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Literature summary for 2.7.11.26 extracted from

  • Lau, K.F.; Miller, C.C.; Anderton, B.H.; Shaw, P.C.
    Molecular cloning and characterization of the human glycogen synthase kinase-3beta promoter (1999), Genomics, 60, 121-128.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens enzyme forms part of the wingless signalling pathway. GSK-3beta activity is negatively regulated by phosphorylation on serine 9 and positively regulated by phosphorylation on tyrosine 216. Enzyme may also be regulated at the transcriptional level ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens P49841
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glycogen synthase + ATP proline-directed kinase Homo sapiens phosphorylated glycogen synthase + ADP
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?
additional information enzyme forms part of the wingless signalling pathway. GSK-3beta activity is negatively regulated by phosphorylation on serine 9 and positively regulated by phosphorylation on tyrosine 216. Enzyme may also be regulated at the transcriptional level Homo sapiens ?
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?
protein tau + ATP the microtubule-associated protein tau is the principal component of the paired helical filaments - PHFs - found in the brains of patients with Alzheimer disease, and PHF-tau is hyperphosphorylated Homo sapiens phosphorylated protein tau + ADP
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?

Synonyms

Synonyms Comment Organism
glycogen synthase kinase 3beta
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Homo sapiens
GSK-3beta
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Homo sapiens