC35, SC35 is a member of the SR family of serine/arginine-rich splicing factors
-
-
?
ATP + tau protein
ADP + phosphorylated tau protein
show the reaction diagram
-
tau in Alzheimer disease brain is highly phosphorylated and aggregates into paired helical filaments comprising characteristic neurofibrillary tangles, overview
-
-
?
ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
show the reaction diagram
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Zn2+
-
high zinc concentrations (0.1-0.5 mM) increase glycogen synthase kinase-3beta phosphorylation on tyrosine 216, a phosphorylation associated with increased activity of this tau kinase, whereas the phosphorylation of GSK-3alpha at Y279 and the level of total GSK-3beta are not affected
additional information
-
not activated by K+, Ca2+ or Zn2+
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2'Z,3'E)-6-bromoindirubin-3'-oxime
(Rp)-adenosine 3',5'-cyclic monophosphorothionate triethyl ammonium salt
-
inhibitor of PKA
1-(4-methoxyphenyl)-6-(5-[[3-(trifluoromethyl)benzyl]sulfanyl]-1,3,4-oxadiazol-2-yl)-1H-benzimidazole
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-
1-(4-methoxyphenyl)-6-(5-[[4-methoxy-3-(trifluoromethyl)benzyl]sulfanyl]-1,3,4-oxadiazol-2-yl)-1H-benzimidazole
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-
1-(cyclopropylmethyl)-3-[4-(5,6-difluoro-1-benzofuran-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-1H-indole-5-carbonitrile
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-
1-ethyl-3-(5-phenyl-1H-pyrazolo[3,4-b]pyridin-3-yl)urea
-
-
-
1-methyl-5-phenyl-1H-pyrazolo[3,4-b]pyridin-3-amine
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1-methyl-6-(5-[[3-(trifluoromethyl)benzyl]sulfanyl]-1,3,4-oxadiazol-2-yl)-1H-benzimidazole
-
-
2-(1,3-benzodioxol-5-yl)-5-[(3-fluoro-4-methoxybenzyl)sulfanyl]-1,3,4-oxadiazole
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-
2-(1-benzofuran-5-yl)-5-[[4-methoxy-3-(trifluoromethyl)benzyl]sulfanyl]-1,3,4-oxadiazole
-
-
2-(2,3-dihydro-1-benzofuran-5-yl)-5-[(3-fluoro-4-methoxybenzyl)sulfanyl]-1,3,4-oxadiazole
-
-
2-(2,3-dihydro-1-benzofuran-5-yl)-5-[(3-fluorobenzyl)sulfanyl]-1,3,4-oxadiazole
-
-
2-(2,3-dihydro-1-benzofuran-5-yl)-5-[(4-methoxybenzyl)sulfanyl]-1,3,4-oxadiazole
-
-
2-(2,3-dihydro-1-benzofuran-5-yl)-5-[2-(3-fluorophenyl)ethyl]-1,3,4-oxadiazole
-
-
2-(2,3-dihydro-1-benzofuran-5-yl)-5-[[(3-fluorophenyl)sulfanyl]methyl]-1,3,4-oxadiazole
-
-
2-(2,3-dihydro-1-benzofuran-5-yl)-5-[[3-(trifluoromethyl)benzyl]sulfanyl]-1,3,4-oxadiazole
-
-
2-(2,3-dihydro-1-benzofuran-5-yl)-5-[[4-methoxy-3-(trifluoromethyl)benzyl]sulfanyl]-1,3,4-oxadiazole
-
-
2-(3-ethylpiperazin-1-yl)-N-[6-(3-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]acetamide
-
-
-
2-(benzylsulfanyl)-5-(2,3-dihydro-1-benzofuran-5-yl)-1,3,4-oxadiazole
-
-
2-amino-N-(2'-(cyclohex-2''-enyl)acetyl)acetimide
-
-
2-amino-N-(2'-(phenyl)acetyl)propanimide
-
-
2-chloro-5-[(2,5-dioxo-4-phenyl-2,5-dihydro-1H-pyrrol-3-yl)amino]benzoic acid
-
-
-
2-chloro-5-[[4-(2-chlorophenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino]benzoic acid
-
-
-
2-chloro-5-[[4-(2-nitrophenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino]benzoic acid
-
-
-
2-chloro-5-[[4-(3-chlorophenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino]benzoic acid
-
-
-
2-chloro-5-[[4-(3-methoxyphenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino]benzoic acid
-
-
-
2-chloro-5-[[4-(3-nitrophenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino]benzoic acid
-
-
-
2-chloro-5-[[4-(4-chlorophenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino]benzoic acid
-
-
-
2-cyanoethyl alsterpaullone
-
-
-
2-methyl-N-(5-phenyl-1H-pyrazolo[3,4-b]pyridin-3-yl)propanamide
-
-
-
2-[(2-chlorobenzyl)sulfanyl]-5-(2,3-dihydro-1-benzofuran-5-yl)-1,3,4-oxadiazole
-
-
2-[(3-chloro-4-methoxybenzyl)sulfanyl]-5-(2,3-dihydro-1-benzofuran-5-yl)-1,3,4-oxadiazole
-
-
2-[(3-chlorobenzyl)sulfanyl]-5-(2,3-dihydro-1-benzofuran-5-yl)-1,3,4-oxadiazole
-
-
2-[(4-chlorobenzyl)sulfanyl]-5-(2,3-dihydro-1-benzofuran-5-yl)-1,3,4-oxadiazole
-
-
2-[3-(4-methoxyphenyl)-1-benzofuran-5-yl]-5-[[3-(trifluoromethyl)benzyl]sulfanyl]-1,3,4-oxadiazole
-
-
2-[3-(4-methoxyphenyl)-1-benzofuran-5-yl]-5-[[4-methoxy-3-(trifluoromethyl)benzyl]sulfanyl]-1,3,4-oxadiazole
-
-
3-(1-(2-(1H-imidazol-1-yl)ethyl)-1H-indol-3-yl)-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione
-
-
3-(1-(3-(1H-imidazol-1-yl)propyl)-1H-indol-3-yl)-1-phenyl-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione
-
-
3-(1-(3-(1H-imidazol-1-yl)propyl)-1H-indol-3-yl)-4-(1-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)-1H-pyrrole-2,5-dione
-
-
3-(1-(3-(1H-imidazol-1-yl)propyl)-1H-indol-3-yl)-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione
-
-
3-(1-(3-(dimethylamino)propyl)-1H-indol-3-yl)-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione
-
-
3-(1-(3-(piperidin-1-yl)propyl)-1H-indol-3-yl)-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione
-
-
3-(1-(3-hydroxypropyl)-1H-indol-3-yl)-4-(1-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)-1H-pyrrole-2,5-dione
-
-
3-(1-(3-morpholinopropyl)-1H-indol-3-yl)-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione
-
-
3-(1-(4-(1H-imidazol-1-yl)butyl)-1H-indol-3-yl)-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione
-
-
3-(1-benzofuran-3-yl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
-
-
3-(1-benzofuran-3-yl)-4-(1-methyl-7-phenoxy-1H-indol-3-yl)-1H-pyrrole-2,5-dione
-
-
3-(1-benzofuran-3-yl)-4-(5-bromo-1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
-
-
3-(1-benzofuran-3-yl)-4-(5-cyclopropyl-1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
-
-
3-(1-benzofuran-3-yl)-4-(5-fluoro-1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
-
-
3-(1-benzofuran-3-yl)-4-(5-fluoro-1H-indol-3-yl)-1H-pyrrole-2,5-dione
-
-
3-(1-benzofuran-3-yl)-4-(5-hydroxy-1H-indol-3-yl)-1H-pyrrole-2,5-dione
-
-
3-(1-benzofuran-3-yl)-4-(5-iodo-1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
-
-
3-(1-benzofuran-3-yl)-4-(6-chloro-5-fluoro-1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
-
-
3-(1-benzofuran-3-yl)-4-(6-chloro-5-methoxy-1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
-
-
3-(1-benzofuran-3-yl)-4-(6-hydroxy-1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
-
-
3-(1-benzofuran-3-yl)-4-(6-iodo-5-methoxy-1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
-
-
3-(1-benzofuran-3-yl)-4-(7-hydroxy-1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
-
-
3-(1-benzofuran-3-yl)-4-[1-(3-hydroxypropyl)-5-phenoxy-1H-indol-3-yl]-1H-pyrrole-2,5-dione
-
-
3-(1-benzofuran-3-yl)-4-[1-methyl-5-(morpholin-4-yl)-1H-indol-3-yl]-1H-pyrrole-2,5-dione
