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Literature summary for 2.7.11.26 extracted from

  • Song, J.S.; Yang, S.D.
    tau Protein kinase I/GSK-3b/kinase FA in heparin phosphorylates Tau on Ser199, Thr231, Ser235, Ser262, Ser369, and Ser400 sites phosphorylated in Alzheimer disease brain (1995), J. Protein Chem., 14, 95-105.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
heparin
-
 Homo sapiens

Application

Application Comment Organism
medicine brain pathology in investigation of Alzheimers's disease, human tau phosphorylated by the kinase carries an epitope of the paired helical filaments that accumulate in the brain Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
45000
-
 SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + protein tau Homo sapiens
-
 ADP + protein tau phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 human
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + protein tau
-
 Homo sapiens ADP + protein tau phosphate
-
 ?
ATP + protein tau enzyme can also phosphorylate bovine tau Homo sapiens ADP + protein tau phosphate
-
 ?

Synonyms

Synonyms Comment Organism
tau protein kinase I/GSK-3beta/kinaseFA
-
 Homo sapiens
TPKI/GSK-3beta/FA
-
 Homo sapiens