Reference on EC 2.1.1.67 - thiopurine S-methyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Remy, C.N.
Metabolism of thiopyrimidines and thiopurines
J. Biol. Chem.
238
1078-1084
1963
Mus musculus, Rattus norvegicus, Mus musculus Swiss-Webster
Woodson, L.C.; Weinshilboum, R.M.
Human kidney thiopurine methyltransferase. Purification and biochemical properties
Biochem. Pharmacol.
32
819-826
1983
Homo sapiens
Loo, G.; Smith, J.T.
Glutathione: an endogenous substrate for thiopurine methyltransferase?
Biochem. Biophys. Res. Commun.
126
1201-1207
1985
Rattus norvegicus
Ames, M.M.; Selassie, C.D.; Woodson, L.C.; Van Loon, J.A.; Hansch, C.; Weinshilboum, R.M.
Thiopurine methyltransferase: structure-activity relationships for benzoic acid inhibitors and thiophenol substrates
J. Med. Chem.
29
354-358
1986
Homo sapiens
Van Loon, J.A.; Weinshilboum, R.M.
Thiopurine methyltransferase isozymes in human renal tissue
Drug Metab. Dispos.
18
632-638
1990
Homo sapiens, Mus musculus
Szumlanski, C.L.; Honchel, R.; Scott, M.C.; Weinshilboum, R.M.
Human liver thiopurine methyltransferase pharmacogenetics: biochemical properties, liver-erythrocyte correlation and presence of isozymes
Pharmacogenetics
2
148-159
1992
Homo sapiens, Mus musculus
Deininger, M.; Szumlanski, C.L.; Otterness, D.M.; Van Loon, J.; Ferber, W.; Weinshilboum, R.M.
Purine substrates for human thiopurine methyltransferase
Biochem. Pharmacol.
48
2135-2138
1994
Homo sapiens
Krynetski, E.Y.; Krynetskaia, N.F.; Yanishevski, Y.; Evans, W.E.
Methylation of mercaptopurine, thioguanine, and their nucleotide metabolites by heterologously expressed human thiopurine S-methyltransferase
Mol. Pharmacol.
47
1141-1147
1995
Homo sapiens
Krynetski, E.Y.; Schuetz, J.D.; Galpin, A.J.; Pui, C.H.; Relling, M.V.; Evans, W.E.
A single point mutation leading to loss of catalytic activity in human thiopurine S-methyltransferase
Proc. Natl. Acad. Sci. USA
92
949-953
1995
BRENDA: Homo sapiens
Textmining: Saccharomyces cerevisiae
Lysaa, R.A.; Giverhaug, T.; Wold, H.L.; Aarbakke, J.
Inhibition of human thiopurine methyltransferase by furosemide, bendroflumethiazide and trichlormethiazide
Eur. J. Clin. Pharmacol.
49
393-396
1996
Homo sapiens
Stupans, I.; Kirlich, A.; McKinnon, R.A.
Human thiopurine methyltransferase: no evidence of activation by its substrates
Life Sci.
62
343-350
1997
Homo sapiens
Fessing, M.Y.; Belkov, V.M.; Krynetski, E.Y.; Evans, W.E.
Molecular cloning and functional characterization of the cDNA encoding the murine thiopurine S-methyltransferase (TPMT)
FEBS Lett.
424
143-145
1998
BRENDA: Homo sapiens, Mus musculus (O55060), Mus musculus
Textmining: Triticum aestivum, Oryctolagus cuniculus
Kroeplin, T.; Iven, H.
Methylation of 6-mercaptopurine and 6-thioguanine by thiopurine S-methyltransferase. A comparison of activity in red blood cell samples of 199 blood donors
Eur. J. Clin. Pharmacol.
56
343-345
2000
Homo sapiens
Dervieux, T.; Blanco, J.G.; Krynetski, E.Y.; Vanin, E.F.; Roussel, M.F.; Relling, M.V.
Differing contribution of thiopurine methyltransferase to mercaptopurine versus thioguanine effects in human leukemic cells
Cancer Res.
61
5810-5816
2001
Homo sapiens, Mus musculus
Weinshilboum, R.
Thiopurine pharmacogenetics: Clinical and molecular studies of thiopurine methyltransferase
Drug Metab. Dispos.
29
601-605
2001
Homo sapiens
Warner, D.R.; Mozier, N.M.; Pearson, J.D.; Hoffman, J.L.
Cloning and base sequence analysis of a cDNA encoding mouse lung thioether S-methyltransferase
Biochim. Biophys. Acta
1246
160-166
1995
Mus musculus, Mus musculus (P40936)
Keizer-Garritsen, J.J.; Brouwer, C.; Lambooy, L.H.; Ter Riet, P.; Bokkerink, J.P.; Trijbels, F.J.; De Abreu, R.A.
Measurement of thiopurine S-methyltransferase activity in human blood samples based on high-performance liquid chromatography: reference values in erythrocytes from children
Ann. Clin. Biochem.
40
86-93
2003
Homo sapiens
Hamdan-Khalil, R.; Allorge, D.; Lo-Guidice, J.M.; Cauffiez, C.; Chevalier, D.; Spire, C.; Houdret, N.; Libersa, C.; Lhermitte, M.; Colombel, J.F.; Gala, J.L.; Broly, F.
In vitro characterization of four novel non-functional variants of the thiopurine S-methyltransferase
Biochem. Biophys. Res. Commun.
309
1005-1010
2003
BRENDA: Homo sapiens
Textmining: Saccharomyces cerevisiae
Hamdan-Khalil, R.; Gala, J.L.; Allorge, D.; Lo-Guidice, J.M.; Horsmans, Y.; Houdret, N.; Broly, F.
Identification and functional analysis of two rare allelic variants of the thiopurine S-methyltransferase gene, TPMT*16 and TPMT*19
Biochem. Pharmacol.
69
525-529
2005
BRENDA: Homo sapiens (P51580), Homo sapiens
Textmining: Saccharomyces cerevisiae
Brouwer, C.; de Abreu, R.A.; Keizer-Garritsen, J.J.; Lambooy, L.H.; Ament, K.; ter Riet, P.G.; van Wering, E.R.; Trijbels, F.J.; Veerman, A.J.; Hoogerbrugge, P.M.; Bokkerink, J.P.
Thiopurine methyltransferase in acute lymphoblastic leukaemia: biochemical and molecular biological aspects
Eur. J. Cancer
41
613-623
2005
Homo sapiens
Xin, H.W.; Fischer, C.; Schwab, M.; Klotz, U.
Thiopurine S-methyltransferase as a target for drug interactions
Eur. J. Clin. Pharmacol.
61
395-398
2005
Homo sapiens
Ford, L.T.; Berg, J.D.
Determination of thiopurine S-methyltransferase activity in erythrocytes using 6-thioguanine as substrate and a non-extraction liquid chromatographic technique
J. Chromatogr. B
798
111-115
2003
Homo sapiens
Winter, J.W.; Gaffney, D.; Shapiro, D.; Spooner, R.J.; Marinaki, A.M.; Sanderson, J.D.; Mills, P.R.
Assessment of thiopurine methyltransferase enzyme activity is superior to genotype in predicting myelosuppression following azathioprine therapy in patients with inflammatory bowel disease
Aliment. Pharmacol. Ther.
25
1069-1077
2007
Homo sapiens
Winter, J.W.; Marinaki, A.M.; Sanderson, J.D.; Mills, P.R.
TPMT genotype and the response to azathioprine in inflammatory bowel disease: authors reply to comments
Aliment. Pharmacol. Ther.
26
1084-1085
2007
Homo sapiens
Palmieri, O.; Latiano, A.; Bossa, F.; Vecchi, M.; DInca, R.; Guagnozzi, D.; Tonelli, F.; Cucchiara, S.; Valvano, M.R.; Latiano, T.; Andriulli, A.; Annese, V.
Sequential evaluation of thiopurine methyltransferase, inosine triphosphate pyrophosphatase, and HPRT1 genes polymorphisms to explain thiopurines toxicity and efficacy
Aliment. Pharmacol. Ther.
26
737-745
2007
Homo sapiens
Roblin, X.; Biroulet, L.P.; Phelip, J.M.; Nancey, S.; Flourie, B.
A 6-Thioguanine Nucleotide Threshold Level of 400 pmol/8 x 10(8) Erythrocytes Predicts Azathioprine Refractoriness in Patients With Inflammatory Bowel Disease and Normal TPMT Activity
Am. J. Gastroenterol.
102
1-8
2007
Homo sapiens
Tumer, T.B.; Ulusoy, G.; Adali, O.; Sahin, G.; Gozdasoglu, S.; Arinc, E.
The low frequency of defective TPMT alleles in Turkish population: a study on pediatric patients with acute lymphoblastic leukemia
Am. J. Hematol.
82
906-910
2007
Homo sapiens
Yenson, P.R.; Forrest, D.; Schmiegelow, K.; Dalal, B.I.
Azathioprine-associated acute myeloid leukemia in a patient with Crohns disease and thiopurine S-methyltransferase deficiency
Am. J. Hematol.
83
80-83
2008
Homo sapiens
Litos, I.K.; Emmanouilidou, E.; Glynou, K.M.; Laios, E.; Ioannou, P.C.; Christopoulos, T.K.; Kampa, M.; Castanas, E.; Gravanis, A.
Rapid genotyping of CYP2D6, CYP2C19 and TPMT polymorphisms by primer extension reaction in a dipstick format
Anal. Bioanal. Chem.
389
1849-1857
2007
Homo sapiens (P51580)
Firooz, A.; Ghandi, N.; Hallaji, Z.; Chams-Davatchi, C.; Valikhani, M.; Karbakhsh Davari, M.
Role of thiopurine methyltransferase activity in the safety and efficacy of azathioprine in the treatment of pemphigus vulgaris
Arch. Dermatol.
144
1143-1147
2008
BRENDA: Homo sapiens
Textmining: Pemphigus
Hogarth, L.A.; Redfern, C.P.; Teodoridis, J.M.; Hall, A.G.; Anderson, H.; Case, M.C.; Coulthard, S.A.
The effect of thiopurine drugs on DNA methylation in relation to TPMT expression
Biochem. Pharmacol.
76
1024-1035
2008
Homo sapiens
Garat, A.; Cauffiez, C.; Renault, N.; Lo-Guidice, J.M.; Allorge, D.; Chevalier, D.; Houdret, N.; Chavatte, P.; Loriot, M.A.; Gala, J.L.; Broly, F.
Characterisation of novel defective thiopurine S-methyltransferase allelic variants
Biochem. Pharmacol.
76
404-415
2008
BRENDA: Homo sapiens (P51580), Homo sapiens
Textmining: Saccharomyces cerevisiae
Peng, Y.; Feng, Q.; Wilk, D.; Adjei, A.A.; Salavaggione, O.E.; Weinshilboum, R.M.; Yee, V.C.
Structural basis of substrate recognition in thiopurine s-methyltransferase
Biochemistry
47
6216-6225
2008
Mus musculus (O55060), Mus musculus, Homo sapiens (P51580), Homo sapiens
Haglund, S.; Taipalensuu, J.; Peterson, C.; Almer, S.
IMPDH activity in thiopurine-treated patients with inflammatory bowel disease - relation to TPMT activity and metabolite concentrations
Br. J. Clin. Pharmacol.
65
69-77
2008
Homo sapiens
Hartford, C.; Vasquez, E.; Schwab, M.; Edick, M.J.; Rehg, J.E.; Grosveld, G.; Pui, C.H.; Evans, W.E.; Relling, M.V.
Differential effects of targeted disruption of thiopurine methyltransferase on mercaptopurine and thioguanine pharmacodynamics
Cancer Res.
67
4965-4972
2007
BRENDA: Mus musculus
Textmining: Homo sapiens, Mus sp.
Tamm, R.; Oselin, K.; Kallassalu, K.; Magi, R.; Anier, K.; Remm, M.; Metspalu, A.
Thiopurine S-methyltransferase (TPMT) pharmacogenetics: three new mutations and haplotype analysis in the Estonian population
Clin. Chem. Lab. Med.
46
974-979
2008
Homo sapiens
Zhang, L.; Song, D.; Zhang, W.; Zhao, J.; Jia, L.; Xing, D.
Efficient screening method of the thiopurine methyltransferase polymorphisms for patients considering taking thiopurine drugs in a Chinese Han population in Henan Province (central China)
Clin. Chim. Acta
376
45-51
2007
BRENDA: Homo sapiens
Textmining: Dialysis
Lee, S.S.; Kim, W.Y.; Jang, Y.J.; Shin, J.G.
Duplex pyrosequencing of the TPMT3C and TPMT6 alleles in Korean and Vietnamese populations
Clin. Chim. Acta
398
82-85
2008
Homo sapiens
Gardiner, S.J.; Gearry, R.B.; Begg, E.J.; Zhang, M.; Barclay, M.L.
Thiopurine dose in intermediate and normal metabolizers of thiopurine methyltransferase may differ three-fold
Clin. Gastroenterol. Hepatol.
6; 654-60
quiz 604
2008
Homo sapiens
Jones, T.S.; Yang, W.; Evans, W.E.; Relling, M.V.
Using HapMap tools in pharmacogenomic discovery: the thiopurine methyltransferase polymorphism
Clin. Pharmacol. Ther.
81
729-734
2007
Homo sapiens
Zhou, S.; Chowbay, B.
Clinical significance of thiopurine S-methyltransferase gene polymorphisms
Curr. Pharmacogenomics
5
103-115
2007
Mammalia
-
Gisbert, J.P.; Gomollon, F.; Cara, C.; Luna, M.; Gonzalez-Lama, Y.; Pajares, J.M.; Mate, J.; Guijarro, L.G.
Thiopurine methyltransferase activity in Spain: a study of 14,545 patients
Dig. Dis. Sci.
52
1262-1269
2007
BRENDA: Homo sapiens
Textmining: Pemphigus, Areas
Kwan, L.Y.; Devlin, S.M.; Mirocha, J.M.; Papadakis, K.A.
Thiopurine methyltransferase activity combined with 6-thioguanine metabolite levels predicts clinical response to thiopurines in patients with inflammatory bowel disease
Dig. Liver Dis.
40
425-432
2008
Homo sapiens
Oselin, K.; Anier, K.
Inhibition of human thiopurine S-methyltransferase by various nonsteroidal anti-inflammatory drugs in vitro: a mechanism for possible drug interactions
Drug Metab. Dispos.
35
1452-1454
2007
Homo sapiens
Oliveira, E.; Quental, S.; Alves, S.; Amorim, A.; Prata, M.J.
Do the distribution patterns of polymorphisms at the thiopurine S-methyltransferase locus in sub-Saharan populations need revision? Hints from Cabinda and Mozambique
Eur. J. Clin. Pharmacol.
63
703-706
2007
Homo sapiens
Kham, S.K.; Soh, C.K.; Liu, T.C.; Chan, Y.H.; Ariffin, H.; Tan, P.L.; Yeoh, A.E.
Thiopurine S-methyltransferase activity in three major Asian populations: a population-based study in Singapore
Eur. J. Clin. Pharmacol.
64
373-379
2008
Homo sapiens
Bezier, M.; Reguiai, Z.; Vitry, F.; Broly, F.; Bernard, P.
Thiopurine S-methyltransferase genotypic analysis in autoimmune bullous diseases
Eur. J. Dermatol.
18
512-517
2008
Homo sapiens
Perri, D.; Cole, D.E.; Friedman, O.; Piliotis, E.; Mintz, S.; Adhikari, N.K.
Azathioprine and diffuse alveolar haemorrhage: the pharmacogenetics of thiopurine methyltransferase
Eur. Respir. J.
30
1014-1017
2007
Homo sapiens
Richard, V.S.; Al-Ismail, D.; Salamat, A.
Should we test TPMT enzyme levels before starting azathioprine?
Hematology
12
359-360
2007
Homo sapiens
Compagni, A.; Bartoli, S.; Buehrlen, B.; Fattore, G.; Ibarreta, D.; de Mesa, E.G.
Avoiding adverse drug reactions by pharmacogenetic testing: a systematic review of the economic evidence in the case of TPMT and AZA-induced side effects
Int. J. Technol. Assess. Health Care
24
294-302
2008
Homo sapiens
Fargher, E.A.; Tricker, K.; Newman, W.; Elliott, R.; Roberts, S.A.; Shaffer, J.L.; Bruce, I.; Payne, K.
Current use of pharmacogenetic testing: a national survey of thiopurine methyltransferase testing prior to azathioprine prescription
J. Clin. Pharm. Ther.
32
187-195
2007
Homo sapiens
Fakhoury, M.; Andreu-Gallien, J.; Mahr, A.; Medard, Y.; Azougagh, S.; Vilmer, E.; Jacqz-Aigrain, E.
Should TPMT genotype and activity be used to monitor 6-mercaptopurine treatment in children with acute lymphoblastic leukaemia?
J. Clin. Pharm. Ther.
32
633-639
2007
Homo sapiens
Hoover, S.; Striker, R.
Thiopurines inhibit bovine viral diarrhea virus production in a thiopurine methyltransferase-dependent manner
J. Gen. Virol.
89
1000-1009
2008
BRENDA: Bos taurus, Homo sapiens
Textmining: Bovine viral diarrhea virus 1, Flaviviridae, Yellow fever virus
Rutherford, K.; Daggett, V.
Four human thiopurine s-methyltransferase alleles severely affect protein structure and dynamics
J. Mol. Biol.
379
803-814
2008
Homo sapiens
Chowdhury, J.; Kagiala, G.V.; Pushpakom, S.; Lauzon, J.; Makin, A.; Atrazhev, A.; Stickel, A.; Newman, W.G.; Backhouse, C.J.; Pilarski, L.M.
Microfluidic platform for single nucleotide polymorphism genotyping of the thiopurine S-methyltransferase gene to evaluate risk for adverse drug events
J. Mol. Diagn.
9
521-529
2007
Homo sapiens
Tamori, A.; Shinzaki, M.; Kosaka, S.; Hayashi, T.; Iwai, S.; Enomoto, M.; Habu, D.; Sakaguchi, H.; Kawada, N.; Hino, M.; Shiomi, S.; Nishiguchi, S.
Thiopurine S-methyltransferase gene polymorphism in Japanese patients with autoimmune liver diseases
Liver Int.
27
95-100
2007
BRENDA: Homo sapiens
Textmining: Hepacivirus C
Taja-Chayeb, L.; Vidal-Millan, S.; Gutierrez, O.; Ostrosky-Wegman, P.; Duenas-Gonzalez, A.; Candelaria, M.
Thiopurine S-methyltransferase gene (TMPT) polymorphisms in a Mexican population of healthy individuals and leukemic patients
Med. Oncol.
25
56-62
2008
Homo sapiens
Slanar, O.; Bortlik, M.; Buzkova, H.; Donoval, R.; Pechandova, K.; Sebesta, I.; Lukas, M.; Perlik, F.
Polymorphisms of the TPMT gene in the Czech healthy population and patients with inflammatory bowel disease
Nucleosides Nucleotides Nucleic Acids
27
835-838
2008
Homo sapiens
Lindqvist, M.; Skoglund, K.; Karlgren, A.; Soederkvist, P.; Peterson, C.; Kidhall, I.; Almer, S.
Explaining TPMT genotype/phenotype discrepancy by haplotyping of TPMT*3A and identification of a novel sequence variant, TPMT*23
Pharmacogenet. Genomics
17
891-895
2007
Homo sapiens
Roberts, R.L.; Gearry, R.B.; Bland, M.V.; Sies, C.W.; George, P.M.; Burt, M.; Marinaki, A.M.; Arenas, M.; Barclay, M.L.; Kennedy, M.A.
Trinucleotide repeat variants in the promoter of the thiopurine S-methyltransferase gene of patients exhibiting ultra-high enzyme activity
Pharmacogenet. Genomics
18
434-438
2008
Homo sapiens
Ujiie, S.; Sasaki, T.; Mizugaki, M.; Ishikawa, M.; Hiratsuka, M.
Functional characterization of 23 allelic variants of thiopurine S-methyltransferase gene (TPMT*2 - *24)
Pharmacogenet. Genomics
18
887-893
2008
Homo sapiens
Cooper, S.C.; Ford, L.T.; Berg, J.D.; Lewis, M.J.
Ethnic variation of thiopurine S-methyltransferase activity: a large, prospective population study
Pharmacogenomics
9
303-309
2008
Homo sapiens
Chrzanowska, M.; Kurzawski, M.; Dro?dzik, M.; Mazik, M.; Oko, A.; Czekalski, S.
Thiopurine S-methyltransferase phenotype-genotype correlation in hemodialyzed patients
Pharmacol. Rep.
58
973-978
2006
BRENDA: Homo sapiens
Textmining: Dialysis
Dilger, K.; Schaeffeler, E.; Lukas, M.; Strauch, U.; Herfarth, H.; Mueller, R.; Schwab, M.
Monitoring of thiopurine methyltransferase activity in postsurgical patients with Crohns disease during 1 year of treatment with azathioprine or mesalazine
Ther. Drug Monit.
29
1-5
2007
Homo sapiens
de Boer, N.K.; van Bodegraven, A.A.; de Graaf, P.; van der Hulst, R.W.; Zoetekouw, L.; van Kuilenburg, A.B.
Paradoxical elevated thiopurine S-methyltransferase activity after pancytopenia during azathioprine therapy: potential influence of red blood cell age
Ther. Drug Monit.
30
390-393
2008
BRENDA: Homo sapiens
Textmining: Cytomegalovirus
Uchiyama, K.; Nakamura, M.; Kubota, T.; Yamane, T.; Fujise, K.; Tajiri, H.
Thiopurine S-methyltransferase and inosine triphosphate pyrophosphohydrolase genes in Japanese patients with inflammatory bowel disease in whom adverse drug reactions were induced by azathioprine/6-mercaptopurine treatment
J. Gastroenterol.
44
197-203
2009
Homo sapiens
Alvarez Beltran, M.; Infante Pina, D.; Tormo Carnice, R.; Segarra Canton, O.; Redecillas Ferreiro, S.
Optimising azathioprine treatment: determination of thiopurine methyltransferase activity and thiopurine metabolites
An. Pediatr. (Barc. )
70
126-131
2009
Homo sapiens
el-Azhary, R.A.; Farmer, S.A.; Drage, L.A.; Rogers, R.S.; McEvoy, M.T.; Davis, M.D.; Bridges, A.G.; Gibson, L.E.
Thioguanine nucleotides and thiopurine methyltransferase in immunobullous diseases: optimal levels as adjunctive tools for azathioprine monitoring
Arch. Dermatol.
145
644-652
2009
BRENDA: Homo sapiens
Textmining: Pemphigus
Milek, M.; Karas Kuzelicki, N.; Smid, A.; Mlinaric-Rascan, I.
S-adenosylmethionine regulates thiopurine methyltransferase activity and decreases 6-mercaptopurine cytotoxicity in MOLT lymphoblasts
Biochem. Pharmacol.
77
1845-1853
2009
Homo sapiens
Feng, Q.; Vannaprasaht, S.; Peng, Y.; Angsuthum, S.; Avihingsanon, Y.; Yee, V.C.; Tassaneeyakul, W.; Weinshilboum, R.M.
Thiopurine S-methyltransferase pharmacogenetics: Functional characterization of a novel rapidly degraded variant allozyme
Biochem. Pharmacol.
79
1053-1061
2009
BRENDA: Homo sapiens (P51580), Homo sapiens
Textmining: Oryctolagus cuniculus
Kham, S.K.; Soh, C.K.; Aw, D.C.; Yeoh, A.E.
TPMT*26 (208F-->L), a novel mutation detected in a Chinese
Br. J. Clin. Pharmacol.
68
120-123
2009
Homo sapiens
Tsui, N.
Multiple thiopurine S-methyltransferase variation detection: A step toward personalized medicine
Clin. Chem.
54
1598-1599
2008
Homo sapiens
Schaeffeler, E.; Zanger, U.M.; Eichelbaum, M.; Asante-Poku, S.; Shin, J.G.; Schwab, M.
Highly multiplexed genotyping of thiopurine S-methyltransferase variants using MALD-TOF mass spectrometry: reliable genotyping in different ethnic groups
Clin. Chem.
54
1637-1647
2008
BRENDA: Homo sapiens
Textmining: shrimp
Vestergaard, T.; Bygum, A.
An audit of thiopurine methyltransferase genotyping and phenotyping before intended azathioprine treatment for dermatological conditions
Clin. Exp. Dermatol.
35
140-144
2010
Homo sapiens
Gisbert, J.
Role of monitoring thiopurine methyltransferase (TPMT) activity in the individualized therapy with azathioprine or 6-mercaptopurine
Curr. Pharmacogenomics Person. Med.
6
33-44
2008
Homo sapiens
-
Egle, R.; Milek, M.; Mlinaric-Rascan, I.; Fahr, A.; Kristl, J.
A novel gene delivery system for stable transfection of thiopurine-S-methyltransferase gene in versatile cell types
Eur. J. Pharm. Biopharm.
69
23-30
2008
Homo sapiens
Stocco, G.; Crews, K.R.; Evans, W.E.
Genetic polymorphism of inosine-triphosphate-pyrophosphatase influences mercaptopurine metabolism and toxicity during treatment of acute lymphoblastic leukemia individualized for thiopurine-S-methyl-transferase status
Expert. Opin. Drug Saf.
9
23-37
2010
Homo sapiens
Cheon, J.H.; Kim, J.H.; Kim, B.Y.; Kim, S.W.; Hong, S.Y.; Eun, C.S.; Hong, S.S.; Byeon, J.S.; Kim, T.I.; Han, D.S.; Yang, S.K.; Lee, K.R.; Kim, W.H.
