Literature summary for 2.1.1.67 extracted from

Ames, M.M.; Selassie, C.D.; Woodson, L.C.; Van Loon, J.A.; Hansch, C.; Weinshilboum, R.M.
Thiopurine methyltransferase: structure-activity relationships for benzoic acid inhibitors and thiophenol substrates (1986), J. Med. Chem., 29, 354-358.

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Application

Application	Comment	Organism
medicine	enzyme activity might represent one factor responsible for variations in the therapeutic or toxic effects of thiopurine and thiopyrimidine drugs used clinically to treat recipients of transplanted kidneys and patients with renal disease such as glomerulonephritis	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
3,4,5-triiodobenzoic acid	-	Homo sapiens
3,4-dimethoxybenzoic acid	-	Homo sapiens
3,5-dichlorobenzoic acid	-	Homo sapiens
3,5-dihydroxy-4-methoxybenzoic acid	-	Homo sapiens
3,5-dimethylbenzoic acid	-	Homo sapiens
3,5-dinitrobenzoic acid	-	Homo sapiens
3-bromo-5-hydroxy-4-methoxybenzoic acid	-	Homo sapiens
3-chloro-5-hydroxy-4-methoxybenzoic acid	-	Homo sapiens
3-hydroxy-4,5-dimethoxybenzoic acid	-	Homo sapiens
3-hydroxy-4-methoxy-5-(dimethylamino)benzoic acid	-	Homo sapiens
3-hydroxy-4-methoxy-5-nitrobenzoic acid	-	Homo sapiens
3-hydroxy-4-methoxybenzoic acid	-	Homo sapiens
3-hydroxy-5-iodo-4-methoxybenzoic acid	-	Homo sapiens
4-hydroxy-3-methoxybenzoic acid	-	Homo sapiens
benzoic acid	substituted benzoic acids, benzoic acid compounds, noncompetitive inhibition	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
additional information	-	additional information	various thiophenols as substrates, Km 0.0008-0.0078	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
S-adenosyl-L-methionine + a thiopurine	Homo sapiens	enzyme plays an important role in metabolism of heterocyclic sulfhydryl drugs such as 6-thiopurine and 6-thioguanine	S-adenosyl-L-homocysteine + a thiopurine S-methylether	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	human	-

Purification (Commentary)

Purification (Comment)	Organism
partially	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
erythrocyte	-	Homo sapiens	-
kidney	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + 2-aminothiophenol	-	Homo sapiens	S-adenosyl-L-homocysteine + 2-methylsulfanylphenylamine	-	?
S-adenosyl-L-methionine + 2-bromothiophenol	-	Homo sapiens	S-adenosyl-L-homocysteine + 1-bromo-2-methylsulfanylbenzene	-	?
S-adenosyl-L-methionine + 2-methoxythiophenol	-	Homo sapiens	S-adenosyl-L-homocysteine + 1-methoxy-2-methylsulfanylbenzene	-	?
S-adenosyl-L-methionine + 3-methoxythiophenol	-	Homo sapiens	S-adenosyl-L-homocysteine + 1-methylsulfanyl-3-methoxybenzene	-	?
S-adenosyl-L-methionine + 4-(aminomethoxy)thiophenol	-	Homo sapiens	S-adenosyl-L-homocysteine + 1-aminomethoxy-4-methylsulfanylbenzene	-	?
S-adenosyl-L-methionine + 4-bromothiophenol	-	Homo sapiens	S-adenosyl-L-homocysteine + 1-bromo-4-methylsulfanylbenzene	-	?
S-adenosyl-L-methionine + 4-chlorothiophenol	-	Homo sapiens	S-adenosyl-L-homocysteine + 1-chloro-4-methylsulfanylbenzene	-	?
S-adenosyl-L-methionine + 4-fluorothiophenol	-	Homo sapiens	S-adenosyl-L-homocysteine + 1-fluoro-4-methylsulfanylbenzene	-	?
S-adenosyl-L-methionine + 4-methoxythiophenol	-	Homo sapiens	S-adenosyl-L-homocysteine + 1-methoxy-4-methylsulfanylbenzene	-	?
S-adenosyl-L-methionine + 4-methylthiophenol	-	Homo sapiens	S-adenosyl-L-homocysteine + 1-methyl-4-methylsulfanylbenzene	-	?
S-adenosyl-L-methionine + 4-nitrothiophenol	-	Homo sapiens	S-adenosyl-L-homocysteine + 1-methylsulfanyl-4-nitrobenzene	-	?
S-adenosyl-L-methionine + 4-thiobenzoate	-	Homo sapiens	S-adenosyl-L-homocysteine + 4-methylsulfanyl benzoate	-	?
S-adenosyl-L-methionine + 6-thiopurine	-	Homo sapiens	S-adenosyl-L-homocysteine + 6-methylthiopurine	-	?
S-adenosyl-L-methionine + a thiopurine	-	Homo sapiens	S-adenosyl-L-homocysteine + a thiopurine S-methylether	-	?
S-adenosyl-L-methionine + a thiopurine	enzyme plays an important role in metabolism of heterocyclic sulfhydryl drugs such as 6-thiopurine and 6-thioguanine	Homo sapiens	S-adenosyl-L-homocysteine + a thiopurine S-methylether	-	?

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Release 2023.1 (January 2023)