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Literature summary for 2.1.1.67 extracted from
- Clinical significance of thiopurine S-methyltransferase gene polymorphisms (2007), Curr. Pharmacogenomics, 5, 103-115.
No PubMed abstract available
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| A154T | polymorphism TPMT*3B | Mammalia |
| A154T/Y240C | polymorphism TPMT*3A | Mammalia |
| A154T/Y240C/E98STOP | polymorphism TPMT*3D | Mammalia |
| A80P | polymorphism TPMT*2 | Mammalia |
| C132Y | polymorphism TPMT*11 | Mammalia |
| E28V | polymorphism TPMT*13 | Mammalia |
| G144R | polymorphism TPMT*10 | Mammalia |
| G36S/K238E | polymorphism TPMT*20 | Mammalia |
| G71R | polymorphism TPMT*18 | Mammalia |
| H227E | polymorphism TPMT*7 | Mammalia |
| K122T | polymorphism TPMT*19 | Mammalia |
| L49S | polymorphism TPMT*5 | Mammalia |
| L69V | polymorphism TPMT*21 | Mammalia |
| additional information | no amino acid substitutions in the polymorphisms TPMT*4 and TPMT*15, Met-Val substitution in the start codon of TPMT*14 | Mammalia |
| Q42E | polymorphism TPMT*17 | Mammalia |
| R163H | polymorphism TPMT*16 | Mammalia |
| R163P | polymorphism TPMT*22 | Mammalia |
| R215H | polymorphism TPMT*8 | Mammalia |
| S125L | polymorphism TPMT*12 | Mammalia |
| Y180F | polymorphism TPMT*6 | Mammalia |
| Y240C | polymorphism TPMT*3C | Mammalia |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| aspirin | - |
Mammalia |  |
| bendroflumethiazide | - |
Mammalia | |
| Disulfiram | - |
Mammalia | |
| Furosemide | - |
Mammalia | |
| mesalazine | - |
Mammalia | |
| olsalazine | - |
Mammalia | |
| sulfasalazine | - |
Mammalia | |
| trichlormethiazide | - |
Mammalia | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Mammalia | 5829 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 35000 | - |
- |
Mammalia |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + a thiopurine | Mammalia | - |
S-adenosyl-L-homocysteine + a thiopurine S-methylether | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mammalia | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| erythrocyte | - |
Mammalia | - |
| heart | - |
Mammalia | - |
| intestine | - |
Mammalia | - |
| kidney | - |
Mammalia | - |
| liver | - |
Mammalia | - |
| lymphocyte | - |
Mammalia | - |
| pancreas | - |
Mammalia | - |
| placenta | - |
Mammalia | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + 6-mercaptopurine | - |
Mammalia | S-adenosyl-L-homocysteine + 6-methylmercaptopurine | - |
? | |
| S-adenosyl-L-methionine + 6-thioguanine | - |
Mammalia | S-adenosyl-L-homocysteine + 6-methylthioguanine | - |
? | |
| S-adenosyl-L-methionine + 6-thioinosine-monophosphate | - |
Mammalia | S-adenosyl-L-homocysteine + 6-methylthioinosine-monophosphate | - |
? | |
| S-adenosyl-L-methionine + a thiopurine | - |
Mammalia | S-adenosyl-L-homocysteine + a thiopurine S-methylether | - |
? | |
| S-adenosyl-L-methionine + azathioprine | azathioprine is converted to mercaptopurine, which is subsequently metabolized through TPMT | Mammalia | S-adenosyl-L-homocysteine + 6-methylmercaptopurine + ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| thiopurine S-methyltransferase | - |
Mammalia |
| TPMT | - |
Mammalia |
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