-
-
3-(1-benzofuran-3-yl)-4-[5-(benzyloxy)-1H-indol-3-yl]-1H-pyrrole-2,5-dione
-
-
3-(1-benzofuran-3-yl)-4-[5-bromo-1-(3-hydroxypropyl)-1H-indol-3-yl]-1H-pyrrole-2,5-dione
-
-
3-(1-benzofuran-3-yl)-4-[6-(benzyloxy)-1-methyl-1H-indol-3-yl]-1H-pyrrole-2,5-dione
-
-
3-(1-benzofuran-3-yl)-4-[7-(hydroxymethyl)-1-methyl-1H-indol-3-yl]-1H-pyrrole-2,5-dione
-
-
3-(1-benzofuran-3-yl)-4-[7-(methoxymethyl)-1-methyl-1H-indol-3-yl]-1H-pyrrole-2,5-dione
-
-
3-(1-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)-4-(1-(2-morpholinoethyl)-1H-indol-3-yl)-1H-pyrrole-2,5-dione
-
-
3-(1-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)-4-(1-(3-morpholinopropyl)-1H-indol-3-yl)-1H-pyrrole-2,5-dione
-
-
3-(1H-indol-3-yl)-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione
-
-
3-(2,3-dihydro-1H-indol-1-yl)-4-(2-methoxyphenyl)-1H-pyrrole-2,5-dione
-
-
-
3-(2,3-dihydro-1H-indol-1-yl)-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione
-
-
-
3-(2,3-dihydro-1H-indol-1-yl)-4-(3-nitrophenyl)-1H-pyrrole-2,5-dione
-
-
-
3-(2,3-dihydro-1H-indol-1-yl)-4-(4-methoxyphenyl)-1H-pyrrole-2,5-dione
-
-
-
3-(2-chlorophenyl)-4-(2,3-dihydro-1H-indol-1-yl)-1H-pyrrole-2,5-dione
-
-
-
3-(2-chlorophenyl)-4-(phenylamino)-1H-pyrrole-2,5-dione
-
-
-
3-(2-chlorophenyl)-4-[(3,5-dichloro-4-hydroxyphenyl)amino]-1H-pyrrole-2,5-dione
-
-
-
3-(2-chlorophenyl)-4-[(3-chlorophenyl)amino]-1H-pyrrole-2,5-dione
-
-
-
3-(2-chlorophenyl)-4-[(3-hydroxyphenyl)amino]-1H-pyrrole-2,5-dione
-
-
-
3-(2-chlorophenyl)-4-[[4-(methylsulfanyl)phenyl]amino]-1H-pyrrole-2,5-dione
-
-
-
3-(2-methoxyphenyl)-4-(phenylamino)-1H-pyrrole-2,5-dione
-
-
-
3-(2-methoxyphenyl)-4-[[4-(methylsulfanyl)phenyl]amino]-1H-pyrrole-2,5-dione
-
-
-
3-(3-chlorophenyl)-4-(2,3-dihydro-1H-indol-1-yl)-1H-pyrrole-2,5-dione
-
-
-
3-(3-chlorophenyl)-4-[(3,5-dichloro-4-hydroxyphenyl)amino]-1H-pyrrole-2,5-dione
-
-
-
3-(3-chlorophenyl)-4-[(3-hydroxyphenyl)amino]-1H-pyrrole-2,5-dione
-
-
-
3-(3-chlorophenyl)-4-[[4-(methylsulfanyl)phenyl]amino]-1H-pyrrole-2,5-dione
-
-
-
3-(3-methoxyphenyl)-4-[[4-(methylsulfanyl)phenyl]amino]-1H-pyrrole-2,5-dione
-
-
-
3-(3-nitrophenyl)-4-(phenylamino)-1H-pyrrole-2,5-dione
-
-
-
3-(4-chlorophenyl)-4-(2,3-dihydro-1H-indol-1-yl)-1H-pyrrole-2,5-dione
-
-
-
3-(4-chlorophenyl)-4-(phenylamino)-1H-pyrrole-2,5-dione
-
-
-
3-(4-chlorophenyl)-4-[(3,5-dichloro-4-hydroxyphenyl)amino]-1H-pyrrole-2,5-dione
-
-
-
3-(4-chlorophenyl)-4-[(3-chlorophenyl)amino]-1H-pyrrole-2,5-dione
-
-
-
3-(4-chlorophenyl)-4-[(3-hydroxyphenyl)amino]-1H-pyrrole-2,5-dione
-
-
-
3-(4-chlorophenyl)-4-[(4-hydroxyphenyl)amino]-1H-pyrrole-2,5-dione
-
-
-
3-(4-chlorophenyl)-4-[methyl(phenyl)amino]-1H-pyrrole-2,5-dione
-
-
-
3-(4-chlorophenyl)-4-[[4-(methylsulfanyl)phenyl]amino]-1H-pyrrole-2,5-dione
-
-
-
3-(4-methoxyphenyl)-4-(phenylamino)-1H-pyrrole-2,5-dione
-
-
-
3-(4-methoxyphenyl)-4-[[4-(methylsulfanyl)phenyl]amino]-1H-pyrrole-2,5-dione
-
-
-
3-(5,6-difluoro-1-benzofuran-3-yl)-4-(1-methyl-1H-benzo[g]indol-3-yl)-1H-pyrrole-2,5-dione
-
-
3-(5,7-dibromo-1-methyl-1H-indol-3-yl)-4-(7-methoxy-1-benzofuran-3-yl)-1H-pyrrole-2,5-dione
-
-
3-(5-bromo-1-(3-(1H-imidazol-1-yl)propyl)-1H-indol-3-yl)-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione
-
-
3-(5-bromo-1-benzofuran-3-yl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
-
-
3-(5-bromo-1-methyl-1H-indol-3-yl)-4-(7-methoxy-1-benzofuran-3-yl)-1H-pyrrole-2,5-dione
-
-
3-(5-bromo-1-methyl-1H-indol-3-yl)-4-[6-(4-methoxyphenoxy)-1-benzofuran-3-yl]-1H-pyrrole-2,5-dione
-
-
3-(5-bromo-1-methyl-1H-indol-3-yl)-4-[6-(hydroxymethyl)-1-benzofuran-3-yl]-1H-pyrrole-2,5-dione
-
-
3-(5-bromo-1-methyl-1H-indol-3-yl)-4-[6-(prop-2-en-1-yloxy)-1-benzofuran-3-yl]-1H-pyrrole-2,5-dione
-
-
3-(5-bromo-1-methyl-1H-indol-3-yl)-4-[6-(prop-2-yn-1-yloxy)-1-benzofuran-3-yl]-1H-pyrrole-2,5-dione
-
-
3-(5-chloro-1-methyl-1H-indol-3-yl)-4-(5-fluoro-1-benzofuran-3-yl)-1H-pyrrole-2,5-dione
-
-
3-(5-fluoro-1-benzofuran-3-yl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
-
-
3-(5-fluoro-1-benzofuran-3-yl)-4-(5-iodo-1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
-
-
3-(5-fluoro-1-benzofuran-3-yl)-4-(6-hydroxy-1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
-
-
3-(5-fluoro-1-methyl-1H-indol-3-yl)-4-(6-hydroxy-1-benzofuran-3-yl)-1H-pyrrole-2,5-dione
-
-
3-(5-fluoro-1-methyl-1H-indol-3-yl)-4-[6-(hydroxymethyl)-1-benzofuran-3-yl]-1H-pyrrole-2,5-dione
-
-
3-(5-fluoro-1-methyl-1H-indol-3-yl)-4-[6-(methoxymethyl)-1-benzofuran-3-yl]-1H-pyrrole-2,5-dione
-
-
3-(5-fluoro-6-iodo-1-methyl-1H-indol-3-yl)-4-(7-methoxy-1-benzofuran-3-yl)-1H-pyrrole-2,5-dione
-
-
3-(5-methoxy-1-(3-(1H-imidazol-1-yl)propyl)-1H-indol-3-yl)-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione
-
-
3-(5-methoxy-1-(3-(dimethylamino)propyl)-1H-indol-3-yl)-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione
-
-
3-(5H-[1,3]dioxolo[4,5-f]indol-7-yl)-4-(5-fluoro-1-benzofuran-3-yl)-1H-pyrrole-2,5-dione
-
-
3-(6-bromo-1-(3-(1H-imidazol-1-yl)propyl)-1H-indol-3-yl)-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione
-
-
3-(6-bromo-1-(3-(dimethylamino)propyl)-1H-indol-3-yl)-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione
-
-
3-(6-chloro-5-fluoro-1-methyl-1H-indol-3-yl)-4-(6-methoxy-1-benzofuran-3-yl)-1H-pyrrole-2,5-dione
-
-
3-(6-chloro-5-fluoro-1-methyl-1H-indol-3-yl)-4-(7-methoxy-1-benzofuran-3-yl)-1H-pyrrole-2,5-dione
-
-
3-(6-chloro-5-fluoro-1-methyl-1H-indol-3-yl)-4-[6-(cyclobutylmethoxy)-1-benzofuran-3-yl]-1H-pyrrole-2,5-dione
-
-
3-(6-chloro-5-fluoro-1-methyl-1H-indol-3-yl)-4-[6-(cyclopropylmethoxy)-1-benzofuran-3-yl]-1H-pyrrole-2,5-dione
-
-
3-(6-chloro-5-fluoro-1-methyl-1H-indol-3-yl)-4-[6-(hydroxymethyl)-1-benzofuran-3-yl]-1H-pyrrole-2,5-dione
-
-
3-(6-fluoro-1-(3-(1H-imidazol-1-yl)propyl)-1H-indol-3-yl)-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione
-
-
3-(6-fluoro-1-(3-(dimethylamino)propyl)-1H-indol-3-yl)-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione
-
-
3-(7-methoxy-1-benzofuran-3-yl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
-
-
3-(7-methoxy-1-benzofuran-3-yl)-4-[1-methyl-6-(trifluoromethyl)-1H-indol-3-yl]-1H-pyrrole-2,5-dione
-
-
3-([[5-(2,3-dihydro-1-benzofuran-5-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]methyl)benzo-nitrile
-
-
3-benzyl-N-[5-bromo-6-(furan-2-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrrolidine-1-carboxamide
-
-
-
3-phenyl-4-(phenylamino)-1H-pyrrole-2,5-dione
-
-
-
3-[(2,5-dioxo-4-phenyl-2,5-dihydro-1H-pyrrol-3-yl)amino]benzoic acid
-
-
-
3-[(3,5-dichloro-4-hydroxyphenyl)amino]-4-(2-methoxyphenyl)-1H-pyrrole-2,5-dione
-
-
-
3-[(3,5-dichloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione
-