Allele frequency of thiopurine methyltransferase and inosine triphosphate pyrophosphatase gene polymorphisms in Korean patients with inflammatory bowel diseases
Hepatogastroenterology
56
421-423
2009
Homo sapiens
Tomkova, J.; Friedecky, D.; Polynkova, A.; Adam, T.
Capillary electrophoresis determination of thiopurine methyl transferase activity in erythrocytes
J. Chromatogr. B
877
1943-1945
2009
Homo sapiens
Gonzalez-Del Angel, A.; Bermadez-Lapez, C.; Alcantara-Ortigoza, M.; Vela-Amieva, M.; Castillo-Cruz, R.; Martinez, V.; Torres-Espadola, L.
Thiopurine S-methyltransferase (TPMT) genetic polymorphisms in Mexican newborns
J. Clin. Pharm. Ther.
34
703-708
2009
Homo sapiens
Hindorf, U.; Jahed, K.; Bergquist, A.; Verbaan, H.; Prytz, H.; Wallerstedt, S.; Werner, M.; Olsson, R.; Bjoernsson, E.; Peterson, C.; Almer, S.H.
Characterisation and utility of thiopurine methyltransferase and thiopurine metabolite measurements in autoimmune hepatitis
J. Hepatol.
52
106-111
2010
Homo sapiens
Schmiegelow, K.; Forestier, E.; Kristinsson, J.; Soederhaell, S.; Vettenranta, K.; Weinshilboum, R.; Wesenberg, F.; Wesenberg, F.
Thiopurine methyltransferase activity is related to the risk of relapse of childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study
Leukemia
23
557-564
2009
Homo sapiens
Sheffield, L.J.; Irving, P.; Gupta, A.; Byron, K.; Macrae, F.A.; Phillimore, H.; Dronavalli, M.; Rose, R.; George, P.; Walmsley, T.; Dixon, B.; Poole, S.; Dooley, M.; Sparrow, M.
Thiopurine methyltransferase and thiopurine metabolite testing in patients with inflammatory bowel disease who are taking thiopurine drugs
Pharmacogenomics
10
1091-1099
2009
BRENDA: Homo sapiens
Textmining: Areas
Karas-Kuzelicki, N.; Mlinaric-Rascan, I.
Individualization of thiopurine therapy: thiopurine S-methyltransferase and beyond
Pharmacogenomics
10
1309-1322
2009
Homo sapiens
Serpe, L.; Calvo, P.L.; Muntoni, E.; DAntico, S.; Giaccone, M.; Avagnina, A.; Baldi, M.; Barbera, C.; Curti, F.; Pera, A.; Eandi, M.; Zara, G.P.; Canaparo, R.
Thiopurine S-methyltransferase pharmacogenetics in a large-scale healthy Italian-Caucasian population: differences in enzyme activity
Pharmacogenomics
10
1753-1765
2009
Homo sapiens
Silva, M.R.; de Oliveira, B.M.; Viana, M.B.; Murao, M.; Romanha, A.J.
Thiopurine S-methyltransferase (TPMT) gene polymorphism in Brazilian children with acute lymphoblastic leukemia: association with clinical and laboratory data
Ther. Drug Monit.
30
700-704
2008
Homo sapiens
Milek, M.; Smid, A.; Tamm, R.; Kuzelicki, N.K.; Metspalu, A.; Mlinaric-Rascan, I.
Post-translational stabilization of thiopurine S-methyltransferase by S-adenosyl-L-methionine reveals regulation of TPMT*1 and *3C allozymes
Biochem. Pharmacol.
83
969-976
2012
Homo sapiens
Wennerstrand, P.; Dametto, P.; Hennig, J.; Klingstedt, T.; Skoglund, K.; Lindqvist Appell, M.; Martensson, L.G.
Structural characteristics determine the cause of the low enzyme activity of two thiopurine S-methyltransferase allelic variants: a biophysical characterization of TPMT*2 and TPMT*5
Biochemistry
51
5912-5920
2012
BRENDA: Homo sapiens
Textmining: Escherichia coli
Pavlovic, S.; Zukic, B.
Individualized therapy: Role of thiopurine S-methyltransferase protein and genetic variants
J. Med. Biochem.
29
150-155
2010
Homo sapiens
-
Hosni-Ahmed, A.; Barnes, J.D.; Wan, J.; Jones, T.S.
Thiopurine methyltransferase predicts the extent of cytotoxicty and DNA damage in astroglial cells after thioguanine exposure
PLoS ONE
6
e29163
2011
Homo sapiens, Mus musculus
Kasirer, Y.; Mevorach, R.; Renbaum, P.; Algur, N.; Soiferman, D.; Beeri, R.; Rachman, Y.; Segel, R.; Turner, D.
Thiopurine S-methyltransferase (TPMT) activity is better determined by biochemical assay versus genotyping in the Jewish population
Digest. Dis. Sci.
59
1207-1212
2014
Homo sapiens (P51580)
Wennerstrand, P.; Martensson, L.G.; Soederhaell, S.; Zimdahl, A.; Appell, M.L.
Methotrexate binds to recombinant thiopurine S-methyltransferase and inhibits enzyme activity after high-dose infusions in childhood leukaemia
Eur. J. Clin. Pharmacol.
69
1641-1649
2013
Homo sapiens (P51580), Homo sapiens
Roberts, R.L.; Wallace, M.C.; Drake, J.M.; Stamp, L.K.
Identification of a novel thiopurine S-methyltransferase allele (TPMT 37)
Pharmacogenet. Genomics
24
320-323
2014
Homo sapiens (P51580)
Wennerstrand, P.; Blissing, A.; Martensson, L.G.
In vitro protein stability of two naturally occurring thiopurine S-methyltransferase variants biophysical characterization of TPMT*6 and TPMT*8
ACS Omega
2
4991-4999
2017
Homo sapiens (P51580)
Citterio-Quentin, A.; El Mahmoudi, A.; Perret, T.; Conway, A.; Ryan, A.; Beringer, A.; Lachaux, A.; Boulieu, R.
Red Blood cell IMPDH activity in adults and children with or without azathioprine Relationship between thiopurine metabolites, ITPA and TPMT activities
Basic Clin. Pharmacol. Toxicol.
124
600-606
2019
Homo sapiens
Mei, S.; Li, X.; Gong, X.; Zhang, X.; Li, X.; Yang, L.; Zhu, L.; Zhou, H.; Liu, Y.; Zhou, A.; Zhang, X.; Zhao, Z.
Comparison of 6-mercaptopurine with 6-thioguanine for the analysis of thiopurine S-methyltransferase activity in human erythrocyte by LC-MS/MS
Biomed. Chromatogr.
31
e3959
2017
Homo sapiens
Ma, J.; Sies, C.W.; Pike, L.S.
Analytical and clinical validation of an LC-MS/MS method to measure thiopurine S-methyltransferase activity by quantifying d3-6-MMP
Clin. Biochem.
54
100-105
2018
Homo sapiens
Rieger, H.; Schmidt, P.; Schaeffeler, E.; Abe, M.; Schiffhauer, M.; Schwab, M.; von Ahsen, N.; Zurek, G.; Kirchherr, H.; Shipkova, M.; Wieland, E.
Validation of a high-performance liquid chromatography method for thiopurine S-methyltransferase activity in whole blood using 6-mercaptopurine as substrate
Clin. Chem. Lab. Med.
56
803-809
2018
Homo sapiens
Maw, H.H.; Zeng, X.; Campbell, S.; Taub, M.E.; Teitelbaum, A.M.
N-Methylation of BI 187004 by thiol S-methyltransferase
Drug Metab. Dispos.
46
770-778
2018
Homo sapiens, Homo sapiens (P50135)
Pashazadeh, P.; Marjani, A.; Asadi, J.; Khoshnia, M.
Thiopurine methyltransferase genetic polymorphisms and activity and metabolic products of azathioprine in patients with inflammatory bowel disease
Endocr. Metab. Immune Disord. Drug Targets
19
541-547
2019
Homo sapiens
Illamola, S.M.; Echaabi, A.K.; Mazeron, C.; Deshayes, S.; Loriot, M.A.; Pallet, N.
Development and validation of a UPLC-UV method for the quantification of thiopurine methyltransferase enzyme activity in human erythrocytes
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
1113
91-97
2019
Homo sapiens
Pecher, D.; Dokupilova, S.; Zelinkova, Z.; Peppelenbosch, M.; Mikusova, V.; Mikus, P.
Determination of thiopurine S-methyltransferase activity by hydrophilic interaction liquid chromatography hyphenated with mass spectrometry
J. Pharm. Biomed. Anal.
142
244-251
2017
Homo sapiens
Jung, YS; Cheon, JH; Park, JJ; Moon, CM; Kim, ES; Lee, JH; Kim, SW; Kim, JH; Hong, SP; Kim, TI; Kim, WH
Correlation of genotypes for thiopurine methyltransferase and inosine triphosphate pyrophosphatase with long-term clinical outcomes in Korean patients with inflammatory bowel diseases during treatment with thiopurine drugs.
J Hum Genet
55
121-3
2010
Homo sapiens
Dorababu, P; Nagesh, N; Linga, VG; Gundeti, S; Kutala, VK; Reddanna, P; Digumarti, R
Epistatic interactions between thiopurine methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) variations determine 6-mercaptopurine toxicity in Indian children with acute lymphoblastic leukemia.
Eur J Clin Pharmacol
68
379-87
2012
Homo sapiens
Dorababu, P; Naushad, SM; Kutala, VK; Digumarti, R
Impact of age, gender and haplotypes of thiopurine methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) genes on 6-mercaptopurine toxicity in children with acute lymphoblastic leukemia.
Eur J Clin Pharmacol
2011
Homo sapiens
Haglund, S; Vikingsson, S; Sderman, J; Hindorf, U; Grnn, C; Danelius, M; Coulthard, S; Peterson, C; Almer, S
The Role of Inosine-5'-Monophosphate Dehydrogenase in Thiopurine Metabolism in Patients With Inflammatory Bowel Disease.
Ther Drug Monit
33
200-208
2011
Homo sapiens
De Santi, C; Donatelli, P; Giulianotti, PC; Pietrabissa, A; Mosca, F; Pacifici, GM
Interindividual variability of histamine N-methyltransferase in the human liver and kidney.
Xenobiotica
28
571-7
1998
Homo sapiens
Pacifici, GM; Romiti, P; Santerini, S; Giuliani, L
S-methyltransferases in human intestine: differential distribution of the microsomal thiol methyltransferase and cytosolic thiopurine methyltransferase along the human bowel.
Xenobiotica
23
671-9
1993
Homo sapiens
Glauser, TA; Nelson, AN; Zembower, DE; Lipsky, JJ; Weinshilboum, RM
Diethyldithiocarbamate S-methylation: evidence for catalysis by human liver thiol methyltransferase and thiopurine methyltransferase.
J Pharmacol Exp Ther
266
23-32
1993
Homo sapiens
Ma, XL; Li, WJ; Zheng, J; Wang, B; Jin, M; Zhang, DW; Li, ZG; Zhang, YX
[Thiopurine S-Methyltransferase Gene Sequence Analysis of ALL Children Severely Intolerant to 6-Mercaptopurine].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
20
876-9
2012
Homo sapiens
Weinshilboum, RM; Raymond, FA; Pazmiño, PA
Human erythrocyte thiopurine methyltransferase: radiochemical microassay and biochemical properties.
Clin Chim Acta
85
323-33
1978
Homo sapiens
Van Loon, JA; Szumlanski, CL; Weinshilboum, RM
Human kidney thiopurine methyltransferase. Photoaffinity labeling with S-adenosyl-L-methionine.
Biochem Pharmacol
44
775-85
1992
Homo sapiens
Tinel, M; Berson, A; Pessayre, D; Letteron, P; Cattoni, MP; Horsmans, Y; Larrey, D
Pharmacogenetics of human erythrocyte thiopurine methyltransferase activity in a French population.
Br J Clin Pharmacol
32
729-34
1991
Homo sapiens
Pacifici, GM; Romiti, P; Giuliani, L; Rane, A
Thiopurine methyltransferase in humans: development and tissue distribution.
Dev Pharmacol Ther
17
16-23
1991
Homo sapiens
Hernández, JS; Van Loon, JA; Otterness, DM; Guerciolini, R; Weinshilboum, RM
Thiopurine methyltransferase regulation in rat kidney: immunoprecipitation studies.
Xenobiotica
21
451-9
1991
Metazoa, Oryctolagus cuniculus, Rattus
Hernandez, JS; Van Loon, JA; Otterness, DM; Weinshilboum, RM
Mouse thiopurine methyltransferase pharmacogenetics: correlation of immunoreactive protein and enzymatic activity.
J Pharmacol Exp Ther
252
568-73
1990
Mus musculus, Homo sapiens, Oryctolagus cuniculus, Mus sp., Metazoa
Otterness, DM; Weinshilboum, RM
Mouse thiopurine methyltransferase pharmacogenetics: monogenic inheritance.
J Pharmacol Exp Ther
240
817-24
1987
Mus musculus, Homo sapiens, Mus sp., Metazoa, animal
Van Loon, JA; Weinshilboum, RM
Human lymphocyte thiopurine methyltransferase pharmacogenetics: effect of phenotype on 6-mercaptopurine-induced inhibition of mitogen stimulation.
J Pharmacol Exp Ther
242
21-6
1987
Homo sapiens
Otterness, DM; Weinshilboum, RM
Mouse thiopurine methyltransferase pharmacogenetics: biochemical studies and recombinant inbred strains.
J Pharmacol Exp Ther
243
180-6
1987
Mus musculus, Homo sapiens, Mus sp.
Otterness, DM; Keith, RA; Weinshilboum, RM
Thiopurine methyltransferase: mouse kidney and liver assay conditions, biochemical properties and strain variation.
Biochem Pharmacol
34
3823-30
1985
Mus musculus, Homo sapiens, Mus sp., Metazoa, animal
Woodson, LC; Dunnette, JH; Weinshilboum, RM
Pharmacogenetics of human thiopurine methyltransferase: kidney-erythrocyte correlation and immunotitration studies.
J Pharmacol Exp Ther
222
174-81
1982
Homo sapiens
Van Loon, JA; Weinshilboum, RM
Thiopurine methyltransferase biochemical genetics: human lymphocyte activity.
Biochem Genet
20
637-58
1982
Homo sapiens
Walker, RC; Woodson, LC; Weinshilboum, RM
Rat thiopurine methyltransferase assay procedure, developmental changes and strain variation.
Biochem Pharmacol
30
115-21
1981
Rattus
Woodson, LC; Maus, TP; Reiter, C; Weinshilboum, RM
Rat thiopurine methyltransferase: regulation by testosterone.
J Pharmacol Exp Ther
218
734-8
1981
Rattus
Lee, D; Szumlanski, C; Houtman, J; Honchel, R; Rojas, K; Overhauser, J; Wieben, ED; Weinshilboum, RM
Thiopurine methyltransferase pharmacogenetics. Cloning of human liver cDNA and a processed pseudogene on human chromosome 18q21.1.
Drug Metab Dispos
23
398-405
1995
Homo sapiens
Anstey, A; Lennard, L
The role of genetic variation in thiopurine methyltransferase activity and efficacy and/or side effects of azathioprine therapy in dermatologic patients.
Arch Dermatol
131
1087-8
1995
Homo sapiens
McLeod, HL; Relling, MV; Liu, Q; Pui, CH; Evans, WE
Polymorphic thiopurine methyltransferase in erythrocytes is indicative of activity in leukemic blasts from children with acute lymphoblastic leukemia.
Blood
85
1897-902
1995
Homo sapiens
Vuchetich, JP; Weinshilboum, RM; Price, RA
Segregation analysis of human red blood cell thiopurine methyltransferase activity.
Genet Epidemiol
12
1-11
1995
Homo sapiens
Snow, JL; Gibson, LE
The role of genetic variation in thiopurine methyltransferase activity and the efficacy and/or side effects of azathioprine therapy in dermatologic patients.
Arch Dermatol
131
193-7
1995
Homo sapiens
Lennard, L; Singleton, HJ
High-performance liquid chromatographic assay of human red blood cell thiopurine methyltransferase activity.
J Chromatogr B Biomed Appl
661
25-33
1994
Homo sapiens
Honchel, R; Aksoy, IA; Szumlanski, C; Wood, TC; Otterness, DM; Wieben, ED; Weinshilboum, RM
Human thiopurine methyltransferase: molecular cloning and expression of T84 colon carcinoma cell cDNA.
Mol Pharmacol
43
878-87
1993
Homo sapiens, Oryctolagus cuniculus
Szumlanski, C; Otterness, D; Her, C; Lee, D; Brandriff, B; Kelsell, D; Spurr, N; Lennard, L; Wieben, E; Weinshilboum, R
Thiopurine methyltransferase pharmacogenetics: human gene cloning and characterization of a common polymorphism.
DNA Cell Biol
15
17-30
1996
Homo sapiens
Park-Hah, JO; Klemetsdal, B; Lysaa, R; Choi, KH; Aarbakke, J
Thiopurine methyltransferase activity in a Korean population sample of children.
Clin Pharmacol Ther
60
68-74
1996
Homo sapiens
Schütz, E; Gummert, J; Armstrong, VW; Mohr, FW; Oellerich, M
Azathioprine pharmacogenetics: the relationship between 6-thioguanine nucleotides and thiopurine methyltransferase in patients after heart and kidney transplantation.
Eur J Clin Chem Clin Biochem
34
199-205
1996
Homo sapiens
Jackson, H; Hughes, BP; Stupans, I
Baculovirus-mediated high level expression of a human thiopurine methyl transferase.
Biochem Mol Biol Int
38
357-64
1996
Homo sapiens
Jackson, AP; Hall, AG; McLelland, J
Thiopurine methyltransferase levels should be measured before commencing patients on azathioprine.
Br J Dermatol
136
133-4
1997
Homo sapiens
Micheli, V; Jacomelli, G; Fioravanti, A; Morozzi, G; Marcolongo, R; Pompucci, G
Thiopurine methyltransferase activity in the erythrocytes of adults and children: and HPLC-linked assay.
Clin Chim Acta
259
161-8
1997
Homo sapiens
Tai, HL; Krynetski, EY; Schuetz, EG; Yanishevski, Y; Evans, WE
Enhanced proteolysis of thiopurine S-methyltransferase (TPMT) encoded by mutant alleles in humans (TPMT*3A, TPMT*2): mechanisms for the genetic polymorphism of TPMT activity.
Proc Natl Acad Sci U S A
94
6444-9
1997
Homo sapiens, Saccharomyces cerevisiae, Oryctolagus cuniculus
Otterness, D; Szumlanski, C; Lennard, L; Klemetsdal, B; Aarbakke, J; Park-Hah, JO; Iven, H; Schmiegelow, K; Branum, E; O'Brien, J; Weinshilboum, R
Human thiopurine methyltransferase pharmacogenetics: gene sequence polymorphisms.
Clin Pharmacol Ther
62
60-73
1997
Homo sapiens
Krynetski, EY; Fessing, MY; Yates, CR; Sun, D; Schuetz, JD; Evans, WE
Promoter and intronic sequences of the human thiopurine S-methyltransferase (TPMT) gene isolated from a human PAC1 genomic library.
Pharm Res
14
1672-8
1997
Homo sapiens, Chondrichthyes
Otterness, DM; Szumlanski, CL; Wood, TC; Weinshilboum, RM
Human thiopurine methyltransferase pharmacogenetics. Kindred with a terminal exon splice junction mutation that results in loss of activity.
J Clin Invest
101
1036-44
1998
Homo sapiens
Andersen, JB; Szumlanski, C; Weinshilboum, RM; Schmiegelow, K
Pharmacokinetics, dose adjustments, and 6-mercaptopurine/methotrexate drug interactions in two patients with thiopurine methyltransferase deficiency.
Acta Paediatr
87
108-11
1998
Homo sapiens
Kröplin, T; Weyer, N; Gutsche, S; Iven, H
Thiopurine S-methyltransferase activity in human erythrocytes: a new HPLC method using 6-thioguanine as substrate.
Eur J Clin Pharmacol
54
265-71
1998
Homo sapiens
Loennechen, T; Yates, CR; Fessing, MY; Relling, MV; Krynetski, EY; Evans, WE
Isolation of a human thiopurine S-methyltransferase (TPMT) complementary DNA with a single nucleotide transition A719G (TPMT*3C) and its association with loss of TPMT protein and catalytic activity in humans.
Clin Pharmacol Ther
64
46-51
1998
Homo sapiens
Coulthard, SA; Howell, C; Robson, J; Hall, AG
The relationship between thiopurine methyltransferase activity and genotype in blasts from patients with acute leukemia.
Blood
92
2856-62
1998
Homo sapiens
Stolk, JN; Boerbooms, AM; de Abreu, RA; de Koning, DG; van Beusekom, HJ; Muller, WH; van de Putte, LB
Reduced thiopurine methyltransferase activity and development of side effects of azathioprine treatment in patients with rheumatoid arthritis.
Arthritis Rheum
41
1858-66
1998
Homo sapiens
Fessing, MY; Krynetski, EY; Zambetti, GP; Evans, WE
Functional characterization of the human thiopurine S-methyltransferase (TPMT) gene promoter.
Eur J Biochem
256
510-7
1998
Homo sapiens, Drosophila
Naughton, MA; Battaglia, E; O'Brien, S; Walport, MJ; Botto, M
Identification of thiopurine methyltransferase (TPMT) polymorphisms cannot predict myelosuppression in systemic lupus erythematosus patients taking azathioprine.
Rheumatology (Oxford)
38
640-4
1999
Homo sapiens
Korshunova, GA; Krynetski, EY; Mtchedlidze, MT; Agapkin, DV; Evans, WE; Krynetskaia, NF
Synthesis of modified thiopurine nucleosides for structural characterization of human thiopurine S-methyltransferase.
Nucleosides Nucleotides
18
1747-8
0
Homo sapiens
Tai, HL; Fessing, MY; Bonten, EJ; Yanishevsky, Y; d'Azzo, A; Krynetski, EY; Evans, WE
Enhanced proteasomal degradation of mutant human thiopurine S-methyltransferase (TPMT) in mammalian cells: mechanism for TPMT protein deficiency inherited by TPMT*2, TPMT*3A, TPMT*3B or TPMT*3C.
Pharmacogenetics
9
641-50
1999
Homo sapiens, Saccharomyces cerevisiae, Oryctolagus cuniculus
Dervieux, T; Médard, Y; Baudouin, V; Maisin, A; Zhang, D; Loirat, C; Jacqz-Aigrain, E
Monitoring azathioprine therapy in pediatric renal transplant patients with red blood cell thiopurine methyltransferase.
Transplant Proc
32
361-3
2000
Homo sapiens
Colombel, JF; Ferrari, N; Debuysere, H; Marteau, P; Gendre, JP; Bonaz, B; Soulé, JC; Modigliani, R; Touze, Y; Catala, P; Libersa, C; Broly, F
Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy.
Gastroenterology
118
1025-30
2000
Homo sapiens
Kader, HA; Wenner, WJ; Telega, GW; Maller, ES; Baldassano, RN
Normal thiopurine methyltransferase levels do not eliminate 6-mercaptopurine or azathioprine toxicity in children with inflammatory bowel disease.
J Clin Gastroenterol
30
409-13
2000
Homo sapiens
Corominas, H; Domènech, M; González, D; Diaz, C; Roca, M; García-González, MA; Peña, S; Baiget, M
Allelic variants of the thiopurine S-methyltransferase deficiency in patients with ulcerative colitis and in healthy controls.
Am J Gastroenterol
95
2313-7
2000
Homo sapiens
White, SD; Rosychuk, RA; Outerbridge, CA; Fieseler, KV; Spier, S; Ihrke, PJ; Chapman, PL
Thiopurine methyltransferase in red blood cells of dogs, cats, and horses.
J Vet Intern Med
14
499-502
0
Canis lupus familiaris, Felis catus, Equidae, Homo sapiens
Foster, AP; Shaw, SE; Duley, JA; Shobowale-Bakre, EM; Harbour, DA
Demonstration of thiopurine methyltransferase activity in the erythrocytes of cats.
J Vet Intern Med
14
552-4
0
Felis catus, Homo sapiens, Canis lupus familiaris, Mammalia
Hongeng, S; Sasanakul, W; Chuansumrit, A; Pakakasama, S; Chattananon, A; Hathirat, P
Frequency of thiopurine S-methyltransferase genetic variation in Thai children with acute leukemia.
Med Pediatr Oncol
35
410-4
2000
Homo sapiens
McBride, KL; Gilchrist, GS; Smithson, WA; Weinshilboum, RM; Szumlanski, CL
Severe 6-thioguanine-induced marrow aplasia in a child with acute lymphoblastic leukemia and inherited thiopurine methyltransferase deficiency.
J Pediatr Hematol Oncol
22
441-5
0
Homo sapiens
Evans, WE; Hon, YY; Bomgaars, L; Coutre, S; Holdsworth, M; Janco, R; Kalwinsky, D; Keller, F; Khatib, Z; Margolin, J; Murray, J; Quinn, J; Ravindranath, Y; Ritchey, K; Roberts, W; Rogers, ZR; Schiff, D; Steuber, C; Tucci, F; Kornegay, N; Krynetski, EY; Relling, MV
Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity among patients intolerant to mercaptopurine or azathioprine.
J Clin Oncol
19
2293-301
2001
Homo sapiens
Ando, M; Ando, Y; Hasegawa, Y; Sekido, Y; Shimokata, K; Horibe, K
Genetic polymorphisms of thiopurine S-methyltransferase and 6-mercaptopurine toxicity in Japanese children with acute lymphoblastic leukaemia.
Pharmacogenetics
11
269-73
2001
Homo sapiens
Decaux, G; Horsmans, Y; Houssiau, F; Desager, JP
High 6-thioguanine nucleotide levels and low thiopurine methyltransferase activity in patients with lupus erythematosus treated with azathioprine.
