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Literature summary for 2.1.1.67 extracted from

  • el-Azhary, R.A.; Farmer, S.A.; Drage, L.A.; Rogers, R.S.; McEvoy, M.T.; Davis, M.D.; Bridges, A.G.; Gibson, L.E.
    Thioguanine nucleotides and thiopurine methyltransferase in immunobullous diseases: optimal levels as adjunctive tools for azathioprine monitoring (2009), Arch. Dermatol., 145, 644-652.
    View publication on PubMed
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Application

Application Comment Organism
medicine induction of thiopurine methyltransferase is associated with recalcitrant disease Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + 6-thioguanine
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methylthioguanine
-
 ?

Synonyms

Synonyms Comment Organism
thiopurine methyltransferase
-
 Homo sapiens
TPMT
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens longitudinal induction of thiopurine methyltransferase activity is observed during 6-thioguanine treatment up