-
-
3-[(3,5-dichloro-4-hydroxyphenyl)amino]-4-(3-methoxyphenyl)-1H-pyrrole-2,5-dione
-
-
-
3-[(3,5-dichloro-4-hydroxyphenyl)amino]-4-(3-nitrophenyl)-1H-pyrrole-2,5-dione
-
-
-
3-[(3,5-dichloro-4-hydroxyphenyl)amino]-4-(4-methoxyphenyl)-1H-pyrrole-2,5-dione
-
-
-
3-[(3,5-dichloro-4-hydroxyphenyl)amino]-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione
-
-
-
3-[(3,5-dichloro-4-hydroxyphenyl)amino]-4-phenyl-1H-pyrrole-2,5-dione
-
-
-
3-[(3-chloro-4-hydroxyphenyl)amino]-4-(2-chlorophenyl)-1H-pyrrole-2,5-dione
-
-
-
3-[(3-chloro-4-hydroxyphenyl)amino]-4-(2-methoxyphenyl)-1H-pyrrole-2,5-dione
-
-
-
3-[(3-chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione
-
-
-
3-[(3-chloro-4-hydroxyphenyl)amino]-4-(3-chlorophenyl)-1H-pyrrole-2,5-dione
-
-
-
3-[(3-chloro-4-hydroxyphenyl)amino]-4-(3-nitrophenyl)-1H-pyrrole-2,5-dione
-
-
-
3-[(3-chloro-4-hydroxyphenyl)amino]-4-(4-chlorophenyl)-1H-pyrrole-2,5-dione
-
-
-
3-[(3-chlorophenyl)amino]-4-(2-methoxyphenyl)-1H-pyrrole-2,5-dione
-
-
-
3-[(3-chlorophenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione
-
-
-
3-[(3-chlorophenyl)amino]-4-(3-methoxyphenyl)-1H-pyrrole-2,5-dione
-
-
-
3-[(3-chlorophenyl)amino]-4-(3-nitrophenyl)-1H-pyrrole-2,5-dione
-
-
-
3-[(3-chlorophenyl)amino]-4-(4-methoxyphenyl)-1H-pyrrole-2,5-dione
-
-
-
3-[(3-chlorophenyl)amino]-4-phenyl-1H-pyrrole-2,5-dione
-
-
-
3-[(3-hydroxyphenyl)amino]-4-(2-methoxyphenyl)-1H-pyrrole-2,5-dione
-
-
-
3-[(3-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione
-
-
-
3-[(3-hydroxyphenyl)amino]-4-(3-methoxyphenyl)-1H-pyrrole-2,5-dione
-
-
-
3-[(3-hydroxyphenyl)amino]-4-(3-nitrophenyl)-1H-pyrrole-2,5-dione
-
-
-
3-[(3-hydroxyphenyl)amino]-4-(4-methoxyphenyl)-1H-pyrrole-2,5-dione
-
-
-
3-[(3-hydroxyphenyl)amino]-4-phenyl-1H-pyrrole-2,5-dione
-
-
-
3-[(4-hydroxyphenyl)amino]-4-(3-nitrophenyl)-1H-pyrrole-2,5-dione
-
-
-
3-[(5E)-5-methyl-4-oxo-2-hydroxy-5-octenyl]glutarimide
-
-
3-[([5-[1-(4-methoxyphenyl)-1H-benzimidazol-6-yl]-1,3,4-oxadiazol-2-yl]sulfanyl)methyl]benzonitrile
-
-
3-[([5-[3-(4-methoxyphenyl)-1-benzofuran-5-yl]-1,3,4-oxadiazol-2-yl]sulfanyl)methyl]benzonitrile
-
-
3-[4-(6-ethyl-1-benzofuran-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-1-methyl-1H-indole-5-carbonitrile
-
-
3-[5-(cyclopropylethynyl)-1-methyl-1H-indol-3-yl]-4-(5-fluoro-1-benzofuran-3-yl)-1H-pyrrole-2,5-dione
-
-
3-[6-(4-chlorophenyl)-5-fluoro-1-methyl-1H-indol-3-yl]-4-(7-methoxy-1-benzofuran-3-yl)-1H-pyrrole-2,5-dione
-
-
3-[6-(benzyloxy)-1-methyl-1H-indol-3-yl]-4-(5-fluoro-1-benzofuran-3-yl)-1H-pyrrole-2,5-dione
-
-
3-[6-(hydroxymethyl)-1-benzofuran-3-yl]-4-[7-(hydroxymethyl)-1-methyl-1H-indol-3-yl]-1H-pyrrole-2,5-dione
-
-
3-[methyl(phenyl)amino]-4-(3-nitrophenyl)-1H-pyrrole-2,5-dione
-
-
-
3-[methyl(phenyl)amino]-4-phenyl-1H-pyrrole-2,5-dione
-
-
-
3-[[4-(2-chlorophenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino]benzoic acid
-
-
-
3-[[4-(3-chlorophenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino]benzoic acid
-
-
-
3-[[4-(3-methoxyphenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino]benzoic acid
-
-
-
3-[[4-(3-nitrophenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino]benzoic acid
-
-
-
3-[[4-(4-chlorophenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino]benzoic acid
-
-
-
3-[[4-(4-methoxyphenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino]benzoic acid
-
-
-
3-[[4-(methylsulfanyl)phenyl]amino]-4-(3-nitrophenyl)-1H-pyrrole-2,5-dione
-
-
-
3-[[4-(methylsulfanyl)phenyl]amino]-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione
-
-
-
3-[[4-(methylsulfanyl)phenyl]amino]-4-phenyl-1H-pyrrole-2,5-dione
-
-
-
3alpha,5alpha-tetrahydroprogesterone
-
decreases only expression of GSK-3 beta in the cerebellum but not in the hypothalamus
4,5-diphenyl-1H-pyrazolo[3,4-c]pyridazin-3-amine
-
-
4-benzyl-2-methyl-1, 2, 4-thiadiazolidine-3,5-dione
-
TDZD-8
-
4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
4-phenyl-1H-pyrazolo[3,4-b]pyridin-3-amine
-
-
4-{(2R)-2-[(1R,3R,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione
-
-
5-(2,3-dihydro-1-benzofuran-5-yl)-N-(3-fluorobenzyl)-1,3,4-oxadiazol-2-amine
-
-
5-(5-[[4-methoxy-3-(trifluoromethyl)benzyl]sulfanyl]-1,3,4-oxadiazol-2-yl)-1H-indazole
-
-
5-([ [5-(2,3-dihydro-1-benzofuran-5-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]methyl)-2-methoxybenzonitrile
-
-
5-phenyl-1H-pyrazolo[3,4-b]pyridin-3-amine
-
-
5-phenyl-1H-pyrazolo[3,4-c]pyridazin-3-amine
-
-
5-phenyl-1H-pyrazolo[3,4-c]pyridin-3-amine
-
-
5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-amine
-
-
5-phenyl[1,2]oxazolo[5,4-b]pyridin-3-amine
-
-
5alpha-dihydroprogesterone
-
decreases only expression of GSK-3 beta in the cerebellum but not in the hypothalamus
6-(5-[[4-methoxy-3-(trifluoromethyl)benzyl]sulfanyl]-1,3,4-oxadiazol-2-yl)-1,3-benzothiazole
-
-
6-(5-[[4-methoxy-3-(trifluoromethyl)benzyl]sulfanyl]-1,3,4-oxadiazol-2-yl)imidazo[1,2-a]pyridine
-
-
6-(5-[[4-methoxy-3-(trifluoromethyl)benzyl]sulfanyl]-1,3,4-oxadiazol-2-yl)quinoline
-
-
6-bromo-5-methylindirubin-3'-oxime
-
potent inhibitor
-
6-bromo-indirubin-3'-acetoxime
-
potent inhibitor
-
6-bromo-indirubin-3'-oxime
6-bromoindirubin-3'-oxim
-
-
6-bromoindirubin-3'-oxime
-
-
6-O-methyl-7-O-alpha-L-rhamnopyranosyldaidzein
-
-
7-O-alpha-L-rhamnopyranosyldaidzein
-
-
A-582941
-
attenuates beta-amyloid peptide 1-42-induced activation of GSK-3beta
alpha-bungarotoxin
-
attenuates beta-amyloid peptide 1-42-induced activation of GSK-3beta
alsterpaullone
-
-
AMP-PNP
-
ATP analogue adenosine 5'-(beta,gamma-imino)triphosphate
AR-A014418
-
selective ATP-competitive inhibitor of GSK3
Butyrolactone
-
cdk5 inhibitor, isoenzyme TPKII
caffeic acid
-
0.02 mg/ml caffeic acid decreases the activating phosphorylation of GSK-3beta
carteriosulfonic acid A
-
low micromolar inhibitor of GSK-3beta
carteriosulfonic acid B
-
low micromolar inhibitor of GSK-3beta
carteriosulfonic acid C
-
low micromolar inhibitor of GSK-3beta
CHIR98023
-
attenuates beta-amyloid peptide 1-42-induced activation of GSK-3beta
CT99021
-
-
-
cycloheximide
-
-
dantrolene
-
in the presence of dantrolene, GSK-3beta activation and tau phosphorylation are decreased
disheveled protein
-
-
-
DMSO
-
complete inhibition at 0.4% (v/v)
enzastaurin
-
activation-related phosphorylation of Y216/Y276 is dramatically decreased following exposure to enzastaurin whereas the inhibitory phosphorylation of S21 is significantly up-regulated in glioma cells. GSK3 inhibition results in glioma cell death and reduced tumorigenicity
GF 109203X
-
-
GSK-3 inhibitor IX
-
-
-
GSK3betaI
-
0.0001 mM
-
GTPgamma-S
-
-
Insulin
-
insulin induces phosphorylation of the Ser9 residue, thereby inactivating GSK-3beta