Am J Ther
8
147-50
0
Homo sapiens
Weyer, N; Kröplin, T; Fricke, L; Iven, H
Human thiopurine S-methyltransferase activity in uremia and after renal transplantation.
Eur J Clin Pharmacol
57
129-36
2001
Homo sapiens, Dialysis
Menor, C; Fueyo, JA; Escribano, O; Cara, C; Fernández-Moreno, MD; Román, ID; Guijarro, LG
Determination of thiopurine methyltransferase activity in human erythrocytes by high-performance liquid chromatography: comparison with the radiochemical method.
Ther Drug Monit
23
536-41
2001
Homo sapiens
Lowry, PW; Franklin, CL; Weaver, AL; Pike, MG; Mays, DC; Tremaine, WJ; Lipsky, JJ; Sandborn, WJ
Measurement of thiopurine methyltransferase activity and azathioprine metabolites in patients with inflammatory bowel disease.
Gut
49
665-70
2001
Homo sapiens
Lennard, L; Chew, TS; Lilleyman, JS
Human thiopurine methyltransferase activity varies with red blood cell age.
Br J Clin Pharmacol
52
539-46
2001
Homo sapiens
Brouwer, C; Keizer-Garritsen, JJ; Lambooy, LH; Ament, K; Ter Riet, PG; De Abreu, RA; Bökkerink, JP; Van Wering, ER; Van Der Does-Van Den Berg, A; Veerman, AJ; Trijbels, JP
Thiopurine methyl transferase: activity and genotyping in patients with acute lymphoblastic leukemia.
Adv Exp Med Biol
486
327-31
2000
Homo sapiens
Campbell, S; Kingstone, K; Ghosh, S
Relevance of thiopurine methyltransferase activity in inflammatory bowel disease patients maintained on low-dose azathioprine.
Aliment Pharmacol Ther
16
389-98
2002
Homo sapiens
Paerregaard, A; Schmiegelow, K
Monitoring azathioprine metabolite levels and thiopurine methyl transferase (TPMT) activity in children with inflammatory bowel disease.
Scand J Gastroenterol
37
371-2
2002
Homo sapiens
Pettersson, B; Almer, S; Albertioni, F; Söderhäll, S; Peterson, C
Differences between children and adults in thiopurine methyltransferase activity and metabolite formation during thiopurine therapy: possible role of concomitant methotrexate.
Ther Drug Monit
24
351-8
2002
Homo sapiens
Menor, C; Fueyo, J; Escribano, O; Piña, MJ; Redondo, P; Cara, C; Román, ID; Fernández-Moreno, MD; Guijarro, LG
Thiopurine methyltransferase activity in a Spanish population sample: decrease of enzymatic activity in multiple sclerosis patients.
Mult Scler
8
243-8
2002
Homo sapiens
Kham, SK; Tan, PL; Tay, AH; Heng, CK; Yeoh, AE; Quah, TC
Thiopurine methyltransferase polymorphisms in a multiracial asian population and children with acute lymphoblastic leukemia.
J Pediatr Hematol Oncol
24
353-9
0
Homo sapiens
Schwab, M; Schäffeler, E; Marx, C; Fischer, C; Lang, T; Behrens, C; Gregor, M; Eichelbaum, M; Zanger, UM; Kaskas, BA
Azathioprine therapy and adverse drug reactions in patients with inflammatory bowel disease: impact of thiopurine S-methyltransferase polymorphism.
Pharmacogenetics
12
429-36
2002
Homo sapiens
Murphy, LA; Atherton, D
A retrospective evaluation of azathioprine in severe childhood atopic eczema, using thiopurine methyltransferase levels to exclude patients at high risk of myelosuppression.
Br J Dermatol
147
308-15
2002
Homo sapiens
Pandya, B; Thomson, W; Poulton, K; Bruce, I; Payne, D; Qasim, F
Azathioprine toxicity and thiopurine methyltransferase genotype in renal transplant patients.
Transplant Proc
34
1642-5
2002
Homo sapiens
Rosen, R; Integlia, MJ; Bousvaros, A
Severe pancytopenia from thiopurine methyltransferase deficiency: a preventable complication of 6-mercaptopurine therapy in children with Crohn disease.
J Pediatr Gastroenterol Nutr
35
695-9
2002
Homo sapiens
Salavaggione, OE; Kidd, L; Prondzinski, JL; Szumlanski, CL; Pankratz, VS; Wang, L; Trepanier, L; Weinshilboum, RM
Canine red blood cell thiopurine S-methyltransferase: companion animal pharmacogenetics.
Pharmacogenetics
12
713-24
2002
Canis lupus familiaris, animal, Homo sapiens, Metazoa
Marra, CA; Esdaile, JM; Anis, AH
Practical pharmacogenetics: the cost effectiveness of screening for thiopurine s-methyltransferase polymorphisms in patients with rheumatological conditions treated with azathioprine.
J Rheumatol
29
2507-12
2002
Homo sapiens
Kaskas, BA; Louis, E; Hindorf, U; Schaeffeler, E; Deflandre, J; Graepler, F; Schmiegelow, K; Gregor, M; Zanger, UM; Eichelbaum, M; Schwab, M
Safe treatment of thiopurine S-methyltransferase deficient Crohn's disease patients with azathioprine.
Gut
52
140-2
2003
Homo sapiens
Reuther, LO; Sonne, J; Larsen, N; Dahlerup, JF; Thomsen, OO; Schmiegelow, K
Thiopurine methyltransferase genotype distribution in patients with Crohn's disease.
Aliment Pharmacol Ther
17
65-8
2003
Homo sapiens
Gisbert, JP; Luna, M; Maté, J; González-Guijarro, L; Cara, C; Pajares, JM
[Thiopurine methyltransferase activity and myelosuppression in inflammatory bowel disease patients treated with azathioprine and 6-mercaptopurine]
Med Clin (Barc)
121
1-5
2003
Homo sapiens, Nicotiana tabacum
Ranjard, L; Nazaret, S; Cournoyer, B
Freshwater bacteria can methylate selenium through the thiopurine methyltransferase pathway.
Appl Environ Microbiol
69
3784-90
2003
Bacteria, Pseudomonas aeruginosa, Pseudomonas syringae, Vibrio cholerae, Homo sapiens, Rattus, Escherichia coli, Pseudomonas anguilliseptica
Laróvere, LE; de Kremer, RD; Lambooy, LH; De Abreu, RA
Genetic polymorphism of thiopurine S-methyltransferase in Argentina.
Ann Clin Biochem
40
388-93
2003
Argentina, Argentina sphyraena
Gearry, RB; Barclay, ML; Burt, MJ; Collett, JA; Chapman, BA; Roberts, RL; Kennedy, MA
Thiopurine S-methyltransferase (TPMT) genotype does not predict adverse drug reactions to thiopurine drugs in patients with inflammatory bowel disease.
Aliment Pharmacol Ther
18
395-400
2003
Homo sapiens
Indjova, D; Shipkova, M; Atanasova, S; Niedmann, PD; Armstrong, VW; Svinarov, D; Oellerich, M
Determination of thiopurine methyltransferase phenotype in isolated human erythrocytes using a new simple nonradioactive HPLC method.
Ther Drug Monit
25
637-44
2003
Homo sapiens
Scheuermann, TH; Lolis, E; Hodsdon, ME
Tertiary structure of thiopurine methyltransferase from Pseudomonas syringae, a bacterial orthologue of a polymorphic, drug-metabolizing enzyme.
J Mol Biol
333
573-85
2003
Pseudomonas syringae, Homo sapiens
Clunie, GP; Lennard, L
Relevance of thiopurine methyltransferase status in rheumatology patients receiving azathioprine.
Rheumatology (Oxford)
43
13-8
2004
Homo sapiens
Gisbert, JP; González-Guijarro, L; Cara, C; Pajares, JM; Moreno-Otero, R
[Thiopurine methyltransferase activity in patients with autoimmune hepatitis]
Med Clin (Barc)
121
481-4
2003
Homo sapiens
Salavaggione, OE; Yang, C; Kidd, LB; Thomae, BA; Pankratz, VS; Trepanier, LA; Weinshilboum, RM
Cat red blood cell thiopurine S-methyltransferase: companion animal pharmacogenetics.
J Pharmacol Exp Ther
308
617-26
2004
animal, Felis catus, Homo sapiens, Metazoa
Reuther, LO; Vainer, B; Sonne, J; Larsen, NE
Thiopurine methyltransferase (TPMT) genotype distribution in azathioprine-tolerant and -intolerant patients with various disorders. The impact of TPMT genotyping in predicting toxicity.
Eur J Clin Pharmacol
59
797-801
2004
Homo sapiens
Murphy, LA; Atherton, DJ
Azathioprine as a treatment for severe atopic eczema in children with a partial thiopurine methyl transferase (TPMT) deficiency.
Pediatr Dermatol
20
531-4
0
Homo sapiens
Shipkova, M; Niedmann, PD; Armstrong, VW; Oellerich, M; Wieland, E
Determination of thiopurine methyltransferase activity in isolated human erythrocytes does not reflect putative in vivo enzyme inhibition by sulfasalazine.
Clin Chem
50
438-41
2004
Homo sapiens
Wusk, B; Kullak-Ublick, GA; Rammert, C; von Eckardstein, A; Fried, M; Rentsch, KM
Thiopurine S-methyltransferase polymorphisms: efficient screening method for patients considering taking thiopurine drugs.
Eur J Clin Pharmacol
60
5-10
2004
Homo sapiens
Kidd, LB; Salavaggione, OE; Szumlanski, CL; Miller, JL; Weinshilboum, RM; Trepanier, L
Thiopurine methyltransferase activity in red blood cells of dogs.
J Vet Intern Med
18
214-8
0
Canis lupus familiaris, Homo sapiens
Rodriguez, DB; Mackin, A; Easley, R; Boyle, CR; Hou, W; Langston, C; Walsh, AM; Province, MA; McLeod, HL
Relationship between red blood cell thiopurine methyltransferase activity and myelotoxicity in dogs receiving azathioprine.
J Vet Intern Med
18
339-45
0
Canis lupus familiaris, Homo sapiens
Zhang, JP; Guan, YY; Wu, JH; Xu, AL; Zhou, S; Huang, M
Phenotyping and genotyping study of thiopurine S-methyltransferase in healthy Chinese children: a comparison of Han and Yao ethnic groups.
Br J Clin Pharmacol
58
163-8
2004
Homo sapiens
Winter, J; Walker, A; Shapiro, D; Gaffney, D; Spooner, RJ; Mills, PR
Cost-effectiveness of thiopurine methyltransferase genotype screening in patients about to commence azathioprine therapy for treatment of inflammatory bowel disease.
Aliment Pharmacol Ther
20
593-9
2004
Homo sapiens
Konstantopoulou, M; Belgi, A; Griffiths, KD; Seale, JR; Macfarlane, AW
Azathioprine-induced pancytopenia in a patient with pompholyx and deficiency of erythrocyte thiopurine methyltransferase.
BMJ
330
350-1
2005
Pompholyx
Xin, H; Fischer, C; Schwab, M; Klotz, U
Effects of aminosalicylates on thiopurine S-methyltransferase activity: an ex vivo study in patients with inflammatory bowel disease.
Aliment Pharmacol Ther
21
1105-9
2005
Homo sapiens
Wang, L; Nguyen, TV; McLaughlin, RW; Sikkink, LA; Ramirez-Alvarado, M; Weinshilboum, RM
Human thiopurine S-methyltransferase pharmacogenetics: variant allozyme misfolding and aggresome formation.
Proc Natl Acad Sci U S A
102
9394-9
2005
Homo sapiens, Oryctolagus cuniculus
Gisbert, JP; Gomollón, F; Cara, C; Luna, M; González-Lama, Y; Pajares, JM; Maté, J; Guijarro, LG
[Thiopurine methyltransferase activity in inflammatory bowel disease. A study on 7046 Spanish patients]
Med Clin (Barc)
125
281-5
2005
Homo sapiens
Dervieux, T; Meyer, G; Barham, R; Matsutani, M; Barry, M; Boulieu, R; Neri, B; Seidman, E
Liquid chromatography-tandem mass spectrometry analysis of erythrocyte thiopurine nucleotides and effect of thiopurine methyltransferase gene variants on these metabolites in patients receiving azathioprine/6-mercaptopurine therapy.
Clin Chem
51
2074-84
2005
Homo sapiens
Okada, Y; Nakamura, K; Kodama, T; Ueki, K; Tsukada, Y; Maezawa, A; Tsukamoto, N; Nojima, Y; Ishizaki, T; Horiuchi, R; Yamamoto, K
Thiopurine methyltransferase genotype and phenotype status in Japanese patients with systemic lupus erythematosus.
Biol Pharm Bull
28
2117-9
2005
Homo sapiens
Jun, JB; Cho, DY; Kang, C; Bae, SC
Thiopurine S-methyltransferase polymorphisms and the relationship between the mutant alleles and the adverse effects in systemic lupus erythematosus patients taking azathioprine.
Clin Exp Rheumatol
23
873-6
0
Homo sapiens
Wang, LN; Zhang, L; Nan, F; Cheng, JQ; Bu, H; Liang, MZ; Lu, YR
[HPLC determination and diversity analysis of thiopurine methyltransferase activity in human and pig]
Sichuan Da Xue Xue Bao Yi Xue Ban
37
460-3
2006
Homo sapiens, Sus scrofa
Schedel, J; Gödde, A; Schütz, E; Bongartz, TA; Lang, B; Schölmerich, J; Müller-Ladner, U
Impact of thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrations in patients with chronic inflammatory diseases.
Ann N Y Acad Sci
1069
477-91
2006
Homo sapiens
Heneghan, MA; Allan, ML; Bornstein, JD; Muir, AJ; Tendler, DA
Utility of thiopurine methyltransferase genotyping and phenotyping, and measurement of azathioprine metabolites in the management of patients with autoimmune hepatitis.
J Hepatol
45
584-591
2006
Homo sapiens
Sasaki, T; Goto, E; Konno, Y; Hiratsuka, M; Mizugaki, M
Three novel single nucleotide polymorphisms of the human thiopurine s-methyltransferase gene in Japanese individuals.
Drug Metab Pharmacokinet
21
332-6
2006
Homo sapiens
Davison, JE; McMullin, MF; Catherwood, MA
Genotyping of thiopurine methyltransferase in patients with acute leukemia using LightCycler PCR.
Leuk Lymphoma
47
1624-8
2006
Homo sapiens
Lennard, L; Richards, S; Cartwright, CS; Mitchell, C; Lilleyman, JS; Vora, A; ,
The thiopurine methyltransferase genetic polymorphism is associated with thioguanine-related veno-occlusive disease of the liver in children with acute lymphoblastic leukemia.
Clin Pharmacol Ther
80
375-83
2006
Homo sapiens
Gisbert, JP; Niño, P; Rodrigo, L; Cara, C; Guijarro, LG
Thiopurine methyltransferase (TPMT) activity and adverse effects of azathioprine in inflammatory bowel disease: long-term follow-up study of 394 patients.
Am J Gastroenterol
101
2769-76
2006
Homo sapiens
Derijks, LJ; van Helden, RB; Hommes, DW; Stokkers, PC
Dosing azathioprine in thiopurine S-methyltransferase deficient inflammatory bowel disease patients.
Gut
57
872
2008
Homo sapiens
Ban, H; Andoh, A; Tanaka, A; Tsujikawa, T; Sasaki, M; Saito, Y; Fujiyama, Y
Analysis of thiopurine S-methyltransferase genotypes in Japanese patients with inflammatory bowel disease.
Intern Med
47
1645-8
2008
Homo sapiens
Dokmanović, L; Janić, D; Krstovski, N; Zukić, B; Tosić, N; Pavlović, S
[Importance of genotyping of thiopurine S-methyltransferase in children with acute lymphoblastic leukaemia during maintenance therapy]
Srp Arh Celok Lek
136
609-16
0
Homo sapiens
Cao, Q; Zhu, Q; Shang, Y; Gao, M; Si, J
Thiopurine methyltransferase gene polymorphisms in Chinese patients with inflammatory bowel disease.
Digestion
79
58-63
2009
Homo sapiens
Tani, C; Mosca, M; Colucci, R; Gori, G; d'Ascanio, A; Ghisu, N; Fornai, M; Di Paolo, A; Blandizzi, C; Del Tacca, M; Bombardieri, S
Genetic polymorphisms of thiopurine S-methyltransferase in a cohort of patients with systemic autoimmune diseases.
Clin Exp Rheumatol
27
321-4
0
Homo sapiens
Takatsu, N; Matsui, T; Murakami, Y; Ishihara, H; Hisabe, T; Nagahama, T; Maki, S; Beppu, T; Takaki, Y; Hirai, F; Yao, K
Adverse reactions to azathioprine cannot be predicted by thiopurine S-methyltransferase genotype in Japanese patients with inflammatory bowel disease.
J Gastroenterol Hepatol
24
1258-64
2009
Homo sapiens
Kapoor, G; Sinha, R; Naithani, R; Chandgothia, M
Thiopurine S-methyltransferase gene polymorphism and 6-mercaptopurine dose intensity in Indian children with acute lymphoblastic leukemia.
Leuk Res
2010
Homo sapiens
Gazouli, M; Pachoula, I; Panayotou, I; Mantzaris, G; Syriopoulou, VP; Goutas, N; Vlachodimitropoulos, D; Anagnou, NP; Roma-Giannikou, E
Thiopurine S-methyltransferase genotype and the use of thiopurines in paediatric inflammatory bowel disease Greek patients.
J Clin Pharm Ther
35
93-7
2010
Homo sapiens
Mokmak, W; Tongsima, S; Jenwitheesuk, E
Molecular dynamics simulation of a human thiopurine S-methyltransferase complexed with 6-mercaptopurine model.
Bioinformation
4
59-62
2009
Homo sapiens
Kim, JH; Cheon, JH; Hong, SS; Eun, CS; Byeon, JS; Hong, SY; Kim, BY; Kwon, SH; Kim, SW; Han, DS; Yang, SK; Kim, WH
Influences of Thiopurine Methyltransferase Genotype and Activity on Thiopurine-induced Leukopenia in Korean Patients With Inflammatory Bowel Disease: A Retrospective Cohort Study.
J Clin Gastroenterol
2010
Homo sapiens
Barlow, NL; Graham, V; Berg, JD
Expressing thiopurine S-methyltransferase activity as units per litre of whole-blood overcomes misleading high results in patients with anaemia.
Ann Clin Biochem
47
408-14
2010
Homo sapiens
Appell, ML; Wennerstrand, P; Peterson, C; Hertervig, E; Mrtensson, LG
Characterization of a novel sequence variant, TPMT*28, in the human thiopurine methyltransferase gene.
Pharmacogenet Genomics
20
700-7
2010
Homo sapiens, Escherichia coli
Dewit, O
Usefulness of thiopurine methyltransferase and thiopurine metabolite analysis in clinical practice in patients with inflammatory bowel diseases.
Acta Gastroenterol Belg
73
331-5
0
Homo sapiens
Peregud-Pogorzelski, J; Tetera-Rudnicka, E; Kurzawski, M; Brodkiewicz, A; Adrianowska, N; Mlynarski, W; Januszkiewicz, D; Drozdzik, M
Thiopurine S-methyltransferase (TPMT) polymorphisms in children with acute lymphoblastic leukemia, and the need for reduction or cessation of 6-mercaptopurine doses during maintenance therapy: The Polish multicenter analysis.
Pediatr Blood Cancer
2011
Homo sapiens
Donnan, JR; Ungar, WJ; Mathews, M; Hancock-Howard, RL; Rahman, P
A cost effectiveness analysis of thiopurine methyltransferase testing for guiding 6-mercaptopurine dosing in children with acute lymphoblastic leukemia.
Pediatr Blood Cancer
2011
Homo sapiens
Albayrak, M; Konyssova, U; Kaya, Z; Gursel, T; Guntekin, S; Percin, EF; Kocak, U
Thiopurine methyltransferase polymorphisms and mercaptopurine tolerance in Turkish children with acute lymphoblastic leukemia.
Cancer Chemother Pharmacol
2011
Homo sapiens
Loit, E; Tricco, AC; Tsouros, S; Sears, M; Ansari, MT; Booth, RA
Pre-analytic and analytic sources of variations in thiopurine methyltransferase activity measurement in patients prescribed thiopurine-based drugs: A systematic review.
Clin Biochem
2011
Homo sapiens
Booth, RA; Ansari, MT; Loit, E; Tricco, AC; Weeks, L; Doucette, S; Skidmore, B; Sears, M; Sy, R; Karsh, J
Assessment of thiopurine S-methyltransferase activity in patients prescribed thiopurines: a systematic review.
Ann Intern Med
154
814-23, W-295-8
2011
Homo sapiens
Uppugunduri, CR; Ansari, M
Influence of age, sex, and haplotypes of thiopurine methyltransferase (TPMT) gene on 6- mercaptopurine toxicity in children with acute lymphoblastic leukemia.
Eur J Clin Pharmacol
2011
Homo sapiens
Larussa, T; Suraci, E; Lentini, M; Nazionale, I; Gallo, L; Abenavoli, L; Imeneo, M; Costanzo, FS; Cuda, G; Luzza, F
High prevalence of polymorphism and low activity of thiopurine methyltransferase in patients with inflammatory bowel disease.
Eur J Intern Med
23
273-7
2012
Homo sapiens
Lee, CK; Loh, TP; Wong, ST; Lee, HK; Huan, PT; Chiu, LL; Koay, ES
Detection of a Novel Single Nucleotide Polymorphism of the Human Thiopurine S-Methyltransferase gene in a Chinese Individual.
Drug Metab Pharmacokinet
2012
Homo sapiens, Pompholyx
Chrzanowska, M; Kuehn, M; Januszkiewicz-Lewandowska, D; Kurzawski, M; Dro?dzik, M
Thiopurine S-methyltransferase phenotype-genotype correlation in children with acute lymphoblastic leukemia.
Acta Pol Pharm
69
405-10
0
Homo sapiens
Desatova, B; Hlavaty, T; Balakova, D; Pav, I; Celec, P; Gregus, M; Zakuciova, M; Hlista, M; Horakova, M; Kadasi, L; Huorka, M; Batovsky, M
Prevalence of mutations in thiopurine S-methyltransferase gene among Slovak IBD patients.
Bratisl Lek Listy
113
282-4
2012
Homo sapiens
Zhu, Q; Cao, Q
Thiopurine methyltransferase gene polymorphisms and activity in Chinese patients with inflammatory bowel disease treated with azathioprine.
Chin Med J (Engl)
125
3665-70
2012
Homo sapiens
Booth, RA; Ansari, MT; Tricco, AC; Loit, E; Weeks, L; Doucette, S; Skidmore, B; Hoch, JS; Tsouros, S; Sears, M; Sy, R; Karsh, J; Mani, S; Galipeau, J; Yurkiewich, A; Daniel, R; Tsertsvadze, A; Yazdi, F
Assessment of thiopurine methyltransferase activity in patients prescribed azathioprine or other thiopurine-based drugs.
Evid Rep Technol Assess (Full Rep)
1-282
2010
Homo sapiens
Fangbin, Z; Xiang, G; Minhu, C; Liang, D; Feng, X; Min, H; Pinjin, H
Should thiopurine methyltransferase genotypes and phenotypes be measured before thiopurine therapy in patients with inflammatory bowel disease?
Ther Drug Monit
34
695-701
2012
Homo sapiens
Garrido, C; Santizo, VG; Mllers, P; Soriano, DR; Avila, GB; Dean, M; Jimenez-Morales, S
Frequency of thiopurine S-methyltransferase mutant alleles in indigenous and admixed Guatemalan patients with acute lymphoblastic leukemia.
Med Oncol
30
474
2013
Homo sapiens
Chocholova, A; Soltysova, A; Minarik, G; Cierna, I; Sufliarska, S; Mladosievicova, B
Thiopurine s-methyltransferase gene polymorphisms in a healthy slovak population and pediatric patients with inflammatory bowel disease.
Nucleosides Nucleotides Nucleic Acids
32
239-46
2013
Homo sapiens
Desatova, B; Hlavaty, T; Balakova, D; Pav, I; Celec, P; Gregus, M; Zakuciova, M; Hlista, M; Horakova, M; Kadasi, L; Huorka, M; Batovsky, M
Prevalence of mutations in thiopurine S-methyltransferase gene among Slovak IBD patients.
Bratisl Lek Listy
114
330-2
2013
Homo sapiens
Karim, H; Ghalali, A; Lafolie, P; Vitols, S; Fotoohi, AK
Differential role of thiopurine methyltransferase in the cytotoxic effects of 6-mercaptopurine and 6-thioguanine on human leukemia cells.
Biochem Biophys Res Commun
437
280-6
2013
Homo sapiens
Moreno-Guerrero, SS; Ramrez-Pacheco, A; Dorantes-Acosta, EM; Medina-Sanson, A
[Analysis of genetic polymorphisms of thiopurine S-methyltransferase (TPMT) in Mexican pediatric patients with cancer].
Rev Invest Clin
65
156-64
0
Homo sapiens
Karim, H; Appell, ML; Fotoohi, A
Comparison of three methods for measuring thiopurine methyltransferase activity in red blood cells and human leukemia cells.
J Chromatogr B Analyt Technol Biomed Life Sci
939
80-5
2013
Homo sapiens
Chen, D; Lian, F; Yuan, S; Wang, Y; Zhan, Z; Ye, Y; Qiu, Q; Xu, H; Liang, L; Yang, X
Association of thiopurine methyltransferase status with azathioprine side effects in Chinese patients with systemic lupus erythematosus.
