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Literature summary for 2.7.11.26 extracted from

  • LaPointe, N.E.; Morfini, G.; Pigino, G.; Gaisina, I.N.; Kozikowski, A.P.; Binder, L.I.; Brady, S.T.
    The amino terminus of tau inhibits kinesin-dependent axonal transport: implications for filament toxicity (2009), J. Neurosci. Res., 87, 440-451.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + protein tau Homo sapiens
-
 ADP + protein tau phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + KRREILSRRPpSYR KRREILSRRPpSYR is selectively phosphorylated by GSK-3 and therefore acts as a competitive inhibitor of other GSK-3 substrates Homo sapiens ADP + ?
-
 ?
ATP + protein tau
-
 Homo sapiens ADP + protein tau phosphate
-
 ?

Synonyms

Synonyms Comment Organism
glycogen synthase kinase-3
-
 Homo sapiens
GSK-3beta isoform Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function GSK-3 activity is required for tau filaments to inhibit kinesin-dependent FAT Homo sapiens