-
insulin-like growth factor-I
-
-
-
kenpaullone
KRM-189
-
74% inhibition at 0.01 mM, competes with ATP for GSK-3beta, leading to decreased Vmax and constant Km with increasing concentrations of ATP
KRM-191
-
84% inhibition at 0.01 mM, competes with ATP for GSK-3beta, leading to decreased Vmax and constant Km with increasing concentrations of ATP
KRM-192
-
75% inhibition at 0.01 mM
KRM-195
-
80% inhibition at 0.01 mM
KRM-296
-
65% inhibition at 0.01 mM
KRM-7777
-
65% inhibition at 0.01 mM
leptin
-
-
-
lithium
lithium chloride
methyl 3-([[5-(2,3-dihydro-1-benzofuran-5-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]methyl)benzoate
-
-
methyllycaconitine
-
attenuates beta-amyloid peptide 1-42-induced activation of GSK-3beta
N-(1H-pyrazolo[3,4-b]pyridin-3-yl)butanamide
-
-
-
N-(4,5-diphenyl-1H-pyrazolo[3,4-c]pyridazin-3-yl)butanamide
-
-
-
N-(5,6-diphenyl-1H-pyrazolo[3,4-b]pyridin-3-yl)cyclopropanecarboxamide
-
-
-
N-(5-bromo-6-phenyl-1H-pyrazolo[3,4-b]pyridin-3-yl)-4-methylpiperidine-1-carboxamide
-
-
-
N-(5-bromo-6-phenyl-1H-pyrazolo[3,4-b]pyridin-3-yl)cyclopropanecarboxamide
-
-
-
N-(5-chloro-6-phenyl-1H-pyrazolo[3,4-b]pyridin-3-yl)cyclopropanecarboxamide
-
-
-
N-(5-cyano-6-phenyl-1H-pyrazolo[3,4-b]pyridin-3-yl)cyclopropanecarboxamide
-
-
-
N-(5-phenyl-1H-indazol-3-yl)butanamide
-
-
-
N-(5-phenyl-1H-pyrazolo[3,4-b]pyridin-3-yl)acetamide
-
-
-
N-(5-phenyl-1H-pyrazolo[3,4-b]pyridin-3-yl)butanamide
-
-
-
N-(5-phenyl-1H-pyrazolo[3,4-b]pyridin-3-yl)cyclopentanecarboxamide
-
-
-
N-(5-phenyl-1H-pyrazolo[3,4-b]pyridin-3-yl)methanesulfonamide
-
-
N-(5-phenyl-1H-pyrazolo[3,4-b]pyridin-3-yl)propanamide
-
-
-
N-(5-phenyl-1H-pyrazolo[3,4-c]pyridin-3-yl)butanamide
-
-
-
N-(5-phenyl-1H-pyrazolo[4,3-d]pyrimidin-3-yl)butanamide
-
-
-
N-(6-phenyl-1H-indazol-3-yl)cyclopropanecarboxamide
-
-
-
N-(6-phenyl-1H-pyrazolo[3,4-b]pyridin-3-yl)cyclopropanecarboxamide
-
-
-
N-[4-[3-(4-ethylpiperazin-1-yl)propyl]-5-phenyl-1H-pyrazolo[3,4-c]pyridazin-3-yl]butanamide
-
-
-
N-[4-[3-(dimethylamino)propyl]-5-phenyl-1H-pyrazolo[3,4-c]pyridazin-3-yl]butanamide
-
-
-
N-[4-[3-(morpholin-4-yl)propyl]-5-phenyl-1H-pyrazolo[3,4-c]pyridazin-3-yl]butanamide
-
-
-
N-[4-[ethyl(piperidin-1-ylmethyl)amino]-5-phenyl-1H-pyrazolo[3,4-c]pyridazin-3-yl]butanamide
-
-
-
N-[4-[methyl(piperidin-1-yl)amino]-5-phenyl-1H-pyrazolo[3,4-c]pyridazin-3-yl]butanamide
-
-
-
N-[5-(2,3-difluorophenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]butanamide
-
-
-
N-[5-(2-chlorophenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]butanamide
-
-
-
N-[5-(2-fluorophenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]butanamide
-
-
-
N-[5-(3-fluorophenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]butanamide
-
-
-
N-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]butanamide
-
-
-
N-[5-(6,6-difluorocyclohexa-1,3-dien-1-yl)-4-[3-(dimethylamino)propyl]-1H-pyrazolo[3,4-c]pyridazin-3-yl]butanamide
-
-
-
N-[5-(biphenyl-4-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]butanamide
-
-
-
N-[5-(naphthalen-1-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]butanamide
-
-
-
N-[5-(naphthalen-2-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]butanamide
-
-
-
N-[5-(pyridin-3-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]butanamide
-
-
-
N-[5-(pyridin-4-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]butanamide
-
-
-
N-[5-bromo-6-(4-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-(4-ethylpiperazin-1-yl)butanamide
-
-
-
N-[5-bromo-6-(4-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-methylpiperidine-1-carboxamide
-
-
-
N-[5-bromo-6-(4-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]cyclopropanecarboxamide
-
-
-
N-[5-bromo-6-(furan-2-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]cyclopropanecarboxamide
-
-
-
N-[5-bromo-6-(tetrahydrothiophen-3-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]cyclopropanecarboxamide
-
-
-
N-[5-bromo-6-(thiophen-2-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-2-(4-methylpiperidin-1-yl)acetamide
-
-
-
N-[5-bromo-6-(thiophen-2-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]cyclopropanecarboxamide
-
-
-
N-[5-chloro-6-(4-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]cyclopropanecarboxamide
-
-
-
N-[5-phenyl-4-[3-(pyrrolidin-1-yl)propyl]-1H-pyrazolo[3,4-c]pyridazin-3-yl]butanamide
-
-
-
N-[6-(1H-indol-5-yl)-1H-indazol-3-yl]cyclopropanecarboxamide
-
-
-
N-[6-(2,5-difluorophenyl)-1H-indazol-3-yl]cyclopropanecarboxamide
-
-
-
N-[6-(2-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]cyclopropanecarboxamide
-
-
-
N-[6-(2-methoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]cyclopropanecarboxamide
-
-
-
N-[6-(2H-pyrrol-2-yl)-1H-indazol-3-yl]cyclopropanecarboxamide
-
-
-
N-[6-(3,4-dihydroxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]cyclopropanecarboxamide
-
-
-
N-[6-(3-bromo-4-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]cyclopropanecarboxamide
-
-
-
N-[6-(3-chloro-4-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]cyclopropanecarboxamide
-
-
-
N-[6-(3-fluorophenyl)-1H-indazol-3-yl]cyclopropanecarboxamide
-
-
-
N-[6-(3-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]cyclopropanecarboxamide
-
-
-
N-[6-(3-methoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]cyclopropanecarboxamide
-
-
-
N-[6-(3-sulfamoylphenyl)-1H-indazol-3-yl]cyclopropanecarboxamide
-
-
-
N-[6-(4-hydroxyphenyl)-1H-indazol-3-yl]cyclopropanecarboxamide
-
-
-
N-[6-(4-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-methylpiperidine-1-carboxamide
-
-
-
N-[6-(4-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]cyclopropanecarboxamide
-
-
-
N-[6-(4-hydroxyphenyl)-5-methyl-1H-pyrazolo[3,4-b]pyridin-3-yl]cyclopropanecarboxamide
-
-
-
N-[6-(4-hydroxyphenyl)-5-phenyl-1H-pyrazolo[3,4-b]pyridin-3-yl]cyclopropanecarboxamide
-
-
-
N-[6-(4-methoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]cyclopropanecarboxamide
-
-
-
N-[6-(furan-2-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]cyclopropanecarboxamide
-
-
-
N-[6-(furan-3-yl)-1H-indazol-3-yl]cyclopropanecarboxamide
-
-
-
N-[6-(tetrahydrothiophen-3-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]cyclopropanecarboxamide
-
-
-
N-[6-(thiophen-2-yl)-1H-indazol-3-yl]cyclopropanecarboxamide
-
-
-
N-[6-(thiophen-2-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]cyclopropanecarboxamide
-
-
-
N-[6-(thiophen-3-yl)-1H-indazol-3-yl]cyclopropanecarboxamide
-
-
-
naramycin B
-
-
Nicotine
-
attenuates beta-amyloid peptide 1-42-induced activation of GSK-3beta
p25
-
p25 overexpressing mice have reduced GSK3beta activity
-
progesterone
-