Clin Rheumatol
33
499-503
2014
Homo sapiens
Ayesh, BM; Harb, WM; Abed, AA
Thiopurine methyltransferase genotyping in Palestinian childhood acute lymphoblastic leukemia patients.
BMC Hematol
13
3
2013
Homo sapiens
Zhang, B; Xu, XW; Zeng, XJ; Li, DK
Correlation of thiopurine methyltransferase activity and 6-thioguanine nucleotide concentration in Han Chinese patients treated with azathioprine 25 to 100 mg: A 1-year, single-center, prospective study.
Curr Ther Res Clin Exp
67
270-82
2006
Homo sapiens
Ramsey, LB; Janke, LJ; Edick, MJ; Cheng, C; Williams, RT; Sherr, CJ; Evans, WE; Relling, MV
Host thiopurine methyltransferase status affects mercaptopurine antileukemic effectiveness in a murine model.
Pharmacogenet Genomics
24
263-71
2014
Mus musculus, Homo sapiens
Gazouli, M; Pachoula, I; Panayotou, I; Chouliaras, G; Anagnou, NP; Chroussos, G; Roma, E
Thiopurine methyltransferase genotype and thiopurine S-methyltransferase activity in Greek children with inflammatory bowel disease.
Ann Gastroenterol
25
249-253
2012
Homo sapiens
Azimi, F; Jafariyan, M; Khatami, S; Mortazavi, Y; Azad, M
Assessment of Thiopurine-based drugs according to Thiopurine S-methyltransferase genotype in patients with Acute Lymphoblastic Leukemia.
Iran J Ped Hematol Oncol
4
32-8
2014
Homo sapiens
Xie, C; Yue, LJ; Ding, H; Ren, YF; Yang, CL; Zheng, MM
[Correlations between 6-mercaptopurine treatment-related adverse reactions in children with acute lymphoblastic leukemia and polymorphisms of thiopurine methyltransferase gene].
Zhongguo Dang Dai Er Ke Za Zhi
16
499-503
2014
Homo sapiens
Linga, VG; Patchva, DB; Mallavarapu, KM; Tulasi, V; Kalpathi, KI; Pillai, A; Gundeti, S; Rajappa, SJ; Digumarti, R
Thiopurine methyltransferase polymorphisms in children with acute lymphoblastic leukemia.
Indian J Med Paediatr Oncol
35
276-80
2014
Homo sapiens
Liu, YP; Wu, HY; Yang, X; Xu, HQ; Li, YC; Shi, DC; Huang, JF; Huang, Q; Fu, WL
Association between thiopurine S-methyltransferase polymorphisms and thiopurine-induced adverse drug reactions in patients with inflammatory bowel disease: a meta-analysis.
PLoS One
10
e0121745
2015
Homo sapiens
Emmungil, H; Durusoy, R; Kalfa, M; Yargucu Zihni, F; zmen, M; Keser, G; Gcenmez, S; Yilmaz, Z; Aksu, K
Plasma thiopurine S-methyltransferase levels and azathioprine-related adverse events in patients with Behet's disease.
Clin Exp Rheumatol
33
S40-5
0
Homo sapiens
Liu, YP; Xu, HQ; Li, M; Yang, X; Yu, S; Fu, WL; Huang, Q
Association between Thiopurine S-Methyltransferase Polymorphisms and Azathioprine-Induced Adverse Drug Reactions in Patients with Autoimmune Diseases: A Meta-Analysis.
PLoS One
10
e0144234
2015
Homo sapiens
El-Rashedy, FH; Ragab, SM; Dawood, AA; Temraz, SA
Clinical implication of thiopurine methyltransferase polymorphism in children with acute lymphoblastic leukemia: A preliminary Egyptian study.
Indian J Med Paediatr Oncol
36
265-70
0
Homo sapiens
Roy, LM; Zur, RM; Uleryk, E; Carew, C; Ito, S; Ungar, WJ
Thiopurine S-methyltransferase testing for averting drug toxicity in patients receiving thiopurines: a systematic review.
Pharmacogenomics
2016
Homo sapiens
Zhu, X; Wang, XD; Chao, K; Zhi, M; Zheng, H; Ruan, HL; Xin, S; Ding, N; Hu, PJ; Huang, M; Gao, X
NUDT15 polymorphisms are better than thiopurine S-methyltransferase as predictor of risk for thiopurine-induced leukopenia in Chinese patients with Crohn's disease.
Aliment Pharmacol Ther
2016
Homo sapiens
Di Salvo, A; Fabiano, C; Mannara, V; Dimarco, M; Orlando, A; Affronti, M; Macaluso, FS; Cottone, M
Frequency of thiopurine methyltransferase mutation in patients of Mediterranean area with inflammatory bowel disease and autoimmune disorders.
Dig Liver Dis
48
1506-1509
2016
Homo sapiens
Jimnez-Morales, S; Ramrez-Florencio, M; Meja-Arangur, JM; Nez-Enrquez, JC; Bekker-Mendez, C; Torres-Escalante, JL; Flores-Lujano, J; Jimnez-Hernndez, E; Del Carmen Rodrguez-Zepeda, M; Leal, YA; Gonzlez-Montalvo, PM; Pantoja-Guillen, F; Pealoza-Gonzalez, JG; Gutirrez-Jurez, EI; Nez-Villegas, NN; Prez-Saldivar, ML; Guerra-Castillo, FX; Flores-Villegas, LV; Ramos-Cervantes, MT; Fragoso, JM; Garca-Escalante, MG; Del Carmen Pinto-Escalante, D; Ramrez-Bello, J; Hidalgo-Miranda, A
Analysis of Thiopurine S-Methyltransferase Deficient Alleles in Acute Lymphoblastic Leukemia Patients in Mexican Patients.
Arch Med Res
47
615-622
2016
Homo sapiens
Bahrehmand, F; Vaisi-Raygani, A; Kiani, A; Bashiri, H; Zobeiri, M; Tanhapour, M; Pourmotabbed, T
Whole-Blood Thiopurine S-Methyltransferase Genotype and Phenotype Concordance in Iranian Kurdish Ulcerative Colitis (UC) Patients.
Clin Lab
63
947-954
2017
Homo sapiens
Wiwattanakul, S; Prommas, S; Jenjirattithigarn, N; Santon, S; Puangpetch, A; Pakakasama, S; Anurathapan, U; Sukasem, C
Development and validation of a reliable method for thiopurine methyltransferase (TPMT) enzyme activity in human whole blood by LC-MS/MS: An application for phenotypic and genotypic correlations.
J Pharm Biomed Anal
145
758-764
2017
Homo sapiens
Coucoutsi, C; Emmanouil, G; Goulielmos, G; Sfakianaki, O; Koutroubakis, IE; Kouroumalis, EA
Prevalence of thiopurine S-methyltransferase gene polymorphisms in patients with inflammatory bowel disease from the island of Crete, Greece.
Eur J Gastroenterol Hepatol
2017
Homo sapiens
Lee, M; Seo, J; Bang, D; Kim, DY
Thiopurine S-Methyltransferase Polymorphisms in Korean Dermatologic Patients.
Ann Dermatol
29
529-535
2017
Homo sapiens
Gong, X; Mei, S; Li, X; Li, X; Zhou, H; Liu, Y; Zhou, A; Yang, L; Zhao, Z; Zhang, X
Association between TPMT*3C and decreased thiopurine S-methyltransferase activity in patients with neuromyelitis optica spectrum disorders in China.
Int J Neurosci
128
549-553
2018
Homo sapiens
Ramirez-Florencio, M; Jimnez-Morales, S; Barbosa-Cobos, RE; Lpez-Cano, DJ; Ramrez-Bello, J
High frequency of mutant thiopurine S-methyltransferase genotypes in Mexican patients with systemic lupus erythematosus and rheumatoid arthritis.
Clin Rheumatol
37
963-970
2018
Homo sapiens
Tantawy, AAG; Ebeid, FSE; Adly, AAM; El-Ghoroury, E; Mostafa, M
Influence of thiopurine methyltransferase gene polymorphism on Egyptian children with acute lymphoblastic leukaemia.
J Genet
96
905-910
2017
Homo sapiens
Guillotin, V; Galli, G; Viallard, JF
[Usefulness of thiopurine methyltransferase polymorphism study and metabolites measurement for patients treated by azathioprine].
Rev Med Interne
2018
Homo sapiens
Alsous, M; Yousef, AM; Abdel Jalil, M; Zawiah, M; Yacoub, S; Momani, D; Gharabli, A; Omar, S; Rihani, R
Genetic Polymorphism of Thiopurine S-methyltransferase in Children with Acute Lymphoblastic Leukemia in Jordan
Asian Pac J Cancer Prev
19
199-205
2018
Homo sapiens
Gong, X; Mei, S; Li, X; Li, X; Zhou, H; Liu, Y; Zhou, A; Yang, L; Zhao, Z; Zhang, X
WITHDRAWN: Association between TPMT*3C and decreased thiopurine S-methyltransferase activity in patients with neuromyelitis optica spectrum disorders in China.
J Clin Neurosci
2018
Homo sapiens
Buhl, MA; Gmez, G; Collado, MV; Oddo, EM; Khoury, M; Azurmendi, PJ; Sarano, J
[Genetic polymorphisms of thiopurine methyltransferase and incidence of adverse events in patients with medical indication of azathioprine].
Medicina (B Aires)
78
65-70
2018
Homo sapiens
Sobiak, J; Skalska-Sadowska, J; Chrzanowska, M; Resztak, M; Ko?tan, S; Wysocki, M; Wachowiak, J
Thiopurine methyltransferase activity in children with acute myeloid leukemia.
Oncol Lett
16
4699-4706
2018
Homo sapiens
Ak?n, DF; A?lar-ner, D; Kreki, E; Akar, N
Frequency of thiopurine S-methyltransferase gene variations in Turkish children with acute leukemia.
Turk J Pediatr
60
147-152
2018
Homo sapiens
Ambar, G; Vandana, A; Lalit, D; Jyoti, K
Thiopurine S-methyltransferase (TPMT) Mutation Prevalence and Myelosuppression Frequency in North Indian Patients with Autoimmune Disorders.
J Assoc Physicians India
66
39-44
2018
Homo sapiens
Trnok, A
[Frequency of serious adverse events of thiopurine treatment in normal thiopurine S-methyltransferase genotype children with inflammatory bowel disease].
Orv Hetil
160
179-185
2019
Homo sapiens
Rucci, F; Cigoli, MS; Marini, V; Fucile, C; Mattioli, F; Robbiano, L; Cavallari, U; Scaglione, F; Perno, CF; Penco, S; Marocchi, A
Combined evaluation of genotype and phenotype of thiopurine S-methyltransferase (TPMT) in the clinical management of patients in chronic therapy with azathioprine.
Drug Metab Pers Ther
34
2019
Homo sapiens
Ribaldone, DG; Adriani, A; Caviglia, GP; Nicol, A; Agnesod, D; Simiele, M; Rigan, D; Pellicano, R; Canaparo, R; Perri, GD; D'Avolio, A; Luzza, F; Saracco, GM; Astegiano, M
Correlation between Thiopurine S-Methyltransferase Genotype and Adverse Events in Inflammatory Bowel Disease Patients.
Medicina (Kaunas)
55
2019
Homo sapiens
Su, SS; Lin, YF; Zhou, H
Association of thiopurine S-methyltransferase and NUDT15 polymorphisms with azathioprine-induced myelotoxicity in Chinese patients with rheumatological disease.
Chin Med J (Engl)
2020
Homo sapiens
Zalizko, P; Stefanovics, J; Sokolovska, J; Paramonova, N; Klavina, E; Erts, R; Rovite, V; Klovins, J; Pukitis, A
Thiopurine S-methyltransferase genetic polymorphisms in adult patients with inflammatory bowel diseases in the Latvian population.
Therap Adv Gastroenterol
13
1756284820937426
2020
Homo sapiens
Mokhtari, M; Mostanbet, F; Nekooee Fard, S; Shekarkhar, G; Sepaskhah, M; Sadati, MS
Thiopurine S-methyltransferase and Pemphigus Vulgaris: A Phenotype-Genotype Study.
Iran J Pathol
15
299-305
2020
Pemphigus
Bayoumy, AB; Mulder, CJJ; Loganayagam, A; Sanderson, JD; Anderson, S; Boekema, PJ; Derijks, LJJ; Ansari, AR
Relationship Between Thiopurine S-Methyltransferase Genotype/Phenotype and 6-Thioguanine Nucleotide Levels in 316 Patients With Inflammatory Bowel Disease on 6-Thioguanine.
Ther Drug Monit
43
617-623
2021
Homo sapiens
Stocco, G; Cuzzoni, E; De Iudicibus, S; Franca, R; Favretto, D; Malus, N; Londero, M; Cont, G; Bartoli, F; Martelossi, S; Ventura, A; Decorti, G
Deletion of Glutathione-S-Transferase M1 Reduces Azathioprine Metabolite Concentrations in Young Patients With Inflammatory Bowel Disease.
J Clin Gastroenterol
2013
Homo sapiens
Kerstens, PJ; Stolk, JN; De Abreu, RA; Lambooy, LH; van de Putte, LB; Boerbooms, AA
Azathioprine-related bone marrow toxicity and low activities of purine enzymes in patients with rheumatoid arthritis.
Arthritis Rheum
38
142-5
1995
Homo sapiens
Stolk, JN; Boerbooms, AM; De Abreu, RA; Kerstens, PJ; de Koning, DG; de Graaf, R; Mulder, J; van de Putte, LB
Purine enzyme activities in recent onset rheumatoid arthritis: are there differences between patients and healthy controls?
Ann Rheum Dis
55
733-8
1996
Homo sapiens
Ridder, L; Dieren, JM; Van Deventer, HJ; Stokkers, PC; Van der Woude, JC; Van Vuuren, AJ; Benninga, MA; Escher, JC; Hommes, DW
Pharmacogenetics of thiopurine therapy in paediatric IBD patients.
Aliment Pharmacol Ther
23
1137-41
2006
Homo sapiens
Schaeffeler, E; Jaeger, SU; Klumpp, V; Yang, JJ; Igel, S; Hinze, L; Stanulla, M; Schwab, M
Impact of NUDT15 genetics on severe thiopurine-related hematotoxicity in patients with European ancestry.
Genet Med
2019
Homo sapiens
Park, Y; Kim, H; Choi, JY; Yun, S; Min, BJ; Seo, ME; Im, HJ; Kang, HJ; Kim, JH
Star Allele-Based Haplotyping versus Gene-Wise Variant Burden Scoring for Predicting 6-Mercaptopurine Intolerance in Pediatric Acute Lymphoblastic Leukemia Patients.
Front Pharmacol
10
654
2019
Homo sapiens
Wahlund, M; Nilsson, A; Kahlin, AZ; Broliden, K; Myrberg, IH; Appell, ML; Berggren, A
The Role of TPMT, ITPA, and NUDT15 Variants during Mercaptopurine Treatment of Swedish Pediatric Patients with Acute Lymphoblastic Leukemia.
J Pediatr
216
150-157.e1
2020
Homo sapiens
Lee, MN; Kang, B; Choi, SY; Kim, MJ; Woo, SY; Kim, JW; Choe, YH; Lee, SY
Impact of Genetic Polymorphisms on 6-Thioguanine Nucleotide Levels and Toxicity in Pediatric Patients with IBD Treated with Azathioprine.
Inflamm Bowel Dis
21
2897-908
2015
Homo sapiens
Wan Rosalina, WR; Teh, LK; Mohamad, N; Nasir, A; Yusoff, R; Baba, AA; Salleh, MZ
Polymorphism of ITPA 94C>A and risk of adverse effects among patients with acute lymphoblastic leukaemia treated with 6-mercaptopurine.
J Clin Pharm Ther
2011
Homo sapiens
Zabala-Fernndez, W; Barreiro-de Acosta, M; Echarri, A; Carpio, D; Lorenzo, A; Castro, J; Martnez-Ares, D; Pereira, S; Martin-Granizo, I; Corton, M; Carracedo, A; Barros, F
A pharmacogenetics study of TPMT and ITPA genes detects a relationship with side effects and clinical response in patients with inflammatory bowel disease receiving Azathioprine.
J Gastrointestin Liver Dis
20
247-53
2011
Homo sapiens
Odahara, S; Uchiyama, K; Kubota, T; Ito, Z; Takami, S; Kobayashi, H; Saito, K; Koido, S; Ohkusa, T
A Prospective Study Evaluating Metabolic Capacity of Thiopurine and Associated Adverse Reactions in Japanese Patients with Inflammatory Bowel Disease (IBD).
PLoS One
10
e0137798
2015
Homo sapiens
Steponaitiene, R; Kupcinskas, J; Survilaite, S; Varkalaite, G; Jonaitis, L; Kiudelis, G; Denapiene, G; Valantinas, J; Skieceviciene, J; Kupcinskas, L
TPMT and ITPA genetic variants in Lithuanian inflammatory bowel disease patients: Prevalence and azathioprine-related side effects.
Adv Med Sci
61
135-40
2016
Homo sapiens
Fotoohi, AK; Lindqvist, M; Peterson, C; Albertioni, F
Impaired transport as a mechanism of resistance to thiopurines in human T-lymphoblastic leukemia cells.
Nucleosides Nucleotides Nucleic Acids
25
1039-44
2006
Homo sapiens
Lee, DH; Kim, DH
S-methylation of 2-mercaptopyrazine in rat liver microsomes and cytosol.
Xenobiotica
29
909-16
1999
Rattus
Aroz, HV; D'Aloi, K; Foncuberta, ME; Sanchez La Rosa, CG; Alonso, CN; Chertkoff, L; Felice, M
Pharmacogenetic studies in children with acute lymphoblastic leukemia in Argentina.
Leuk Lymphoma
56
1370-8
2015
Homo sapiens, Argentina
Schmiegelow, K; Heyman, M; Gustafsson, G; Lausen, B; Wesenberg, F; Kristinsson, J; Vettenranta, K; Schroeder, H; Forestier, E; Rosthoej, S; ,
The degree of myelosuppression during maintenance therapy of adolescents with B-lineage intermediate risk acute lymphoblastic leukemia predicts risk of relapse.
Leukemia
24
715-20
2010
Homo sapiens
Revollo, J; Petibone, DM; McKinzie, P; Knox, B; Morris, SM; Ning, B; Dobrovolsky, VN
Whole genome and normalized mRNA sequencing reveal genetic status of TK6, WTK1, and NH32 human B-lymphoblastoid cell lines.
Mutat Res Genet Toxicol Environ Mutagen
795
60-9
2016
Homo sapiens
Weinshilboum, RM
Human pharmacogenetics of methyl conjugation.
Fed Proc
43
2303-7
1984
Homo sapiens
Yang, JJ; Lim, JY; Huang, J; Bass, J; Wu, J; Wang, C; Fang, J; Stewart, E; Harstead, EH; E, S; Robinson, GW; Evans, WE; Pappo, A; Zuo, J; Relling, MV; Onar-Thomas, A; Gajjar, A; Stewart, CF
The role of inherited TPMT and COMT genetic variation in cisplatin-induced ototoxicity in children with cancer.
Clin Pharmacol Ther
94
252-9
2013
Homo sapiens, Mus sp.
Hagleitner, MM; Coenen, MJ; Patino-Garcia, A; de Bont, ES; Gonzalez-Neira, A; Vos, HI; van Leeuwen, FN; Gelderblom, H; Hoogerbrugge, PM; Guchelaar, HJ; Te Loo, MW
Influence of genetic variants in TPMT and COMT associated with cisplatin induced hearing loss in patients with cancer: two new cohorts and a meta-analysis reveal significant heterogeneity between cohorts.
PLoS One
9
e115869
2014
Homo sapiens
Loo, G; Smith, JT
Effect of S-adenosylhomocysteine on sulfhydryl xenobiotic transmethylases in rat liver.
Biochem Biophys Res Commun
128
965-71
1985
Rattus, Metazoa
Evans, WE; Horner, M; Chu, YQ; Kalwinsky, D; Roberts, WM
Altered mercaptopurine metabolism, toxic effects, and dosage requirement in a thiopurine methyltransferase-deficient child with acute lymphocytic leukemia.
J Pediatr
119
985-9
1991
Homo sapiens
Qing, WG; Powell, KL; Stoica, G; Szumlanski, CL; Weinshilboum, RM; Macleod, MC
Toxicity and metabolism in mice of 2,6-dithiopurine, a potential chemopreventive agent.
Drug Metab Dispos
23
854-60
1995
Mus sp., Mus musculus, Metazoa
Kearns, GL
Pharmacogenetics and development: are infants and children at increased risk for adverse outcomes?
Curr Opin Pediatr
7
220-33
1995
Homo sapiens
Giverhaug, T; Fuskevaag, OM; Aarbakke, J
Methotrexate increases red blood cell concentrations of 6-methylmercaptopurine ribonucleotide in rats in vivo.
Cancer Chemother Pharmacol
40
367-70
1997
Rattus
Relling, MV; Yanishevski, Y; Nemec, J; Evans, WE; Boyett, JM; Behm, FG; Pui, CH
Etoposide and antimetabolite pharmacology in patients who develop secondary acute myeloid leukemia.
Leukemia
12
346-52
1998
Homo sapiens
Pui, CH; Boyett, JM; Relling, MV; Harrison, PL; Rivera, GK; Behm, FG; Sandlund, JT; Ribeiro, RC; Rubnitz, JE; Gajjar, A; Evans, WE
Sex differences in prognosis for children with acute lymphoblastic leukemia.
J Clin Oncol
17
818-24
1999
Homo sapiens
Dewit, O; Vanheuverzwyn, R; Desager, JP; Horsmans, Y
Interaction between azathioprine and aminosalicylates: an in vivo study in patients with Crohn's disease.
Aliment Pharmacol Ther
16
79-85
2002
Homo sapiens
Dubinsky, MC; Yang, H; Hassard, PV; Seidman, EG; Kam, LY; Abreu, MT; Targan, SR; Vasiliauskas, EA
6-MP metabolite profiles provide a biochemical explanation for 6-MP resistance in patients with inflammatory bowel disease.
Gastroenterology
122
904-15
2002
Homo sapiens
Hibi, T; Naganuma, M; Kitahora, T; Kinjyo, F; Shimoyama, T
Low-dose azathioprine is effective and safe for maintenance of remission in patients with ulcerative colitis.
J Gastroenterol
38
740-6
2003
Homo sapiens
Haglund, S; Lindqvist, M; Almer, S; Peterson, C; Taipalensuu, J
Pyrosequencing of TPMT alleles in a general Swedish population and in patients with inflammatory bowel disease.
Clin Chem
50
288-95
2004
Homo sapiens
Watters, JW; Zhang, W; Meucci, MA; Hou, W; Ma, MK; McLeod, HL
Analysis of variation in mouse TPMT genotype, expression and activity.
Pharmacogenetics
14
247-54
2004
Mus musculus
Derijks, LJ; Gilissen, LP; Engels, LG; Bos, LP; Bus, PJ; Lohman, JJ; Curvers, WL; Van Deventer, SJ; Hommes, DW; Hooymans, PM
Pharmacokinetics of 6-mercaptopurine in patients with inflammatory bowel disease: implications for therapy.
Ther Drug Monit
26
311-8
2004
Homo sapiens
Roblin, X; Serre-Debeauvais, F; Phelip, JM; Faucheron, JL; Hardy, G; Chartier, A; Helluwaert, F; Bessard, G; Bonaz, B
6-tioguanine monitoring in steroid-dependent patients with inflammatory bowel diseases receiving azathioprine.
Aliment Pharmacol Ther
21
829-39
2005
Homo sapiens
Hisamatsu, T; Hibi, T
[Immunosuppressants for therapy of patients with ulcerative colitis]
Nippon Rinsho
63
831-5
2005
Homo sapiens
Gilissen, LP; Bierau, J; Derijks, LJ; Bos, LP; Hooymans, PM; van Gennip, A; Stockbrügger, RW; Engels, LG
The pharmacokinetic effect of discontinuation of mesalazine on mercaptopurine metabolite levels in inflammatory bowel disease patients.
Aliment Pharmacol Ther
22
605-11
2005
Homo sapiens
Dubinsky, MC; Reyes, E; Ofman, J; Chiou, CF; Wade, S; Sandborn, WJ
A cost-effectiveness analysis of alternative disease management strategies in patients with Crohn's disease treated with azathioprine or 6-mercaptopurine.
Am J Gastroenterol
100
2239-47
2005
Homo sapiens
Hindorf, U; Lindqvist, M; Hildebrand, H; Fagerberg, U; Almer, S
Adverse events leading to modification of therapy in a large cohort of patients with inflammatory bowel disease.
Aliment Pharmacol Ther
24
331-42
2006
Homo sapiens
Zhan, ZP; Yang, XY; Liang, LQ; Wang, YX; Huang, M; Lian, F
[The profile and clinical significance of azathioprine metabolic enzymes activity in rheumatological patients]
Zhonghua Nei Ke Za Zhi
45
537-9
2006
Homo sapiens
Morales, A; Salguti, S; Miao, CL; Lewis, JD
Relationship between 6-mercaptopurine dose and 6-thioguanine nucleotide levels in patients with inflammatory bowel disease.
Inflamm Bowel Dis
13
380-5
2007
Homo sapiens
Wu, H; Horton, JR; Battaile, K; Allali-Hassani, A; Martin, F; Zeng, H; Loppnau, P; Vedadi, M; Bochkarev, A; Plotnikov, AN; Cheng, X
Structural basis of allele variation of human thiopurine-S-methyltransferase.
Proteins
67
198-208
2007
Homo sapiens, Bacteria
Zhan, ZP; Liang, LQ; Yang, XY; Wang, YX; Huang, M; Li, H
[Association between metabolic enzyme genotype of azathioprine and drug tolerance in patients with rheumatic diseases]
Zhonghua Yi Xue Za Zhi
87
1734-7
2007
Homo sapiens
Wise, M; Callen, JP
Azathioprine: a guide for the management of dermatology patients.
