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Literature summary for 2.7.11.26 extracted from

  • Xu, J.; Sato, S.; Okuyama, S.; Swan, R.J.; Jacobsen, M.T.; Strunk, E.; Ikezu, T.
    Tau-tubulin kinase 1 enhances prefibrillar tau aggregation and motor neuron degeneration in P301L FTDP-17 tau-mutant mice (2010), FASEB J., 24, 2904-2915.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information generation of bigenic mice co-overexpressing full-length TTBK1 and the P301L tau mutant Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [tau-protein] Homo sapiens
-
ADP + O-phospho-[tau-protein]
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q5TCY1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [tau-protein]
-
Homo sapiens ADP + O-phospho-[tau-protein]
-
?

Synonyms

Synonyms Comment Organism
Tau-tubulin kinase 1
-
Homo sapiens
TTBK1
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens

General Information

General Information Comment Organism
malfunction tau-tubulin kinase 1 enhances prefibrillar tau aggregation, forming small oligomers, and motor neuron degeneration in P301L FTDP-17 tau-mutant mice. TTBK1 up-regulation enhances tau phosphorylation and oligomerization, whose toxicity results in enhanced neurodegeneration and locomotor dysfunction in a tauopathy animal model, overview. The bigenic mice show enhanced tau phosphorylation at multiple sites, i.e. AT8, 12E8, PHF-1, and pS422, and they show significant locomotor dysfunction as determined by both rotorod and grip strength tests, as well as enhanced loss of motor neurons in the L4-L5 spinal cord. The neuronal dysfunction and degeneration is associated with increased levels of tau oligomers, cyclin-dependent protein kinase 5 activators p35 and p25, and pY216 phosphorylated glycogen synthase kinase 3-beta Homo sapiens