decreases expression and phosphorylation of GSK-3 beta in the cerebellum but not in the hypothalamus, regulation of tau expression and phosphorylation by progesterone may contribute to the hormonal regulation of cerebellar function by the modification of neuronal cytoskeleton
Protein kinase C
-
protein kinase C inhibits GSK-3beta by phosphorylating its auto-inhibitory domain at Ser9
-
Ro 31-8220
-
-
roscovitine
SB 216743
-
-
-
SB 216763
-
GSK-3-specific inhibitor
-
SB-216763
SB-415286
SB216763
SB415286
-
-
SRN-003-556
-
-
staurosporine
-
-
TDZD-8
-
selective GSK-3beta inhibitor, induces phosphorylation of the Ser9 residue, thereby inactivating GSK-3beta
trans-activating transcriptor-eIF2B
ZM336372
-
inhibits GSK-3beta through phosphorylation at Ser9, a dose-dependent increase in phosphorylation of GSK-3beta occurs after treatment with ZM336372 (0.025-0.1 mM)
additional information
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
amyloid-beta 1-42 peptide
-
0.005 mM
-
AT7519
-
0.0005 mM AT7519 inhibits glycogen synthase kinase 3beta phosphorylation, AT7519 dephosphorylates GSK-3beta independent of inhibition of transcription
beta-amyloid peptide
-
-
-
beta-amyloid peptide 1-42
-
0.01 mM, induces phosphorylation at Tyr216 activating GSK-3beta
-
carbonyl cyanide p-trifluoromethoxyphenylhydrazone
-
-
cholesterol 3-sulfate
-
potent stimulator for the GSK-3beta-mediated phosphorylation of tau protein (about 10fold stimulation in the presence of 0.003 mM)
cisplatin
-
GSK-3 is activated by cisplatin treatment of HEI-OC1 cells, 0.02 mM cisplatin induces phosphorylation of Tyr216 GSK-3beta in HEI-OC1 cells but reduces the phosphorylation of Ser9 GSK-3beta, the activity of GSK-3beta is regulated negatively by the phosphorylation of Ser9 and positively by the phosphorylation of Tyr216
CP-681301
-
CP-681301 treatment reverses the inhibition of GSK3beta activity
D-galactosylceramide-3-O-sulfate
-
potent stimulator for the GSK-3beta-mediated phosphorylation of tau protein (about 11fold stimulation in the presence of 0.003 mM)
Dickkopf-1
-
100 ng/ml
-
ether
-
dramatic increase in the phosphorylation level of Ser9 of TPKI/GSK3beta immediately and 10 min after ether administration, followed by rapid virtual reversion to baseline by 20 min, no significant changes in the protein level or Tyr216 phosphorylation level of the enzyme
forskolin
FRAT-2
-
i.e. frequently rearranged in advanced T-cell lymphoma protein 2, activates phosphorylation of primed sites of tau protein about 8fold, no effect on unprimed site phosphorylation
-
Frizzled-8
-
100 ng/ml
-
GF-109203X
-
-
heparin
-
-
L-Dopa
-
activates GSK-3beta at high dose
p35
-
tightly bound neuronal activator of cdk5, required for activity with regulatory function, p39 activates to a greater extent compared to p35 in vitro
-
p39
-
tightly bound neuronal activator of cdk5, required for activity with regulatory function, p39 activates to a greater extent compared to p35 in vitro, p39 is the activator activator in vivo
-
protein 14-3-3
soluble beta-amyloid oligomers
syndapin 1
-
highly stimulates the GSK-3beta-mediated phosphorylation of protein tau (about 4.3fold stimulation in the presence of 0.003 mM)
-
tubulin
Wortmannin
additional information
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0000025
1-(4-methoxyphenyl)-6-(5-[[3-(trifluoromethyl)benzyl]sulfanyl]-1,3,4-oxadiazol-2-yl)-1H-benzimidazole
Homo sapiens
-
in 25 mM HEPES, pH 7.5, 10 mM magnesium acetate, 1 mM dithiothreitol, and 0.01% bovine serum albumin
0.0000086
1-(4-methoxyphenyl)-6-(5-[[4-methoxy-3-(trifluoromethyl)benzyl]sulfanyl]-1,3,4-oxadiazol-2-yl)-1H-benzimidazole
Homo sapiens
-
in 25 mM HEPES, pH 7.5, 10 mM magnesium acetate, 1 mM dithiothreitol, and 0.01% bovine serum albumin
0.000125 - 0.000131
1-(cyclopropylmethyl)-3-[4-(5,6-difluoro-1-benzofuran-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-1H-indole-5-carbonitrile
0.00281
1-ethyl-3-(5-phenyl-1H-pyrazolo[3,4-b]pyridin-3-yl)urea
Homo sapiens
-
-
-
0.023
1-methyl-5-phenyl-1H-pyrazolo[3,4-b]pyridin-3-amine
Homo sapiens
-
-
0.0000094
1-methyl-6-(5-[[3-(trifluoromethyl)benzyl]sulfanyl]-1,3,4-oxadiazol-2-yl)-1H-benzimidazole
Homo sapiens
-
in 25 mM HEPES, pH 7.5, 10 mM magnesium acetate, 1 mM dithiothreitol, and 0.01% bovine serum albumin
0.000065
2-(1,3-benzodioxol-5-yl)-5-[(3-fluoro-4-methoxybenzyl)sulfanyl]-1,3,4-oxadiazole
Homo sapiens
-
in 25 mM HEPES, pH 7.5, 10 mM magnesium acetate, 1 mM dithiothreitol, and 0.01% bovine serum albumin
0.0000049
2-(1-benzofuran-5-yl)-5-[[4-methoxy-3-(trifluoromethyl)benzyl]sulfanyl]-1,3,4-oxadiazole
Homo sapiens
-
in 25 mM HEPES, pH 7.5, 10 mM magnesium acetate, 1 mM dithiothreitol, and 0.01% bovine serum albumin
0.000044
2-(2,3-dihydro-1-benzofuran-5-yl)-5-[(3-fluoro-4-methoxybenzyl)sulfanyl]-1,3,4-oxadiazole
Homo sapiens
-
in 25 mM HEPES, pH 7.5, 10 mM magnesium acetate, 1 mM dithiothreitol, and 0.01% bovine serum albumin
0.000054
2-(2,3-dihydro-1-benzofuran-5-yl)-5-[(3-fluorobenzyl)sulfanyl]-1,3,4-oxadiazole
Homo sapiens
-
in 25 mM HEPES, pH 7.5, 10 mM magnesium acetate, 1 mM dithiothreitol, and 0.01% bovine serum albumin
0.00022
2-(2,3-dihydro-1-benzofuran-5-yl)-5-[(4-methoxybenzyl)sulfanyl]-1,3,4-oxadiazole
Homo sapiens
-
in 25 mM HEPES, pH 7.5, 10 mM magnesium acetate, 1 mM dithiothreitol, and 0.01% bovine serum albumin
0.00034
2-(2,3-dihydro-1-benzofuran-5-yl)-5-[2-(3-fluorophenyl)ethyl]-1,3,4-oxadiazole
Homo sapiens
-
in 25 mM HEPES, pH 7.5, 10 mM magnesium acetate, 1 mM dithiothreitol, and 0.01% bovine serum albumin
0.00068
2-(2,3-dihydro-1-benzofuran-5-yl)-5-[[(3-fluorophenyl)sulfanyl]methyl]-1,3,4-oxadiazole
Homo sapiens
-
in 25 mM HEPES, pH 7.5, 10 mM magnesium acetate, 1 mM dithiothreitol, and 0.01% bovine serum albumin
0.000068
2-(2,3-dihydro-1-benzofuran-5-yl)-5-[[3-(trifluoromethyl)benzyl]sulfanyl]-1,3,4-oxadiazole
Homo sapiens
-
in 25 mM HEPES, pH 7.5, 10 mM magnesium acetate, 1 mM dithiothreitol, and 0.01% bovine serum albumin
0.0000057
2-(2,3-dihydro-1-benzofuran-5-yl)-5-[[4-methoxy-3-(trifluoromethyl)benzyl]sulfanyl]-1,3,4-oxadiazole
Homo sapiens
-
in 25 mM HEPES, pH 7.5, 10 mM magnesium acetate, 1 mM dithiothreitol, and 0.01% bovine serum albumin
0.000021
2-(3-ethylpiperazin-1-yl)-N-[6-(3-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]acetamide
Homo sapiens
-
-
-
0.00021
2-(benzylsulfanyl)-5-(2,3-dihydro-1-benzofuran-5-yl)-1,3,4-oxadiazole
Homo sapiens
-
in 25 mM HEPES, pH 7.5, 10 mM magnesium acetate, 1 mM dithiothreitol, and 0.01% bovine serum albumin
0.000143
2-chloro-5-[(2,5-dioxo-4-phenyl-2,5-dihydro-1H-pyrrol-3-yl)amino]benzoic acid
Homo sapiens
-
-
-
0.000074
2-chloro-5-[[4-(2-chlorophenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino]benzoic acid
Homo sapiens