Dermatol Ther
20
206-15
0
Homo sapiens
de Boer, NK; van Bodegraven, AA; Jharap, B; de Graaf, P; Mulder, CJ
Drug Insight: pharmacology and toxicity of thiopurine therapy in patients with IBD.
Nat Clin Pract Gastroenterol Hepatol
4
686-94
2007
Homo sapiens
Hawwa, AF; Collier, PS; Millership, JS; McCarthy, A; Dempsey, S; Cairns, C; McElnay, JC
Population pharmacokinetic and pharmacogenetic analysis of 6-mercaptopurine in paediatric patients with acute lymphoblastic leukaemia.
Br J Clin Pharmacol
66
826-37
2008
Transformation, Homo sapiens
Roblin, X; Peyrin-Biroulet, L; Biroulet, LP; Phelip, JM; Nancey, S; Flourie, B
A 6-thioguanine nucleotide threshold level of 400 pmol/8 x 10(8) erythrocytes predicts azathioprine refractoriness in patients with inflammatory bowel disease and normal TPMT activity.
Am J Gastroenterol
103
3115-22
2008
Homo sapiens
Hindorf, U; Johansson, M; Eriksson, A; Kvifors, E; Almer, SH
Mercaptopurine treatment should be considered in azathioprine intolerant patients with inflammatory bowel disease.
Aliment Pharmacol Ther
29
654-61
2009
Homo sapiens
van Asseldonk, DP; Kanis, BM; de Boer, NK; van Bodegraven, AA
Leukopenia due to Parvovirus B19 in a Crohn's Disease Patient Using Azathioprine.
Digestion
79
211-214
2009
Homo sapiens
Desire, S; Balasubramanian, P; Bajel, A; George, B; Viswabandya, A; Mathews, V; Srivastava, A; Chandy, M
Frequency of TPMT alleles in Indian patients with acute lymphatic leukemia and effect on the dose of 6-mercaptopurine.
Med Oncol
2009
Homo sapiens
Chen, XW; Yue, LJ; Li, CR; Li, CG; Shi, HS; Zhang, M
[Studies on the mutation and polymorphism of the TPMT gene in Chinese children with acute leukemia]
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
26
457-60
2009
Homo sapiens
Higgs, JE; Payne, K; Roberts, C; Newman, WG
Are patients with intermediate TPMT activity at increased risk of myelosuppression when taking thiopurine medications?
Pharmacogenomics
11
177-88
2010
Homo sapiens
Ferucci, ED; Hurlburt, KJ; Mayo, MJ; Livingston, S; Deubner, H; Gove, J; Plotnik, J; McMahon, BJ
Azathioprine metabolite measurements are not useful in following treatment of autoimmune hepatitis in Alaska Native and other non-Caucasian people.
Can J Gastroenterol
25
21-7
2011
Homo sapiens
Jharap, B; de Boer, NK; Vos, RM; Smid, K; Zwiers, A; Peters, GJ; Mulder, CJ; Wilhelm, AJ; van Bodegraven, AA
Biotransformation of 6-thioguanine in inflammatory bowel disease patients: a comparison of oral and intravenous administration of 6-thioguanine.
Br J Pharmacol
2011
Homo sapiens
Hindorf, U; Andersson, P
How are thiopurines used and monitored by Swedish gastroenterologists when treating patients with inflammatory bowel disease?
Scand J Gastroenterol
2011
Homo sapiens
Hlavaty, T; Batovsky, M; Balakova, D; Pav, I; Celec, P; Gregus, M; Zakuciova, M; Hlista, M; Horakova, M; Desatova, B; Koller, T; Toth, J; Kadasi, L; Huorka, M
The impact of thiopurine-S-methyltransferase genotype on the adverse drug reactions to azathioprine in patients with inflammatory bowel diseases.
Bratisl Lek Listy
114
199-205
2013
Homo sapiens
Davavala, SK; Desai, DC; Abraham, P; Ashavaid, T; Joshi, A; Gupta, T
Prevalence of TPMT polymorphism in Indian patients requiring immunomodulator therapy and its clinical significance.
Indian J Gastroenterol
2013
Homo sapiens
Stensman, LM; Kjeldsen, E; Nersting, J; Schmiegelow, K; Hasle, H
Treatment-related Myelodysplastic Syndrome in a Child With Acute Myeloid Leukemia and TPMT Heterozygosity.
J Pediatr Hematol Oncol
2014
Homo sapiens
Kim, MJ; Lee, SY; Choe, YH
Monitoring thiopurine metabolites in korean pediatric patients with inflammatory bowel disease.
Yonsei Med J
55
1289-96
2014
Homo sapiens
Coenen, MJ; de Jong, DJ; van Marrewijk, CJ; Derijks, LJ; Vermeulen, SH; Wong, DR; Klungel, OH; Verbeek, AL; Hooymans, PM; Peters, WH; te Morsche, RH; Newman, WG; Scheffer, H; Guchelaar, HJ; Franke, B; ,
Identification of Patients With Variants in TPMT and Dose Reduction Reduces Hematologic Events During Thiopurine Treatment of Inflammatory Bowel Disease.
Gastroenterology
149
907-17.e7
2015
Homo sapiens
Wong, DR; Coenen, MJ; Vermeulen, SH; Derijks, LJ; van Marrewijk, CJ; Klungel, OH; Scheffer, H; Franke, B; Guchelaar, HJ; de Jong, DJ; Engels, LG; Verbeek, AL; Hooymans, PM; ,
Early Assessment of Thiopurine Metabolites Identifies Patients at Risk of Thiopurine-induced Leukopenia in Inflammatory Bowel Disease.
J Crohns Colitis
2016
Homo sapiens
Zgheib, NK; Akika, R; Mahfouz, R; Aridi, CA; Ghanem, KM; Saab, R; Abboud, MR; Tarek, N; El Solh, H; Muwakkit, SA
NUDT15 and TPMT genetic polymorphisms are related to 6-mercaptopurine intolerance in children treated for acute lymphoblastic leukemia at the Children's Cancer Center of Lebanon.
Pediatr Blood Cancer
2016
Homo sapiens
McAtee, CL; Schneller, N; Brackett, J; Bernhardt, MB; Schafer, ES
Treatment-related sinusoidal obstruction syndrome in children with de novo acute lymphoblastic leukemia during intensification.
Cancer Chemother Pharmacol
80
1261-1264
2017
Homo sapiens
Fei, X; Shu, Q; Zhu, H; Hua, B; Wang, S; Guo, L; Fang, Y; Ge, W
NUDT15 R139C Variants Increase the Risk of Azathioprine-Induced Leukopenia in Chinese Autoimmune Patients.
Front Pharmacol
9
460
2018
Homo sapiens
Hessels, AC; Sanders, JSF; van de Ven, AAJM; Kroesen, BJ; Lambeck, AJA; Rutgers, A; Stegeman, CA
Azathioprine Hypersensitivity Syndrome in a Cohort of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Patients.
J Allergy Clin Immunol Pract
2018
Homo sapiens
Vinayaga-Pavan, M; Frampton, M; Pontikos, N; Levine, AP; Smith, PJ; Jonasson, JG; Bjrnsson, ES; Segal, AW; Smith, AM
Elevation in Cell Cycle and Protein Metabolism Gene Transcription in Inactive Colonic Tissue From Icelandic Patients With Ulcerative Colitis.
Inflamm Bowel Dis
25
317-327
2019
Homo sapiens
Sluiter, RL; van Marrewijk, C; de Jong, D; Scheffer, H; Guchelaar, HJ; Derijks, L; Wong, DR; Hooymans, P; Vermeulen, SH; Verbeek, ALM; Franke, B; van der Wilt, GJ; Kievit, W; Coenen, MJH
Genotype-guided thiopurine dosing does not lead to additional costs in patients with inflammatory bowel disease.
J Crohns Colitis
2019
Homo sapiens
Fan, X; Yin, D; Men, R; Xu, H; Yang, L
NUDT15 Polymorphism Confer Increased Susceptibility to Thiopurine-Induced Leukopenia in Patients With Autoimmune Hepatitis and Related Cirrhosis.
Front Pharmacol
10
346
2019
Homo sapiens
Zhou, XL; Zhan, TY; Zhou, YH; Shrestha, K; Lan, TJ; Li, W
Complete remission of refractory pemphigus vulgaris in a Chinese patient with mutated NUDT15 by combination of minimal doses of azathioprine and prednisone.
Dermatol Ther
e14079
2020
Pemphigus, Homo sapiens
Devasia, AJ; Illangeswaran, RSS; Raj, IX; George, B; Balasubramanian, P
NUDT15 polymorphism explains serious toxicity to azathioprine in Indian patients with chronic immune thrombocytopenia and autoimmune hemolytic anemia: a case series.
Drug Metab Pers Ther
2020
Homo sapiens
Rosdiana, DS; Setiabudy, R; Andalusia, R; Gatot, D; Louisa, M; Bardosono, S; Instiaty, I
TPMT Genetic Variability and Its Association with Hematotoxicity in Indonesian Children with Acute Lymphoblastic Leukemia in Maintenance Therapy.
Pharmgenomics Pers Med
14
199-210
2021
Homo sapiens
Zeng, D; Huang, X; Lin, S; Lin, R; Weng, X; Huang, P
Cost-effectiveness analysis of genotype screening and therapeutic drug monitoring in patients with inflammatory bowel disease treated with azathioprine therapy: a Chinese healthcare perspective using real-world data.
Ann Transl Med
9
1138
2021
Homo sapiens
Aw, W; Lezhava, A; Andoh, A; Tanaka, H; Hayashizaki, Y; Ishikawa, T
The SmartAmp Method: Rapid Detection of SNPs in Thiopurine S-Methyltransferase and ABC Transporters ABCC4 and ABCG2.
Curr Drug Metab
13
968-77
2012
Homo sapiens
Liu, C; Janke, LJ; Yang, JJ; Evans, WE; Schuetz, JD; Relling, MV
Differential effects of thiopurine methyltransferase (TPMT) and multidrug resistance-associated protein gene 4 (MRP4) on mercaptopurine toxicity.
Cancer Chemother Pharmacol
80
287-293
2017
Mus musculus, Mus sp.
Marinaki, AM; Ansari, A; Duley, JA; Arenas, M; Sumi, S; Lewis, CM; Shobowale-Bakre, el-M; Escuredo, E; Fairbanks, LD; Sanderson, JD
Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase).
Pharmacogenetics
14
181-7
2004
Homo sapiens
von Ahsen, N; Armstrong, VW; Behrens, C; von Tirpitz, C; Stallmach, A; Herfarth, H; Stein, J; Bias, P; Adler, G; Shipkova, M; Oellerich, M; Kruis, W; Reinshagen, M
Association of inosine triphosphatase 94C>A and thiopurine S-methyltransferase deficiency with adverse events and study drop-outs under azathioprine therapy in a prospective Crohn disease study.
Clin Chem
51
2282-8
2005
Homo sapiens
Zelinkova, Z; Derijks, LJ; Stokkers, PC; Vogels, EW; van Kampen, AH; Curvers, WL; Cohn, D; van Deventer, SJ; Hommes, DW
Inosine triphosphate pyrophosphatase and thiopurine s-methyltransferase genotypes relationship to azathioprine-induced myelosuppression.
Clin Gastroenterol Hepatol
4
44-9
2006
Homo sapiens
Xiong, H; Xin, HW; Wu, XC; Li, Q; Xiong, L; Yu, AR
Association between inosine triphosphate pyrophosphohydrolase deficiency and azathioprine-related adverse drug reactions in the Chinese kidney transplant recipients.
Fundam Clin Pharmacol
2009
Homo sapiens
Arenas, M; Marinaki, A; Ansari, A; Sanderson, J
Typing TPMT and ITPase to detect azathioprine toxicity.
Per Med
3
45-59
2006
Homo sapiens
Ouerhani, S; Cherif, N; Bahri, I; Safra, I; Menif, S; Abbes, S
Genetic polymorphisms of NQO1, CYP1A1 and TPMT and susceptibility to acute lymphoblastic leukemia in a Tunisian population.
Mol Biol Rep
40
1307-14
2013
Homo sapiens
Shimasaki, N; Mori, T; Torii, C; Sato, R; Shimada, H; Tanigawara, Y; Kosaki, K; Takahashi, T
Influence of MTHFR and RFC1 polymorphisms on toxicities during maintenance chemotherapy for childhood acute lymphoblastic leukemia or lymphoma.
J Pediatr Hematol Oncol
30
347-52
2008
Homo sapiens
Wray, L; Vujkovic, M; McWilliams, T; Cannon, S; Devidas, M; Stork, L; Aplenc, R
TPMT and MTHFR genotype is not associated with altered risk of thioguanine-related sinusoidal obstruction syndrome in pediatric acute lymphoblastic leukemia: A report from the Children's Oncology Group.
Pediatr Blood Cancer
61
2086-8
2014
Homo sapiens
Weinshilboum, RM
Methylation pharmacogenetics: thiopurine methyltransferase as a model system.
Xenobiotica
22
1055-71
0
animal, Homo sapiens, Mus sp.
Chocair, PR; Duley, JA; Simmonds, HA; Cameron, JS
The importance of thiopurine methyltransferase activity for the use of azathioprine in transplant recipients.
Transplantation
53
1051-6
1992
Homo sapiens, Dialysis
Lennard, L; Van Loon, JA; Weinshilboum, RM
Pharmacogenetics of acute azathioprine toxicity: relationship to thiopurine methyltransferase genetic polymorphism.
Clin Pharmacol Ther
46
149-54
1989
Homo sapiens
Lennard, L; Van Loon, JA; Lilleyman, JS; Weinshilboum, RM
Thiopurine pharmacogenetics in leukemia: correlation of erythrocyte thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrations.
Clin Pharmacol Ther
41
18-25
1987
Homo sapiens
Woodson, LC; Ames, MM; Selassie, CD; Hansch, C; Weinshilboum, RM
Thiopurine methyltransferase. Aromatic thiol substrates and inhibition by benzoic acid derivatives.
Mol Pharmacol
24
471-8
1983
Homo sapiens
Klemetsdal, B; Flaegstad, T; Aarbakke, J
Is there a gender difference in red blood cell thiopurine methyltransferase activity in healthy children?
Med Pediatr Oncol
25
445-9
1995
Homo sapiens
Mircheva, J; Legendre, C; Soria-Royer, C; Thervet, E; Beaune, P; Kreis, H
Monitoring of azathioprine-induced immunosuppression with thiopurine methyltransferase activity in kidney transplant recipients.
Transplantation
60
639-42
1995
Homo sapiens
Szumlanski, CL; Weinshilboum, RM
Sulphasalazine inhibition of thiopurine methyltransferase: possible mechanism for interaction with 6-mercaptopurine and azathioprine.
Br J Clin Pharmacol
39
456-9
1995
Homo sapiens
Jacqz-Aigrain, E; Bessa, E; Medard, Y; Mircheva, Y; Vilmer, E
Thiopurine methyltransferase activity in a French population: h.p.l.c. assay conditions and effects of drugs and inhibitors.
Br J Clin Pharmacol
38
1-8
1994
Homo sapiens
Lennard, L; Gibson, BE; Nicole, T; Lilleyman, JS
Congenital thiopurine methyltransferase deficiency and 6-mercaptopurine toxicity during treatment for acute lymphoblastic leukaemia.
Arch Dis Child
69
577-9
1993
Homo sapiens
Klemetsdal, B; Wist, E; Aarbakke, J
Gender difference in red blood cell thiopurine methyltransferase activity.
Scand J Clin Lab Invest
53
747-9
1993
Homo sapiens
McLeod, HL; Lin, JS; Scott, EP; Pui, CH; Evans, WE
Thiopurine methyltransferase activity in American white subjects and black subjects.
Clin Pharmacol Ther
55
15-20
1994
Homo sapiens
Jones, CD; Smart, C; Titus, A; Blyden, G; Dorvil, M; Nwadike, N
Thiopurine methyltransferase activity in a sample population of black subjects in Florida.
Clin Pharmacol Ther
53
348-53
1993
Homo sapiens
Klemetsdal, B; Straume, B; Wist, E; Aarbakke, J
Identification of factors regulating thiopurine methyltransferase activity in a Norwegian population.
Eur J Clin Pharmacol
44
147-52
1993
Homo sapiens
Ben Ari, Z; Mehta, A; Lennard, L; Burroughs, AK
Azathioprine-induced myelosuppression due to thiopurine methyltransferase deficiency in a patient with autoimmune hepatitis.
J Hepatol
23
351-4
1995
Homo sapiens
Klemetsdal, B; Straume, B; Lysaa, R; Giverhaug, T; Aarbakke, J
Erythrocyte fraction affects red blood cell thiopurine methyltransferase activity.
Eur J Clin Pharmacol
48
495-9
1995
Homo sapiens
Tai, HL; Krynetski, EY; Yates, CR; Loennechen, T; Fessing, MY; Krynetskaia, NF; Evans, WE
Thiopurine S-methyltransferase deficiency: two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians.
Am J Hum Genet
58
694-702
1996
Homo sapiens
Giverhaug, T; Klemetsdal, B; Lysaa, R; Aarbakke, J
Intraindividual variability in red blood cell thiopurine methyltransferase activity.
Eur J Clin Pharmacol
50
217-20
1996
Homo sapiens
Lennard, L; Lilleyman, JS
Individualizing therapy with 6-mercaptopurine and 6-thioguanine related to the thiopurine methyltransferase genetic polymorphism.
Ther Drug Monit
18
328-34
1996
Homo sapiens
Keuzenkamp-Jansen, CW; Leegwater, PA; De Abreu, RA; Lambooy, MA; Bokkerink, JP; Trijbels, JM
Thiopurine methyltransferase: a review and a clinical pilot study.
J Chromatogr B Biomed Appl
678
15-22
1996
Homo sapiens
Krynetski, EY; Tai, HL; Yates, CR; Fessing, MY; Loennechen, T; Schuetz, JD; Relling, MV; Evans, WE
Genetic polymorphism of thiopurine S-methyltransferase: clinical importance and molecular mechanisms.
Pharmacogenetics
6
279-90
1996
Homo sapiens, Pierinae
Jang, IJ; Shin, SG; Lee, KH; Yim, DS; Lee, MS; Koo, HH; Kim, HK; Sohn, DR
Erythrocyte thiopurine methyltransferase activity in a Korean population.
Br J Clin Pharmacol
42
638-41
1996
Homo sapiens
Yates, CR; Krynetski, EY; Loennechen, T; Fessing, MY; Tai, HL; Pui, CH; Relling, MV; Evans, WE
Molecular diagnosis of thiopurine S-methyltransferase deficiency: genetic basis for azathioprine and mercaptopurine intolerance.
Ann Intern Med
126
608-14
1997
Homo sapiens
Bergan, S; Rugstad, HE; Klemetsdal, B; Giverhaug, T; Bentdal, O; Sødal, G; Hartmann, A; Aarbakke, J; Stokke, O
Possibilities for therapeutic drug monitoring of azathioprine: 6-thioguanine nucleotide concentrations and thiopurine methyltransferase activity in red blood cells.
Ther Drug Monit
19
318-26
1997
Homo sapiens
Lennard, L; Lewis, IJ; Michelagnoli, M; Lilleyman, JS
Thiopurine methyltransferase deficiency in childhood lymphoblastic leukaemia: 6-mercaptopurine dosage strategies.
Med Pediatr Oncol
29
252-5
1997
Homo sapiens
Leipold, G; Schütz, E; Haas, JP; Oellerich, M
Azathioprine-induced severe pancytopenia due to a homozygous two-point mutation of the thiopurine methyltransferase gene in a patient with juvenile HLA-B27-associated spondylarthritis.
Arthritis Rheum
40
1896-8
1997
Homo sapiens
Lennard, L; Welch, JC; Lilleyman, JS
Thiopurine drugs in the treatment of childhood leukaemia: the influence of inherited thiopurine methyltransferase activity on drug metabolism and cytotoxicity.
Br J Clin Pharmacol
44
455-61
1997
Homo sapiens
Cournoyer, B; Watanabe, S; Vivian, A
A tellurite-resistance genetic determinant from phytopathogenic pseudomonads encodes a thiopurine methyltransferase: evidence of a widely-conserved family of methyltransferases.
Biochim Biophys Acta
1397
161-8
1998
Bordetella pertussis, Escherichia coli, Homo sapiens, Pisum sativum, Pseudomonas syringae, Synechocystis
Spire-Vayron de la Moureyre, C; Debuysere, H; Mastain, B; Vinner, E; Marez, D; Lo Guidice, JM; Chevalier, D; Brique, S; Motte, K; Colombel, JF; Turck, D; Noel, C; Flipo, RM; Pol, A; Lhermitte, M; Lafitte, JJ; Libersa, C; Broly, F
Genotypic and phenotypic analysis of the polymorphic thiopurine S-methyltransferase gene (TPMT) in a European population.
Br J Pharmacol
125
879-87
1998
Homo sapiens
Black, AJ; McLeod, HL; Capell, HA; Powrie, RH; Matowe, LK; Pritchard, SC; Collie-Duguid, ES; Reid, DM
Thiopurine methyltransferase genotype predicts therapy-limiting severe toxicity from azathioprine.
Ann Intern Med
129
716-8
1998
Homo sapiens
Escousse, A; Guedon, F; Mounie, J; Rifle, G; Mousson, C; D'Athis, P
6-Mercaptopurine pharmacokinetics after use of azathioprine in renal transplant recipients with intermediate or high thiopurine methyl transferase activity phenotype.
J Pharm Pharmacol
50
1261-6
1998
Homo sapiens
Krynetski, EY; Evans, WE
Pharmacogenetics as a molecular basis for individualized drug therapy: the thiopurine S-methyltransferase paradigm.
Pharm Res
16
342-9
1999
Homo sapiens
McLeod, HL; Coulthard, S; Thomas, AE; Pritchard, SC; King, DJ; Richards, SM; Eden, OB; Hall, AG; Gibson, BE
Analysis of thiopurine methyltransferase variant alleles in childhood acute lymphoblastic leukaemia.
Br J Haematol
105
696-700
1999
Homo sapiens
Spire-Vayron de la Moureyre, C; Debuysère, H; Fazio, F; Sergent, E; Bernard, C; Sabbagh, N; Marez, D; Lo Guidice, JM; D'halluin, JC; Broly, F
Characterization of a variable number tandem repeat region in the thiopurine S-methyltransferase gene promoter.
Pharmacogenetics
9
189-98
1999
Homo sapiens
Alves, S; Prata, MJ; Ferreira, F; Amorim, A
Thiopurine methyltransferase pharmacogenetics: alternative molecular diagnosis and preliminary data from Northern Portugal.
Pharmacogenetics
9
257-61
1999
Homo sapiens
Relling, MV; Hancock, ML; Rivera, GK; Sandlund, JT; Ribeiro, RC; Krynetski, EY; Pui, CH; Evans, WE
Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus.
J Natl Cancer Inst
91
2001-8
1999
Homo sapiens
Dervieux, T; Médard, Y; Baudouin, V; Maisin, A; Zhang, D; Broly, F; Loirat, C; Jacqz-Aigrain, E
Thiopurine methyltransferase activity and its relationship to the occurrence of rejection episodes in paediatric renal transplant recipients treated with azathioprine.
Br J Clin Pharmacol
48
793-800
1999
Homo sapiens
Ishioka, S; Hiyama, K; Sato, H; Yamanishi, Y; McLeod, HL; Kumagai, K; Maeda, H; Yamakido, M
Thiopurine methyltransferase genotype and the toxicity of azathioprine in Japanese.
Intern Med
38
944-7
1999
Homo sapiens
Alves, S; Prata, MJ; Ferreira, F; Amorim, A
Screening of thiopurine S-methyltransferase mutations by horizontal conformation-sensitive gel electrophoresis.
Hum Mutat
15
246-53
2000
Homo sapiens
McLeod, HL; Krynetski, EY; Relling, MV; Evans, WE
Genetic polymorphism of thiopurine methyltransferase and its clinical relevance for childhood acute lymphoblastic leukemia.
Leukemia
14
567-72
2000
Homo sapiens
Sebbag, L; Boucher, P; Davelu, P; Boissonnat, P; Champsaur, G; Ninet, J; Dureau, G; Obadia, JF; Vallon, JJ; Delaye, J
Thiopurine S-methyltransferase gene polymorphism is predictive of azathioprine-induced myelosuppression in heart transplant recipients.
Transplantation
69
1524-7
2000
Homo sapiens
Krynetski, EY; Evans, WE
Genetic polymorphism of thiopurine S-methyltransferase: molecular mechanisms and clinical importance.
Pharmacology
61
136-46
2000
Homo sapiens
Yan, L; Zhang, S; Eiff, B; Szumlanski, CL; Powers, M; O'Brien, JF; Weinshilboum, RM
Thiopurine methyltransferase polymorphic tandem repeat: genotype-phenotype correlation analysis.
Clin Pharmacol Ther
68
210-9
2000
Homo sapiens
Coulthard, SA; Rabello, C; Robson, J; Howell, C; Minto, L; Middleton, PG; Gandhi, MK; Jackson, G; McLelland, J; O'Brien, H; Smith, S; Reid, MM; Pearson, AD; Hall, AG
A comparison of molecular and enzyme-based assays for the detection of thiopurine methyltransferase mutations.
Br J Haematol
110
599-604
2000
Homo sapiens
Schütz, E; von Ahsen, N; Oellerich, M
Genotyping of eight thiopurine methyltransferase mutations: three-color multiplexing, "two-color/shared" anchor, and fluorescence-quenching hybridization probe assays based on thermodynamic nearest-neighbor probe design.