-
-
-
0.000028
2-chloro-5-[[4-(2-nitrophenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino]benzoic acid
Homo sapiens
-
-
-
0.000076
2-chloro-5-[[4-(3-chlorophenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino]benzoic acid
Homo sapiens
-
-
-
0.000085
2-chloro-5-[[4-(3-methoxyphenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino]benzoic acid
Homo sapiens
-
-
-
0.000026
2-chloro-5-[[4-(3-nitrophenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino]benzoic acid
Homo sapiens
-
-
-
0.000109
2-chloro-5-[[4-(4-chlorophenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino]benzoic acid
Homo sapiens
-
-
-
0.000019
2-methyl-N-(5-phenyl-1H-pyrazolo[3,4-b]pyridin-3-yl)propanamide
Homo sapiens
-
-
-
0.000094
2-[(2-chlorobenzyl)sulfanyl]-5-(2,3-dihydro-1-benzofuran-5-yl)-1,3,4-oxadiazole
Homo sapiens
-
in 25 mM HEPES, pH 7.5, 10 mM magnesium acetate, 1 mM dithiothreitol, and 0.01% bovine serum albumin
0.000013
2-[(3-chloro-4-methoxybenzyl)sulfanyl]-5-(2,3-dihydro-1-benzofuran-5-yl)-1,3,4-oxadiazole
Homo sapiens
-
in 25 mM HEPES, pH 7.5, 10 mM magnesium acetate, 1 mM dithiothreitol, and 0.01% bovine serum albumin
0.0002
2-[(3-chlorobenzyl)sulfanyl]-5-(2,3-dihydro-1-benzofuran-5-yl)-1,3,4-oxadiazole
Homo sapiens
-
in 25 mM HEPES, pH 7.5, 10 mM magnesium acetate, 1 mM dithiothreitol, and 0.01% bovine serum albumin
0.00028
2-[(4-chlorobenzyl)sulfanyl]-5-(2,3-dihydro-1-benzofuran-5-yl)-1,3,4-oxadiazole
Homo sapiens
-
in 25 mM HEPES, pH 7.5, 10 mM magnesium acetate, 1 mM dithiothreitol, and 0.01% bovine serum albumin
0.000084
2-[3-(4-methoxyphenyl)-1-benzofuran-5-yl]-5-[[3-(trifluoromethyl)benzyl]sulfanyl]-1,3,4-oxadiazole
Homo sapiens
-
in 25 mM HEPES, pH 7.5, 10 mM magnesium acetate, 1 mM dithiothreitol, and 0.01% bovine serum albumin
0.000025
2-[3-(4-methoxyphenyl)-1-benzofuran-5-yl]-5-[[4-methoxy-3-(trifluoromethyl)benzyl]sulfanyl]-1,3,4-oxadiazole
Homo sapiens
-
in 25 mM HEPES, pH 7.5, 10 mM magnesium acetate, 1 mM dithiothreitol, and 0.01% bovine serum albumin
0.00026
3-(1-(2-(1H-imidazol-1-yl)ethyl)-1H-indol-3-yl)-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.07334
3-(1-(3-(1H-imidazol-1-yl)propyl)-1H-indol-3-yl)-1-phenyl-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.00066
3-(1-(3-(1H-imidazol-1-yl)propyl)-1H-indol-3-yl)-4-(1-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.00055
3-(1-(3-(1H-imidazol-1-yl)propyl)-1H-indol-3-yl)-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.01358
3-(1-(3-(dimethylamino)propyl)-1H-indol-3-yl)-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.01245
3-(1-(3-(piperidin-1-yl)propyl)-1H-indol-3-yl)-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.00114
3-(1-(3-hydroxypropyl)-1H-indol-3-yl)-4-(1-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.00179
3-(1-(3-morpholinopropyl)-1H-indol-3-yl)-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.00085
3-(1-(4-(1H-imidazol-1-yl)butyl)-1H-indol-3-yl)-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.000035
3-(1-benzofuran-3-yl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.00022
3-(1-benzofuran-3-yl)-4-(1-methyl-7-phenoxy-1H-indol-3-yl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.000007
3-(1-benzofuran-3-yl)-4-(5-bromo-1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.000235
3-(1-benzofuran-3-yl)-4-(5-cyclopropyl-1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.000026
3-(1-benzofuran-3-yl)-4-(5-fluoro-1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.00036
3-(1-benzofuran-3-yl)-4-(5-fluoro-1H-indol-3-yl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.00069
3-(1-benzofuran-3-yl)-4-(5-hydroxy-1H-indol-3-yl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.0000345
3-(1-benzofuran-3-yl)-4-(5-iodo-1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.000184
3-(1-benzofuran-3-yl)-4-(6-chloro-5-fluoro-1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.00044
3-(1-benzofuran-3-yl)-4-(6-chloro-5-methoxy-1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.000015
3-(1-benzofuran-3-yl)-4-(6-hydroxy-1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.000223
3-(1-benzofuran-3-yl)-4-(6-iodo-5-methoxy-1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.000055
3-(1-benzofuran-3-yl)-4-(7-hydroxy-1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.00022
3-(1-benzofuran-3-yl)-4-[1-(3-hydroxypropyl)-5-phenoxy-1H-indol-3-yl]-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.001304
3-(1-benzofuran-3-yl)-4-[1-methyl-5-(morpholin-4-yl)-1H-indol-3-yl]-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.00165
3-(1-benzofuran-3-yl)-4-[5-(benzyloxy)-1H-indol-3-yl]-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.0000016
3-(1-benzofuran-3-yl)-4-[5-bromo-1-(3-hydroxypropyl)-1H-indol-3-yl]-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.0009
3-(1-benzofuran-3-yl)-4-[6-(benzyloxy)-1-methyl-1H-indol-3-yl]-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.0000054
3-(1-benzofuran-3-yl)-4-[7-(hydroxymethyl)-1-methyl-1H-indol-3-yl]-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.00000012
3-(1-benzofuran-3-yl)-4-[7-(methoxymethyl)-1-methyl-1H-indol-3-yl]-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.0009
3-(1-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)-4-(1-(2-morpholinoethyl)-1H-indol-3-yl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.00076
3-(1-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)-4-(1-(3-morpholinopropyl)-1H-indol-3-yl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.0306
3-(1H-indol-3-yl)-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.000187
3-(2,3-dihydro-1H-indol-1-yl)-4-(2-methoxyphenyl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.000131
3-(2,3-dihydro-1H-indol-1-yl)-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.000161
3-(2,3-dihydro-1H-indol-1-yl)-4-(3-nitrophenyl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.000694
3-(2,3-dihydro-1H-indol-1-yl)-4-(4-methoxyphenyl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.000337
3-(2-chlorophenyl)-4-(2,3-dihydro-1H-indol-1-yl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.000216
3-(2-chlorophenyl)-4-(phenylamino)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.000093
3-(2-chlorophenyl)-4-[(3,5-dichloro-4-hydroxyphenyl)amino]-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.000195
3-(2-chlorophenyl)-4-[(3-chlorophenyl)amino]-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.000374
3-(2-chlorophenyl)-4-[(3-hydroxyphenyl)amino]-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.000161
3-(2-chlorophenyl)-4-[[4-(methylsulfanyl)phenyl]amino]-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.000216
3-(2-methoxyphenyl)-4-(phenylamino)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.00011
3-(2-methoxyphenyl)-4-[[4-(methylsulfanyl)phenyl]amino]-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.00046
3-(3-chlorophenyl)-4-(2,3-dihydro-1H-indol-1-yl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.000058
3-(3-chlorophenyl)-4-[(3,5-dichloro-4-hydroxyphenyl)amino]-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.001478
3-(3-chlorophenyl)-4-[(3-hydroxyphenyl)amino]-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.000532
3-(3-chlorophenyl)-4-[[4-(methylsulfanyl)phenyl]amino]-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.000203
3-(3-methoxyphenyl)-4-[[4-(methylsulfanyl)phenyl]amino]-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.000141
3-(3-nitrophenyl)-4-(phenylamino)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.001412
3-(4-chlorophenyl)-4-(2,3-dihydro-1H-indol-1-yl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.000514
3-(4-chlorophenyl)-4-(phenylamino)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.000091
3-(4-chlorophenyl)-4-[(3,5-dichloro-4-hydroxyphenyl)amino]-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.000447
3-(4-chlorophenyl)-4-[(3-chlorophenyl)amino]-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.000407
3-(4-chlorophenyl)-4-[(3-hydroxyphenyl)amino]-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.000317
3-(4-chlorophenyl)-4-[(4-hydroxyphenyl)amino]-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.002285
3-(4-chlorophenyl)-4-[methyl(phenyl)amino]-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.000529
3-(4-chlorophenyl)-4-[[4-(methylsulfanyl)phenyl]amino]-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.00039
3-(4-methoxyphenyl)-4-(phenylamino)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.000243
3-(4-methoxyphenyl)-4-[[4-(methylsulfanyl)phenyl]amino]-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.000314
3-(5,6-difluoro-1-benzofuran-3-yl)-4-(1-methyl-1H-benzo[g]indol-3-yl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.0000887
3-(5,7-dibromo-1-methyl-1H-indol-3-yl)-4-(7-methoxy-1-benzofuran-3-yl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.00014
3-(5-bromo-1-(3-(1H-imidazol-1-yl)propyl)-1H-indol-3-yl)-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.00055
3-(5-bromo-1-benzofuran-3-yl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.0000075
3-(5-bromo-1-methyl-1H-indol-3-yl)-4-(7-methoxy-1-benzofuran-3-yl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.000335
3-(5-bromo-1-methyl-1H-indol-3-yl)-4-[6-(4-methoxyphenoxy)-1-benzofuran-3-yl]-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.00000051
3-(5-bromo-1-methyl-1H-indol-3-yl)-4-[6-(hydroxymethyl)-1-benzofuran-3-yl]-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.0000483
3-(5-bromo-1-methyl-1H-indol-3-yl)-4-[6-(prop-2-en-1-yloxy)-1-benzofuran-3-yl]-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.0000253
3-(5-bromo-1-methyl-1H-indol-3-yl)-4-[6-(prop-2-yn-1-yloxy)-1-benzofuran-3-yl]-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.000042
3-(5-chloro-1-methyl-1H-indol-3-yl)-4-(5-fluoro-1-benzofuran-3-yl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.00067
3-(5-fluoro-1-benzofuran-3-yl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.00018
3-(5-fluoro-1-benzofuran-3-yl)-4-(5-iodo-1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.000014
3-(5-fluoro-1-benzofuran-3-yl)-4-(6-hydroxy-1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.0000035
3-(5-fluoro-1-methyl-1H-indol-3-yl)-4-(6-hydroxy-1-benzofuran-3-yl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.00000035
3-(5-fluoro-1-methyl-1H-indol-3-yl)-4-[6-(hydroxymethyl)-1-benzofuran-3-yl]-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.0000238
3-(5-fluoro-1-methyl-1H-indol-3-yl)-4-[6-(methoxymethyl)-1-benzofuran-3-yl]-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.000247
3-(5-fluoro-6-iodo-1-methyl-1H-indol-3-yl)-4-(7-methoxy-1-benzofuran-3-yl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.00048
3-(5-methoxy-1-(3-(1H-imidazol-1-yl)propyl)-1H-indol-3-yl)-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.02246
3-(5-methoxy-1-(3-(dimethylamino)propyl)-1H-indol-3-yl)-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.000708
3-(5H-[1,3]dioxolo[4,5-f]indol-7-yl)-4-(5-fluoro-1-benzofuran-3-yl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.00095
3-(6-bromo-1-(3-(1H-imidazol-1-yl)propyl)-1H-indol-3-yl)-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.00226
3-(6-bromo-1-(3-(dimethylamino)propyl)-1H-indol-3-yl)-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.000866
3-(6-chloro-5-fluoro-1-methyl-1H-indol-3-yl)-4-(6-methoxy-1-benzofuran-3-yl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.000114
3-(6-chloro-5-fluoro-1-methyl-1H-indol-3-yl)-4-(7-methoxy-1-benzofuran-3-yl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.004092
3-(6-chloro-5-fluoro-1-methyl-1H-indol-3-yl)-4-[6-(cyclobutylmethoxy)-1-benzofuran-3-yl]-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.00104
3-(6-chloro-5-fluoro-1-methyl-1H-indol-3-yl)-4-[6-(cyclopropylmethoxy)-1-benzofuran-3-yl]-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.00000095
3-(6-chloro-5-fluoro-1-methyl-1H-indol-3-yl)-4-[6-(hydroxymethyl)-1-benzofuran-3-yl]-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.00031
3-(6-fluoro-1-(3-(1H-imidazol-1-yl)propyl)-1H-indol-3-yl)-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.01244
3-(6-fluoro-1-(3-(dimethylamino)propyl)-1H-indol-3-yl)-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.00018
3-(7-methoxy-1-benzofuran-3-yl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.000831
3-(7-methoxy-1-benzofuran-3-yl)-4-[1-methyl-6-(trifluoromethyl)-1H-indol-3-yl]-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.000091
3-([[5-(2,3-dihydro-1-benzofuran-5-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]methyl)benzo-nitrile
Homo sapiens
-
in 25 mM HEPES, pH 7.5, 10 mM magnesium acetate, 1 mM dithiothreitol, and 0.01% bovine serum albumin
0.000014
3-benzyl-N-[5-bromo-6-(furan-2-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrrolidine-1-carboxamide
Homo sapiens
-
-
-
0.00059
3-phenyl-4-(phenylamino)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.000291
3-[(2,5-dioxo-4-phenyl-2,5-dihydro-1H-pyrrol-3-yl)amino]benzoic acid
Homo sapiens
-
-
-
0.000082
3-[(3,5-dichloro-4-hydroxyphenyl)amino]-4-(2-methoxyphenyl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.000052
3-[(3,5-dichloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.000142
3-[(3,5-dichloro-4-hydroxyphenyl)amino]-4-(3-methoxyphenyl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.00002