Clin Chem
46
1728-37
2000
Homo sapiens
Corominas, H; Domènech, M; González-Juan, D; González-Suárez, B; Díaz, C; Pujol, J; Vázquez, G; Baiget, M
[Aplasia after azathioprine administration: role of the thiopurine methyltransferase genetic polymorphism]
Med Clin (Barc)
115
299-301
2000
Homo sapiens
Hall, AG; Hamilton, P; Minto, L; Coulthard, SA
The use of denaturing high-pressure liquid chromatography for the detection of mutations in thiopurine methyltransferase.
J Biochem Biophys Methods
47
65-71
2001
Homo sapiens
Schaeffeler, E; Lang, T; Zanger, UM; Eichelbaum, M; Schwab, M
High-throughput genotyping of thiopurine S-methyltransferase by denaturing HPLC.
Clin Chem
47
548-55
2001
Homo sapiens
Lysaa , RA; Warren, DJ; Sylte, I; Aarbakke, J
Effect of the glutathione/glutathione disulfide redox couple on thiopurine methyltransferase.
Biochem Pharmacol
61
707-14
2001
Homo sapiens
Kubota, T; Chiba, K
Frequencies of thiopurine S-methyltransferase mutant alleles (TPMT*2, *3A, *3B and *3C) in 151 healthy Japanese subjects and the inheritance of TPMT*3C in the family of a propositus.
Br J Clin Pharmacol
51
475-7
2001
Homo sapiens
Alves, S; Amorim, A; Ferreira, F; Prata, MJ
Influence of the variable number of tandem repeats located in the promoter region of the thiopurine methyltransferase gene on enzymatic activity.
Clin Pharmacol Ther
70
165-74
2001
Homo sapiens
Dervieux, T; Médard, Y; Verpillat, P; Guigonis, V; Duval, M; Lescoeur, B; Suciu, S; Vilmer, E; Jacqz-Aigrain, E
Possible implication of thiopurine S-methyltransferase in occurrence of infectious episodes during maintenance therapy for childhood lymphoblastic leukemia with mercaptopurine.
Leukemia
15
1706-12
2001
Homo sapiens
McLeod, HL; Siva, C
The thiopurine S-methyltransferase gene locus -- implications for clinical pharmacogenomics.
Pharmacogenomics
3
89-98
2002
Homo sapiens
Ranjard, L; Prigent-Combaret, C; Nazaret, S; Cournoyer, B
Methylation of inorganic and organic selenium by the bacterial thiopurine methyltransferase.
J Bacteriol
184
3146-9
2002
Escherichia coli, Pseudomonas syringae
Anglicheau, D; Sanquer, S; Loriot, MA; Beaune, P; Thervet, E
Thiopurine methyltransferase activity: new conditions for reversed-phase high-performance liquid chromatographic assay without extraction and genotypic-phenotypic correlation.
J Chromatogr B Analyt Technol Biomed Life Sci
773
119-27
2002
Homo sapiens
Coulthard, SA; Hogarth, LA; Little, M; Matheson, EC; Redfern, CP; Minto, L; Hall, AG
The effect of thiopurine methyltransferase expression on sensitivity to thiopurine drugs.
Mol Pharmacol
62
102-9
2002
Homo sapiens
Alves, S; Amorim, A; Prata, MJ
Evolution of a VNTR located within the promoter region of the thiopurine methyltransferase gene: inferences from population and sequence data.
Hum Genet
111
172-8
2002
Homo sapiens
Regueiro, M; Mardini, H
Determination of thiopurine methyltransferase genotype or phenotype optimizes initial dosing of azathioprine for the treatment of Crohn's disease.
J Clin Gastroenterol
35
240-4
2002
Homo sapiens
Langley, PG; Underhill, J; Tredger, JM; Norris, S; McFarlane, IG
Thiopurine methyltransferase phenotype and genotype in relation to azathioprine therapy in autoimmune hepatitis.
J Hepatol
37
441-7
2002
Homo sapiens
Ansari, A; Hassan, C; Duley, J; Marinaki, A; Shobowale-Bakre, EM; Seed, P; Meenan, J; Yim, A; Sanderson, J
Thiopurine methyltransferase activity and the use of azathioprine in inflammatory bowel disease.
Aliment Pharmacol Ther
16
1743-50
2002
Homo sapiens
Corominas, H; Domènech, M; Laíz, A; Gich, I; Geli, C; Díaz, C; de Cuevillas, F; Moreno, M; Vázquez, G; Baiget, M
Is thiopurine methyltransferase genetic polymorphism a major factor for withdrawal of azathioprine in rheumatoid arthritis patients?
Rheumatology (Oxford)
42
40-5
2003
Homo sapiens
Marinaki, AM; Arenas, M; Khan, ZH; Lewis, CM; Shobowale-Bakre, el-M; Escuredo, E; Fairbanks, LD; Mayberry, JF; Wicks, AC; Ansari, A; Sanderson, J; Duley, JA
Genetic determinants of the thiopurine methyltransferase intermediate activity phenotype in British Asians and Caucasians.
Pharmacogenetics
13
97-105
2003
Homo sapiens
van Aken, J; Schmedders, M; Feuerstein, G; Kollek, R
Prospects and limits of pharmacogenetics: the thiopurine methyl transferase (TPMT) experience.
Am J Pharmacogenomics
3
149-55
2003
Homo sapiens
Oh, KT; Anis, AH; Bae, SC
Pharmacoeconomic analysis of thiopurine methyltransferase polymorphism screening by polymerase chain reaction for treatment with azathioprine in Korea.
Rheumatology (Oxford)
43
156-63
2004
Homo sapiens
Wang, L; Sullivan, W; Toft, D; Weinshilboum, R
Thiopurine S-methyltransferase pharmacogenetics: chaperone protein association and allozyme degradation.
Pharmacogenetics
13
555-64
2003
Oryctolagus cuniculus
Indjova, D; Atanasova, S; Shipkova, M; Armstrong, VW; Oellerich, M; Svinarov, D
Phenotypic and genotypic analysis of thiopurine s-methyltransferase polymorphism in the bulgarian population.
Ther Drug Monit
25
631-6
2003
Homo sapiens
Ma, XL; Zhu, P; Wu, MY; Li, ZG; Hu, YM
[Relationship between single nucleotide polymorphisms in thiopurine methyltransferase gene and tolerance to thiopurines in acute leukemia]
Zhonghua Er Ke Za Zhi
41
929-33
2003
Homo sapiens
Corominas, H; Baiget, M
Clinical utility of thiopurine S-methyltransferase genotyping.
Am J Pharmacogenomics
4
1-8
2004
Homo sapiens
Ganiere-Monteil, C; Medard, Y; Lejus, C; Bruneau, B; Pineau, A; Fenneteau, O; Bourin, M; Jacqz-Aigrain, E
Phenotype and genotype for thiopurine methyltransferase activity in the French Caucasian population: impact of age.
Eur J Clin Pharmacol
60
89-96
2004
Homo sapiens
Lindqvist, M; Haglund, S; Almer, S; Peterson, C; Taipalensu, J; Hertervig, E; Lyrenäs, E; Söderkvist, P
Identification of two novel sequence variants affecting thiopurine methyltransferase enzyme activity.
Pharmacogenetics
14
261-5
2004
Homo sapiens
Cuffari, C; Dassopoulos, T; Turnbough, L; Thompson, RE; Bayless, TM
Thiopurine methyltransferase activity influences clinical response to azathioprine in inflammatory bowel disease.
Clin Gastroenterol Hepatol
2
410-7
2004
Homo sapiens
Kubota, T; Nishida, A; Takeuchi, K; Iida, T; Yokota, H; Higashi, K; Nakahara, K; Hanai, H; Iga, T
Frequency distribution of thiopurine S-methyltransferase activity in red blood cells of a healthy Japanese population.
Ther Drug Monit
26
319-21
2004
Homo sapiens
Srimartpirom, S; Tassaneeyakul, W; Kukongviriyapan, V; Tassaneeyakul, W
Thiopurine S-methyltransferase genetic polymorphism in the Thai population.
Br J Clin Pharmacol
58
66-70
2004
Thais
Alves, S; Rocha, J; Amorim, A; Prata, MJ
Tracing the origin of the most common thiopurine methyltransferase (TPMT) variants: preliminary data from the patterns of haplotypic association with two CA repeats.
Ann Hum Genet
68
313-23
2004
Homo sapiens
Schaeffeler, E; Fischer, C; Brockmeier, D; Wernet, D; Moerike, K; Eichelbaum, M; Zanger, UM; Schwab, M
Comprehensive analysis of thiopurine S-methyltransferase phenotype-genotype correlation in a large population of German-Caucasians and identification of novel TPMT variants.
Pharmacogenetics
14
407-17
2004
Homo sapiens
Evans, WE
Pharmacogenetics of thiopurine S-methyltransferase and thiopurine therapy.
Ther Drug Monit
26
186-91
2004
Homo sapiens
Sanderson, J; Ansari, A; Marinaki, T; Duley, J
Thiopurine methyltransferase: should it be measured before commencing thiopurine drug therapy?
Ann Clin Biochem
41
294-302
2004
Homo sapiens
Ford, LT; Cooper, SC; Lewis, MJ; Berg, JD
Reference intervals for thiopurine S-methyltransferase activity in red blood cells using 6-thioguanine as substrate and rapid non-extraction liquid chromatography.
Ann Clin Biochem
41
303-8
2004
Homo sapiens
Fabre, MA; Jones, DC; Bunce, M; Morris, PJ; Friend, PJ; Welsh, KI; Marshall, SE
The impact of thiopurine S-methyltransferase polymorphisms on azathioprine dose 1 year after renal transplantation.
Transpl Int
17
531-9
2004
Homo sapiens
Scheuermann, TH; Keeler, C; Hodsdon, ME
Consequences of binding an S-adenosylmethionine analogue on the structure and dynamics of the thiopurine methyltransferase protein backbone.
Biochemistry
43
12198-209
2004
Homo sapiens, Pseudomonas syringae
Kurzawski, M; Gawronska-Szklarz, B; Drozdzik, M
Frequency distribution of thiopurine S-methyltransferase alleles in a polish population.
Ther Drug Monit
26
541-5
2004
Homo sapiens
Formea, CM; Myers-Huentelman, H; Wu, R; Crabtree, J; Fujita, S; Hemming, A; Reed, A; Howard, R; Karlix, JL
Thiopurine S-methyltransferase genotype predicts azathioprine-induced myelotoxicity in kidney transplant recipients.
Am J Transplant
4
1810-7
2004
Homo sapiens
Hindorf, U; Peterson, C; Almer, S
Assessment of thiopurine methyltransferase and metabolite formation during thiopurine therapy: results from a large Swedish patient population.
Ther Drug Monit
26
673-8
2004
Homo sapiens
Arenas, M; Duley, JA; Ansari, A; Shobowale-Bakre, EA; Fairbanks, L; Soon, SY; Sanderson, J; Marinaki, AM
Genetic determinants of the pre- and post-azathioprine therapy thiopurine methyltransferase activity phenotype.
Nucleosides Nucleotides Nucleic Acids
23
1403-5
2004
Homo sapiens
Sies, C; Florkowski, C; George, P; Gearry, R; Barclay, M; Harraway, J; Pike, L; Walmsley, T
Measurement of thiopurine methyl transferase activity guides dose-initiation and prevents toxicity from azathioprine.
N Z Med J
118
U1324
2005
Homo sapiens
Sayani, FA; Prosser, C; Bailey, RJ; Jacobs, P; Fedorak, RN
Thiopurine methyltransferase enzyme activity determination before treatment of inflammatory bowel disease with azathioprine: effect on cost and adverse events.
Can J Gastroenterol
19
147-51
2005
Homo sapiens
Stanulla, M; Schaeffeler, E; Flohr, T; Cario, G; Schrauder, A; Zimmermann, M; Welte, K; Ludwig, WD; Bartram, CR; Zanger, UM; Eichelbaum, M; Schrappe, M; Schwab, M
Thiopurine methyltransferase (TPMT) genotype and early treatment response to mercaptopurine in childhood acute lymphoblastic leukemia.
JAMA
293
1485-9
2005
Homo sapiens
Heckmann, JM; Lambson, EM; Little, F; Owen, EP
Thiopurine methyltransferase (TPMT) heterozygosity and enzyme activity as predictive tests for the development of azathioprine-related adverse events.
J Neurol Sci
231
71-80
2005
Homo sapiens
Okada, Y; Nakamura, K; Wada, M; Nakamura, T; Tsukamoto, N; Nojima, Y; Horiuchi, R; Yamamoto, K
Genotyping of thiopurine methyltransferase using pyrosequencing.
Biol Pharm Bull
28
677-81
2005
Homo sapiens, Terminator
Khalil, MN; Erb, N; Khalil, PN; Escherich, G; Janka-Schaub, GE
Interference free and simplyfied liquid chromatography-based determination of thiopurine S-methyltransferase activity in erythrocytes.
J Chromatogr B Analyt Technol Biomed Life Sci
821
105-11
2005
Homo sapiens
Udaka, T; Torii, C; Takahashi, D; Mori, T; Aramaki, M; Kosaki, R; Tanigawara, Y; Takahashi, T; Kosaki, K
Comprehensive screening of the thiopurine methyltransferase polymorphisms by denaturing high-performance liquid chromatography.
Genet Test
9
85-92
2005
Homo sapiens
Kurzawski, M; Dziewanowski, K; Gawrońska-Szklarz, B; Domański, L; Droździk, M
The impact of thiopurine s-methyltransferase polymorphism on azathioprine-induced myelotoxicity in renal transplant recipients.
Ther Drug Monit
27
435-41
2005
Homo sapiens
Wei, H; Zhou, S; Li, C; Zhang, J; Wu, J; Huang, M
Phenotyping and genotyping studies of thiopurine S-methyltransferase in Kazaks.
Pharm Res
22
1762-6
2005
Homo sapiens
Gearry, RB; Barclay, ML; Roberts, RL; Harraway, J; Zhang, M; Pike, LS; George, PM; Florkowski, CM
Thiopurine methyltransferase and 6-thioguanine nucleotide measurement: early experience of use in clinical practice.
Intern Med J
35
580-5
2005
Homo sapiens
Salavaggione, OE; Wang, L; Wiepert, M; Yee, VC; Weinshilboum, RM
Thiopurine S-methyltransferase pharmacogenetics: variant allele functional and comparative genomics.
Pharmacogenet Genomics
15
801-15
2005
Pseudomonas, Homo sapiens
Frohman, EM; Havrdova, E; Levinson, B; Slanar, O
Azathioprine myelosuppression in multiple sclerosis: characterizing thiopurine methyltransferase polymorphisms.
Mult Scler
12
108-11
2006
Homo sapiens
Oselin, K; Anier, K; Tamm, R; Kallassalu, K; Mäeorg, U
Determination of thiopurine S-methyltransferase (TPMT) activity by comparing various normalization factors: reference values for Estonian population using HPLC-UV assay.
J Chromatogr B Analyt Technol Biomed Life Sci
834
77-83
2006
Homo sapiens
Meggitt, SJ; Gray, JC; Reynolds, NJ
Azathioprine dosed by thiopurine methyltransferase activity for moderate-to-severe atopic eczema: a double-blind, randomised controlled trial.
Lancet
367
839-46
2006
Homo sapiens
Oender, K; Lanschuetzer, CM; Laimer, M; Klausegger, A; Paulweber, B; Kofler, B; Hintner, H; Bauer, JW
Introducing a fast and simple PCR-RFLP analysis for the detection of mutant thiopurine S-methyltransferase alleles TPMT*3A and TPMT*3C.
J Eur Acad Dermatol Venereol
20
396-400
2006
Homo sapiens, Pemphigus
Nasedkina, TV; Fedorova, OE; Glotov, AS; Chupova, NV; Samochatova, EV; Maiorova, OA; Zemlyakova, VV; Roudneva, AE; Chudinov, AV; Yurasov, RA; Kozhekbaeva, JM; Barsky, VE; Krynetskiy, EY; Krynetskaia, NF; Cheng, C; Ribeiro, RC; Evans, WE; Roumyantsev, AG; Zasedatelev, AS
Rapid genotyping of common deficient thiopurine S-methyltransferase alleles using the DNA-microchip technique.
Eur J Hum Genet
14
991-8
2006
Homo sapiens
Czaja, AJ; Carpenter, HA
Thiopurine methyltransferase deficiency and azathioprine intolerance in autoimmune hepatitis.
Dig Dis Sci
51
968-75
2006
Homo sapiens
Rossino, R; Vincis, C; Alves, S; Prata, MJ; Macis, MD; Nucaro, AL; Schirru, E; Congia, M
Frequency of the thiopurine S-methyltransferase alleles in the ancient genetic population isolate of Sardinia.
J Clin Pharm Ther
31
283-7
2006
Homo sapiens
Gisbert, JP; Luna, M; Maté, J; González-Guijarro, L; Cara, C; Pajares, JM
Choice of azathioprine or 6-mercaptopurine dose based on thiopurine methyltransferase (TPMT) activity to avoid myelosuppression. A prospective study.
Hepatogastroenterology
53
399-404
0
Homo sapiens
van den Akker-van Marle, ME; Gurwitz, D; Detmar, SB; Enzing, CM; Hopkins, MM; Gutierrez de Mesa, E; Ibarreta, D
Cost-effectiveness of pharmacogenomics in clinical practice: a case study of thiopurine methyltransferase genotyping in acute lymphoblastic leukemia in Europe.
Pharmacogenomics
7
783-92
2006
Homo sapiens
Schaeffeler, E; Eichelbaum, M; Reinisch, W; Zanger, UM; Schwab, M
Three novel thiopurine S-methyltransferase allelic variants (TPMT*20, *21, *22) - association with decreased enzyme function.
Hum Mutat
27
976
2006
Danio rerio
Gardiner, SJ; Gearry, RB; Barclay, ML; Begg, EJ
Two cases of thiopurine methyltransferase (TPMT) deficiency - a lucky save and a near miss with azathioprine.
Br J Clin Pharmacol
62
473-6
2006
Homo sapiens
Ford, L; Graham, V; Berg, J
Whole-blood thiopurine S-methyltransferase activity with genotype concordance: a new, simplified phenotyping assay.
Ann Clin Biochem
43
354-60
2006
Homo sapiens
Lindqvist, M; Hindorf, U; Almer, S; Söderkvist, P; Ström, M; Hjortswang, H; Peterson, C
No induction of thiopurine methyltransferase during thiopurine treatment in inflammatory bowel disease.
Nucleosides Nucleotides Nucleic Acids
25
1033-7
2006
Homo sapiens
Gisbert, JP; González-Lama, Y; Maté, J
[Monitoring of thiopurine methyltransferase and thiopurine metabolites to optimize azathioprine therapy in inflammatory bowel disease]
Gastroenterol Hepatol
29
568-83
2006
Homo sapiens
Ma, XL; Wu, MY; Hu, YM; Zu, P; Li, ZG
[Relationships between thiopurine methyltransferase gene polymorphisms and its enrymatic activity]
Zhonghua Zhong Liu Za Zhi
28
456-9
2006
Homo sapiens
Dokmanovic, L; Urosevic, J; Janic, D; Jovanovic, N; Petrucev, B; Tosic, N; Pavlovic, S
Analysis of thiopurine S-methyltransferase polymorphism in the population of Serbia and Montenegro and mercaptopurine therapy tolerance in childhood acute lymphoblastic leukemia.
Ther Drug Monit
28
800-6
2006
Homo sapiens
Zhou, S
Clinical pharmacogenomics of thiopurine S-methyltransferase.
Curr Clin Pharmacol
1
119-28
2006
Homo sapiens
Li, F; Wang, L; Burgess, RJ; Weinshilboum, RM
Thiopurine S-methyltransferase pharmacogenetics: autophagy as a mechanism for variant allozyme degradation.
Pharmacogenet Genomics
18
1083-94
2008
Saccharomyces cerevisiae, Homo sapiens
Xin, HW; Xiong, H; Wu, XC; Li, Q; Xiong, L; Yu, AR
Relationships between thiopurine S-methyltransferase polymorphism and azathioprine-related adverse drug reactions in Chinese renal transplant recipients.
Eur J Clin Pharmacol
65
249-55
2009
Homo sapiens
Ford, L; Kampanis, P; Berg, J
Thiopurine S-methyltransferase genotype-phenotype concordance: used as a quality assurance tool to help control the phenotype assay.
Ann Clin Biochem
46
152-4
2009
Homo sapiens
Leung, M; Piatkov, I; Rochester, C; Boyages, SC; Leong, RW
Normal thiopurine methyltransferase phenotype testing in a Crohn disease patient with azathioprine induced myelosuppression.
Intern Med J
39
121-6
2009
Homo sapiens
Stanulla, M; Schaeffeler, E; Möricke, A; Coulthard, SA; Cario, G; Schrauder, A; Kaatsch, P; Dördelmann, M; Welte, K; Zimmermann, M; Reiter, A; Eichelbaum, M; Riehm, H; Schrappe, M; Schwab, M
Thiopurine methyltransferase genetics is not a major risk factor for secondary malignant neoplasms after treatment of childhood acute lymphoblastic leukemia on Berlin-Frankfurt-Münster protocols.
Blood
114
1314-8
2009
Homo sapiens
Alvarez L, L; Venegas S, M; Larrondo L, M; Becerra B, N; Castro L, A; Quera P, R
[Thiopurine S-methyltransferase gene polymorphism in Chilean blood donors]
Rev Med Chil
137
185-92
2009
Homo sapiens
Kapoor, G; Maitra, A; , ; Brahmachari, V
Application of SNaPshot for analysis of thiopurine methyltransferase gene polymorphism.
Indian J Med Res
129
500-5
2009
Homo sapiens
Kolorz, M; Bartosova, L; Hosek, J; Dvorackova, D; Chylkova, A; Zboril, V; Batovsky, M; Bartos, M
Importance of thiopurine S-Methyltransferase gene polymorphisms for prediction of azathioprine toxicity.
Neuro Endocrinol Lett
30 Suppl 1
137-42
2009
Homo sapiens
Ford, LT; Berg, JD
Thiopurine S-methyltransferase (TPMT) assessment prior to starting thiopurine drug treatment; a pharmacogenomic test whose time has come.
J Clin Pathol
63
288-95
2010
Homo sapiens
Hakooz, N; Arafat, T; Payne, D; Ollier, W; Pushpakom, S; Andrews, J; Newman, W
Genetic analysis of thiopurine methyltransferase polymorphism in the Jordanian population.
Eur J Clin Pharmacol
66
999-1003
2010
Homo sapiens
Martel, RM; Melwani, P; Islas, D; Peate, Y; Borrego, L
[Safety of azathioprine therapy adjusted to thiopurine methyltransferase activity in the treatment of infantile atopic dermatitis. Report on 7 cases]
Actas Dermosifiliogr
101
415-20
2010
Homo sapiens, Canaria
Dong, XW; Zheng, Q; Zhu, MM; Tong, JL; Ran, ZH
Thiopurine S-methyltransferase polymorphisms and thiopurine toxicity in treatment of inflammatory bowel disease.
World J Gastroenterol
16
3187-95
2010
Homo sapiens
Ngo, S; Sauvetre, G; Vittecoq, O; Lvesque, H; Marie, I
[Azathioprine-associated severe myelosuppression: Indication of routine determination of thiopurine S-methyltransferase variant?]
Rev Med Interne
2010
Homo sapiens
Ramos, MA; Mares, RE; Avalos, ED; Hernndez, A; Hernndez, R; Lameda, R; Malvez, AE; Rodrguez, CA; Rodrguez, R
Pharmacogenetic Screening of N-Acetyltransferase 2, Thiopurine S-Methyltransferase, and 5,10-Methylene-Tetrahydrofolate Reductase Polymorphisms in Northwestern Mexicans.
Genet Test Mol Biomarkers
2011
California
Relling, MV; Gardner, EE; Sandborn, WJ; Schmiegelow, K; Pui, CH; Yee, SW; Stein, CM; Carrillo, M; Evans, WE; Klein, TE; ,
Clinical Pharmacogenetics Implementation Consortium guidelines for thiopurine methyltransferase genotype and thiopurine dosing.
Clin Pharmacol Ther
89
387-91
2011
Homo sapiens
Mladosievicova, B; Dzurenkova, A; Sufliarska, S; Carter, A
Clinical relevance of thiopurine S-methyltransferase gene polymorphisms.
Neoplasma
58
277-82
2011
Homo sapiens
Aghdaie, MH; Azarpira, N; Geramizadeh, B; Sagheb, M; Darai, M; Rahsaz, M; Malekhoseini, SA
Thiopurine s-methyltransferase polymorphism in Iranian kidney transplant recipients.
Exp Clin Transplant
9
241-6
2011
Homo sapiens
Moini, M; Ghaderi, F; Sagheb, MM; Tavasolli, AR; Azarpira, N; Darai, M; Geramizadeh, B
The frequency and distribution of thiopurine S-methyltransferase alleles in south Iranian population.
Mol Biol Rep
39
4581-7
2012
Homo sapiens
Sipeky, C; Masz, A; Tarls, G; Komlsi, K; Pollk, ; Melegh, B
[Significance of thiopurine s-methyltransferase gene test in a clinical case].
Orv Hetil
153
191-4
2012
Homo sapiens
Colleoni, L; Kapetis, D; Maggi, L; Camera, G; Canioni, E; Cavalcante, P; Kerlero de Rosbo, N; Baggi, F; Antozzi, C; Confalonieri, P; Mantegazza, R; Bernasconi, P
A New Thiopurine S-Methyltransferase Haplotype Associated With Intolerance to Azathioprine.
J Clin Pharmacol
2012
Homo sapiens
Hindorf, U; Appell, ML
Genotyping should be considered the primary choice for pre-treatment evaluation of thiopurine methyltransferase function.