3-[(3,5-dichloro-4-hydroxyphenyl)amino]-4-(3-nitrophenyl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.000083
3-[(3,5-dichloro-4-hydroxyphenyl)amino]-4-(4-methoxyphenyl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.000071
3-[(3,5-dichloro-4-hydroxyphenyl)amino]-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.000149
3-[(3,5-dichloro-4-hydroxyphenyl)amino]-4-phenyl-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.000152
3-[(3-chloro-4-hydroxyphenyl)amino]-4-(2-chlorophenyl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.000139
3-[(3-chloro-4-hydroxyphenyl)amino]-4-(2-methoxyphenyl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.000104
3-[(3-chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.000094
3-[(3-chloro-4-hydroxyphenyl)amino]-4-(3-chlorophenyl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.000059
3-[(3-chloro-4-hydroxyphenyl)amino]-4-(3-nitrophenyl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.000173
3-[(3-chloro-4-hydroxyphenyl)amino]-4-(4-chlorophenyl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.000114
3-[(3-chlorophenyl)amino]-4-(2-methoxyphenyl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.000104
3-[(3-chlorophenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.000257
3-[(3-chlorophenyl)amino]-4-(3-methoxyphenyl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.00007
3-[(3-chlorophenyl)amino]-4-(3-nitrophenyl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.000156
3-[(3-chlorophenyl)amino]-4-(4-methoxyphenyl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.000301
3-[(3-chlorophenyl)amino]-4-phenyl-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.000259
3-[(3-hydroxyphenyl)amino]-4-(2-methoxyphenyl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.000251
3-[(3-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.000472
3-[(3-hydroxyphenyl)amino]-4-(3-methoxyphenyl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.000236
3-[(3-hydroxyphenyl)amino]-4-(3-nitrophenyl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.000481
3-[(3-hydroxyphenyl)amino]-4-(4-methoxyphenyl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.000704
3-[(3-hydroxyphenyl)amino]-4-phenyl-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.000123
3-[(4-hydroxyphenyl)amino]-4-(3-nitrophenyl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.0000023
3-[([5-[1-(4-methoxyphenyl)-1H-benzimidazol-6-yl]-1,3,4-oxadiazol-2-yl]sulfanyl)methyl]benzonitrile
Homo sapiens
-
in 25 mM HEPES, pH 7.5, 10 mM magnesium acetate, 1 mM dithiothreitol, and 0.01% bovine serum albumin
0.0000035
3-[([5-[3-(4-methoxyphenyl)-1-benzofuran-5-yl]-1,3,4-oxadiazol-2-yl]sulfanyl)methyl]benzonitrile
Homo sapiens
-
in 25 mM HEPES, pH 7.5, 10 mM magnesium acetate, 1 mM dithiothreitol, and 0.01% bovine serum albumin
0.0000132
3-[4-(6-ethyl-1-benzofuran-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-1-methyl-1H-indole-5-carbonitrile
Homo sapiens
-
-
0.0000226
3-[5-(cyclopropylethynyl)-1-methyl-1H-indol-3-yl]-4-(5-fluoro-1-benzofuran-3-yl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.007
3-[6-(4-chlorophenyl)-5-fluoro-1-methyl-1H-indol-3-yl]-4-(7-methoxy-1-benzofuran-3-yl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.00016
3-[6-(benzyloxy)-1-methyl-1H-indol-3-yl]-4-(5-fluoro-1-benzofuran-3-yl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.0000051
3-[6-(hydroxymethyl)-1-benzofuran-3-yl]-4-[7-(hydroxymethyl)-1-methyl-1H-indol-3-yl]-1H-pyrrole-2,5-dione
Homo sapiens
-
-
0.001398
3-[methyl(phenyl)amino]-4-(3-nitrophenyl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.002613
3-[methyl(phenyl)amino]-4-phenyl-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.000136
3-[[4-(2-chlorophenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino]benzoic acid
Homo sapiens
-
-
-
0.000134
3-[[4-(3-chlorophenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino]benzoic acid
Homo sapiens
-
-
-
0.000195
3-[[4-(3-methoxyphenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino]benzoic acid
Homo sapiens
-
-
-
0.000079
3-[[4-(3-nitrophenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino]benzoic acid
Homo sapiens
-
-
-
0.000186
3-[[4-(4-chlorophenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino]benzoic acid
Homo sapiens
-
-
-
0.000214
3-[[4-(4-methoxyphenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino]benzoic acid
Homo sapiens
-
-
-
0.000152
3-[[4-(methylsulfanyl)phenyl]amino]-4-(3-nitrophenyl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.000392
3-[[4-(methylsulfanyl)phenyl]amino]-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.000404
3-[[4-(methylsulfanyl)phenyl]amino]-4-phenyl-1H-pyrrole-2,5-dione
Homo sapiens
-
-
-
0.00025
4,5-diphenyl-1H-pyrazolo[3,4-c]pyridazin-3-amine
Homo sapiens
-
-
0.023
4-phenyl-1H-pyrazolo[3,4-b]pyridin-3-amine
Homo sapiens
-
-
0.00033
5-(2,3-dihydro-1-benzofuran-5-yl)-N-(3-fluorobenzyl)-1,3,4-oxadiazol-2-amine
Homo sapiens
-
in 25 mM HEPES, pH 7.5, 10 mM magnesium acetate, 1 mM dithiothreitol, and 0.01% bovine serum albumin
0.000016
5-(5-[[4-methoxy-3-(trifluoromethyl)benzyl]sulfanyl]-1,3,4-oxadiazol-2-yl)-1H-indazole
Homo sapiens
-
in 25 mM HEPES, pH 7.5, 10 mM magnesium acetate, 1 mM dithiothreitol, and 0.01% bovine serum albumin
0.000028
5-([ [5-(2,3-dihydro-1-benzofuran-5-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]methyl)-2-methoxybenzonitrile
Homo sapiens
-
in 25 mM HEPES, pH 7.5, 10 mM magnesium acetate, 1 mM dithiothreitol, and 0.01% bovine serum albumin
0.00043
5-phenyl-1H-pyrazolo[3,4-b]pyridin-3-amine
Homo sapiens
-
-
0.00053
5-phenyl-1H-pyrazolo[3,4-c]pyridazin-3-amine
Homo sapiens
-
-
0.00126
5-phenyl-1H-pyrazolo[3,4-c]pyridin-3-amine
Homo sapiens
-
-
0.023
5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-amine
0.0000031
6-(5-[[4-methoxy-3-(trifluoromethyl)benzyl]sulfanyl]-1,3,4-oxadiazol-2-yl)-1,3-benzothiazole
Homo sapiens
-
in 25 mM HEPES, pH 7.5, 10 mM magnesium acetate, 1 mM dithiothreitol, and 0.01% bovine serum albumin
0.0000065
6-(5-[[4-methoxy-3-(trifluoromethyl)benzyl]sulfanyl]-1,3,4-oxadiazol-2-yl)imidazo[1,2-a]pyridine
Homo sapiens
-
in 25 mM HEPES, pH 7.5, 10 mM magnesium acetate, 1 mM dithiothreitol, and 0.01% bovine serum albumin
0.000018
6-(5-[[4-methoxy-3-(trifluoromethyl)benzyl]sulfanyl]-1,3,4-oxadiazol-2-yl)quinoline
Homo sapiens
-
in 25 mM HEPES, pH 7.5, 10 mM magnesium acetate, 1 mM dithiothreitol, and 0.01% bovine serum albumin
0.0125
carteriosulfonic acid A
Oryctolagus cuniculus
-
at 37°C
0.0068
carteriosulfonic acid B
0.000548
KRM-189
Homo sapiens
-
-
0.000467
KRM-191
Homo sapiens
-
-
0.001012
KRM-192
Homo sapiens