J Crohns Colitis
2011
Homo sapiens
Cabaleiro, T; Romn, M; Gisbert, JP; Abad-Santos, F
Utility of assessing thiopurine S-methyltransferase polymorphisms before azathioprine therapy.
Curr Drug Metab
2012
Homo sapiens
Prigent-Combaret, C; Sanguin, H; Champier, L; Bertrand, C; Monnez, C; Colinon, C; Blaha, D; Ghigo, JM; Cournoyer, B
The bacterial thiopurine methyltransferase tellurite resistance process is highly dependent upon aggregation properties and oxidative stress response.
Environ Microbiol
2012
Escherichia coli, Escherichia coli str. K-12 substr. MG1655, Electron
Lennard, L; Cartwright, CS; Wade, R; Richards, SM; Vora, A
Thiopurine methyltransferase genotype-phenotype discordance, and thiopurine active metabolite formation, in childhood acute lymphoblastic leukaemia.
Br J Clin Pharmacol
2012
Homo sapiens
Benkov, K; Lu, Y; Patel, A; Rahhal, R; Russell, G; Teitelbaum, J; ,
Role of Thiopurine Metabolite Testing and Thiopurine Methyltransferase Determination in Pediatric IBD.
J Pediatr Gastroenterol Nutr
56
333-40
2013
Homo sapiens
Taylor-Gjevre, RM; Gjevre, JA; Nair, BV; Matern, D
Thiopurine methyltransferase screening before azathioprine prescription: a physician survey.
J Popul Ther Clin Pharmacol
20
e13-7
2013
Homo sapiens
Colleoni, L; Kapetis, D; Maggi, L; Camera, G; Canioni, E; Cavalcante, P; Kerlero de Rosbo, N; Baggi, F; Antozzi, C; Confalonieri, P; Mantegazza, R; Bernasconi, P
A new thiopurine s-methyltransferase haplotype associated with intolerance to azathioprine.
J Clin Pharmacol
53
67-74
2013
Homo sapiens
Ben Salah, L; Belkhiria el Haj Amor, M; Chbili, C; Khlifi, S; Fathallah, N; Bougmiza, I; Ben Jazia, E; Houdret, N; Ben Salem, C; Saguem, S
Analysis of thiopurine S-methyltransferase phenotype-genotype in a Tunisian population with Crohn's disease.
Eur J Drug Metab Pharmacokinet
38
241-4
2013
Homo sapiens
Kim, S; Lee, HW; Lee, W; Chun, S; Min, WK
Validation of new allele-specific real-time PCR system for thiopurine methyltransferase genotyping in Korean population.
Biomed Res Int
2013
305704
2013
Homo sapiens
Cao, L; Zhang, ZX; Chai, YH; Hu, SY; Wang, Y; Zhao, WL; He, HL; Lu, J
[The effect of the adverse events with thiopurine S-methyltransferase gene mutation on outcome of childhood acute lymphoblastic leukemia].
Zhonghua Xue Ye Xue Za Zhi
34
247-52
2013
Homo sapiens
van Egmond, R; Barclay, ML; Chin, PK; Sies, CW; Florkowski, CM
Biological variation of thiopurine methyltransferase enzyme activity: when has a significant change taken place?
Ann Clin Biochem
50
473-8
2013
Homo sapiens
Yeter, K; Afkhami, M; Brynes, R; Quismorio, F
Aplastic anemia secondary to azathioprine in systemic lupus erythematosus: report of a case with normal thiopurine S-methyltransferase enzyme activity and review of the literature.
Lupus
2013
Homo sapiens
Demlova, R; Mrkvicova, M; Sterba, J; Bernatikova, H; Stary, J; Sukova, M; Mikuskova, A; Chocholova, A; Mladosievicova, B; Soltysova, A; Behulova, D; Pilatova, K; Zdrazilova-Dubska, L; Valik, D
Augmenting Clinical Interpretability of Thiopurine Methyltransferase Laboratory Evaluation.
Oncology
86
152-158
2014
Homo sapiens
Levinsen, M; Rosthj, S; Nygaard, U; Heldrup, J; Harila-Saari, A; Jonsson, OG; Bechensteen, AG; Abrahamsson, J; Lausen, B; Frandsen, TL; Weinshilboum, RM; Schmiegelow, K
Myelotoxicity after high-dose methotrexate in childhood acute leukemia is influenced by 6-mercaptopurine dosing but not by intermediate thiopurine methyltransferase activity.
Cancer Chemother Pharmacol
75
59-66
2015
Homo sapiens
Lennard, L; Cartwright, CS; Wade, R; Vora, A
Thiopurine dose intensity and treatment outcome in childhood lymphoblastic leukaemia: the influence of thiopurine methyltransferase pharmacogenetics.
Br J Haematol
2014
Homo sapiens
Zeglam, HB; Benhamer, A; Aboud, A; Rtemi, H; Mattardi, M; Saleh, SS; Bashein, A; Enattah, N
Polymorphisms of the thiopurine S-methyltransferase gene among the Libyan population.
Libyan J Med
10
27053
2015
Homo sapiens
Lennard, L; Cartwright, CS; Wade, R; Vora, A
Thiopurine methyltransferase and treatment outcome in the UK acute lymphoblastic leukaemia trial ALL2003.
Br J Haematol
170
550-8
2015
Homo sapiens
Zur, RM; Roy, LM; Ito, S; Beyene, J; Carew, C; Ungar, WJ
Thiopurine S-methyltransferase testing for averting drug toxicity: a meta-analysis of diagnostic test accuracy.
Pharmacogenomics J
16
305-11
2016
Homo sapiens
Bahrehmand, F; Kiani, A; Vaisi-Raygani, A; Bashiri, H; Zobeiri, M; Tanhapour, M; Pourmotabbed, T
Pharmacogenetics of drug metabolizing enzyme: thiopurine methyl transferase phenotypes and multidrug resistance 1 gene polymorphism in inflammatory bowel disease.
Cell Mol Biol (Noisy-le-grand)
62
102-9
2016
Homo sapiens
Hessels, AC; Rutgers, A; Sanders, JSF; Stegeman, CA
Thiopurine methyltransferase genotype and activity cannot predict outcomes of azathioprine maintenance therapy for antineutrophil cytoplasmic antibody associated vasculitis: A retrospective cohort study.
PLoS One
13
e0195524
2018
Homo sapiens
Zimdahl Kahlin, A; Helander, S; Skoglund, K; Sderkvist, P; Mrtensson, LG; Appell, ML
Comprehensive study of thiopurine methyltransferase genotype, phenotype, and genotype-phenotype discrepancies in Sweden.
Biochem Pharmacol
164
263-272
2019
Homo sapiens
Fukumoto, Y; Yamada, H; Matsuhashi, K; Okada, W; Tanaka, YK; Suzuki, N; Ogra, Y
Production of a Urinary Selenium Metabolite, Trimethylselenonium, by Thiopurine S-Methyltransferase and Indolethylamine N-Methyltransferase.
Chem Res Toxicol
33
2467-2474
2020
Homo sapiens
Chansavang, A; Maalej, S; Narjoz, C; Loriot, MA; Pallet, N
Identification of rare defective allelic variants in cases of thiopurine S-methyltransferase deficient activity.
Pharmacogenomics
21
1217-1226
2020
Homo sapiens
Nielsen, SN; Toksvang, LN; Grell, K; Nersting, J; Abrahamsson, J; Lund, B; Kanerva, J; Jnsson, G; Vaitkeviciene, G; Pruunsild, K; Appell, ML; Hjalgrim, LL; Schmiegelow, K
No association between relapse hazard and thiopurine methyltransferase geno- or phenotypes in non-high risk acute lymphoblastic leukemia: a NOPHO ALL2008 sub-study.
Cancer Chemother Pharmacol
88
271-279
2021
Homo sapiens
Ding, L; Zhang, FB; Liu, H; Gao, X; Bi, HC; Wang, XD; Chen, BL; Zhang, Y; Zhao, LZ; Zhong, GP; Hu, PJ; Chen, MH; Huang, M
Hypoxanthine guanine phosphoribosyltransferase activity is related to 6-thioguanine nucleotide concentrations and thiopurine-induced leukopenia in the treatment of inflammatory bowel disease.
Inflamm Bowel Dis
2011
Homo sapiens
Ansari, A; Aslam, Z; de Sica, A; Smith, M; Gilshenan, K; Fairbanks, L; Marinaki, A; Sanderson, J; Duley, J
Influence of xanthine oxidase on thiopurine metabolism in Crohn's disease.
Aliment Pharmacol Ther
28
749-57
2008
Homo sapiens
Innocenti, F; Iyer, L; Ratain, MJ
Pharmacogenetics: a tool for individualizing antineoplastic therapy.
Clin Pharmacokinet
39
315-25
2000
Homo sapiens
Dervieux, T; Bala, MV
Overview of the pharmacoeconomics of pharmacogenetics.
Pharmacogenomics
7
1175-84
2006
Homo sapiens
Vegter, S; Boersma, C; Rozenbaum, M; Wilffert, B; Navis, G; Postma, MJ
Pharmacoeconomic evaluations of pharmacogenetic and genomic screening programmes: a systematic review on content and adherence to guidelines.
Pharmacoeconomics
26
569-87
2008
insertion sequences
Gardiner, SJ; Begg, EJ
Pharmacogenetic testing for drug metabolizing enzymes: is it happening in practice?
Pharmacogenet Genomics
15
365-9
2005
Homo sapiens
Kerstens, PJ; Stolk, JN; Boerbooms, AM; Lambooy, LH; de Graaf, R; De Abreu, RA; van de Putte, LB
Purine enzymes in rheumatoid arthritis: possible association with response to azathioprine. A pilot study.
Ann Rheum Dis
53
608-11
1994
Homo sapiens
Yatscoff, RW; Aspeslet, LJ; Gallant, HL
Pharmacodynamic monitoring of immunosuppressive drugs.
Clin Chem
44
428-32
1998
Homo sapiens
Bruns, T; Stallmach, A
Drug monitoring in inflammatory bowel disease: helpful or dispensable?
Dig Dis
27
394-403
2009
Homo sapiens
Cannon, LM; Butler, FN; Wan, W; Zhou, ZS
A stereospecific colorimetric assay for (S,S)-adenosylmethionine quantification based on thiopurine methyltransferase-catalyzed thiol methylation.
Anal Biochem
308
358-63
2002
Homo sapiens, Transformation, Ursidae
Dreisig, K; Brnner, ED; Marquart, HV; Helt, LR; Nersting, J; Frandsen, TL; Jonsson, OG; Taskinen, M; Vaitkeviciene, G; Lund, B; Abrahamsson, J; Lepik, K; Schmiegelow, K
TPMT polymorphisms and minimal residual disease after 6-mercaptopurine post-remission consolidation therapy of childhood acute lymphoblastic leukaemia.
Pediatr Hematol Oncol
38
227-238
2021
Homo sapiens
Hasegawa, Y
[Pharmacogenomic approaches for prevention of drug toxicity in cancer chemotherapy]
Gan To Kagaku Ryoho
30
325-33
2003
Homo sapiens
Candelaria, M; Taja-Chayeb, L; Arce-Salinas, C; Vidal-Millan, S; Serrano-Olvera, A; Dueñas-Gonzalez, A
Genetic determinants of cancer drug efficacy and toxicity: practical considerations and perspectives.
Anticancer Drugs
16
923-33
2005
Homo sapiens
Bosch, TM; Meijerman, I; Beijnen, JH; Schellens, JH
Genetic polymorphisms of drug-metabolising enzymes and drug transporters in the chemotherapeutic treatment of cancer.
Clin Pharmacokinet
45
253-85
2006
Homo sapiens
Jena, A; Jha, DK; Kumar-M, P; Kasudhan, KS; Kumar, A; Sarwal, D; Mishra, S; Singh, AK; Bhatia, P; Patil, A; Sharma, V
Prevalence of polymorphisms in thiopurine metabolism and association with adverse outcomes: a South Asian region-specific systematic review and meta-analysis.
Expert Rev Clin Pharmacol
14
491-501
2021
Homo sapiens
Sandborn, WJ; Faubion, WA
Clinical pharmacology of inflammatory bowel disease therapies.
Curr Gastroenterol Rep
2
440-5
2000
Homo sapiens
Anthony, M; Berg, MJ
Biologic and molecular mechanisms for sex differences in pharmacokinetics, pharmacodynamics, and pharmacogenetics: Part I.
J Womens Health Gend Based Med
11
601-15
2002
Homo sapiens
Marsh, S; King, CR; Ahluwalia, R; McLeod, HL
Distribution of ITPA P32T alleles in multiple world populations.
J Hum Genet
49
579-81
2004
Homo sapiens
Breen, DP; Marinaki, AM; Arenas, M; Hayes, PC
Pharmacogenetic association with adverse drug reactions to azathioprine immunosuppressive therapy following liver transplantation.
Liver Transpl
11
826-33
2005
Homo sapiens
Gilissen, LP; Derijks, LJ; Verhoeven, HM; Bierau, J; Hooymans, PM; Hommes, DW; Engels, LG
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
Dig Liver Dis
39
182-6
2007
Cytomegalovirus, Herpesviridae sp.
Derijks, LJ; Gilissen, LP; Hooymans, PM; Hommes, DW
Review article: thiopurines in inflammatory bowel disease.
Aliment Pharmacol Ther
24
715-29
2006
Homo sapiens
Sahasranaman, S; Howard, D; Roy, S
Clinical pharmacology and pharmacogenetics of thiopurines.
Eur J Clin Pharmacol
64
753-67
2008
Homo sapiens
Ansari, A; Arenas, M; Greenfield, SM; Morris, D; Lindsay, J; Gilshenan, K; Smith, M; Lewis, C; Marinaki, A; Duley, J; Sanderson, J
Prospective evaluation of the pharmacogenetics of azathioprine in the treatment of inflammatory bowel disease.
Aliment Pharmacol Ther
28
973-83
2008
Homo sapiens
Hawwa, AF; Millership, JS; Collier, PS; Vandenbroeck, K; McCarthy, A; Dempsey, S; Cairns, C; Collins, J; Rodgers, C; McElnay, JC
Pharmacogenomic studies of the anticancer and immunosuppressive thiopurines mercaptopurine and azathioprine.
Br J Clin Pharmacol
66
517-28
2008
Homo sapiens
Kurzawski, M; Dziewanowski, K; Lener, A; Drozdzik, M
TPMT but not ITPA gene polymorphism influences the risk of azathioprine intolerance in renal transplant recipients.
Eur J Clin Pharmacol
65
533-40
2009
Homo sapiens
Derijks, LJ; Wong, DR
Pharmacogenetics of thiopurines in inflammatory bowel disease.
Curr Pharm Des
16
145-54
2010
Homo sapiens
Yamamoto, I; Azuma, J
[Individualization of drug therapy and pharmacogenetics]
Nippon Rinsho
56
579-83
1998
Homo sapiens
Hiratsuka, M; Agatsuma, Y; Omori, F; Narahara, K; Inoue, T; Kishikawa, Y; Mizugaki, M
High throughput detection of drug-metabolizing enzyme polymorphisms by allele-specific fluorogenic 5' nuclease chain reaction assay.
Biol Pharm Bull
23
1131-5
2000
Homo sapiens
Daly, AK
Individualized drug therapy.
Curr Opin Drug Discov Devel
10
29-36
2007
Homo sapiens
Stojiljkovic, M; Patrinos, GP; Pavlovic, S
Clinical Applicability of Sequence Variations in Genes Related to Drug Metabolism.
Curr Drug Metab
2011
Homo sapiens
Kim, JY; Cheong, HS; Park, TJ; Shin, HJ; Seo, DW; Na, HS; Chung, MW; Shin, HD
Screening for 392 polymorphisms in 141 pharmacogenes.
Biomed Rep
2
463-476
2014
Homo sapiens
Fotoohi, AK; Lindqvist, M; Peterson, C; Albertioni, F
Involvement of the concentrative nucleoside transporter 3 and equilibrative nucleoside transporter 2 in the resistance of T-lymphoblastic cell lines to thiopurines.
Biochem Biophys Res Commun
343
208-15
2006
Homo sapiens
Peyrin-Biroulet, L; Cadranel, JF; Nousbaum, JB; Oussalah, A; Seddik, M; Canva, V; Cortot, A; Sogni, P; Gueant, JL; Bigard, MA; Roblin, X; Bronowicki, JP
Interaction of ribavirin with azathioprine metabolism potentially induces myelosuppression.
Aliment Pharmacol Ther
28
984-93
2008
Homo sapiens
Wojtuszkiewicz, A; Barcelos, A; Dubbelman, B; De Abreu, R; Brouwer, C; Bkkerink, JP; de Haas, V; de Groot-Kruseman, H; Jansen, G; Kaspers, GL; Cloos, J; Peters, GJ
Assessment of mercaptopurine (6MP) metabolites and 6MP metabolic key-enzymes in childhood acute lymphoblastic leukemia.
Nucleosides Nucleotides Nucleic Acids
33
422-33
2014
Homo sapiens
Yamazaki, H
[Pharmacogenomic data for personalized medicines]
Gan To Kagaku Ryoho
32
1886-90
2005
Homo sapiens
Mini, E; Nobili, S
Pharmacogenetics: implementing personalized medicine.
Clin Cases Miner Bone Metab
6
17-24
2009
Areas
Bo, J; Schrøder, H; Kristinsson, J; Madsen, B; Szumlanski, C; Weinshilboum, R; Andersen, JB; Schmiegelow, K
Possible carcinogenic effect of 6-mercaptopurine on bone marrow stem cells: relation to thiopurine metabolism.
Cancer
86
1080-6
1999
Homo sapiens
Schmiegelow, K; Al-Modhwahi, I; Andersen, MK; Behrendtz, M; Forestier, E; Hasle, H; Heyman, M; Kristinsson, J; Nersting, J; Nygaard, R; Svendsen, AL; Vettenranta, K; Weinshilboum, R
Methotrexate/6-mercaptopurine maintenance therapy influences the risk of a second malignant neoplasm after childhood acute lymphoblastic leukemia - results from the NOPHO ALL-92 study.
Blood
2009
Homo sapiens
Schmiegelow, K
Epidemiology of therapy-related myeloid neoplasms after treatment for pediatric acute lymphoblastic leukemia in the nordic countries.
Mediterr J Hematol Infect Dis
3
e2011020
2011
Homo sapiens
Karas-Kueli?ki, N; Mencej-Bedra?, S; Jazbec, J; Marc, J; Mlinari?-Ra?an, I
Risk factors for symptomatic osteonecrosis in childhood ALL: A retrospective study of a Slovenian pediatric ALL population between 1970 and 2004.
Exp Ther Med
12
840-846
2016
Homo sapiens
Pazmiño, PA; Sladek, SL; Weinshilboum, RM
Thiol S-methylation in uremia: erythrocyte enzyme activities and plasma inhibitors.
Clin Pharmacol Ther
28
356-67
1980
Homo sapiens
Kerremans, AL; Lipsky, JJ; Van Loon, J; Gallego, MO; Weinshilboum, RM
Cephalosporin-induced hypoprothrombinemia: possible role for thiol methylation of 1-methyltetrazole-5-thiol and 2-methyl-1,3,4-thiadiazole-5-thiol.
J Pharmacol Exp Ther
235
382-8
1985
Homo sapiens
Lennard, L; Lilleyman, JS; Van Loon, J; Weinshilboum, RM
Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia.
Lancet
336
225-9
1990
Homo sapiens
Chocair, PR; Duley, JA; Sabbaga, E; Arap, S; Simmonds, HA; Cameron, JS
Fast and slow methylators: do racial differences influence risk of allograft rejection?
Q J Med
86
359-63
1993
Homo sapiens
Bostrom, B; Erdmann, G
Cellular pharmacology of 6-mercaptopurine in acute lymphoblastic leukemia.
Am J Pediatr Hematol Oncol
15
80-6
1993
Homo sapiens
Gummert, JF; Schütz, E; Oellerich, M; Mohr, FW; Dalichau, H
Monitoring of TPMT in heart transplant recipients under immunosuppressive therapy with azathioprine.
Artif Organs
19
918-20
1995
Homo sapiens
Schütz, E; Gummert, J; Mohr, FW; Armstrong, VW; Oellerich, M
Should 6-thioguanine nucleotides be monitored in heart transplant recipients given azathioprine?
Ther Drug Monit
18
228-33
1996
Homo sapiens
Tan, BB; Lear, JT; Gawkrodger, DJ; English, JS
Azathioprine in dermatology: a survey of current practice in the U.K.
Br J Dermatol
136
351-5
1997
Pemphigus
Pui, CH
Acute lymphoblastic leukemia.
Pediatr Clin North Am
44
831-46
1997
Homo sapiens
Lewis, LD; Benin, A; Szumlanski, CL; Otterness, DM; Lennard, L; Weinshilboum, RM; Nierenberg, DW
Olsalazine and 6-mercaptopurine-related bone marrow suppression: a possible drug-drug interaction.
Clin Pharmacol Ther
62
464-75
1997
Homo sapiens
Oellerich, M; Schütz, E; Armstrong, VW
Monitoring of cyclosporin and azathioprine in organ transplantation.
Drug Metabol Drug Interact
14
17-31
1997
Homo sapiens
Relling, MV; Hancock, ML; Boyett, JM; Pui, CH; Evans, WE
Prognostic importance of 6-mercaptopurine dose intensity in acute lymphoblastic leukemia.
Blood
93
2817-23
1999
Homo sapiens
Glied, M; Rico, MJ
Treatment of autoimmune blistering diseases.
Dermatol Clin
17
431-40, x
1999
Homo sapiens
Relling, MV; Rubnitz, JE; Rivera, GK; Boyett, JM; Hancock, ML; Felix, CA; Kun, LE; Walter, AW; Evans, WE; Pui, CH
High incidence of secondary brain tumours after radiotherapy and antimetabolites.
Lancet
354
34-9
1999
Homo sapiens
Scerri, L
Azathioprine in dermatological practice. An overview with special emphasis on its use in non-bullous inflammatory dermatoses.
Adv Exp Med Biol
455
343-8
1999
Homo sapiens
Tavadia, SM; Mydlarski, PR; Reis, MD; Mittmann, N; Pinkerton, PH; Shear, N; Sauder, DN
Screening for azathioprine toxicity: a pharmacoeconomic analysis based on a target case.
J Am Acad Dermatol
42
628-32
2000
Homo sapiens, Pierinae
Dubinsky, MC; Lamothe, S; Yang, HY; Targan, SR; Sinnett, D; Théorêt, Y; Seidman, EG
Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease.
Gastroenterology
118
705-13
2000
Homo sapiens
Thervet, E; Anglicheau, D; Toledano, N; Houllier, AM; Noel, LH; Kreis, H; Beaune, P; Legendre, C
Long-term results of TMPT activity monitoring in azathioprine-treated renal allograft recipients.
J Am Soc Nephrol
12
170-6
2001
Homo sapiens
Gu, LJ; Ye, QD; Liang, AB; Zhao, JC; Xue, HL; Tang, YN; Chen, J; Ye, YC
[Significance of TPMT activity and TGNs level detection for individualizing 6-mercaptopurine chemotherapy]
Zhonghua Xue Ye Xue Za Zhi
24
18-21
2003
Homo sapiens
Baker, DE
Pharmacogenomics of azathioprine and 6-mercaptopurine in gastroenterologic therapy.
Rev Gastroenterol Disord
3
150-7
2003
Homo sapiens
Reuther, LO; Sonne, J; Larsen, NE; Larsen, B; Christensen, S; Rasmussen, SN; Tofteng, F; Haaber, A; Johansen, N; Kjeldsen, J; Schmiegelow, K
Pharmacological monitoring of azathioprine therapy.
Scand J Gastroenterol
38
972-7
2003
Homo sapiens
McLeod, HL; Yu, J
Cancer pharmacogenomics: SNPs, chips, and the individual patient.
Cancer Invest
21
630-40
2003
Homo sapiens
Cheung, ST; Allan, RN
Mistaken identity: misclassification of TPMT phenotype following blood transfusion.
Eur J Gastroenterol Hepatol
15
1245-7
2003
Homo sapiens
Krynetski, E; Evans, WE
Drug methylation in cancer therapy: lessons from the TPMT polymorphism.
Oncogene
22
7403-13
2003
Homo sapiens
Dubinsky, MC
Optimizing immunomodulator therapy for inflammatory bowel disease.
Curr Gastroenterol Rep
5
506-11
2003
Homo sapiens
Wan, W; Zhao, G; Al-Saad, K; Siems, WF; Zhou, ZS
Rapid screening for S-adenosylmethionine-dependent methylation products by enzyme-transferred isotope patterns analysis.
Rapid Commun Mass Spectrom
18
319-24
2004
Homo sapiens
Bessard, G; Hardy, G; Chartier, A; Stanke-Labesque, F
[Genetic polymorphism and treatment of chronic bowel inflammatory diseases: the example of azathioprine]
Therapie
59
71-5
0
Homo sapiens
Kontorinis, N; Agarwal, K; Gondolesi, G; Fiel, MI; O'Rourke, M; Schiano, TD
Diagnosis of 6 mercaptopurine hepatotoxicity post liver transplantation utilizing metabolite assays.
Am J Transplant
4
1539-42
2004
Homo sapiens
Hindorf, U; Lyrenäs, E; Nilsson, A; Schmiegelow, K
Monitoring of long-term thiopurine therapy among adults with inflammatory bowel disease.
Scand J Gastroenterol
39
1105-12
2004
Homo sapiens
Ford, L; Prout, C; Gaffney, D; Berg, J
Whose TPMT activity is it anyway?
Ann Clin Biochem
41
498-500
2004
Homo sapiens
Anstey, AV; Wakelin, S; Reynolds, NJ; ,
Guidelines for prescribing azathioprine in dermatology.
Br J Dermatol
151
1123-32
2004
Homo sapiens
Gearry, RB; Barclay, ML
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
J Gastroenterol Hepatol
20
1149-57
2005
Homo sapiens
Eichelbaum, M; Ingelman-Sundberg, M; Evans, WE
PHARMACOGENOMICS AND INDIVIDUALIZED DRUG THERAPY.
Annu Rev Med
57
119-137
2006
Homo sapiens
Heneghan, MA; Al-Chalabi, T; McFarlane, IG
Cost-effectiveness of pharmacotherapy for autoimmune hepatitis.
Expert Opin Pharmacother
7
145-56
2006
Homo sapiens
Hindorf, U; Lindqvist, M; Peterson, C; Söderkvist, P; Ström, M; Hjortswang, H; Pousette, A; Almer, S
Pharmacogenetics during standardised initiation of thiopurine treatment in inflammatory bowel disease.
Gut
55
1423-31
2006
Homo sapiens
Pierik, M; Rutgeerts, P; Vlietinck, R; Vermeire, S
Pharmacogenetics in inflammatory bowel disease.
World J Gastroenterol
12
3657-67
2006
Homo sapiens
Priest, VL; Begg, EJ; Gardiner, SJ; Frampton, CM; Gearry, RB; Barclay, ML; Clark, DW; Hansen, P
Pharmacoeconomic analyses of azathioprine, methotrexate and prospective pharmacogenetic testing for the management of inflammatory bowel disease.
Pharmacoeconomics
24
767-81
2006
Homo sapiens
Banerjee, S; Bishop, WP
Evolution of thiopurine use in pediatric inflammatory bowel disease in an academic center.
J Pediatr Gastroenterol Nutr
43
324-30
2006
Homo sapiens
Kugathasan, S
Pediatric inflammatory bowel disease: clinical and therapeutic aspects.
Curr Opin Gastroenterol
17
350-5
2001
Homo sapiens
Kitamura, Y; Ihara, T; Tsujimura, Y; Osawa, Y; Jyo, A
Colorimetric allele analysis based on the DNA-directed cooperative formation of luminous lanthanide complexes.
Nucleic Acids Symp Ser (Oxf)
105-6
2006
Chelator
Engen, RM; Marsh, S; Van Booven, DJ; McLeod, HL
Ethnic differences in pharmacogenetically relevant genes.
Curr Drug Targets
7
1641-8
2006
Homo sapiens
Song, DK; Zhao, J; Zhang, LR
TPMT genotype and its clinical implication in renal transplant recipients with azathioprine treatment.
J Clin Pharm Ther
31
627-35
2006
Homo sapiens
Marsh, S
Impact of pharmacogenomics on clinical practice in oncology.
Mol Diagn Ther
11
79-82
2007
Homo sapiens
Reinshagen, M; Schütz, E; Armstrong, VW; Behrens, C; von Tirpitz, C; Stallmach, A; Herfarth, H; Stein, J; Bias, P; Adler, G; Shipkova, M; Kruis, W; Oellerich, M; von Ahsen, N
6-thioguanine nucleotide-adapted azathioprine therapy does not lead to higher remission rates than standard therapy in chronic active crohn disease: results from a randomized, controlled, open trial.
Clin Chem
53
1306-14
2007
Homo sapiens
Boonsrirat, U; Angsuthum, S; Vannaprasaht, S; Kongpunvijit, J; Hirankarn, N; Tassaneeyakul, W; Avihingsanon, Y
Azathioprine-induced fatal myelosuppression in systemic lupus erythematosus patient carrying TPMT*3C polymorphism.
Lupus
17
132-4
2008
Homo sapiens
Shah, JA; Edwards, CM; Probert, CS
Should azathioprine and 5-aminosalicylates be coprescribed in inflammatory bowel disease?: an audit of adverse events and outcome.
Eur J Gastroenterol Hepatol
20
169-73
2008
Homo sapiens
Czaja, AJ
Safety issues in the management of autoimmune hepatitis.
Expert Opin Drug Saf
7
319-33
2008
Homo sapiens
Slanar, O; Chalupná, P; Novotný, A; Bortlík, M; Krska, Z; Lukás, M
Fatal myelotoxicity after azathioprine treatment.
Nucleosides Nucleotides Nucleic Acids
27
661-5
2008
Homo sapiens
Samochatova, EV; Chupova, NV; Rudneva, A; Makarova, O; Nasedkina, TV; Fedorova, OE; Glotov, AS; Kozhekbaeva, Zh; Maiorova, OA; Roumyantsev, AG; Krynetski, EY; Krynetskaia, NF; Evans, WE; Ribeiro, RC
TPMT genetic variations in populations of the Russian Federation.
Pediatr Blood Cancer
52
203-8
2009
Homo sapiens
Ansari, A; Elliott, T; Baburajan, B; Mayhead, P; O'Donohue, J; Chocair, P; Sanderson, J; Duley, J
Long-term outcome of using allopurinol co-therapy as a strategy for overcoming thiopurine hepatotoxicity in treating inflammatory bowel disease.
Aliment Pharmacol Ther
28
734-41
2008
Homo sapiens
Gurwitz, D; Rodríguez-Antona, C; Payne, K; Newman, W; Gisbert, JP; de Mesa, EG; Ibarreta, D
Improving pharmacovigilance in Europe: TPMT genotyping and phenotyping in the UK and Spain.
Eur J Hum Genet
2009
Homo sapiens
Prandota, J
Advances of Molecular Clinical Pharmacology in Gastroenterology and Hepatology.
Am J Ther
2009
Homo sapiens, Hepacivirus C
Colletti, RB; Baldassano, RN; Milov, DE; Margolis, PA; Bousvaros, A; Crandall, WV; Crissinger, KD; D'Amico, MA; Day, AS; Denson, LA; Dubinsky, M; Ebach, DR; Hoffenberg, EJ; Kader, HA; Keljo, DJ; Leibowitz, IH; Mamula, P; Pfefferkorn, MD; Qureshi, MA; ,
Variation in care in pediatric crohn disease.
J Pediatr Gastroenterol Nutr
49
297-303
2009
Homo sapiens
Lewis, JD; Abramson, O; Pascua, M; Liu, L; Asakura, LM; Velayos, FS; Hutfless, SM; Alison, JE; Herrinton, LJ
Timing of Myelosuppression During Thiopurine Therapy for Inflammatory Bowel Disease: Implications for Monitoring Recommendations.
Clin Gastroenterol Hepatol
2009
Homo sapiens
Vannaprasaht, S; Angsuthum, S; Avihingsanon, Y; Sirivongs, D; Pongskul, C; Makarawate, P; Praditpornsilpa, K; Tassaneeyakul, W; Tassaneeyakul, W
Impact of the heterozygous TPMT*1/*3C genotype on azathioprine-induced myelosuppression in kidney transplant recipients in Thailand.
Clin Ther
31
1524-33
2009
Homo sapiens, Porcine parvovirus, Thais
Schmiegelow, K; Forestier, E; Hellebostad, M; Heyman, M; Kristinsson, J; Söderhäll, S; Taskinen, M; ,
Long-term results of NOPHO ALL-92 and ALL-2000 studies of childhood acute lymphoblastic leukemia.
Leukemia
24
345-54
2010
Homo sapiens
Hanai, H; Iida, T; Takeuchi, K; Arai, O; Watanabe, F; Abe, J; Maruyama, Y; Oohata, A; Ikeya, K; Kageoka, M; Miwa, I; Yoshirou, S; Hosoda, Y; Kubota, T
Thiopurine maintenance therapy for ulcerative colitis: The clinical significance of monitoring 6-thioguanine nucleotide.
Inflamm Bowel Dis
2010
Homo sapiens
Leung, Y; Hanauer, SB
Conventional treatment in inflammatory bowel disease--recent trends. Immunosuppressants and biologic agents: should they or need they be used together? How to use immunosuppressive therapy better (and safer) tomorrow?
Gastroenterol Clin Biol
33 Suppl 3
S202-8
2009
Homo sapiens
Smith, MA; Marinaki, AM; Sanderson, JD
Pharmacogenomics in the treatment of inflammatory bowel disease.
Pharmacogenomics
11
421-37
2010
Homo sapiens
Zukic, B; Radmilovic, M; Stojiljkovic, M; Tosic, N; Pourfarzad, F; Dokmanovic, L; Janic, D; Colovic, N; Philipsen, S; Patrinos, GP; Pavlovic, S
Functional analysis of the role of the TPMT gene promoter VNTR polymorphism in TPMT gene transcription.
Pharmacogenomics
11
547-57
2010
Homo sapiens
Jourdil, N; Fonrose, X; Boulieu, R; Stanke-Labesque, F; ,
[Therapeutic drug monitoring of 6-thioguanine nucleotides in inflammatory bowel disease: interest and limits].
Therapie
65
177-86
0
Homo sapiens
Fakhoury, M; de Beaumais, T; Mdard, Y; Jacqz-Aigrain, E; ,
[Therapeutic drug monitoring of 6-thioguanine nucleotides in paediatric acute lymphoblastic leukaemia: interest and limits].
Therapie
65
187-93
0
Homo sapiens
Cuffari, C
The genetics of inflammatory bowel disease: diagnostic and therapeutic implications.
World J Pediatr
6
203-9
2010
Homo sapiens, Bacteria
Sandborn, WJ
State-of-the-art: immunosuppression and biologic therapy.
Dig Dis
28
536-42
2010
Homo sapiens
Ben Salem, C; Ben Salah, L; Belajouza, C; Bouraoui, K
Azathioprine-induced severe cholestatic hepatitis in patient carrying TPMT*3C polymorphism.
Pharm World Sci
2010
Homo sapiens, Pemphigus, Icterus
Riello, L; Talbotec, C; Garnier-Lenglin, H; Pigneur, B; Svahn, J; Canioni, D; Goulet, O; Schmitz, J; Ruemmele, FM
Tolerance and efficacy of azathioprine in pediatric Crohn's disease.
Inflamm Bowel Dis
2011
Homo sapiens
Roblin, X; Oussalah, A; Chevaux, JB; Sparrow, M; Peyrin-Biroulet, L
Use of thiopurine testing in the management of inflammatory bowel diseases in clinical practice: A worldwide survey of experts.
Inflamm Bowel Dis
2011
Homo sapiens
Budhiraja, P; Popovtzer, M
Azathioprine-related myelosuppression in a patient homozygous for TPMT(*)3A.
Nat Rev Nephrol
7
478-84
2011
Homo sapiens
Waxweiler, WT; Agans, R; Morrell, DS
Systemic treatment of pediatric atopic dermatitis with azathioprine and mycophenolate mofetil.
Pediatr Dermatol
28
689-94
0
Homo sapiens
Hoentjen, F; Hanauer, SB; de Boer, NK; Rubin, DT
Two brothers with skewed thiopurine metabolism in ulcerative colitis treated successfully with allopurinol and mercaptopurine dose reduction.
Dig Dis Sci
57
250-3
2012
Homo sapiens
Levesque, BG; Loftus, EV
Initiating Azathioprine for Crohn's Disease.
Clin Gastroenterol Hepatol
2012
Homo sapiens
Ciccolini, J; Evrard, A; M'batchi, L; Pourroy, B; Mercier, C; Iliadis, A; Lacarelle, B; Verschuur, A; Ouafik, L; Andr, N
CDA deficiency as a possible culprit for life-threatening toxicities after cytarabine plus 6-mercaptopurine therapy: pharmacogenetic investigations.
Pharmacogenomics
13
393-7
2012
Homo sapiens
Crandall, WV; Margolis, PA; Kappelman, MD; King, EC; Pratt, JM; Boyle, BM; Duffy, LF; Grunow, JE; Kim, SC; Leibowitz, I; Schoen, BT; Colletti, RB; ,
Improved Outcomes in a Quality Improvement Collaborative for Pediatric Inflammatory Bowel Disease.
Pediatrics
2012
Homo sapiens
Romn, M; Cabaleiro, T; Ochoa, D; Novalbos, J; Chaparro, M; Gisbert, JP; Abad-Santos, F
Validation of a Genotyping Method for Analysis of TPMTPolymorphisms.
Clin Ther
2012
Homo sapiens
Dhaliwal, HK; Anderson, R; Thornhill, EL; Schneider, S; McFarlane, E; Gleeson, D; Lennard, L
Clinical significance of azathioprine metabolites for the maintenance of remission in autoimmune hepatitis.
Hepatology
2012
Homo sapiens
Dassopoulos, T; Sninsky, CA
Optimizing immunomodulators and anti-TNF agents in the therapy of Crohn disease.
Gastroenterol Clin North Am
41
393-409, ix
2012
Homo sapiens
Roberts, RL; Barclay, ML
The Current Relevance of Pharmacogenetics in Immunomodulation Treatment for Crohn's Disease.
J Gastroenterol Hepatol
2012
Homo sapiens
Stocco, G; Yang, W; Crews, KR; Thierfelder, WE; Decorti, G; Londero, M; Franca, R; Rabusin, M; Valsecchi, MG; Pei, D; Cheng, C; Paugh, SW; Ramsey, LB; Diouf, B; McCorkle, JR; Jones, TS; Pui, CH; Relling, MV; Evans, WE
PACSIN2 polymorphism influences TPMT activity and mercaptopurine-related gastrointestinal toxicity.
Hum Mol Genet
2012
Homo sapiens
Caufield, M; Tom, WL
Oral azathioprine for recalcitrant pediatric atopic dermatitis: Clinical response and thiopurine monitoring.
J Am Acad Dermatol
2012
Homo sapiens
Lorenz, M; Weise, A; Prause, S; Klemm, M; Eidens, M; Luchi, M; Forst, T; Pftzner, A; Weber, MM
Development and validation of a rapid and reliable method for TPMT genotyping using real-time PCR.
Clin Lab
58
959-71
2012
Homo sapiens
Appell, ML; Wagner, A; Hindorf, U
A skewed thiopurine metabolism is a common clinical phenomenon that can be successfully managed with a combination of low-dose azathioprine and allopurinol.
J Crohns Colitis
2012
Homo sapiens
Skrzypczak-Zielinska, M; Borun, P; Milanowska, K; Jakubowska-Burek, L; Zakerska, O; Dobrowolska-Zachwieja, A; Plawski, A; Froster, UG; Szalata, M; Slomski, R
High-resolution melting analysis of the TPMT gene: a study in the Polish population.
Genet Test Mol Biomarkers
17
153-9
2013
Homo sapiens
Elawi, AM; Irshaid, YM; Ismail, SI; Mustafa, KN
Thiopurine S-methytransferase Gene Polymorphism in Rheumatoid Arthritis.
Arch Med Res
44
105-9
2013
Homo sapiens
Liang, JJ; Geske, JR; Boilson, BA; Frantz, RP; Edwards, BS; Kushwaha, SS; Kremers, WK; Weinshilboum, RM; Pereira, NL
TPMT genetic variants are associated with increased rejection with azathioprine use in heart transplantation.
Pharmacogenet Genomics
23
658-65
2013
Homo sapiens
Lee, MN; Woo, HI; Lee, YM; Kang, B; Kim, JW; Choe, YH; Lee, SY
Successful azathioprine treatment with metabolite monitoring in a pediatric inflammatory bowel disease patient homozygous for TPMT*3C.
Yonsei Med J
54
1545-9
2013
Homo sapiens
Neuraz, A; Chouchana, L; Malamut, G; Le Beller, C; Roche, D; Beaune, P; Degoulet, P; Burgun, A; Loriot, MA; Avillach, P
Phenome-wide association studies on a quantitative trait: application to TPMT enzyme activity and thiopurine therapy in pharmacogenomics.
PLoS Comput Biol
9
e1003405
2013
Homo sapiens
Levinsen, M; Rotevatn, E; Rosthj, S; Nersting, J; Abrahamsson, J; Appell, ML; Bergan, S; Bechensteen, AG; Harila-Saari, A; Heyman, M; Jonsson, OG; Maxild, JB; Niemi, M; Sderhll, S; Schmiegelow, K; ,
Pharmacogenetically based dosing of thiopurines in childhood acute lymphoblastic leukemia: Influence on cure rates and risk of second cancer.
Pediatr Blood Cancer
61
797-802
2014
Homo sapiens
Chen, D; Yang, Z; Xia, H; Huang, JF; Zhang, Y; Jiang, TN; Wang, GY; Chuai, ZR; Fu, WL; Huang, Q
Enhanced Specificity of TPMT*2 Genotyping Using Unidirectional Wild-Type and Mutant Allele-Specific Scorpion Primers in a Single Tube.
PLoS One
9
e91824
2014
clinical samples
Kopylov, U; Amre, D; Theoret, Y; Deslandres, C; Seidman, EG
Thiopurine metabolite ratios for monitoring therapy in pediatric crohn disease.
J Pediatr Gastroenterol Nutr
59
511-5
2014
Homo sapiens
Schmiegelow, K; Nielsen, SN; Frandsen, TL; Nersting, J
Mercaptopurine/Methotrexate maintenance therapy of childhood acute lymphoblastic leukemia: clinical facts and fiction.
J Pediatr Hematol Oncol
36
503-17
2014
Homo sapiens
Burchard, PR; Abou Tayoun, AN; Lefferts, JA; Lewis, LD; Tsongalis, GJ; Cervinski, MA
Development of a rapid clinical TPMT genotyping assay.
Clin Biochem
47
126-9
2014
Homo sapiens
Nielsen, SN; Frandsen, TL; Nersting, J; Hjalgrim, LL; Schmiegelow, K
Pharmacokinetics of 6-Thioguanine and 6-Mercaptopurine Combination Maintenance Therapy of Childhood ALL: Hypothesis and Case Report.
J Pediatr Hematol Oncol
37
e206-9
2015
Homo sapiens
Kim, HY; Lee, SH; Lee, MN; Kim, JW; Kim, YH; Kim, MJ; Lee, YM; Kang, B; Choe, YH; Lee, NH; Kim, DH; Yoo, KH; Sung, KW; Lee, SY; Koo, HH
Complete sequence-based screening of TPMT variants in the Korean population.
Pharmacogenet Genomics
25
143-6
2015
Homo sapiens
Misdaq, M; Ziegler, S; von Ahsen, N; Oellerich, M; Asif, AR
Thiopurines induce oxidative stress in T-lymphocytes: a proteomic approach.
Mediators Inflamm
2015
434825
2015
Homo sapiens
Bernek, M; Drastkov, M; Bure, J; Pali?ka, V
Preparing Triple-Compound Heterozygous Control Material for Molecular Diagnostics of TPMT Allelic Variants.
Folia Biol (Praha)
61
91-6
2015
Homo sapiens
Katara, P; Kuntal, H
TPMT Polymorphism: When Shield Becomes Weakness.
Interdiscip Sci
2015
Bacteria, eukaryota
O'Donnell, PH; Danahey, K; Ratain, MJ
The Outlier in All of Us: Why Implementing Pharmacogenomics Could Matter for Everyone.
Clin Pharmacol Ther
99
401-4
2016
Homo sapiens
Fangbin, Z; Xiang, G; Liang, D; Hui, L; Xueding, W; Baili, C; Huichang, B; Yinglian, X; Peng, C; Lizi, Z; Yanjun, C; Feng, X; Minhu, C; Min, H; Pinjin, H
Prospective Evaluation of Pharmacogenomics and Metabolite Measurements upon Azathioprine Therapy in Inflammatory Bowel Disease: An Observational Study.
Medicine (Baltimore)
95
e3326
2016
Homo sapiens
Ladi?, A; Boina, N; Borzan, V; Brinar, M; Vuceli?, B; Cukovi?-Cavka, S
AN EPIDEMIOLOGICAL STUDY OF THIOPURINE-METHYLTRANSFERASE VARIANTS IN A CROATIAN INFLAMMATORY BOWEL DISEASE PATIENT COHORT.
Acta Clin Croat
55
16-22
2016
Homo sapiens
Jourdil, N; Fonrose, X; Boulieu, R; Stanke-Labesque, F; ,
[Not Available].
Therapie
65
177-86
0
Homo sapiens
Fakhoury, M; Jacqz-Aigrain, E; , ; de Beaumais, T; Mdard, Y
[Not Available].
Therapie
65
187-93
0
Homo sapiens
Kiszka-Kanowitz, M; Theede, K; Mertz-Nielsen, A
Randomized clinical trial: a pilot study comparing efficacy of low-dose azathioprine and allopurinol to azathioprine on clinical outcomes in inflammatory bowel disease.
Scand J Gastroenterol
51
1470-1475
2016
Homo sapiens
Wong, DR; Coenen, MJ; Derijks, LJ; Vermeulen, SH; van Marrewijk, CJ; Klungel, OH; Scheffer, H; Franke, B; Guchelaar, HJ; de Jong, DJ; Engels, LG; Verbeek, AL; Hooymans, PM; ,
Early prediction of thiopurine-induced hepatotoxicity in inflammatory bowel disease.
Aliment Pharmacol Ther
45
391-402
2017
Homo sapiens
Liberal, R; de Boer, YS; Andrade, RJ; Bouma, G; Dalekos, GN; Floreani, A; Gleeson, D; Hirschfield, GM; Invernizzi, P; Lenzi, M; Lohse, AW; Macedo, G; Milkiewicz, P; Terziroli, B; van Hoek, B; Vierling, JM; Heneghan, MA; ,
Expert clinical management of autoimmune hepatitis in the real world.
Aliment Pharmacol Ther
45
723-732
2017
Homo sapiens
Stocco, G; Martelossi, S; Arrigo, S; Barabino, A; Aloi, M; Martinelli, M; Miele, E; Knafelz, D; Romano, C; Naviglio, S; Favretto, D; Cuzzoni, E; Franca, R; Decorti, G; Ventura, A
Multicentric Case-Control Study on Azathioprine Dose and Pharmacokinetics in Early-onset Pediatric Inflammatory Bowel Disease.
Inflamm Bowel Dis
23
628-634
2017
Homo sapiens
Mowat, C; Arnott, I; Cahill, A; Smith, M; Ahmad, T; Subramanian, S; Travis, S; Morris, J; Hamlin, J; Dhar, A; Nwokolo, C; Edwards, C; Creed, T; Bloom, S; Yousif, M; Thomas, L; Campbell, S; Lewis, SJ; Sebastian, S; Sen, S; Lal, S; Hawkey, C; Murray, C; Cummings, F; Goh, J; Lindsay, JO; Arebi, N; Potts, L; McKinley, AJ; Thomson, JM; Todd, JA; Collie, M; Dunlop, MG; Mowat, A; Gaya, DR; Winter, J; Naismith, GD; Ennis, H; Keerie, C; Lewis, S; Prescott, RJ; Kennedy, NA; Satsangi, J; ,
Mercaptopurine versus placebo to prevent recurrence of Crohn's disease after surgical resection (TOPPIC): a multicentre, double-blind, randomised controlled trial.
Lancet Gastroenterol Hepatol
1
273-282
2016
Homo sapiens
Bhavsar, AP; Gunaretnam, EP; Li, Y; Hasbullah, JS; Carleton, BC; Ross, CJ
Pharmacogenetic variants in TPMT alter cellular responses to cisplatin in inner ear cell lines.
PLoS One
12
e0175711
2017
Homo sapiens, Mus musculus
Haylett, WJ
The Relationship of Genetics, Nursing Practice, and Informatics Tools in 6-Mercaptopurine Dosing in Pediatric Oncology [Formula: see text].
J Pediatr Oncol Nurs
34
342-346
0
Homo sapiens
Vande Casteele, N; Herfarth, H; Katz, J; Falck-Ytter, Y; Singh, S
American Gastroenterological Association Institute Technical Review on the Role of Therapeutic Drug Monitoring in the Management of Inflammatory Bowel Diseases.
Gastroenterology
153
835-857.e6
2017
Homo sapiens
Raj, LS; Hawthorne, AB
Optimising use of thiopurines in inflammatory bowel disease.
Frontline Gastroenterol
1
44-51
2010
Homo sapiens
Roberts, RL; Gearry, RB; Kennedy, MA; Barclay, ML
Beyond TPMT: genetic influences on thiopurine drug responses in inflammatory bowel disease.
Per Med
5
233-248
2008
Homo sapiens
Jensen, CH; Tiu, J; Catalanotti, JS
Azathioprine-induced pancytopenia with normal TPMT activity presenting with HSV oral ulcers.
BMJ Case Rep
2018
2018
Homo sapiens
Parkar, SP; Dherai, AJ; Desai, DC; Ashavaid, TF
Thiopurine metabolite level and toxicity in Indians with inflammatory bowel disease.
JGH Open
1
25-31
2017
Homo sapiens
Anandi, P; Dickson, AL; Feng, Q; Wei, WQ; Dupont, WD; Plummer, D; Liu, G; Octaria, R; Barker, KA; Kawai, VK; Birdwell, K; Cox, NJ; Hung, A; Stein, CM; Chung, CP
Combining clinical and candidate gene data into a risk score for azathioprine-associated leukopenia in routine clinical practice.
Pharmacogenomics J
2020
Homo sapiens
Harmand, PO; Solassol, J
Thiopurine Drugs in the Treatment of Ulcerative Colitis: Identification of a Novel Deleterious Mutation in TPMT.
Genes (Basel)
11
2020
Homo sapiens
Karol, SE; Yang, JJ
Pharmacogenomics and ALL treatment: How to optimize therapy.
Semin Hematol
57
130-136
2020
Homo sapiens
Taha, N; Hosein, K; Grant-Orser, A; Lin-Shaw, A; Mura, M
TPMT and HLA-DQA1-HLA-DRB genetic profiling to guide the use of azathioprine in the treatment of interstitial lung disease: First experience.
Pulm Pharmacol Ther
66
101988
2021
Homo sapiens
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